Metabolic and molecular action of Trigonella foenum-graecum (fenugreek) and trace metals in experimental diabetic tissues

Journal of Biosciences

Volumn 36, Issue 2, 2011, Pages 383-396

  Baquer, Najma Zaheer ^a   Kumar, Pardeep ^a   Taha, Asia ^a   Kale, Rk ^a   Cowsik, Sm ^a   McLean, P ^b  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Alloxan diabetes; metabolic pathways; sodium orthovanadate; trace metals; Trigonella foenum graecum seed powder

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALLOXAN; AMINE OXIDASE (FLAVIN CONTAINING); AMYLASE; CATALASE; CHOLESTEROL; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MANGANESE; PHOSPHOPROTEIN PHOSPHATASE; PYRUVATE DEHYDROGENASE; SUCROSE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL; TRIGONELLA FOENUM GRAECUM EXTRACT; VANADATE SODIUM; VANADIC ACID; VANADIUM; ANTIDIABETIC AGENT; PLANT EXTRACT;

DIABETES; ENZYME ACTIVITY; EXPERIMENTAL STUDY; GLUCOSE; MANGANESE; METABOLISM; MOLECULAR ANALYSIS; SEED; SODIUM; TOXICITY; TRACE METAL; VANADIUM;

ADIPOSE TISSUE; ALLOXAN DIABETES MELLITUS; ANTIOXIDANT ACTIVITY; APOPTOSIS; BIOCHEMISTRY; CLINICAL TRIAL (TOPIC); DIABETES MELLITUS; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; DIARRHEA; DIZZINESS; DRUG HYPERSENSITIVITY; DRUG MECHANISM; DRUG POTENTIATION; DRUG SAFETY; ENZYME INHIBITION; ENZYME REGULATION; ERYTHROCYTE; FENUGREEK; FLATULENCE; GLYCEMIC CONTROL; HEART; HISTOCHEMISTRY; HUMAN; HYPERLIPIDEMIA; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN RELEASE; KIDNEY PARENCHYMA; LIPOGENESIS; LIVER PARENCHYMA; MEMBRANE FLUIDITY; MEMBRANE STRUCTURE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PERIPHERAL NERVE; PLANT LEAF; PLANT SEED; POWDER; REVIEW; SIDE EFFECT; SKELETAL MUSCLE; WEIGHT REDUCTION; ANIMAL; DRUG EFFECT; GLUCOSE BLOOD LEVEL; LIPID METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYTOTHERAPY;

ANIMALIA; TRIGONELLA; TRIGONELLA FOENUM-GRAECUM;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; HUMANS; HYPOGLYCEMIC AGENTS; LIPID METABOLISM; MANGANESE; PHYTOTHERAPY; PLANT EXTRACTS; SEEDS; TRIGONELLA; VANADIUM;

EID: 80053470100     PISSN: 02505991     EISSN: 09737138     Source Type: Journal    
DOI: 10.1007/s12038-011-9042-0     Document Type: Review

References (84)

1. JA Abdel-Barry IA Abdel-Hassan AM Jawad MH al-Hakiem 2000 Hypoglycaemic effect of aqueous extract of the leaves of Trigonella foenum-graecum in healthy volunteers East Mediterr. Health J. 6 83 88 11370345 1:STN:280: DC%2BD3M3nsVCluw%3D%3D
2. L Agius WJ Vaartje 1982 The effects of orthovanadate on fatty acid synthesis in isolated rat hepatocytes Biochem. J. 202 791 794 7046738 1:CAS:528:DyaL38XktVCisLg%3D (Pubitemid 12110923)
3. M Al-Habori A Raman 1998 Antidiabetic and hypocholesterolaemic effect of fenugreek Phytother. Res. 12 233 242 10.1002/(SICI)1099-1573(199806)12:4<233: :AID-PTR294>3.0.CO;2-V (Pubitemid 28331456)
4. M Al-Habori A Raman MJ Lawrence P Skett 2001 In vitro effect of fenugreek extracts on intestinal sodium-dependent glucose uptake and hepatic glycogen phosphorylase A Int. J. Exp. Diabetes Res 2 91 99 12369721 10.1155/EDR.2001.91 1:STN:280:DC%2BD38nhtlWitg%3D%3D
