In vivo effect of Trigonella foenum graecum on the expression of pyruvate kinase, phosphoenolpyruvate carboxykinase, and distribution of glucose transporter (GLUT4) in alloxan-diabetic rats

Canadian Journal of Physiology and Pharmacology

Volumn 84, Issue 6, 2006, Pages 647-654

  Mohammad, Sameer ^a   Taha, Asia ^a   Akhtar, Kamal ^a   Bamezai, R N K ^a   Baquer, Najma Zaheer ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

Alloxan diabetes; Glucose transporter (GLUT4); Phosphoenolpyruvate carboxykinase (PEPCK); Pyruvate kinase; Trigonella foenum graecum

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PYRUVATE KINASE; TRIGONELLA FOENUM GRAECUM EXTRACT;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MASS; CONTROLLED STUDY; DNA SEQUENCE; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; IN VIVO STUDY; LIVER; NONHUMAN; PLANT SEED; POWDER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SKELETAL MUSCLE;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; GLUCOSE TRANSPORTER TYPE 4; LIVER; PLANT EXTRACTS; POWDERS; PROTEIN-SERINE-THREONINE KINASES; PYRUVATE KINASE; RATS; RATS, WISTAR; SEEDS; TISSUE DISTRIBUTION; TREATMENT OUTCOME; TRIGONELLA;

EID: 33750220797     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y05-164     Document Type: Article

References (36)

