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Volumn 33, Issue 2, 1997, Pages 91-102

Clinical pharmacokinetics and pharmacodynamics of selegiline: An update

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; DRUG METABOLITE; MONOAMINE OXIDASE B INHIBITOR; SELEGILINE;

EID: 0030832391     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-199733020-00002     Document Type: Review
Times cited : (113)

References (44)
  • 1
    • 76549174465 scopus 로고
    • Phenylisopropylmethyl propinylamine (E-250), a new spectrum psychic energizer
    • Knoll J, Ecscri Z, Kelemen K, et al. Phenylisopropylmethyl propinylamine (E-250), a new spectrum psychic energizer. Arch Int Pharmacodyn 1965; 155: 154-64
    • (1965) Arch Int Pharmacodyn , vol.155 , pp. 154-164
    • Knoll, J.1    Ecscri, Z.2    Kelemen, K.3
  • 3
    • 0023502710 scopus 로고
    • Deprenyl facilitates the activity of the nigrostrialal dopaminergic neuron
    • Knoll J. Deprenyl facilitates the activity of the nigrostrialal dopaminergic neuron. J Neural Transm 1987: 25 Suppl.: 45-66
    • (1987) J Neural Transm , vol.25 , Issue.SUPPL. , pp. 45-66
    • Knoll, J.1
  • 4
    • 0029845388 scopus 로고    scopus 로고
    • Monoamine oxidase B inhibitors: Current status and future potential
    • Bentué-Ferrcr D, Menard G, Allain H. Monoamine oxidase B inhibitors: current status and future potential. CNS Drugs 1996; 6: 217-36
    • (1996) CNS Drugs , vol.6 , pp. 217-236
    • Bentué-Ferrcr, D.1    Menard, G.2    Allain, H.3
  • 5
    • 0021357120 scopus 로고
    • Chromatographic determination of nanogram levels of 2-(methylpropargylamino)-l-phenylpropane (Jumex, Deprenyl) in plasma
    • Juvanez Z, Rotonyi I, Toth A, et al. Chromatographic determination of nanogram levels of 2-(methylpropargylamino)-l-phenylpropane (Jumex, Deprenyl) in plasma. J Chromatogr 1984; 286: 363-9
    • (1984) J Chromatogr , vol.286 , pp. 363-369
    • Juvanez, Z.1    Rotonyi, I.2    Toth, A.3
  • 6
    • 0026474638 scopus 로고
    • Gas chromatographicmass spectrometric determination of plasma selegiline using a deuteraled internal standard
    • Patrick K, Nguyen B, McCallister J, Gas chromatographicmass spectrometric determination of plasma selegiline using a deuteraled internal standard. J Chromatogr 1992; 583: 254-8
    • (1992) J Chromatogr , vol.583 , pp. 254-258
    • Patrick, K.1    Nguyen, B.2    McCallister, J.3
  • 7
    • 0028018502 scopus 로고
    • An enzymatic assay for the analysis of sclegiline in plasma
    • Mahmood I.,Neau SH, Mason WD. An enzymatic assay for the analysis of sclegiline in plasma. J Pharm Biomed Anal 1994; 12: 895-9
    • (1994) J Pharm Biomed Anal , vol.12 , pp. 895-899
    • Mahmood, I.1    Neau, S.H.2    Mason, W.D.3
  • 8
    • 0010476575 scopus 로고
    • Pharmacokinetics of L-deprenyl and N-desmethylselegiline in blood versus plasma after single oral administration of I 10mg selegiline
    • Michaelis K, Waitainger J, Agavaz U, et al. Pharmacokinetics of L-deprenyl and N-desmethylselegiline in blood versus plasma after single oral administration of I 10mg selegiline. Pharm Res 1993; 10 Suppl.: 331
    • (1993) Pharm Res , vol.10 , Issue.SUPPL. , pp. 331
    • Michaelis, K.1    Waitainger, J.2    Agavaz, U.3
  • 9
    • 8544258862 scopus 로고
