Molecular multi-effect screening of environmental pollutants using the MolDarT

Environmental Toxicology

Volumn 23, Issue 1, 2008, Pages 59-67

  Liedtke, Anja ^a   Muncke, Jane ^a   Rüfenacht, Karin ^a   Eggen, Rik I L ^a  

^a SWISS FEDERAL INSTITUTE OF AQUATIC SCIENCE AND TECHNOLOGY   (Switzerland)

Author keywords

cyp1a1; Detoxification; Developing zebrafish; Immune disruption; Metal toxicity; Metallothionein 2; Molecular effect; rag1

Indexed keywords

ACTIVATION GENE; ECOTOXICOLOGICAL SCREENING; ENVIRONMENTAL POLLUTANTS; MOLECULAR EFFECT DETECTION;

BIOMOLECULES; ENVIRONMENTAL PROTECTION; GENE ENCODING;

TOXIC MATERIALS;

1,5 DIMETHYLNAPHTHALENE; 4,4' ISOPROPYLIDENEDIPHENOL; AGRICULTURAL CHEMICAL; ATRAZINE; CADMIUM CHLORIDE; CYPROCONAZOL; CYTOCHROME P450 1A1; ESTRADIOL; ETHINYLESTRADIOL; METALLOTHIONEIN II; NAPHTHALENE DERIVATIVE; NONYLPHENOL; RAG1 PROTEIN; UNCLASSIFIED DRUG; ZINC SULFATE;

CHEMICAL ANALYSIS; CYPRINID; DETECTION METHOD; DETOXIFICATION; ECOTOXICOLOGY; GENE EXPRESSION; IMMUNE RESPONSE; METALLOTHIONEIN; PAH; POLLUTANT; RECOMBINATION; TOXICITY TEST;

ARTICLE; CONTROLLED STUDY; CYP1A1 GENE; DIAGNOSTIC PROCEDURE; ECOTOXICITY; GENE; GENE EXPRESSION REGULATION; GENE TARGETING; IMMUNOTOXICITY; MOLECULAR EFFECT DETECTION; MT2 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLLUTION MONITORING; PRIORITY JOURNAL; RAG1 GENE; TOXICITY TESTING; TRANSCRIPTION REGULATION; ZEBRA FISH;

ANIMALS; CADMIUM CHLORIDE; CYTOCHROME P-450 CYP1A1; DNA PRIMERS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; ESTROGENS; GENE EXPRESSION; NAPHTHALENES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; ZEBRAFISH; ZEBRAFISH PROTEINS; ZINC SULFATE;

DANIO RERIO;

EID: 39449102387     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20305     Document Type: Article

References (43)