1. Ahmadiani, A., Javan, M., Semnanian, S., Barat, E., and Kamalinejad, M. 2001. Anti-inflammatory and antipyretic effects of Trigonella foenum-graecum leaves extract in the rat. J. Ethnopharmacol. 75: 283-286. doi:10.1016/S0378- 8741(01) 00187-8. PMID: 11297864.
2. Alberti, K.G.M.M., and Press, C.M. 1982. The biochemistry of the complications of diabetes mellitus. 2nd ed. Edited by H. Keen and J. Jarret. Edward Arnold, pp 231-270.
3. Ahmed, I., Adeghate, E., Sharma, A.K., Pallot, D.J., and Singh, J. 1998. Effects of Momordica charantia fruit juice on islet morphology in the pancreas of the streptozotocin-diabetic rat. Diabetes Res. Clin. Pract. 40: 145-151. doi:10.1016/S0168-8227(98)00022-9. PMID: 9716917.
4. Ali, L., Azad Khan, A.K., Hassan, Z., Mosihuzzaman, M., Nahar, N., Nasreen, T., et al. 1995. Characterization of the hypoglycemic effects of Trigonella foenum graecum seed. Planta Med. 61: 358-360. PMID: 7480183.
5. Blair, J.B., Cimbala, M.A., Foster, J.L., and Morgan, R.A. 1976. Hepatic pyruvate kinase. Regulation by glucagon, cyclic adenosine 3′-5′- monophosphate, and insulin in the perfused rat liver. J. Biol. Chem. 251: 3756-3762. PMID: 180008.
6. Board, M., Humm, S., and Newsholme, E.A. 1990. Maximum activities of key enzymes of glycolysis, glutaminolysis, pentose phosphate pathway and tricarboxylic acid cycle in normal, neoplastic and suppressed cells. Biochem. J. 265: 503-509. PMID: 2302181.
7. Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254.
8. Broca, C., Gross, R., Petit, P., Sauvaire, Y., Manteghetti, M., Tournier, M., et al. 1999. 4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties. Am. J. Physiol. 277: E617-E623. PMID: 10516120.
9. Cimbala, M.A., Lamers, W.H., Nelson, K., Monahan, J.E., Yoo-Warren, H., and Hanson, R.W. 1982. Rapid changes in the concentration of phosphoenolpyruvate carboxykinase mRNA in rat liver and kidney. Effects of insulin and cyclic AMP. J. Biol. Chem. 257: 7629-7636. PMID: 6282847.
10. Cushman, S.W., and Wardzala, L.J. 1980. Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane. J. Biol. Chem. 255: 4758-4762. PMID: 6989818.
11. Devasena, T., and Menon, V.P. 2002. Enhancement of circulatory antioxidants by fenugreek during 1, 2-dimethylhydrazine-induced rat colon carcinogenesis. J. Biochem. Mol. Biol. Biophys. 6: 289-292. PMID: 12186747.
12. Gutman, I., and Bernt, E. 1974. Pyruvate kinase: assay in serum and erythrocytes. In Methods in enzymatic analysis. Edited by H.U. Bergmeyer. Academic Press, New York. pp. 774-778.
13. James, D.E., Piper, R.C., and Slot, J.W. 1993. Targeting of mammalian glucose transporters. J. Cell Sci. 104: 607-612. PMID: 8314864.
14. Jomain-Baum, M., and Schramm, V.L. 1978. Kinetic mechanism of Phosphoenolpyruvate carboxykinase (GTP) from rat liver cytosol. J. Biol. Chem. 253: 3648-3659. PMID: 649593.
15. Karnieli, E., Zarnowski, M., Hissin, P., Simpson, I., Salans, L., and Cushman, S. 1981. Insulin-stimulated translocation of glucose transport systems in the isolated rat adipose cell: time-course, reversal, insulin concentration dependency, and relationship to glucose transport activity. J. Biol. Chem. 256: 4772-4777. PMID: 7014557.
16. MacDougald, O.A., and Lane, M.D. 1995. Transcriptional regulation of gene expression during adipocyte differentiation. Annu. Rev. Biochem. 64: 345-373. doi:10.1146/annurev.bi.64.070195. 002021. PMID: 7574486.
17. Mathupala, S.P., Rempel, A., and Pedersen, P.L. 1997. Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase. J. Bioenerg. Biomembr. 29: 339-343. doi:10.1023/A:1022494613613. PMID: 9387094.
18. Mazurek, S., Michel, A., and Eigenbrodt, E. 1997. Effect of extracellular AMP on cell proliferation and metabolism of breast cancer cell lines with high and low glycolytic rates. J. Biol. Chem. 272: 4941-4952. PMID: 9030554.
19. Mishkinsky, J.S., Goldschmied, A., Joseph, B., Ahronson, Z., and Sulman, F.G. 1974. Hypoglycaemic effect of Trigonella foenum graecum and Lupinus termis (leguminosae) seeds and their major alkaloids in alloxan-diabetic and normal rats. Arch. Int. Pharmacodyn. Ther. 210: 27-37. PMID: 4280278.