    • Determination of selegiline and desmethylselegiline in human plasma by GC with mass selective detection
    • Lessard D, Menabo W, Menard C, et al. Determination of selegiline and desmethylselegiline in human plasma by GC with mass selective detection, Pharm Res 1993; 10 Suppl.: 52
    • (1993) Pharm Res , vol.10 , Issue.SUPPL. , pp. 52
    • Lessard, D.1    Menabo, W.2    Menard, C.3
  • 10
    • 0030008656 scopus 로고    scopus 로고
    • The effect of dosing regimen and food on the bioavailability of the extensively metuholiy.cd. highly variable drug eldepryl (selegiline hydrochloride)
    • Barrett JS, Rohatagi S, Dewwitt KE, et al. The effect of dosing regimen and food on the bioavailability of the extensively metuholiy.cd. highly variable drug eldepryl (selegiline hydrochloride). Am J Ther 1996; 3: 298-313
    • (1996) Am J Ther , vol.3 , pp. 298-313
    • Barrett, J.S.1    Rohatagi, S.2    Dewwitt, K.E.3
  • 11
    • 0029832107 scopus 로고    scopus 로고
    • Pharmaenkinetics and safety of selegiline transdermal system relative to single dose oral administration in the elderly
    • Barren JS, Hochadel TJ, Momies RJ, et al. Pharmaenkinetics and safety of selegiline transdermal system relative to single dose oral administration in the elderly. Am J Ther 1996; 3: 1-11
    • (1996) Am J Ther , vol.3 , pp. 1-11
    • Barren, J.S.1    Hochadel, T.J.2    Momies, R.J.3
  • 12
    • 0028803434 scopus 로고
    • Pharmacokinetics and relative bioavailability of selegiline in healthy volunteers
    • Mahmood I, Marinae JS, Willsie S, et al. Pharmacokinetics and relative bioavailability of selegiline in healthy volunteers. Biopharm Drug Disp 1995; 16: 535-45
    • (1995) Biopharm Drug Disp , vol.16 , pp. 535-545
    • Mahmood, I.1    Marinae, J.S.2    Willsie, S.3
  • 13
    • 0043206428 scopus 로고
    • Pharmacokinetic of selegiline after oral dosing
    • Heinonen EH, Anttila M, Karnani H, et al. Pharmacokinetic of selegiline after oral dosing [abstract]. Men Disord 1994; 9 Suppl.: 57
    • (1994) Men Disord , vol.9 , Issue.SUPPL. , pp. 57
    • Heinonen, E.H.1    Anttila, M.2    Karnani, H.3
  • 14
    • 0027973083 scopus 로고
    • The pharmacokinetics and absolute bioavailability of selegiline in the dog
    • Mahmood I, Peters DK, Mason WD. The pharmacokinetics and absolute bioavailability of selegiline in the dog. Biopharm Drug Disp 1994; 15: 653-64
    • (1994) Biopharm Drug Disp , vol.15 , pp. 653-664
    • Mahmood, I.1    Peters, D.K.2    Mason, W.D.3
  • 15
    • 0014890923 scopus 로고
    • Interaction of momumine osidase inhibitors, amines and food stuffs
    • Murley E, Blackwell B. Interaction of momumine osidase inhibitors, amines and food stuffs. Adv Pharmacol Chemother 1970; 8: 186-239
    • (1970) Adv Pharmacol Chemother , vol.8 , pp. 186-239
    • Murley, E.1    Blackwell, B.2
  • 16
    • 0017863880 scopus 로고
    • Deprenyl administration in man: A selective monoamine oxidase B inhibitors without the 'cheese effect'
    • Elsworth JD, Glover V, Reynold GP, et al, Deprenyl administration in man: a selective monoamine oxidase B inhibitors without the 'cheese effect'. Psychopharmacology 1978; 57: 33-8
    • (1978) Psychopharmacology , vol.57 , pp. 33-38
    • Elsworth, J.D.1    Glover, V.2    Reynold, G.P.3
  • 17
