Reciprocal control of pyruvate dehydrogenase kinase and phosphatase by inositol phosphoglycans: Dynamic state set by "push-pull" system

Journal of Biological Chemistry

Volumn 283, Issue 48, 2008, Pages 33428-33436

  McLean, Patricia ^a,b   Kunjara, Sirilaksana ^a,b   Greenbaum, A Leslie ^a,b   Gumaa, Khalid ^b,d   López Prados, Javier ^c   Martin Lomas, Manuel ^c   Rademacher, Thomas W ^a,b,e  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b Sylus Pharmaceuticals   (United Kingdom)

^c INSTITUTO DE INVESTIGACIONES QUÍMICAS   (Spain)

^d ARABIAN GULF UNIVERSITY   (Bahrain)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; CHELATION; CHEMICAL REACTIONS; CYTOLOGY; ENZYMES; GLUCOSE; HORMONES; INSULIN; LAWS AND LEGISLATION; MANGANESE; MANGANESE COMPOUNDS; MEDICAL PROBLEMS; METAL IONS; PHOSPHORYLATION; SUGARS; ZINC;

CELL FUNCTIONS; CRITICAL LEVELS; DYNAMIC EQUILIBRIUMS; DYNAMIC STATES; GLUCOSE HOMEOSTASISES; HEXOSAMINE; HORMONAL CONTROLS; IN CELLS; IN-VIVO; INSULIN MEDIATORS; ISOFORMS; METABOLIC DISORDERS; PULL EFFECTS; PYRUVATE DEHYDROGENASE COMPLEXES; PYRUVATE DEHYDROGENASE KINASES; PYRUVATE DEHYDROGENASES; RECIPROCAL CONTROLS; RECIPROCAL REGULATIONS; REGULATORY FACTORS; REGULATORY FUNCTIONS; REVERSIBLE PHOSPHORYLATIONS; SWITCH OVERS;

CELL MEMBRANES;

INOSITOL; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN IPGP; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE; PYRUVATE DEHYDROGENASE PHOSPHATASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; IN VIVO STUDY; MALE; METABOLIC DISORDER; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; CELL MEMBRANE; DIABETES MELLITUS; GLUCOSE; INOSITOL PHOSPHATES; INSULIN; ISOENZYMES; LIVER; MALE; MANGANESE; MODELS, BIOLOGICAL; PHOSPHORYLATION; POLYSACCHARIDES; PROTEIN-SERINE-THREONINE KINASES; PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE; PYRUVATE DEHYDROGENASE COMPLEX; RATS; RATS, WISTAR; ZINC;

EID: 57749091885     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801781200     Document Type: Article

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