20. Mohamad, S., Taha, A., Bamezai, R.N., Basir, S.F., and Baquer, N.Z. 2004. Lower doses of vanadate in combination with trigonella restore altered carbohydrate metabolism and antioxidant status in alloxan-diabetic rats. Clin. Chim. Acta, 342: 105-114. doi:10.1016/j.cccn.2003.12.005. PMID: 15026271.
21. Mosseri, R., Waner, T., Shefi, M., Shafrir, E., and Meyerovitch, J. 2000. Gluconeogenesis in non-obese diabetic (NOD) mice: in vivo effects of vanadate treatment on hepatic glucose-6-phosphatase and phosphoenolpyruvate carboxykinase. Metabolism, 49: 321-325. doi:10.1016/S0026-0495(00)90132-X. PMID: 10726908.
22. Nandan, S.D., and Beale, E.G. 1992. Regulation of phosphoenol-pyruvate carboxykinase mRNA in mouse liver, kidney, and fat tissues by fasting, diabetes, and insulin. Lab. Anim. Sci. 42: 473-477. PMID: 1460846.
23. Noguchi, T., Inoue, H., and Tanaka, T. 1982. Regulation of rat liver L-type pyruvate kinase mRNA by insulin and by fructose. Eur. J. Biochem. 128: 583-588. PMID: 6759123.
24. Noguchi, T., Inoue, H., Chen, H.L., Matsubara, K., and Tanaka, T. 1983. Molecular cloning of DNA complementary to rat L-type pyruvate kinase mRNA. Nutritional and hormonal regulation of L-type pyruvate kinase mRNA concentration. J. Biol. Chem. 258: 15220-15223. PMID: 6361029.
25. Puri, D., Prabhu, K.M., and Murthy, P.S. 2002. Mechanism of action of a hypoglycemic principle isolated from fenugreek seeds. Indian J. Physiol. Pharmacol. 46: 457-462. PMID: 12683221.
26. Raju, J., Gupta, D., Rao, A.R., Yadava, P.K., and Baquer, N.Z. 2001. Trigonellafoenum graecum (fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic enzymes. Mol. Cell. Biochem. 224: 45-51. doi:10.1023/A: 1011974630828. PMID: 11693199.
27. Rosella, G., Zajac, J.D., Kaczmarczyk, S.J., Andrikopoulos, S., and Proietto, J. 1993. Impaired suppression of gluconeogenesis induced by overexpression of a noninsulin-responsive phosphoenolpyruvate carboxykinase gene. Mol. Endocrinol. 7: 1456-1462. doi:10.1210/me.7.11.1456. PMID: 8114759.
28. Sauvaire, Y., Petit, P., Broca, C., Manteghetti, M., Baissac, Y., Fernandez-Alvarez, J., et al. 1998. 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion. Diabetes, 47: 206-210. PMID: 9519714.
29. Sochor, M., Baquer, N.Z., and Mclean, P. 1985. Glucose over and under utilization in diabetes: comparative studies on the changes in activities of enzymes of glucose metabolism in rat liver and kidney. Mol. Physiol. 7: 51-68.
30. Sur, P., Das, M., Gomes, A., Vedasiromoni, J.R., Sahu, N.P., Banerjee, S., et al. 2001. Trigonella foenum graecum (fenugreek) seed extract as an antineoplastic agent. Phytother. Res. 15: 257-259. doi:10.1002/ptr.718. PMID: 11351364.
31. Suzuki, K., and Kono, T. 1980. Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site. Proc. Natl. Acad. Sci. U.S.A. 77: 2542-2545. doi:10.1073/pnas.77. 5.2542. PMID: 6771756.
32. Thakran, S., Siddiqui, M.R., and Baquer, N.Z. 2004. Trigonella foenum graecum seed powder protects against histopathological abnormalities in tissues of diabetic rats. Mol. Cell. Biochem. 266: 151-159. doi:10.1023/B:MCBI. 0000049153.14295.0d. PMID: 15646037.
33. Valera, A., Pujol, A., Pelegrin, M., and Bosch, F. 1994. Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus. Proc. Natl. Acad. Sci. U.S.A. 91: 9151-9154. doi:10.1073/pnas.91.19.9151. PMID: 8090784.
34. Vats, V., Grover, J.K., and Rathi, S.S. 2002. Evaluation of anti-hyperglycemic and hypoglycemic effect of Trigonella foenumgraecum Linn, Ocimum sanctum Linn and Pterocarpus marsupium Linn in normal and alloxanized diabetic rats. J. Ethnopharmacol. 79: 95-100. doi:10.1016/S0378-8741(01)00374-9. PMID: 11744301.
35. Vats, V., Yadav, S.P., and Grover, J.K. 2003. Effect of T. foenumgraecum on glycogen content of tissues and the key enzymes of carbohydrate metabolism. J. Ethnopharmacol. 85: 237-242. doi:10.1016/S0378-8741(03)00022-9. PMID: 12639747.
36. Zia, T., Hasnain, S.N., and Hasan, S.K. 2001. Evaluation of the oral hypoglycaemic effect of Trigonella foenum-graecum L. (methi) in normal mice. J. Ethnopharmacol. 75: 191-195. doi:10.1016/S0378-8741(01)00186-6. PMID: 11297850.