1. Abbas AK, Lichtman AH, Pober JS. 1994. Cellular and Molecular Immunology. Philadelphila, USA: W.B. Saunders.
2. Andreasen EA, Spitsbergen JM, Tanguay RL, Stegeman JJ, Heideman W, Peterson RE. 2002. Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryos and larvae: Effects of developmental stage and 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Toxicol Sci 68:403-419.
3. Chan KM, Ku LL, Chan PC, Cheuk WK. 2006. Metallothionein gene expression in zebrafish embryo-larvae and ZFL cell-line exposed to heavy metal ions. Mar Environ Res 62 (Suppl 1): S83-S87.
4. Chen WY, John JA, Lin CH, Lin HF, Wu SC, Chang CY. 2004. Expression of metallothionein gene during embryonic and early larval development in zebrafish. Aquat Toxicol 69:215-227.
5. Denison MS, Nagy SR. 2003. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol 43:309-334.
6. Dong W, Teraoka H, Yamazaki K, Tsukiyama S, Imani S, Imagawa T, Stegeman JJ, Peterson RE, Hiraga T. 2002. 2,3,7,8-Tetrachlorodibenzo-p-dioxin toxicity in the zebrafish embryo: Local circulation failure in the dorsal midbrain is associated with increased apoptosis. Toxicol Sci 69:191-201.
7. Eggen RI, Behra R, Burkhardt-Holm P, Escher BI, Schweigert N. 2004. Challenges in ecotoxicology. Environ Sci Technol 38:58A-64A.
8. Falchuk KH. 1998. The molecular basis for the role of zinc in developmental biology. Mol Cell Biochem 188:414-418.
9. Gabriel FL, Giger W, Guenther K, Kohler HP. 2005. Differential degradation of nonylphenol isomers by Sphingomonas xenophaga Bayram. Appl Environ Microbiol 71:1123-1129.
10. Hall JM, Couse JF, Korach KS. 2001. The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 276:36869-36872.
11. Hermann AC, Kim CH. 2005. Effects of arsenic on zebrafish innate immune system. Mar Biotechnol (NY) 7:494-505.
12. Hermann AC, Millard PJ, Blake SL, Kim CH. 2004. Development of a respiratory burst assay using zebrafish kidneys and embryos. J Immunol Methods 292:119-129.
13. Hinton DE, Kullman SW, Hardman RC, Volz DC, Chen PJ, Carney M, Bencic DC. 2005. Resolving mechanisms of toxicity while pursuing ecotoxicological relevance? Mar Pollut Bull 51:635-648.
14. Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF. 1995. Stages of embryonic-development of the zebrafish. Dev Dyn 203:253-310.
15. Lam SH, Chua HL, Gong Z, Lam TJ, Sin YM. 2004. Development and maturation of the immune system in zebrafish, Danio rerio: A gene expression profiling, in situ hybridization and immunological study. Dev Comp Immunol 28:9-28.
16. Lange M, Gebauer W, Markl J, Nagel R. 1995. Comparison of testing acute toxicity an embryo of zebrafish, Brachydanio rerio and Rtg-2 cytotoxicity as possible alternatives to the acute fish test. Chemosphere 30:2087-2102.
17. Langenau DM, Zon LI. 2005. The zebrafish: A new model of T-cell and thymic development. Nat Rev Immunol 5:307-317.
18. Mattingly CJ, Toscano WA. 2001. Posttranscriptional silencing of cytochrome P4501A1 (CYP1A1) during zebrafish (Danio rerio) development. Dev Dyn 222:645-654.
19. Medina KL, Garrett KP, Thompson LF, Rossi MI, Payne KJ, Kincade PW. 2001. Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen. Nat Immunol 2:718-724.
20. Mombaerts P, Iacomini J, Johnson RS, Herrup K, Tonegawa S, Papaioannou VE. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68:869-877.
21. Muller PY, Janovjak H, Miserez AR, Dobbie Z. 2002. Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques 32:1372-1379.
22. Muncke J, Eggen RIL. 2006. Vitellogenin 1 mRNA as an early molecular biomarker for endocrine disruption in developing zebrafish (Danio rerio). Environ Toxicol Chem 25:2734-2741.
23. Muncke J, Junghans M, Eggen RIL. 2007. Testing estrogenicity of known and novel (xeno-)estrogens in the MolDarT. Environ Toxicol 22:185-193.
