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Volumn 100, Issue , 2011, Pages 65-84

The pharmacology of selegiline

Author keywords

Antiapoptotic effect of selegiline; Future perspectives of selegiline; Metabolic studies; Multiplicity of monoamine oxidase; Pharmacokinetics; Selective inhibition of MAO B; Structure activity relationship studies

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CATECHOL METHYLTRANSFERASE; CLORGYLINE; DEPRENYL N OXIDE; DOPAMINE; HYDRAZINE DERIVATIVE; IPRONIAZID; N (1 INDENYL) N METHYL N PROPARGYLAMINE; NORSELEGILINE; PHENELZINE; PHENETHYLAMINE; PROADIFEN; RASAGILINE; SELEGILINE; TRANYLCYPROMINE; UNCLASSIFIED DRUG;

EID: 80053467982     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-386467-3.00004-2     Document Type: Chapter
Times cited : (60)

References (96)
  • 1
    • 34648836544 scopus 로고    scopus 로고
    • Pharmacokinetics and absolute bioavailability of selegiline following treatment of healthy subjects with the selegiline transdermal system (6mg/24 h): a comparison with oral selegiline capsules
    • Azzaro A.J., Ziemniak J., Kemper E., Campbell B.J., VanDenBerg C. Pharmacokinetics and absolute bioavailability of selegiline following treatment of healthy subjects with the selegiline transdermal system (6mg/24 h): a comparison with oral selegiline capsules. J. Clin. Pharmacol. 2007, 47:1256-1267.
    • (2007) J. Clin. Pharmacol. , vol.47 , pp. 1256-1267
    • Azzaro, A.J.1    Ziemniak, J.2    Kemper, E.3    Campbell, B.J.4    VanDenBerg, C.5
  • 3
    • 0029832107 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of a selegiline transdermal system relative to single-dose oral administration in the elderly
    • Barrett J.S., Hochadel T.J., Morales R.J., Rohatagi S., DeWitt K.E., Watson S.K., DiSanto A.R. Pharmacokinetics and safety of a selegiline transdermal system relative to single-dose oral administration in the elderly. Am. J. Ther. 1996, 3:688-698.
    • (1996) Am. J. Ther. , vol.3 , pp. 688-698
    • Barrett, J.S.1    Hochadel, T.J.2    Morales, R.J.3    Rohatagi, S.4    DeWitt, K.E.5    Watson, S.K.6    DiSanto, A.R.7
  • 4
    • 0016414699 scopus 로고
    • The potentiation of the anti akinetic effect after L-dopa treatment by an inhibitor of MAO-B, Deprenil
    • Birkmayer W., Riederer P., Youdim M.B., Linauer W. The potentiation of the anti akinetic effect after L-dopa treatment by an inhibitor of MAO-B, Deprenil. J. Neural Transm. 1975, 36:303-326.
    • (1975) J. Neural Transm. , vol.36 , pp. 303-326
    • Birkmayer, W.1    Riederer, P.2    Youdim, M.B.3    Linauer, W.4
  • 5
    • 0017345412 scopus 로고
    • Implications of combined treatment with 'Madopar' and L-deprenil in Parkinson's disease. A long-term study
    • Birkmayer W., Riederer P., Ambrozi L., Youdim M.B. Implications of combined treatment with 'Madopar' and L-deprenil in Parkinson's disease. A long-term study. Lancet 1977, 1:439-443.
    • (1977) Lancet , vol.1 , pp. 439-443
    • Birkmayer, W.1    Riederer, P.2    Ambrozi, L.3    Youdim, M.B.4
  • 6
    • 0022365018 scopus 로고
    • Increased life expectancy resulting from addition of L-deprenyl to Madopar treatment in Parkinson's disease: a longterm study
    • Birkmayer W., Knoll J., Riederer P., Youdim M.B., Hars V., Marton J. Increased life expectancy resulting from addition of L-deprenyl to Madopar treatment in Parkinson's disease: a longterm study. J. Neural Transm. 1985, 64:113-127.
    • (1985) J. Neural Transm. , vol.64 , pp. 113-127
    • Birkmayer, W.1    Knoll, J.2    Riederer, P.3    Youdim, M.B.4    Hars, V.5    Marton, J.6
  • 7
    • 0014078733 scopus 로고
    • Hypertensive interactions between monoamine oxidase inhibitors and foodstuffs
    • Blackwell B., Marley E., Price J., Taylor D. Hypertensive interactions between monoamine oxidase inhibitors and foodstuffs. Br. J. Psychiatry 1967, 113:349-365.
    • (1967) Br. J. Psychiatry , vol.113 , pp. 349-365
    • Blackwell, B.1    Marley, E.2    Price, J.3    Taylor, D.4
  • 9
    • 0026074120 scopus 로고
    • (-)-Deprenyl induces activities of both superoxide dismutase and catalase but not of glutathione peroxidase in the striatum of young male rats
    • Carrillo M.C., Kanai S., Nokubo M., Kitani K. (-)-Deprenyl induces activities of both superoxide dismutase and catalase but not of glutathione peroxidase in the striatum of young male rats. Life Sci. 1991, 48:517-521.