    • 10244239976 scopus 로고
    • Selegilinc population pharmacokinetics
    • Gaudreault J, Wang S, Lalonde R. Selegilinc population pharmacokinetics. Pharm Res 1994; II Suppl.: 327
    • (1994) Pharm Res , vol.2 , Issue.SUPPL. , pp. 327
    • Gaudreault, J.1    Wang, S.2    Lalonde, R.3
  • 18
    • 0013360343 scopus 로고    scopus 로고
    • Multiple dode pharmacokinetics and dose proportionality of selegiline and metabolites in healthy males following transdermal administration
    • Rohalagi S, Barrett JS, Dewwitt KE, et al. Multiple dode pharmacokinetics and dose proportionality of selegiline and metabolites in healthy males following transdermal administration, Pharm Res 1996: 13 Suppl.: 502
    • (1996) Pharm Res , vol.13 , Issue.SUPPL. , pp. 502
    • Rohalagi, S.1    Barrett, J.S.2    Dewwitt, K.E.3
  • 19
    • 0028971359 scopus 로고
    • Luck of pharmucokinetic interaction between the selective dopaminie agonist cabergolinc and the MAO-B inhibitor selegiline
    • Dostert P, Streilin-Benedetti M. Persiani S, et al. Luck of pharmucokinetic interaction between the selective dopaminie agonist cabergolinc and the MAO-B inhibitor selegiline. J Neural Transm Suppl 1995; 45: 247-57
    • (1995) J Neural Transm Suppl , vol.45 , pp. 247-257
    • Dostert, P.1    Streilin-Benedetti, M.2    Persiani, S.3
  • 20
    • 0029790182 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic interaction between two selective monoamine oxidase inhibitors: Moclobemide and selegiline
    • Dingemanse J, Kneer J, Wallnofer A, et al. Pharmacokinetic-pharmacodynamic interaction between two selective monoamine oxidase inhibitors: moclobemide and selegiline. Clin Neuropharmacol 1996; 19: 399-414
    • (1996) Clin Neuropharmacol , vol.19 , pp. 399-414
    • Dingemanse, J.1    Kneer, J.2    Wallnofer, A.3
  • 21
    • 0026150396 scopus 로고
    • Selegiline: A review of its pharmacology, symptomatic benefits and protective potential in Purkinson's disease
    • Chrisp P, Mammen GJ, Sorkin EM. Selegiline: a review of its pharmacology, symptomatic benefits and protective potential in Purkinson's disease. Drugs Aging 1991; 3: 228-48
    • (1991) Drugs Aging , vol.3 , pp. 228-248
    • Chrisp, P.1    Mammen, G.J.2    Sorkin, E.M.3
  • 22
    • 0022638352 scopus 로고
    • Metabolism of deprenyl, a selective monoaminc oxidase (MAO) B inhibitor in rat: Relationship of metabolism in MAO-B
    • Yoshida T, Yamuada Y, Yamamoto T, et al. Metabolism of deprenyl, a selective monoaminc oxidase (MAO) B inhibitor in rat: relationship of metabolism in MAO-B. Xenohiotic 1986; 16: 129-39
    • (1986) Xenohiotic , vol.16 , pp. 129-139
    • Yoshida, T.1    Yamuada, Y.2    Yamamoto, T.3
  • 23
    • 0342427448 scopus 로고
    • Pharmacokinetics and its major metabolite N-desmethylselegiline after intravenous and inlraduodenal administration of selegilino in dog
    • Yamlahi L, Besner JG, Caille G, Pharmacokinetics and its major metabolite N-desmethylselegiline after intravenous and inlraduodenal administration of selegilino in dog. Pharm Res 1993; 10 Suppl.: 336
    • (1993) Pharm Res , vol.10 , Issue.SUPPL. , pp. 336
    • Yamlahi, L.1    Besner, J.G.2    Caille, G.3
  • 24
    • 0028316987 scopus 로고
    • Atypical metabolism of deprenyl and its enunlinmcr, (S)-(+)-N,a-dimethyl-N-propynlphenethylamine. by cytochrome P4502D6
