Analysis of cagA in helicobacter pylori strains from colombian populations with contrasting gastric cancer risk reveals a biomarker for disease severity

Cancer Epidemiology Biomarkers and Prevention

Volumn 20, Issue 10, 2011, Pages 2237-2249

  Loh, John T ^a   Shaffer, Carrie L ^a   Blanca Piazuelo, M ^a   Bravo, Luis E ^c   McClain, Mark S ^a   Correa, Pelayo ^a   Cover, Timothy L ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSIDAD DEL VALLE   (Colombia)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; BIOLOGICAL MARKER; CAGA PROTEIN;

ADULT; AFRICA; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CAGA GENE; CANCER RISK; CLINICAL ARTICLE; COLOMBIA; DISEASE SEVERITY; GENE EXPRESSION; HELICOBACTER PYLORI; HISTOPATHOLOGY; HUMAN; MALE; NONHUMAN; PHYLOGENY; PRECANCER; PRIORITY JOURNAL; PROTEIN MOTIF; STOMACH BIOPSY; STOMACH CANCER; STOMACH CARCINOGENESIS; TRANSLATION INITIATION;

ADULT; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BIOPSY; BLOTTING, WESTERN; CASE-CONTROL STUDIES; COHORT STUDIES; COLOMBIA; DNA, BACTERIAL; FEMALE; FOLLOW-UP STUDIES; GASTRIC MUCOSA; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; MIDDLE AGED; MUTAGENESIS; NUCLEOTIDE MOTIFS; PRECANCEROUS CONDITIONS; PROGNOSIS; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; RISK FACTORS; STOMACH; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 80053510143     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-11-0548     Document Type: Article

References (55)