    • (1991) Life Sci. , vol.48 , pp. 517-521
    • Carrillo, M.C.1    Kanai, S.2    Nokubo, M.3    Kitani, K.4
  • 10
    • 33846993393 scopus 로고    scopus 로고
    • Forebrain-specific expression of monoamine oxidase A reduces neurotransmitter levels, restores the brain structure, and rescues aggressive behavior in monoamine oxidase A-deficient mice
    • Chen K., Cases O., Rebrin I., Wu W., Gallaher T.K., Seif I., Shih J.C. Forebrain-specific expression of monoamine oxidase A reduces neurotransmitter levels, restores the brain structure, and rescues aggressive behavior in monoamine oxidase A-deficient mice. J. Biol. Chem. 2007, 282:115-123.
    • (2007) J. Biol. Chem. , vol.282 , pp. 115-123
    • Chen, K.1    Cases, O.2    Rebrin, I.3    Wu, W.4    Gallaher, T.K.5    Seif, I.6    Shih, J.C.7
  • 12
    • 0037324318 scopus 로고    scopus 로고
    • L-Deprenyl metabolism by the cytochrome P450 system in monkey (Cercopithecus aethiops) liver microsomes
    • Dragoni S., Bellik L., Frosini M., Sgaragli G., Marini S., Gervasi P.G., Valoti M. l-Deprenyl metabolism by the cytochrome P450 system in monkey (Cercopithecus aethiops) liver microsomes. Xenobiotica 2003, 33:181-195.
    • (2003) Xenobiotica , vol.33 , pp. 181-195
    • Dragoni, S.1    Bellik, L.2    Frosini, M.3    Sgaragli, G.4    Marini, S.5    Gervasi, P.G.6    Valoti, M.7
  • 14
    • 0018777855 scopus 로고
    • Does the B form selective monoamine oxidase inhibitor lose selectivity by long term treatment?
    • Ekstedt B., Magyar K., Knoll J. Does the B form selective monoamine oxidase inhibitor lose selectivity by long term treatment?. Biochem. Pharmacol. 1979, 28:919-923.
    • (1979) Biochem. Pharmacol. , vol.28 , pp. 919-923
    • Ekstedt, B.1    Magyar, K.2    Knoll, J.3
  • 15
    • 33750051620 scopus 로고    scopus 로고
    • Selegiline transdermal system for the treatment of major depressive disorder: an 8-week, double-blind, placebo-controlled, flexible-dose titration trial
    • Feiger A.D., Rickels K., Rynn M.A., Zimbroff D.L., Robinson D.S. Selegiline transdermal system for the treatment of major depressive disorder: an 8-week, double-blind, placebo-controlled, flexible-dose titration trial. J. Clin. Psychiatry 2006, 67:1354-1361.
    • (2006) J. Clin. Psychiatry , vol.67 , pp. 1354-1361
    • Feiger, A.D.1    Rickels, K.2    Rynn, M.A.3    Zimbroff, D.L.4    Robinson, D.S.5
  • 16
    • 0020070356 scopus 로고
    • Deamination of 5-hydroxytryptamine by both forms of monoamine oxidase in the rat brain
    • Fowler C.J., Tipton K.F. Deamination of 5-hydroxytryptamine by both forms of monoamine oxidase in the rat brain. J. Neurochem. 1982, 38:733-736.
    • (1982) J. Neurochem. , vol.38 , pp. 733-736
    • Fowler, C.J.1    Tipton, K.F.2
  • 18
    • 0028316987 scopus 로고
    • Atypical metabolism of deprenyl and its enantiomer, (S)-(+)-N, alpha-dimethyl-N-propynylphenethylamine, by cytochrome P450 2D6
    • Grace J.M., Kinter M.T., Macdonald T.L. Atypical metabolism of deprenyl and its enantiomer, (S)-(+)-N, alpha-dimethyl-N-propynylphenethylamine, by cytochrome P450 2D6. Chem. Res. Toxicol. 1994, 7:286-290.
    • (1994) Chem. Res. Toxicol. , vol.7 , pp. 286-290
    • Grace, J.M.1    Kinter, M.T.2    Macdonald, T.L.3
  • 19
    • 0036802075 scopus 로고    scopus 로고
    • Determination of the norepinephrine level by high-performance liquid chromatography to assess the protective effect of MAO-B inhibitors against DSP-4 toxicity
    • Haberle D., Magyar K., Szoko E. Determination of the norepinephrine level by high-performance liquid chromatography to assess the protective effect of MAO-B inhibitors against DSP-4 toxicity. J. Chromatogr. Sci. 2002, 40:495-499.
    • (2002) J. Chromatogr. Sci. , vol.40 , pp. 495-499
    • Haberle, D.1    Magyar, K.2    Szoko, E.3
  • 20
    • 0001068044 scopus 로고
    • Tyramine oxidase: A new enzyme system in liver
    • Hare M.L. Tyramine oxidase: A new enzyme system in liver. Biochem. J. 1928, 22:968-979.
    • (1928) Biochem. J. , vol.22 , pp. 968-979
    • Hare, M.L.1
  • 22
    • 0028577499 scopus 로고
    • Pharmacokinetic aspects of l-deprenyl (selegiline) and its metabolites
    • Heinonen E.H., Anttila M.I., Lammintausta R.A. Pharmacokinetic aspects of l-deprenyl (selegiline) and its metabolites. Clin. Pharmacol. Ther. 1994, 56:742-749.