    • Grace CM, Kinter MT, Macdonald TL. Atypical metabolism of deprenyl and its enunlinmcr, (S)-(+)-N,a-dimethyl-N-propynlphenethylamine. by cytochrome P4502D6. Chem Res Toxicol 1994; 7: 286-90
    • (1994) Chem Res Toxicol , vol.7 , pp. 286-290
    • Grace, C.M.1    Kinter, M.T.2    Macdonald, T.L.3
  • 25
    • 0031042161 scopus 로고    scopus 로고
    • Selegiline percutaneous absorption in various species and metabolism by human skin
    • Rohutugi S, Barren JS, McDonald LJ, et al. Selegiline percutaneous absorption in various species and metabolism by human skin. Pharm Res 1997; 14: 50-5
    • (1997) Pharm Res , vol.14 , pp. 50-55
    • Rohutugi, S.1    Barren, J.S.2    McDonald, L.J.3
  • 26
    • 0344633928 scopus 로고
    • Domination of dopamine hy monoumine oxidase A and B in rat and in Man
    • Tipton KF, Dosiert P, Slrolin Benedetti M, editors. London: Academic Press
    • Fowler CI, O'Carroll A, Tipton KF. Domination of dopamine hy monoumine oxidase A and B in rat and in Man. In: Tipton KF, Dosiert P, Slrolin Benedetti M, editors. Monoamine oxidase and disease. London: Academic Press. 1984
    • (1984) Monoamine Oxidase and Disease
    • Fowler, C.I.1    O'Carroll, A.2    Tipton, K.F.3
  • 27
    • 0017329403 scopus 로고
    • Substrate- and inhibitor-related characteristics of human platelet monoamine oxidase
    • Donnelly CH, Murphy DL. Substrate- and inhibitor-related characteristics of human platelet monoamine oxidase. Biochcm Pharmacol 1977; 26: 853-8
    • (1977) Biochcm Pharmacol , vol.26 , pp. 853-858
    • Donnelly, C.H.1    Murphy, D.L.2
  • 28
    • 0024205639 scopus 로고
    • Deprenyl as prophylaxis against Parkinson's disease?
    • Sonsala PK, Golbe LI, Deprenyl as prophylaxis against Parkinson's disease? Clin Neuropharmacol 1988; 11: 500-11
    • (1988) Clin Neuropharmacol , vol.11 , pp. 500-511
    • Sonsala, P.K.1    Golbe, L.I.2
  • 29
    • 0017594522 scopus 로고
    • Dopamine is a monoamine oxidase B substrale in man
    • Glover V, Sandier M, Owen F, et al. Dopamine is a monoamine oxidase B substrale in man. Nature 1977; 265: 80-1
    • (1977) Nature , vol.265 , pp. 80-81
    • Glover, V.1    Sandier, M.2    Owen, F.3
  • 30
    • 0021790704 scopus 로고
    • An improved fllurometric assay for brain monoamine oxidase
    • Morinan A, Garrat H, An improved fllurometric assay for brain monoamine oxidase. J Pharmacol Methods 1988; 13: 213-23
    • (1988) J Pharmacol Methods , vol.13 , pp. 213-223
    • Morinan, A.1    Garrat, H.2
  • 31
    • 0020070356 scopus 로고
    • Deamination of 5-hydroxytryptamine by both forms of monoamine oxidase in the rat brain
    • Fowler CJ, Tipton KF. Deamination of 5-hydroxytryptamine by both forms of monoamine oxidase in the rat brain. J Neurochem 1982; 38: 733-6
    • (1982) J Neurochem , vol.38 , pp. 733-736
    • Fowler, C.J.1    Tipton, K.F.2
  • 32
    • 0022192621 scopus 로고
    • Biochemical effects of L-deprenyl in atypical depressives
    • Lichowitz MR, Karroum F, Quitkin FM, et al. Biochemical effects of L-deprenyl in atypical depressives. Biol Psychiatry 1985; 20: 558-65
    • (1985) Biol Psychiatry , vol.20 , pp. 558-565
    • Lichowitz, M.R.1    Karroum, F.2    Quitkin, F.M.3
  • 34
    • 0019429465 scopus 로고