5. R Amin AS Abdul-Ghani MS Suleiman 1987 intestinal absorption. Proceedings of the 47th Annual Meeting of the American Diabetes Association (Indianapolis U.S.A.) Diabetes 36 211
6. CJ Bailey PR Flatt V Marks 1989 Effect of Trigonella feonum graecum on drugs inducing hypoglycemia Pharmacol. Ther. 42 361 384 2672051 10.1016/0163-7258(89)90031-4 1:CAS:528:DyaL1MXkvV2lsb0%3D
7. NZ Baquer JS Hothersall AL Greenbaum P McLean 1975 The modifying effect of manganese on the enzymic profiles and pathways of carbohydrate metabolism in rat liver and adipose tissue during development Biochem. Biophys. Res. Commun. 62 634 641 1120070 10.1016/0006-291X(75)90446-5 1:CAS:528:DyaE2MXhtFSls78%3D
8. NZ Baquer D Gupta J Raju 1998 Regulation of metabolic pathways in liver and kidney during experimental diabetes. Effect of antidiabetic compounds Indian J. Clin. Biochem. 13 63 80 10.1007/BF02867866 1:CAS:528:DyaK1MXjtV2juro%3D
9. NZ Baquer M Sinclair S Kunjara UCS Yadav P Mclean 2003 Regulation of glucose utilization and lipogenesis in adipose tissue of diabetic and fat fed animals. Effect of insulin and manganese J. Biosci. 28 101 107 10.1007/BF02706221
10. NZ Baquer A Taha P Kumar P McLean SM Cowsik RK Kale R Singh D Sharma 2009 A metabolic and functional overview of brain aging linked to neurological disorders Biogerontology 10 377 413 19381858 10.1007/s10522-009-9226-2 1:CAS:528:DC%2BD1MXnsFCgu70%3D
11. AJ Barber E Lieth SA Khin DA Antonetti AG Buchanan TW Gardner 1998 Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin J. Clin. Invest. 102 783 791 9710447 10.1172/JCI2425 1:CAS:528:DyaK1cXlsFaqsrg%3D (Pubitemid 28399611)
12. E Basch C Ulbricht G Kuo P Szapary M Smith 2003 Therapeutic applications of fenugreek Altern. Med. Rev. 8 20 27 12611558 (Pubitemid 36330565)
13. JW Baynes 1991 Role of oxidative stress in development of complications of diabetes Diabetes 40 405 412 2010041 10.2337/diabetes.40.4.405 1:CAS:528:DyaK3MXktVGqur8%3D
14. TC Becker H BeltrandelRio RJ Noel JH Johnson CB Newgard 1994 Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels J. Biol. Chem. 19 21234 21238
15. SM Brichard LN Ongemba J Girard JC Henquin 1994 Tissue-specific correction of lipogenic enzyme gene expression in diabetic rats given vanadate Diabetologia 37 1065 1072 7867878 10.1007/BF00418369 1:CAS:528: DyaK2MXitlGlt7c%3D (Pubitemid 24325549)
16. C Broca R Gross P Petit Y Sauvaire M Manteghetti M Tournier P Masiello R Gomis G Ribes 1999 4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties Am. J. Physiol. 277 E617 E623 10516120 1:CAS:528:DyaK1MXntFCjtrc%3D (Pubitemid 29522613)
17. C Broca M Manteghetti R Gross Y Baissac M Jacob P Petit Y Sauvaire G Ribes 2000 4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion Euro. J. Pharmacol. 390 339 345 10.1016/S0014-2999(00)00030-3 1:CAS:528:DC%2BD3cXhsFKjtr4%3D (Pubitemid 30119951)
18. M Brownlee 1995 The pathological implications of protein glycation Clin. Invest. Med. 18 275 281 8549013 1:CAS:528:DyaK2MXosF2itbw%3D (Pubitemid 26004873)
19. A Ceriello A Quatraro D Giugliano 1992 New insights on non-enzymatic glycosylation may lead to therapeutic approaches for the prevention of diabetic complications Diabet. Med. 9 297 299 1576819 10.1111/j.1464-5491.1992.tb01783.x 1:STN:280:DyaK383kvV2ktw%3D%3D