    • (1994) Clin. Pharmacol. Ther. , vol.56 , pp. 742-749
    • Heinonen, E.H.1    Anttila, M.I.2    Lammintausta, R.A.3
  • 23
    • 0035228701 scopus 로고    scopus 로고
    • Dopamine and Parkinson's disease. A personal view of the past, the present, and the future
    • Hornykiewicz O. Dopamine and Parkinson's disease. A personal view of the past, the present, and the future. Adv. Neurol. 2001, 86:1-11.
    • (2001) Adv. Neurol. , vol.86 , pp. 1-11
    • Hornykiewicz, O.1
  • 24
    • 0036589897 scopus 로고    scopus 로고
    • Dopamine miracle: from brain homogenate to dopamine replacement
    • Hornykiewicz O. Dopamine miracle: from brain homogenate to dopamine replacement. Mov. Disord. 2002, 17:501-508.
    • (2002) Mov. Disord. , vol.17 , pp. 501-508
    • Hornykiewicz, O.1
  • 25
    • 0023238602 scopus 로고
    • The current status of monoamine oxidase and its inhibitors
    • Jarrott B., Vajda F.J. The current status of monoamine oxidase and its inhibitors. Med. J. Aust. 1987, 146:634-638.
    • (1987) Med. J. Aust. , vol.146 , pp. 634-638
    • Jarrott, B.1    Vajda, F.J.2
  • 26
    • 27144488651 scopus 로고    scopus 로고
    • Increased cell-cell adhesion, a novel effect of R-(-)-deprenyl
    • Jenei V., Zor K., Magyar K., Jakus J. Increased cell-cell adhesion, a novel effect of R-(-)-deprenyl. J. Neural Transm. 2005, 112:1433-1445.
    • (2005) J. Neural Transm. , vol.112 , pp. 1433-1445
    • Jenei, V.1    Zor, K.2    Magyar, K.3    Jakus, J.4
  • 27
    • 0014314486 scopus 로고
    • Some observations upon a new inhibitor of monoamine oxidase in brain tissue
    • Johnston J.P. Some observations upon a new inhibitor of monoamine oxidase in brain tissue. Biochem. Pharmacol. 1968, 17:1285-1297.
    • (1968) Biochem. Pharmacol. , vol.17 , pp. 1285-1297
    • Johnston, J.P.1
  • 28
    • 0025057155 scopus 로고
    • Chromatographic studies on the binding, action and metabolism of (-)-deprenyl
    • Kalász H., Kerecsen L., Knoll J., Pucsok J. Chromatographic studies on the binding, action and metabolism of (-)-deprenyl. J. Chromatogr. 1990, 499:589-599.
    • (1990) J. Chromatogr. , vol.499 , pp. 589-599
    • Kalász, H.1    Kerecsen, L.2    Knoll, J.3    Pucsok, J.4
  • 29
    • 0035812215 scopus 로고    scopus 로고
    • Simultaneous determination of selegiline-N-oxide, a new indicator for selegiline administration, and other metabolites in urine by high-performance liquid chromatography-electrospray ionization mass spectrometry
    • Katagi M., Tatsuno M., Miki A., Nishikawa M., Nakajima K., Tsuchihashi H. Simultaneous determination of selegiline-N-oxide, a new indicator for selegiline administration, and other metabolites in urine by high-performance liquid chromatography-electrospray ionization mass spectrometry. J. Chromatogr. B Biomed. Sci. Appl. 2001, 759:125-133.
    • (2001) J. Chromatogr. B Biomed. Sci. Appl. , vol.759 , pp. 125-133
    • Katagi, M.1    Tatsuno, M.2    Miki, A.3    Nishikawa, M.4    Nakajima, K.5    Tsuchihashi, H.6
  • 31
    • 0024267460 scopus 로고
    • The striatal dopamine dependency of life span in male rats. Longevity study with (-)deprenyl
    • Knoll J. The striatal dopamine dependency of life span in male rats. Longevity study with (-)deprenyl. Mech. Ageing Dev. 1988, 46:237-262.
    • (1988) Mech. Ageing Dev. , vol.46 , pp. 237-262
    • Knoll, J.1
  • 32
    • 0015274536 scopus 로고
    • Some puzzling pharmacological effects of monoamine oxidase inhibitors
    • Knoll J., Magyar K. Some puzzling pharmacological effects of monoamine oxidase inhibitors. Adv. Biochem. Psychopharmacol. 1972, 5:393-408.
    • (1972) Adv. Biochem. Psychopharmacol. , vol.5 , pp. 393-408
    • Knoll, J.1    Magyar, K.2
  • 34
    • 0000942494 scopus 로고
    • Phenylisopropylpropanylamine (E-250), a monoamine oxidase inhibitoe antagonizing the effects of tyramine
    • Knoll J., Vizi E.S., Somogyi G. Phenylisopropylpropanylamine (E-250), a monoamine oxidase inhibitoe antagonizing the effects of tyramine. Arzneimittelforschung 1968, 18:109-112.