1. Polk DB, Peek RM Jr. Helicobacter pylori: gastric cancer and beyond. Nat Rev Cancer 2010;10:403-14.
2. Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med 2002;347:1175-86.
3. Atherton JC, Blaser MJ. Coadaptation of Helicobacter pylori and humans: ancient history, modern implications. J Clin Invest 2009;119:2475-87.
4. Amieva MR, El-Omar EM. Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology 2008;134:306-23. (Pubitemid 350309334)
5. Cover TL, Blaser MJ. Helicobacter pylori in health and disease. Gastroenterology 2009;136:1863-73.
6. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process-First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 1992;52:6735-40. (Pubitemid 23006271)
7. Tummuru MK, Cover TL, Blaser MJ. Cloning and expression of a high-molecular- mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production. Infect Immun 1993;61:1799-809. (Pubitemid 23145878)
8. Covacci A, Censini S, Bugnoli M, Petracca R, Burroni D, Macchia G, et al. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci 1993;90:5791-5. (Pubitemid 23176248)
9. Blaser MJ, Perez-Perez GI, Kleanthous H, Cover TL, Peek RM, Chyou PH, et al. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 1995;55:2111-5.
10. Parsonnet J, Friedman GD, Orentreich N, Vogelman H. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut 1997;40:297-301. (Pubitemid 27145639)
11. Huang JQ, Zheng GF, Sumanac K, Irvine EJ, Hunt RH. Meta-analysis of the relationship between cagA seropositivity and gastric cancer. Gastroenterology 2003;125:1636-44. (Pubitemid 37500427)
12. Plummer M, Van Doorn LJ, Franceschi S, Kleter B, Canzian F, Vivas J, et al. Helicobacter pylori cytotoxin-associated genotype and gastric precancerous lesions. J Natl Cancer Inst 2007;99:1328-34. (Pubitemid 47394171)
13. Figueiredo C, Machado JC, Pharoah P, Seruca R, Sousa S, Carvalho R, et al. Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer Inst 2002;94:1680-7. (Pubitemid 35446836)
14. Blaser MJ. The biology of cag in the Helicobacter pylori-human interaction. Gastroenterology 2005;128:1512-5. (Pubitemid 40712200)
15. Tegtmeyer N, Wessler S, Backert S. Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis. FEBS J 2011;278:1190-202.
16. Bourzac KM, Guillemin K. Helicobacter pylori-host cell interactions mediated by type IV secretion. Cell Microbiol 2005;7:911-9. (Pubitemid 40903315)
17. Hatakeyama M. Oncogenic mechanisms of the Helicobacter pylori CagA protein. Nat Rev Cancer 2004;4:688-94. (Pubitemid 39215067)
18. Odenbreit S, Puls J, Sedlmaier B, Gerland E, Fischer W, Haas R. Translocation of Helicobacter pyloriCagA into gastric epithelial cells by type IV secretion. Science 2000;287:1497-500. (Pubitemid 30127145)
19. Stein M, Rappuoli R, Covacci A. Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation. Proc Natl Acad Sci U S A 2000;97:1263-8. (Pubitemid 30080847)
20. Hatakeyama M. Anthropological and clinical implications for the structural diversity of the Helicobacter pylori CagA oncoprotein. Cancer Sci 2011;102:36-43.
21. Tan S, Tompkins LS, Amieva MR. Helicobacter pylori usurps cell polarity to turn the cell surface into a replicative niche. PLoS Pathog 2009;5:e1000407.
22. Backert S, Tegtmeyer N, Selbach M. The versatility of Helicobacter pylori CagA effector protein functions: the master key hypothesis. Helicobacter 2010;15:163-76.
23. Muyskens JB, Guillemin K. Helicobacter pylori CagA disrupts epithelial patterning by activating myosin light chain. PLoS One 2011;6:e17856.
24. Correa P, Cuello C, Duque E, Burbano LC, Garcia FT, Bolanos O, et al. Gastric cancer in Colombia. III. Natural history of precursor lesions. J Natl Cancer Inst 1976;57:1027-35.
25. Cuello C, Correa P, Haenszel W, Gordillo G, Brown C, Archer M, et al. Gastric cancer in Colombia. I. Cancer risk and suspect environmental agents. J Natl Cancer Inst 1976;57:1015-20.
26. Camargo MC, Yepez MC, Ceron C, Guerrero N, Bravo LE, Correa P, et al. Age at acquisition of Helicobacter pylori infection: comparison of two areas with contrasting risk of gastric cancer. Helicobacter 2004;9:262-70. (Pubitemid 38724763)
27. Bravo LE, Van Doom LJ, Realpe JL, Correa P. Virulence-associated genotypes of Helicobacter pylori: do they explain the African enigma? Am J Gastroenterol 2002;97:2839-42. (Pubitemid 35265437)
28. Naito M,Yamazaki T, Tsutsumi R, Higashi H,Onoe K, Yamazaki S, et al. Influence of EPIYA-repeat polymorphism on the phosphorylationdependent biological activity of Helicobacter pylori CagA. Gastroenterology 2006;130:1181-90.
29. Higashi H, Yokoyama K, Fujii Y, Ren S, Yuasa H, Saadat I, et al. EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells. J Biol Chem 2005;280:23130-7. (Pubitemid 40853224)