20. RN Fedorak EB Chang JL Madara M Field 1987 Intestinal adaptation to diabetes. Altered Na-dependent nutrient absorption in streptozotocin-treated chronically diabetic rats J. Clin. Invest. 79 1571 1578 2953760 10.1172/JCI112991 1:CAS:528:DyaL2sXkslGmsrg%3D (Pubitemid 17117258)
21. BA Freeman JD Crapo 1982 Biology of diseases: free radicals and tissue injury Lab. Invest. 47 412 426 6290784 1:CAS:528:DyaL38Xlsl2mu7s%3D (Pubitemid 13229679)
22. S Genet RK Kale NZ Baquer 2002 Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues: effect of vanadate and fenugreek (TSP foenum-graecum) Mol. Cell. Biochem. 236 7 12 12190123 10.1023/A:1016103131408 1:CAS:528:DC%2BD38XltV2jsrs%3D (Pubitemid 34851222)
23. AB Goldfine DC Simonson F Folli ME Patti CR Kahn 1995 Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies J. Clin. Endocrinol. Metab. 80 3311 3320 7593444 10.1210/jc.80.11.3311 1:CAS:528:DyaK2MXptleiu7o%3D
24. JK Grover S Yadav V Vats 2002 Medicinal plants of India with anti-diabetic potential J. Ethnopharmacol. 81 81 100 12020931 10.1016/S0378-8741(02)00059-4 1:STN:280:DC%2BD383otVCqsQ%3D%3D (Pubitemid 34518472)
25. G Gupta M Azam NZ Baquer 1992 Effect of experimental diabetes on the catecholamine metabolism in rat brain J. Neurochem. 58 95 100 1345771 10.1111/j.1471-4159.1992.tb09282.x 1:CAS:528:DyaK38Xls1Knsg%3D%3D
26. D Gupta J Raju NZ Baquer 1999 Modulation of some gluconeogenic enzyme activities in diabetic rat liver and kidney: Effect of antidiabetic compounds Indian J. Exp. Biol. 37 196 199 10641146 1:CAS:528:DyaK1MXhtlyrs7w%3D (Pubitemid 29103983)
27. R Hamaoka J Fujii J Miyagawa M Takahashi M Kishimoto M Moriwaki K Yamamoto Y Kajimoto, et al. 1999 Overexpression of the aldose reductase gene induces apoptosis in pancreatic beta-cells by causing a redox imbalance J. Biochem. (Tokyo) 126 41 47 1:CAS:528:DyaK1MXmtlagt7w%3D (Pubitemid 29355391)
28. CE Heyliger AG Tahiliani JH McNeill 1985 Effect of vanadate on elevated blood glucose and depressed cardiac performance of diabetic rats Science 277 1474 1477 10.1126/science.3156405 (Pubitemid 15146989)
29. L Khalki SB M'hamed M Bennis A Chait Z Sokar 2010 Evaluation of the developmental toxicity of the aqueous extract from Trigonella foenum-graecum (L.) in mice J. Ethnopharmacol. 15 321 325 10.1016/j.jep.2010.06.033
30. GL King M Brownlee 1996 The cellular and molecular mechanism of diabetic complications Endocrinol. Metab. Clin. North Am. 25 255 270 8799700 10.1016/S0889-8529(05)70324-8 1:CAS:528:DyaK28XksFShsrs%3D (Pubitemid 26195621)
31. H King RE Aubert WH Herman 1998 Global burden of diabetes,1995-2025: prevalence, numerical estimates, and projections Diabetes Care 21 1414 1431 9727886 10.2337/diacare.21.9.1414 1:STN:280:DyaK1czpsVyluw%3D%3D (Pubitemid 28405191)
32. Kumar P 2010 Membrane-linked functions and glucose transporter (GLUT4) in diabetic and aging female rats: effect of trigonella foenum-graecum and estradiol, Ph.D thesis, Jawaharlal Nehru University, New Delhi