    • (1968) Arzneimittelforschung , vol.18 , pp. 109-112
    • Knoll, J.1    Vizi, E.S.2    Somogyi, G.3
  • 35
    • 0025242961 scopus 로고
    • Selegiline as neuroprotective therapy in Parkinson's disease: concepts and controversies
    • discussion 67-69
    • Langston J.W. Selegiline as neuroprotective therapy in Parkinson's disease: concepts and controversies. Neurology 1990, 40(Suppl.):61-66. discussion 67-69.
    • (1990) Neurology , vol.40 , Issue.SUPPL. , pp. 61-66
    • Langston, J.W.1
  • 38
    • 0028182738 scopus 로고
    • Behaviour of (-)-deprenyl and its analogues
    • Magyar K. Behaviour of (-)-deprenyl and its analogues. J. Neural Transm. Suppl. 1994, 41:167-175.
    • (1994) J. Neural Transm. Suppl. , vol.41 , pp. 167-175
    • Magyar, K.1
  • 39
    • 1342294971 scopus 로고    scopus 로고
    • The neuroprotective and neuronal rescue effect of (-)-deprenyl
    • Springer-Verlag, Heidelberg, R.G. Cameron, G. Feuer (Eds.)
    • Magyar K., Szende B. The neuroprotective and neuronal rescue effect of (-)-deprenyl. Handbook of Experimental Pharmacology 2000, 457-472. Springer-Verlag, Heidelberg. R.G. Cameron, G. Feuer (Eds.).
    • (2000) Handbook of Experimental Pharmacology , pp. 457-472
    • Magyar, K.1    Szende, B.2
  • 40
    • 0346728595 scopus 로고    scopus 로고
    • (-)-Deprenyl, a selective MAO-B inhibitor, with apoptotic and anti-apoptotic properties
    • Magyar K., Szende B. (-)-Deprenyl, a selective MAO-B inhibitor, with apoptotic and anti-apoptotic properties. Neurotoxicology 2004, 25:233-242.
    • (2004) Neurotoxicology , vol.25 , pp. 233-242
    • Magyar, K.1    Szende, B.2
  • 43
    • 0014166149 scopus 로고
    • Comparative pharmacological analysis of the optical isomers of phenyl-isopropyl-methyl-propinylamine (E-250)
    • Magyar K., Vizi E.S., Ecseri Z., Knoll J. Comparative pharmacological analysis of the optical isomers of phenyl-isopropyl-methyl-propinylamine (E-250). Acta Physiol. Acad. Sci. Hung. 1967, 32:377-387.
    • (1967) Acta Physiol. Acad. Sci. Hung. , vol.32 , pp. 377-387
    • Magyar, K.1    Vizi, E.S.2    Ecseri, Z.3    Knoll, J.4
  • 45
    • 0030300160 scopus 로고    scopus 로고
    • The pharmacology of B-type selective monoamine oxidase inhibitors; milestones in (-)-deprenyl research
    • Magyar K., Szende B., Lengyel J., Tekes K. The pharmacology of B-type selective monoamine oxidase inhibitors; milestones in (-)-deprenyl research. J. Neural Transm. Suppl. 1996, 48:29-43.
    • (1996) J. Neural Transm. Suppl. , vol.48 , pp. 29-43
    • Magyar, K.1    Szende, B.2    Lengyel, J.3    Tekes, K.4
  • 48
    • 38449106403 scopus 로고    scopus 로고
    • Pharmacokinetic studies of (-)-deprenyl and some of its metabolites in mouse
    • Magyar K., Szatmáry I., Szebeni G., Lengyel J. Pharmacokinetic studies of (-)-deprenyl and some of its metabolites in mouse. J. Neural Transm. 2007, (Suppl.):165-173.
    • (2007) J. Neural Transm. , Issue.SUPPL. , pp. 165-173
    • Magyar, K.1    Szatmáry, I.2    Szebeni, G.3    Lengyel, J.4
  • 50
    • 0030832391 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of selegiline. An update
    • Mahmood I. Clinical pharmacokinetics and pharmacodynamics of selegiline. An update. Clin. Pharmacokinet. 1997, 33:91-102.
    • (1997) Clin. Pharmacokinet. , vol.33 , pp. 91-102
    • Mahmood, I.1
  • 51
    • 0027973083 scopus 로고
    • The pharmacokinetics and absolute bioavailability of selegiline in the dog
    • Mahmood I., Peters D.K., Mason W.D. The pharmacokinetics and absolute bioavailability of selegiline in the dog. Biopharm. Drug Dispos. 1994, 15:653-664.
    • (1994) Biopharm. Drug Dispos. , vol.15 , pp. 653-664
    • Mahmood, I.1    Peters, D.K.2    Mason, W.D.3
  • 52
    • 0028803434 scopus 로고
    • Pharmacokinetics and relative bioavailability of selegiline in healthy volunteers
    • Mahmood I., Marinac J.S., Willsie S., Mason W.D. Pharmacokinetics and relative bioavailability of selegiline in healthy volunteers. Biopharm. Drug Dispos. 1995, 16:535-545.
    • (1995) Biopharm. Drug Dispos. , vol.16 , pp. 535-545
    • Mahmood, I.1    Marinac, J.S.2    Willsie, S.3    Mason, W.D.4
  • 53
    • 50549194313 scopus 로고
    • Cheese and monoamine oxidase inhibitors. Interactions in anaesthetised cats
    • Natoff I.L. Cheese and monoamine oxidase inhibitors. Interactions in anaesthetised cats. Lancet 1964, 1:532-533.
