Differences in DNA condensation and release by lysine and arginine homopeptides govern their DNA delivery efficiencies

Molecular Pharmaceutics

Volumn 8, Issue 5, 2011, Pages 1729-1741

  Mann, Anita ^a   Thakur, Garima ^a   Shukla, Vasundhara ^a   Singh, Anand Kamal ^a   Khanduri, Richa ^a   Naik, Rangeetha ^a   Jiang, Yang ^c   Kalra, Namita ^b   Dwarakanath, B S ^b   Langel, Ulo ^c   Ganguli, Munia ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

^c STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

atomic forcemicroscopy; cationic peptides; condensation release balance; DNA condensation; nonviral gene delivery; structure activity correlation

Indexed keywords

ARGININE; DNA; ETHIDIUM BROMIDE; LYSINE;

ANIMAL CELL; ARTICLE; ATOMIC FORCE MICROSCOPY; BIOPHYSICS; COMPLEX FORMATION; CONTROLLED STUDY; DRUG RELEASE; FLOW CYTOMETRY; FLUORESCENCE SPECTROSCOPY; GEL ELECTROPHORESIS; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; PARTICLE SIZE; POLYMERIZATION; PRIORITY JOURNAL; STATIC ELECTRICITY;

ANIMALS; ARGININE; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; CRICETULUS; DNA PACKAGING; DNA, NEOPLASM; DNA, VIRAL; DNA-BINDING PROTEINS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; LYSINE; MOLECULAR WEIGHT; NEOPLASMS; NUCLEIC ACID CONFORMATION; OLIGOPEPTIDES; PARTICLE SIZE; PEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80053527690     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp2000814     Document Type: Article

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