33. S Kunjara DY Wang AL Greenbaum P McLean A Kurtz TW Rademacher 1999 Inositol phosphoglycans in diabetes and obesity: urinary levels of IPG A-type and IPG P-type, and relationship to pathophysiological changes Mol. Genet. Metab. 68 488 502 10607479 10.1006/mgme.1999.2936 1:CAS:528:DyaK1MXotVGgsrs%3D (Pubitemid 30043556)
34. ZL Madder R Thorne 1987 Dietary fiber Prog. Food Nutr. Sci. 11 153 174 (Pubitemid 18075778)
35. Z Madar R Abel S Samish J Arad 1988 Glucose lowering effect of fenugreek in non-insulin dependent diabetics Eur. J. Clin. Nutr. 42 51 54 3286242 1:STN:280:DyaL1c3isV2qtA%3D%3D
36. DH Mak SP Ip PC Li MK Poon KM Ko 1996 Alterations in tissue glutathione antioxidant system in streptozotocin-induced diabetic rats Mol. Cell. Biochem. 162 153 158 8905639 10.1007/BF00227543 1:CAS:528:DyaK28XmsVGmtbw%3D (Pubitemid 26394685)
37. CS Mayanil SM Kazmi NZ Baquer 1982 Changes in monoamine oxidase activity in rat brain during alloxan diabetes J. Neurochem. 38 179 183 7050304 10.1111/j.1471-4159.1982.tb10869.x 1:CAS:528:DyaL38XkslSgtb8%3D (Pubitemid 12189210)
38. JP Mazat R Rossignol M Malgat C Rocher B Faustin T Letellier 2001 What do mitochondrial diseases teach us about normal mitochondrial functions that we already knew: Threshold expression of mitochondrial defects Biochim. Biophys. Acta 1504 20 30 11239482 10.1016/S0005-2728(00)00236-X 1:CAS:528: DC%2BD3MXhsFSit70%3D (Pubitemid 32179655)
39. P McLean S Kunjara AL Greenbaum K Gumaa J López-Prados M Martin-Lomas TW Rademacher 2008 Reciprocal control of pyruvate dehydrogenase kinase and phosphatase by inositol phosphoglycan. Dynamic state set by "push-pull" system J. Biol. Chem. 28 33428 33436 10.1074/jbc. M801781200
40. J Meyerovitch Z Farfel J Sack Y Shechter 1987 Oral administration of vanadate normalizes blood glucose levels in streptozotocin-treated rats. Characterization and mode of action J. Bio. Chem. 262 6658 6662 1:CAS:528:DyaL2sXktVSlt78%3D (Pubitemid 17104143)
41. S Mohammad A Taha RNK Bamezai SF Basir NZ Baquer 2004 Lower doses of vanadium in combination with Trigonella restore altered carbohydrate metabolism and antioxidant status in alloxan diabetic rats Clinica Chimica Acta 342 105 114 10.1016/j.cccn.2003.12.005 (Pubitemid 38352919)
42. S Mohammad A Taha RNK Bamezai NZ Baquer 2006a Modulation of glucose transporter (Glut4) by vanadate and Trigonella in alloxan diabetic rats Life Sci. 18 820 824 10.1016/j.lfs.2005.05.105 (Pubitemid 43082304)
43. S Mohammad A Taha K Akhtar RN Bamezai NZ Baquer 2006 In vivo effect of Trigonella foenum graecum on the expression of Pyruvate kinase, Phosphoenolpyruvate carboxykinase and distribution of glucose transporter (GLUT4) in alloxan diabetic rats Can. J. Physio. Pharm. 84 647 654 10.1139/y05-164 1:CAS:528:DC%2BD28XhtVCgsLbN (Pubitemid 44605728)
44. DE Moller 2001 New drug targets for type 2 diabetes and the metabolic syndrome Nature 13 821 827 10.1038/414821a (Pubitemid 34000786)
45. CJ Mullarky D Edelstein M Brownlee 1990 Free radical generation by early glycation products; a mechanism for accelerated atherogenesis in diabetes Biophys. Res. Commun. 173 932 939 10.1016/S0006-291X(05)80875-7