    • (1964) Lancet , vol.1 , pp. 532-533
    • Natoff, I.L.1
  • 54
    • 3242769927 scopus 로고    scopus 로고
    • Platelet MAO and personality-function and dysfunction
    • Oreland L., Hallman J., Damberg M. Platelet MAO and personality-function and dysfunction. Curr. Med. Chem. 2004, 11:2007-2016.
    • (2004) Curr. Med. Chem. , vol.11 , pp. 2007-2016
    • Oreland, L.1    Hallman, J.2    Damberg, M.3
  • 56
    • 0037436065 scopus 로고    scopus 로고
    • Selegiline attenuates cardiac oxidative stress and apoptosis in heart failure: association with improvement of cardiac function
    • Qin F., Shite J., Mao W., Liang C.S. Selegiline attenuates cardiac oxidative stress and apoptosis in heart failure: association with improvement of cardiac function. Eur. J. Pharmacol. 2003, 461:149-158.
    • (2003) Eur. J. Pharmacol. , vol.461 , pp. 149-158
    • Qin, F.1    Shite, J.2    Mao, W.3    Liang, C.S.4
  • 58
    • 0026492963 scopus 로고
    • Deficits in cholinergic neurotransmission markers induced by ethylcholine mustard aziridinium (AF64A) in the rat hippocampus: sensitivity to treatment with the monoamine oxidase-B inhibitor L-deprenyl
    • Ricci A., Mancini M., Strocchi P., Bongrani S., Bronzetti E. Deficits in cholinergic neurotransmission markers induced by ethylcholine mustard aziridinium (AF64A) in the rat hippocampus: sensitivity to treatment with the monoamine oxidase-B inhibitor L-deprenyl. Drugs Exp. Clin. Res. 1992, 18:163-171.
    • (1992) Drugs Exp. Clin. Res. , vol.18 , pp. 163-171
    • Ricci, A.1    Mancini, M.2    Strocchi, P.3    Bongrani, S.4    Bronzetti, E.5
  • 59
    • 0022496317 scopus 로고
    • Monoamine oxidase activity and monoamine metabolism in brains of parkinsonian patients treated with l-deprenyl
    • Riederer P., Youdim M.B. Monoamine oxidase activity and monoamine metabolism in brains of parkinsonian patients treated with l-deprenyl. J. Neurochem. 1986, 46:1359-1365.
    • (1986) J. Neurochem. , vol.46 , pp. 1359-1365
    • Riederer, P.1    Youdim, M.B.2
  • 61
    • 0030881523 scopus 로고    scopus 로고
    • Integrated pharmacokinetic and metabolic modeling of selegiline and metabolites after transdermal administration
    • Rohatagi S., Barrett J.S., DeWitt K.E., Morales R.J. Integrated pharmacokinetic and metabolic modeling of selegiline and metabolites after transdermal administration. Biopharm. Drug Dispos. 1997, 18:567-584.
    • (1997) Biopharm. Drug Dispos. , vol.18 , pp. 567-584
    • Rohatagi, S.1    Barrett, J.S.2    DeWitt, K.E.3    Morales, R.J.4
  • 63
    • 0019124920 scopus 로고
    • Deprenyl in the management of response fluctuations in patients with Parkinson's disease on levodopa
    • Schachter M., Marsden C.D., Parkes J.D., Jenner P., Testa B. Deprenyl in the management of response fluctuations in patients with Parkinson's disease on levodopa. J. Neurol. Neurosurg. Psychiatry 1980, 43:1016-1021.
    • (1980) J. Neurol. Neurosurg. Psychiatry , vol.43 , pp. 1016-1021
    • Schachter, M.1    Marsden, C.D.2    Parkes, J.D.3    Jenner, P.4    Testa, B.5
  • 64
    • 3242779537 scopus 로고    scopus 로고
    • Regulation of MAO-A and MAO-B gene expression
    • Shih J.C., Chen K. Regulation of MAO-A and MAO-B gene expression. Curr. Med. Chem. 2004, 11:1995-2005.
    • (2004) Curr. Med. Chem. , vol.11 , pp. 1995-2005
    • Shih, J.C.1    Chen, K.2
  • 65
    • 0031010732 scopus 로고    scopus 로고
    • Metabolism of selegiline in humans. Identification, excretion, and stereochemistry of urine metabolites
    • Shin H.S. Metabolism of selegiline in humans. Identification, excretion, and stereochemistry of urine metabolites. Drug Metab. Dispos. 1997, 25:657-662.
    • (1997) Drug Metab. Dispos. , vol.25 , pp. 657-662
    • Shin, H.S.1
  • 66
    • 0017341884 scopus 로고
    • Reduction of tertiary amine N-oxides by rat liver mitochondria
    • Sugiura M., Kato R. Reduction of tertiary amine N-oxides by rat liver mitochondria. J. Pharmacol. Exp. Ther. 1977, 200:25-32.