30. Basso D, Zambon CF, Letley DP, Stranges A, Marchet A, Rhead JL, et al. Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms. Gastroenterology 2008;135:91-9. (Pubitemid 351899019)
31. Sicinschi LA,Correa P, Peek RM,CamargoMC, Piazuelo MB, Romero-Gallo J, et al. CagA C-terminal variations in Helicobacter pylori strains from Colombian patients with gastric precancerous lesions. Clin Microbiol Infect 2009;16:369-78.
32. De Sablet T, Piazuelo MB, Shaffer CL, Schneider BG, Asim M, Chaturvedi R, et al. Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. Gut 2011;60:1189-95 doi:10.1136/gut. 2010.234468.
33. Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, et al. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 1997;388:539-47. (Pubitemid 27339996)
34. Shaffer CL, Gaddy JA, Loh JT, Johnson EM, Hill S, Hennig EE, et al. Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface. PLoS Pathog 2011 (in press).
35. Copass M, Grandi G, Rappuoli R. Introduction of unmarked mutations in the Helicobacter pylori vacA gene with a sucrose sensitivity marker. Infect Immun 1997;65:1949-52. (Pubitemid 27193625)
36. Dailidiene D, Dailide G, Kersulyte D, Berg DE. Contraselectable streptomycin susceptibility determinant for genetic manipulation and analysis of Helicobacter pylori. Appl Environ Microbiol 2006;72:5908-14. (Pubitemid 44414617)
37. Busler VJ, Torres VJ, McClain MS, Tirado O, Friedman DB, Cover TL. Protein-protein interactions among Helicobacter pylori cag proteins. J Bacteriol 2006;188:4787-800. (Pubitemid 43956077)
38. Loh JT, Torres VJ, Cover TL. Regulation of Helicobacter pylori cagA expression in response to salt. Cancer Res 2007;67:4709-15. (Pubitemid 46910177)
39. Cao P, McClain MS, Forsyth MH, Cover TL. Extracellular release of antigenic proteins by Helicobacter pylori. Infect Immun 1998;66:2984-86. (Pubitemid 28261813)
40. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International workshop on the histopathology of gastritis, Houston 1994. Am J Surg Pathol 1996;20:1161-81.
41. Rugge M, Correa P, Dixon MF, Hattori T, Leandro G, Lewin K, et al. Gastric dysplasia: the Padova international classification. Am J Surg Pathol 2000;24:167-76. (Pubitemid 30078704)
42. Spohn G, Beier D, Rappuoli R, Scarlato V. Transcriptional analysis of the divergent cagAB genes encoded by the pathogenicity island of Helicobacter pylori. Mol Microbiol 1997;26:361-72. (Pubitemid 27483684)
43. Sabelnikov AG, Greenberg B, Lacks SA. An extended -10 promoter alone directs transcription of the DpnII operon of Streptococcus pneumoniae. J Mol Biol 1995;250:144-55.
44. Forsyth MH, Cover TL. Mutational analysis of the vacA promoter provides insight into gene transcription in Helicobacter pylori. J Bacteriol 1999;181:2261-6. (Pubitemid 29164983)
45. Sharma CM, Hoffmann S, Darfeuille F, Reignier J, Findeiss S, Sittka A, et al. The primary transcriptome of the major human pathogen Helicobacter pylori. Nature 2010;464:250-5.
46. Waters LS, Storz G. Regulatory RNAs in bacteria. Cell 2009;136:615-28.
47. McCullen CA, Benhammou JN, Majdalani N, Gottesman S. Mechanism of positive regulation by DsrA and RprA small noncoding RNAs: pairing increases translation and protects rpoS mRNA from degradation. J Bacteriol 2010;192:5559-71.
48. McNulty SL, Mole BM, Dailidiene D, Segal I, Ally R, Mistry R, et al. Novel 180- and 480-base-pair insertions in African and African-American strains of Helicobacter pylori. J Clin Microbiol 2004;42:5658-63. (Pubitemid 39664350)
49. Camargo MC, Burk RF, Bravo LE, Piazuelo MB, Hill KE, Fontham ET, et al. Plasma selenium measurements in subjects from areas with contrasting gastric cancer risks in Colombia. Arch Med Res 2008;39:443-51.
50. Piazuelo MB, Camargo MC, Mera RM, Delgado AG, Peek RM Jr, Correa H, et al. Eosinophils and mast cells in chronic gastritis: possible implications in carcinogenesis. Hum Pathol 2008;39:1360-9.
51. Whary MT, Sundina N, Bravo LE, Correa P, Quinones F, Caro F, et al. Intestinal helminthiasis in Colombian children promotes a Th2 response to Helicobacter pylori: possible implications for gastric carcinogenesis. Cancer Epidemiol Biomarkers Prev 2005;14:1464-69. (Pubitemid 40807347)
52. Blot WJ, Li JY, Taylor PR, Guo W, Dawsey S, Wang GQ, et al. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst 1993;85:1483-92. (Pubitemid 23269183)
53. Jenab M, Riboli E, Ferrari P, Sabate J, Slimani N, Norat T, et al. Plasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Carcinogenesis 2006;27:2250-7. (Pubitemid 44644814)
54. Gonzalez CA, Pera G, Agudo A, Bueno-de-Mesquita HB, Ceroti M, Boeing H, et al. Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Int J Cancer 2006;118:2559-66.
55. Elliott DE, Summers RW, Weinstock JV. Helminths as governors of immune-mediated inflammation. Int J Parasitol 2007;37:457-64. (Pubitemid 46399709)