46. Muralidhara K Narasimhamurthy S Viswanatha BS Ramesh 1999 Acute and subchronic toxicity assessment of debitterized fenugreek powder in the mouse and rat Food Chem. Toxicol. 37 831 838 10506006 10.1016/S0278-6915(99)00076-9 1:CAS:528:DyaK1MXmt1ens7g%3D (Pubitemid 29472434)
47. R Nahas M Moher 2009 Complementary and alternative medicine for the treatment of type 2 diabetes Can. Fam. Physician. 55 591 596 19509199
48. S Panda P Tahiliani A Kar 1999 Inhibition of triiodothyronine production by fenugreek seed extract in mice and rats Pharmacol. Res. 40 405 409 10527654 10.1006/phrs.1999.0510 1:STN:280:DyaK1MvlvFSnsw%3D%3D (Pubitemid 29537421)
49. SP Patil PV Niphadkar MM Bapat 1997 Allergy to fenugreek (Trigonella foenum graecum) Ann. Allergy Asthma Immunol. 78 297 300 9087156 10.1016/S1081-1206(10)63185-7 1:STN:280:DyaK2s3kt1Wjsg%3D%3D (Pubitemid 27142900)
50. PR Petit YD Sauvaire DM Hillaire-Buys OM Leconte YG Baissac GR Ponsin GR Ribes 1995 Steroid saponins from fenugreek seeds: extraction, purification, and pharmacological investigation on feeding behaviour and plasma cholesterol Steroids 60 674 680 8539775 10.1016/0039-128X(95)00090-D 1:CAS:528: DyaK2MXotlKis7s%3D
51. A Preet BL Gupta MR Siddiqui PK Yadava NZ Baquer 2005 Restoration of ultrastructural and biochemical changes in alloxan-induced diabetic rat sciatic nerve on treatment with Na3VO4 and Trigonella-a promising antidiabetic agent Mol. Cell. Biochem. 278 21 31 16180085 10.1007/s11010-005-7815-1 1:CAS:528:DC%2BD2MXhtVentr3N (Pubitemid 41418916)
52. A Preet MR Siddiqui A Taha J Badal ME Hussain PK Yadava NZ Baquer 2006 Long term effect of Trigonella foenum graecum and its combination with sodium orthovanadate in preventing histopathological and biochemical abnormalities in diabetic rat ocular tissues Mol. Cell. Biochem. 289 137 147 16718375 10.1007/s11010-006-9156-0 1:CAS:528:DC%2BD28XptVaju78%3D (Pubitemid 44322483)
53. D Puri KM Prabhu PS Murthy 2002 Mechanism of action of a hypoglycemic principle isolated from fenugreek seeds Indian J. Physiol. Pharmacol. 46 457 462 12683221 1:STN:280:DC%2BD3s7ms1agug%3D%3D
54. J Raju D Gupta AR Rao PK Yadava NZ Baquer 2001 TSP foenum graecum (fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic enzymes Mol. Cell. Biochem. 224 45 51 11693199 10.1023/A:1011974630828 1:CAS:528:DC%2BD3MXot1CitbY%3D (Pubitemid 32962651)
55. T Ramasarma 1996 Transmembrane domains participate in functions of integral membrane proteins Indian J. Biochem. Biophys. 33 20 29 8744829 1:CAS:528:DyaK28Xht1Sis7g%3D (Pubitemid 126346679)
56. PU Rao B Sesikeran PS Rao 1996 Short term nutritional and safety evaluation of fenugreek Nutr. Res. 16 1495 1505 10.1016/0271-5317(96)00163-7 1:CAS:528:DyaK28XlvVKntLw%3D (Pubitemid 26282340)
57. ED Saggerson SR Sooranna CJ Evans 1976 Insulin like actions of Nickel and other transition metals in rat fat cells Biochem. J. 154 349 357 938454 1:CAS:528:DyaE28XhslCmsLc%3D
58. H Sakurai 2002 A new concept: The use of vanadium complexes in the treatment of diabetes mellitus Chem. Rec. 2 237 248 12203906 10.1002/tcr.10029 1:CAS:528:DC%2BD3sXovVOgsQ%3D%3D (Pubitemid 44133929)