    • (1977) J. Pharmacol. Exp. Ther. , vol.200 , pp. 25-32
    • Sugiura, M.1    Kato, R.2
  • 67
    • 0028834346 scopus 로고
    • Gas chromatographic procedure for simultaneous determination of selegiline metabolites, amphetamine, methamphetamine and demethyl-deprenyl in pig plasma
    • Szebeni G., Lengyel J., Székács G., Magyar K., Gaál J., Szatmári I. Gas chromatographic procedure for simultaneous determination of selegiline metabolites, amphetamine, methamphetamine and demethyl-deprenyl in pig plasma. Acta Physiol. Hung. 1995, 83:135-141.
    • (1995) Acta Physiol. Hung. , vol.83 , pp. 135-141
    • Szebeni, G.1    Lengyel, J.2    Székács, G.3    Magyar, K.4    Gaál, J.5    Szatmári, I.6
  • 68
    • 40949084122 scopus 로고    scopus 로고
    • Cell proliferation and cell death in relation to dose of various chemical substances
    • Medicina, Budapest, T. Török, I. Klebovich (Eds.)
    • Szende B. Cell proliferation and cell death in relation to dose of various chemical substances. Monoamine Oxidase Inhibitors and Their Role in Neurotransmission 2004, 133-140. Medicina, Budapest. T. Török, I. Klebovich (Eds.).
    • (2004) Monoamine Oxidase Inhibitors and Their Role in Neurotransmission , pp. 133-140
    • Szende, B.1
  • 69
    • 0034476732 scopus 로고    scopus 로고
    • Apoptotic and antiapoptotic effect of (-)-deprenyl and (-)-desmethyl-deprenyl on human cell lines
    • Szende B., Magyar K., Szegedi Z. Apoptotic and antiapoptotic effect of (-)-deprenyl and (-)-desmethyl-deprenyl on human cell lines. Neurobiology (Bp.) 2000, 8:249-255.
    • (2000) Neurobiology (Bp.) , vol.8 , pp. 249-255
    • Szende, B.1    Magyar, K.2    Szegedi, Z.3
  • 71
    • 77954543397 scopus 로고    scopus 로고
    • Cytoprotective effect of (-)-deprenyl, (-)desmethyl-deprenyl and (-)deprenyl-N-oxide on glutathione depleted A-2058 melanoma cells
    • Szende B., Barna G., Magyar K. Cytoprotective effect of (-)-deprenyl, (-)desmethyl-deprenyl and (-)deprenyl-N-oxide on glutathione depleted A-2058 melanoma cells. J. Neural Transm. 2010, 117:695-698.
    • (2010) J. Neural Transm. , vol.117 , pp. 695-698
    • Szende, B.1    Barna, G.2    Magyar, K.3
  • 72
    • 0029077091 scopus 로고
    • Chiral separation of deprenyl and its major metabolites using cyclodextrine-modified capillary zone electrophoresis
    • Szöko{double acute} É., Magyar K. Chiral separation of deprenyl and its major metabolites using cyclodextrine-modified capillary zone electrophoresis. J. Chromatogr. A 1995, 709:157-162.
    • (1995) J. Chromatogr. A , vol.709 , pp. 157-162
    • Szöko, É.1    Magyar, K.2
  • 73
    • 4544326416 scopus 로고    scopus 로고
    • Assessment of the N-oxidation of deprenyl, methamphetamine, and amphetamine enantiomers by chiral capillary electrophoresis: an in vitro metabolism study
    • Szöko{double acute} É., Tábi T., Borbás T., Dalmadi B., Tihanyi K., Magyar K. Assessment of the N-oxidation of deprenyl, methamphetamine, and amphetamine enantiomers by chiral capillary electrophoresis: an in vitro metabolism study. Electrophoresis 2004, 25:2866-2875.
    • (2004) Electrophoresis , vol.25 , pp. 2866-2875
    • Szöko, É.1    Tábi, T.2    Borbás, T.3    Dalmadi, B.4    Tihanyi, K.5    Magyar, K.6
  • 76
    • 0029731378 scopus 로고    scopus 로고
    • Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration
    • Tatton W.G., Chalmers-Redman R.M. Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration. Neurology 1996, 47:S171-S183.
    • (1996) Neurology , vol.47
    • Tatton, W.G.1    Chalmers-Redman, R.M.2
  • 77
    • 0027941312 scopus 로고
    • (-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis
    • Tatton W.G., Ju W.Y., Holland D.P., Tai C., Kwan M. (-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis. J. Neurochem. 1994, 63:1572-1575.
    • (1994) J. Neurochem. , vol.63 , pp. 1572-1575
    • Tatton, W.G.1    Ju, W.Y.2    Holland, D.P.3    Tai, C.4    Kwan, M.5
  • 78
    • 0030300164 scopus 로고    scopus 로고
    • (-)-Deprenyl reduces neuronal apoptosis and facilitates neuronal outgrowth by altering protein synthesis without inhibiting monoamine oxidase
    • Tatton W.G., Wadia J.S., Ju W.Y., Chalmers-Redman R.M., Tatton N.A. (-)-Deprenyl reduces neuronal apoptosis and facilitates neuronal outgrowth by altering protein synthesis without inhibiting monoamine oxidase. J. Neural Transm. Suppl. 1996, 48:45-59.