24. Nagel R. 2002. DarT: The embryo test with the zebrafish Danio rerio - A general model in ecotoxicology and toxicology. Altex-Alternativen Zu Tierexperimenten 19:38-48.
25. Nguyen LT, Janssen CR. 2001. Comparative sensitivity of embryo-larval toxicity assays with African catfish (Clarias gariepinus) and zebra fish (Danio rerio). Environ Toxicol 16:566-571.
26. Nüsslein-Volhard C, Dahm R, editors. 2002. Zebrafish. A Practical Approach. Oxford: Oxford University Press.
27. Peeva E, Zouali M. 2005. Spotlight on the role of hormonal factors in the emergence of autoreactive B-lymphocytes. Immunol Lett 101:123-143.
28. Riggio M, Filosa S, Parisi E, Scudiero R. 2003. Changes in zinc, copper and metallothionein contents during oocyte growth and early development of the teleost Danio rerio (zebrafish). Comp Biochem Physiol C Toxicol Pharmacol 135:191-196.
29. Rijhsinghani AG, Thompson K, Bhatia SK, Waldschmidt TJ. 1996. Estrogen blocks early T cell development in the thymus. Am J Reprod Immunol 36:269-277.
30. Schulte C, Nagel R. 1994. Testing acute toxicity in the embryo of zebrafish, Brachydanio rerio, as an alternative to the acute fish test - Preliminary results. ATLA-Alternatives to Laboratory Animals 22:12-19.
31. Schweigert N, Eggen RIL, Escher BI, Burkhardt-Holm P, Behra R. 2002. Ecotoxicological assessment of surface waters: A modular approach integrating in vitro methods. ALTEX-Alternativen Zu Tierexperimenten 19:30-37.
32. Trant JM, Gavasso S, Ackers J, Chung BC, Place AR. 2001. Developmental expression of cytochrome P450 aromatase genes (CYP19a and CYP19b) in zebrafish fry (Danio rerio). J Exp Zool 290(5):475-483.
33. Traver D, Herbomel P, Patton EE, Murphey RD, Yoder JA, Litman GW, Catic A, Amemiya CT, Zon LI, Trede NS. 2003. The zebrafish as a model organism to study development of the immune system. Adv Immunol 81:253-330.
34. Trede NS, Langenau DM, Traver D, Look AT, Zon LI. 2004. The use of zebrafish to understand immunity. Immunity 20:367-379.
35. Troxel CM, Buhler DR, Hendricks JD, Bailey GS. 1997. CYP1A induction by β-naphthoflavone, Aroclor 1254, and 2,3,7,8-tetrachlorodibenzo-p- dioxin and its influence on aflatoxin B1 metabolism and DNA adduction in zebrafish. Toxicol Appl Pharmacol 146:69-78.
36. Vaccaro E, Meucci V, Intorre L, Soldani G, Di Bello D, Longo V, Gervasi PG, Pretti C. 2005. Effects of 17 β-estradiol, 4-nonylphenol and PCB 126 on the estrogenic activity and phase 1 and 2 biotransformation enzymes in male sea bass (Dicentrarchus labrax). Aquat Toxicol 75:293-305.
37. Van den Belt K, Berckmans P, Vangenechten C, Verheyen R, Witters H. 2004. Comparative study on the in vitro/in vivo estrogenic potencies of 17β-estradiol, estrone, 17α-ethynylestradiol and nonylphenol. Aquat Toxicol 66:183-195.
38. Wienholds E, Schulte-Merker S, Walderich B, Plasterk RH. 2002. Target-selected inactivation of the zebrafish rag1 gene. Science 297:99-102.
39. Willett CE, Cherry JJ, Steiner LA. 1997a. Characterization and expression of the recombination activating genes (rag1 and rag2) of zebrafish. Immunogenetics 45:394-404.
40. Willett CE, Zapata AG, Hopkins N, Steiner LA. 1997b. Expression of zebrafish rag genes during early development identifies the thymus. Dev Biol 182:331-341.
41. Yamazaki K, Teraoka H, Dong W, Stegeman JJ, Hiraga T. 2002. cDNA cloning and expressions of cytochrome P450 1A in zebrafish embryos. J Vet Med Sci 64:829-833.
42. Yan CHM, Chan KM. 2002. Characterization of zebrafish metallothionein gene promoter in a zebrafish caudal fin cell-line, SJD. 1. Mar Environ Res 54:335-339.
43. Yan CHM, Chan KM. 2004. Cloning of zebrafish metallothionein gene and characterization of its gene promoter region in HepG2 cell line. Biochim Biophys Acta 1679:47-58.