59. Salimuddin KC Upadhyaya J Raju NZ Baquer 1999 Modulation of mRNA levels of liver arginase by insulin and vanadate in experimental diabetes Indian J. Biochem. Biophys. 36 125 128 10549172 1:CAS:528:DyaK1MXjvFOisb8%3D (Pubitemid 129486020)
60. Y Sauvaire P Petit C Broca M Manteghetti Y Baissac J Fernandez-Alvarez R Gross M Roye, et al. 1998 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion Diabetes 47 206 210 9519714 10.2337/diabetes.47.2.206 1:CAS:528:DyaK1cXntVOisg%3D%3D (Pubitemid 28079975)
61. N Sekar J Li Y Shechter 1996 Vanadium salts as insulin substitutes: mechanisms of action, a scientific and therapeutic tool in diabetes mellitus research Crit. Rev. Biochem. Mol. Biol. 31 339 359 8994801 10.3109/ 10409239609108721 1:CAS:528:DyaK2sXls1yrsQ%3D%3D (Pubitemid 27024209)
62. R Sharma 1986 An evaluation of hypocholesterolemic factor of fenugreek seeds (T. foenum graecum) in rats Nutr. Rep. Int. 33 669 677 1:CAS:528:DyaL28XitVKjt7o%3D (Pubitemid 16081207)
63. RD Sharma A Sarkar DK Hazra B Misra JB Singh BB Maheshwari 1996 Toxicological evaluation of fenugreek seeds: a long term feeding experiment in diabetic patients Phytother. Res. 10 519 520 10.1002/(SICI)1099-1573(199609)10: 6<519::AID-PTR873>3.0.CO;2-T (Pubitemid 26342060)
64. RD Sharma A Sarkar DK Hazra B Mishra JB Singh SK Sharma BB Maheshwari DM Maheshwari 1996 Use of fenugreek seed powder in the management of non-insulin dependent diabetes mellitus Nutr. Res. 16 1331 1339 10.1016/0271-5317(96)00141-8 (Pubitemid 26266239)
65. JE Shaw RA Sicree PZ Zimmet 2010 Global estimates of the prevalence of diabetes for 2010 and 2030 Diabetes Res. Clin. Pract. 87 4 14 19896746 10.1016/j.diabres.2009.10.007 1:STN:280:DC%2BC3c%2Fot1Witg%3D%3D
66. Y Shechter 1990 Insulin-mimetic effects of vanadate: Possible implications for future treatment of diabetes Diabetes 39 1 5 2210051 10.2337/diabetes.39.1.1 1:CAS:528:DyaK3cXntVSquw%3D%3D (Pubitemid 20022877)
67. UA Shinde AA Mehta RK Goyal 2001 Effect of chronic treatment with Bis(maltolato)oxovanadium (IV) in rat model of non-insulin-dependent diabetes Indian J. Exp. Biol. 39 864 870 11831366 1:CAS:528:DC%2BD3MXntVKhtrg%3D (Pubitemid 32824512)
68. + ATPase activity and GLUT-4 translocation in alloxan diabetic rats Mol. Cell. Biochem. 285 17 27 16622606 10.1007/s11010-005-9002-9 1:CAS:528: DC%2BD28XjvFGhsrc%3D
69. MR Siddiqui A Taha K Moorthy EM Hussain SF Basir NZ Baquer 2005 Amelioration of altered antioxidants status and membrane linked functions by vanadium and Trigonella in alloxan diabetic rat brains J. Biosci. 30 483 490 16184010 10.1007/BF02703722 1:CAS:528:DC%2BD2MXhtFelsbzE (Pubitemid 41391362)
70. M Sochor NZ Baquer P McLean 1979 Regulation of pathways of glucose metabolism in kidney. The effect of experimental diabetes on the activity of the pentose phosphate pathway and glucuronate xylulose pathway Arch. Biochem. Biophys. 198 632 646 160215 10.1016/0003-9861(79)90541-1 1:CAS:528: DyaL3cXjvFWmsQ%3D%3D (Pubitemid 10141056)
71. M Sochor NZ Baquer P McLean 1985 Glucose over and under utilization in diabetes: Comparative studies on the changes in activities of enzymes of glucose metabolism in rat liver and kidney Mol. Physiol. 7 51 68 1:CAS:528: DyaL2MXht12rsLs%3D