    • (1996) J. Neural Transm. Suppl. , vol.48 , pp. 45-59
    • Tatton, W.G.1    Wadia, J.S.2    Ju, W.Y.3    Chalmers-Redman, R.M.4    Tatton, N.A.5
  • 79
    • 0024151927 scopus 로고
    • Effect of MAO inhibitors on the uptake and metabolism of dopamine in rat and human brain
    • Tekes K., Tóthfalusi L., Gaál J., Magyar K. Effect of MAO inhibitors on the uptake and metabolism of dopamine in rat and human brain. Pol. J. Pharmacol. Pharm. 1988, 40:653-658.
    • (1988) Pol. J. Pharmacol. Pharm. , vol.40 , pp. 653-658
    • Tekes, K.1    Tóthfalusi, L.2    Gaál, J.3    Magyar, K.4
  • 80
    • 73849088812 scopus 로고    scopus 로고
    • (-)-Deprenyl inhibits vascular hyperpermeability after hemorrhagic shock
    • Tharakan B., Whaley J.G., Hunter F.A., Smythe W.R., Childs E.W. (-)-Deprenyl inhibits vascular hyperpermeability after hemorrhagic shock. Shock 2010, 33:56-63.
    • (2010) Shock , vol.33 , pp. 56-63
    • Tharakan, B.1    Whaley, J.G.2    Hunter, F.A.3    Smythe, W.R.4    Childs, E.W.5
  • 81
    • 0037198049 scopus 로고    scopus 로고
    • Modulation of neuroendocrine-immune signaling by L-deprenyl and L-desmethyldeprenyl in aging and mammary cancer
    • Thyaga Rajan S., Felten D.L. Modulation of neuroendocrine-immune signaling by L-deprenyl and L-desmethyldeprenyl in aging and mammary cancer. Mech. Ageing Dev. 2002, 123:1065-1079.
    • (2002) Mech. Ageing Dev. , vol.123 , pp. 1065-1079
    • Thyaga Rajan, S.1    Felten, D.L.2
  • 82
    • 0032781645 scopus 로고    scopus 로고
    • L-Deprenyl inhibits tumor growth, reduces serum prolactin, and suppresses brain monoamine metabolism in rats with carcinogen-induced mammary tumors
    • Thyaga Rajan S., Quadri S.K. l-Deprenyl inhibits tumor growth, reduces serum prolactin, and suppresses brain monoamine metabolism in rats with carcinogen-induced mammary tumors. Endocrine 1999, 10:225-232.
    • (1999) Endocrine , vol.10 , pp. 225-232
    • Thyaga Rajan, S.1    Quadri, S.K.2
  • 83
    • 0033367225 scopus 로고    scopus 로고
    • Inhibition of tumor growth by L-deprenyl involves neural-immune interactions in rats with spontaneously developing mammary tumors
    • Thyaga Rajan S., Madden K.S., Stevens S.Y., Felten D.L. Inhibition of tumor growth by L-deprenyl involves neural-immune interactions in rats with spontaneously developing mammary tumors. Anticancer Res. 1999, 19:5023-5028.
    • (1999) Anticancer Res. , vol.19 , pp. 5023-5028
    • Thyaga Rajan, S.1    Madden, K.S.2    Stevens, S.Y.3    Felten, D.L.4
  • 84
    • 0034703188 scopus 로고    scopus 로고
    • Anti-tumor effect of L-deprenyl is associated with enhanced central and peripheral neurotransmission and immune reactivity in rats with carcinogen-induced mammary tumors
    • Thyaga Rajan S., Madden K.S., Stevens S.Y., Felten D.L. Anti-tumor effect of L-deprenyl is associated with enhanced central and peripheral neurotransmission and immune reactivity in rats with carcinogen-induced mammary tumors. J. Neuroimmunol. 2000, 109:95-104.
    • (2000) J. Neuroimmunol. , vol.109 , pp. 95-104
    • Thyaga Rajan, S.1    Madden, K.S.2    Stevens, S.Y.3    Felten, D.L.4
  • 86
    • 55149089422 scopus 로고    scopus 로고
    • Pharmacologic management of Parkinson's disease
    • Lippincott, Williams and Wilkins, Philadelphia, J. Jankovic, E. Tolosa (Eds.)
    • Tolosa E., Katzenschlager R. Pharmacologic management of Parkinson's disease. Parkinson's Disease and Movement Disorders 2007, 110-145. Lippincott, Williams and Wilkins, Philadelphia. J. Jankovic, E. Tolosa (Eds.).
    • (2007) Parkinson's Disease and Movement Disorders , pp. 110-145
    • Tolosa, E.1    Katzenschlager, R.2
  • 87
    • 18744432650 scopus 로고    scopus 로고
    • Antiapoptotic effect of (-)-deprenyl in rat kidney after ischemia-reperfusion
    • Toronyi E., Hamar J., Magyar K., Szende B. Antiapoptotic effect of (-)-deprenyl in rat kidney after ischemia-reperfusion. Med. Sci. Monit. 2002, 8:BR65-BR68.
    • (2002) Med. Sci. Monit. , vol.8
    • Toronyi, E.1    Hamar, J.2    Magyar, K.3    Szende, B.4
  • 88
    • 0034677940 scopus 로고    scopus 로고
    • Cytochrome P450-dependent N-dealkylation of L-deprenyl in C57BL mouse liver microsomes: effects of in vivo pretreatment with ethanol, phenobarbital, beta-naphthoflavone and L-deprenyl
    • Valoti M., Fusi F., Frosini M., Pessina F., Tipton K.F., Sgaragli G.P. Cytochrome P450-dependent N-dealkylation of L-deprenyl in C57BL mouse liver microsomes: effects of in vivo pretreatment with ethanol, phenobarbital, beta-naphthoflavone and L-deprenyl. Eur. J. Pharmacol. 2000, 391:199-206.
    • (2000) Eur. J. Pharmacol. , vol.391 , pp. 199-206
    • Valoti, M.1    Fusi, F.2    Frosini, M.3    Pessina, F.4    Tipton, K.F.5    Sgaragli, G.P.6
  • 89
    • 0014189254 scopus 로고
    • Clinical trial of a new type promptly acting psychoenergetic agent (phenyl-isopropyl-methylpropinyl-HCl, "E-250" )
    • Varga E., Tringer L. Clinical trial of a new type promptly acting psychoenergetic agent (phenyl-isopropyl-methylpropinyl-HCl, "E-250" ). Acta Med. Acad. Sci. Hung. 1967, 23:289-295.
    • (1967) Acta Med. Acad. Sci. Hung. , vol.23 , pp. 289-295
    • Varga, E.1    Tringer, L.2
  • 90
    • 0031890109 scopus 로고    scopus 로고
    • Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: time course and modification by (-)-deprenyl
    • Wadia J.S., Chalmers-Redman R.M., Ju W.J., Carlile G.W., Phillips J.L., Fraser A.D., Tatton W.G. Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: time course and modification by (-)-deprenyl. J. Neurosci. 1998, 18:932-947.
    • (1998) J. Neurosci. , vol.18 , pp. 932-947
    • Wadia, J.S.1    Chalmers-Redman, R.M.2    Ju, W.J.3    Carlile, G.W.4    Phillips, J.L.5    Fraser, A.D.6    Tatton, W.G.7
  • 91
    • 0242643659 scopus 로고    scopus 로고
    • Transdermal selegiline: targeted effects on monoamine oxidases in the brain
    • Wecker L., James S., Copeland N., Pacheco M.A. Transdermal selegiline: targeted effects on monoamine oxidases in the brain. Biol. Psychiatry 2003, 54:1099-1104.
    • (2003) Biol. Psychiatry , vol.54 , pp. 1099-1104
    • Wecker, L.1    James, S.2    Copeland, N.3    Pacheco, M.A.4
  • 92
    • 75349084550 scopus 로고    scopus 로고
    • (-)-Deprenyl inhibits thermal injury-induced apoptotic signaling and hyperpermeability in microvascular endothelial cells
    • Whaley J.G., Tharakan B., Smith B., Hunter F.A., Childs E.W. (-)-Deprenyl inhibits thermal injury-induced apoptotic signaling and hyperpermeability in microvascular endothelial cells. J. Burn Care Res. 2009, 30:1018-1027.
    • (2009) J. Burn Care Res. , vol.30 , pp. 1018-1027
    • Whaley, J.G.1    Tharakan, B.2    Smith, B.3    Hunter, F.A.4    Childs, E.W.5
  • 93
    • 0023461313 scopus 로고
    • Monoamine oxidase B inhibition and the "cheese effect"
    • Youdim M.B., Finberg J.P. Monoamine oxidase B inhibition and the "cheese effect" J. Neural Transm. Suppl. 1987, 25:27-33.
    • (1987) J. Neural Transm. Suppl. , vol.25 , pp. 27-33
    • Youdim, M.B.1    Finberg, J.P.2
  • 94
    • 0037198060 scopus 로고    scopus 로고
    • Novel neuroprotective anti-Alzheimer drugs with anti-depressant activity derived from the anti-Parkinson drug, rasagiline
    • Youdim M.B., Weinstock M. Novel neuroprotective anti-Alzheimer drugs with anti-depressant activity derived from the anti-Parkinson drug, rasagiline. Mech. Ageing Dev. 2002, 123:1081-1086.
    • (2002) Mech. Ageing Dev. , vol.123 , pp. 1081-1086
    • Youdim, M.B.1    Weinstock, M.2
  • 95
    • 0035130289 scopus 로고    scopus 로고
    • Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B
    • Youdim M.B., Gross A., Finberg J.P. Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B. Br. J. Pharmacol. 2001, 132:500-506.
    • (2001) Br. J. Pharmacol. , vol.132 , pp. 500-506
    • Youdim, M.B.1    Gross, A.2    Finberg, J.P.3
  • 96
    • 0001360918 scopus 로고
    • In vivo inhibition of liver and brain monoamine oxidase by 1-Isonicotinyl-2-isopropyl hydrazine
    • Zeller E.A., Barsky J. In vivo inhibition of liver and brain monoamine oxidase by 1-Isonicotinyl-2-isopropyl hydrazine. Proc. Soc. Exp. Biol. Med. 1952, 81:459-461.
    • (1952) Proc. Soc. Exp. Biol. Med. , vol.81 , pp. 459-461
    • Zeller, E.A.1    Barsky, J.2


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