72. K Srinivasan 2006 Fenugreek (Trigonella foenum-graecum): A review of health beneficial physiological effects Food Rev. Int. 22 203 224 10.1080/87559120600586315 1:CAS:528:DC%2BD28XjvVakt7g%3D
73. S Srinivasan M Stevens JW Wiley 2000 Diabetic peripheral neuropathy: Evidence for apoptosis and associated mitochondrial dysfunction Diabetes 49 1932 1938 11078462 10.2337/diabetes.49.11.1932 1:CAS:528:DC%2BD3cXnvVOmtL0%3D
74. S Subasinghe AL Greenbaum P McLean 1985 The insulin mimetic action of Mn2+: Involvement of cyclic nucleotide and insulin in the regulation of hepatic hexokinase and glucokinase Biochem. Med. 34 83 92 2996512 10.1016/0006-2944(85) 90064-X 1:CAS:528:DyaL2MXltFKksLY%3D (Pubitemid 15045300)
75. G Swarup S Cohen DL Garbers 1982 Inhibition of membrane phosphotyrosyl-protein phosphatase activity by Vanadate Biochem. Biophys. Res. Commun. 107 1104 1109 6291515 10.1016/0006-291X(82)90635-0 1:CAS:528: DyaL38Xlt1arsL4%3D (Pubitemid 13207692)
76. R Taylor L Agius 1988 The biochemistry of diabetes Biochem. J. 250 650 740
77. S Thakran Salimuddin NZ Baquer 2003 Oral administration of orthovanadate and Trigonella foenum graecum seed power restore the activities of mitochondrial enzymes in tissues of alloxan-induced diabetic rats Mol. Cell. Biochem. 247 45 53 12841630 10.1023/A:1024188600523 1:CAS:528:DC%2BD3sXksFWgt7g%3D (Pubitemid 36798508)
78. V Vats SP Yadav JK Grover 2003 Effect of T. foenum graecum on glycogen content of tissues and the key enzymes of carbohydrate metabolism J. Ethnopharmacol. 85 237 242 12639747 10.1016/S0378-8741(03)00022-9 1:STN:280:DC%2BD3s7isF2hsg%3D%3D (Pubitemid 36294139)
79. S Verma MC Cam JH McNeill 1998 Nutritional factors that can favorably influence the glucose/insulin system: vanadium J. Am. Coll. Nutr. 17 11 18 9477384 1:CAS:528:DyaK1cXhtFSiu78%3D (Pubitemid 28081135)
80. OH Wieland 1983 Protein modification by non-enzymatic glucosylation: possible role in the development of diabetic complications Mol. Cell. Endocrinol. 29 125 131 6339296 10.1016/0303-7207(83)90207-1 1:CAS:528: DyaL3sXoslSkuw%3D%3D (Pubitemid 13180844)
81. Wolff SP 1987 in The potential role of oxidative stress in diabetes and its complications: scientific aspects (ed) MJC Crabbe (New York: Churchill Livingstone) pp. 167-220
82. UCS Yadav K Moorthy NZ Baquer 2004 Effects of sodium orthovanadate and Trigonella foenum graecum seeds on hepatic and renal lipogenic enzymes and lipid profile during alloxan diabetes J. Biosci. 29 81 91 15286407 10.1007/BF02702565 1:CAS:528:DC%2BD2cXjsFSktbY%3D (Pubitemid 38419558)
83. UCS Yadav K Moorthy NZ Baquer 2005 Combined Treatment of Sodium orthovanadate and Momordica charantia fruit extract prevents alterations in lipid profile and lipogenic enzymes in alloxan diabetic rats Mol. Cell. Biochem. 268 111 120 15724444 10.1007/s11010-005-3703-y 1:CAS:528:DC%2BD2MXhtl2ksLg%3D (Pubitemid 40287833)
84. M Yoshikawa T Murakami M Kadoya Y Li N Murakami J Yamahara H Matsuda 1997 Medicinal foodstuffs. IX. The inhibitors of glucose absorption from the leaves of Gymnema sylvestre R. BR. (Asclepiadaceae): structures of gymnemosides a and b Chem. Pharm. Bull. (Tokyo) 45 1671 1676 1:CAS:528:DyaK2sXntVKqsbc%3D (Pubitemid 27488431)