    • Selective acetylinic 'suicide' and reversible inhibitors of monoamine oxidase types A and B
    • Kalir A, Sabbagh A, Youdim MBH, Selective acetylinic 'suicide' and reversible inhibitors of monoamine oxidase types A and B. Br J Pharmacol 1981; 73: 55-64
    • (1981) Br J Pharmacol , vol.73 , pp. 55-64
    • Kalir, A.1    Sabbagh, A.2    Youdim, M.B.H.3
  • 36
    • 0024419756 scopus 로고
    • Platelet monoamine osidase in Parkinson patients: Effect of L-deprenyl therapy
    • Lee DH, Mendoza M, Dvorozniak MT, et al. Platelet monoamine osidase in Parkinson patients: effect of L-deprenyl therapy. J Neural Transm 1989; 1: 189-94
    • (1989) J Neural Transm , vol.1 , pp. 189-194
    • Lee, D.H.1    Mendoza, M.2    Dvorozniak, M.T.3
  • 37
    • 0022248699 scopus 로고
    • Platelet monoumine oxidase inhibition by deprenyl and trunyleypromine: Implications for clinical use
    • Simpson GM, Frederickson F., Palmer R, et al. Platelet monoumine oxidase inhibition by deprenyl and trunyleypromine: implications for clinical use. Biol Psychiatry 1985; 20: 680-4
    • (1985) Biol Psychiatry , vol.20 , pp. 680-684
    • Simpson, G.M.1    Frederickson, F.2    Palmer, R.3
  • 38
    • 0028577499 scopus 로고
    • Pharmacokinetic aspects of 1-deprenyl (selegiline) and its metabolism
    • Heinonen E, Antilla M, Lammintausta K. Pharmacokinetic aspects of 1-deprenyl (selegiline) and its metabolism. Clin Pharmucol Ther 1994; 56: 742-9
    • (1994) Clin Pharmucol Ther , vol.56 , pp. 742-749
    • Heinonen, E.1    Antilla, M.2    Lammintausta, K.3
  • 39
    • 0026326710 scopus 로고
    • A review of the pharmacology of selegiline
    • Heinonen li, L ammintuusta R. A review of the pharmacology of selegiline. Acta Nourol Stand 1991; 84 Suppl. 136: 44-59
    • (1991) Acta Nourol Stand , vol.84 , Issue.136 SUPPL. , pp. 44-59
    • Heinonen, L.1    Lammintuusta, R.2
  • 40
    • 0023137631 scopus 로고
    • Dose dependent effects of deprenyl on CSF monouminc metubolism in patients with Alzheimer's disease
    • Sunderland T, Tarint PN, Cohen RM, et al. Dose dependent effects of deprenyl on CSF monouminc metubolism in patients with Alzheimer's disease. Psychopharmacology 1987; 91: 293-6
    • (1987) Psychopharmacology , vol.91 , pp. 293-296
    • Sunderland, T.1    Tarint, P.N.2    Cohen, R.M.3
  • 41
    • 0024557734 scopus 로고
    • Monoamine oxidase activity und monoamine metabolism in brains of Parkinsonian patients treated with l-deprenyl
    • Riederer H, Youdim MBH. Monoamine oxidase activity und monoamine metabolism in brains of Parkinsonian patients treated with l-deprenyl. J Neurochem 1989; 52: 515-20
    • (1989) J Neurochem , vol.52 , pp. 515-520
    • Riederer, H.1    Youdim, M.B.H.2
  • 42
    • 8544259633 scopus 로고
    • Desmethylsclcgiline, a metabolite of selegiline, is an irreversible inhibitor of MAO-B in human subjects
    • Heinonen EH, Anttila M, Nynuin L, et al. Desmethylsclcgiline, a metabolite of selegiline, is an irreversible inhibitor of MAO-B in human subjects. Neurology 1993; 43 Suppl.: A156
    • (1993) Neurology , vol.43 , Issue.SUPPL.
    • Heinonen, E.H.1    Anttila, M.2    Nynuin, L.3
  • 43
    • 0025583426 scopus 로고
    • Kinetic evaluation of MAO-B activity following oral administration of selegiline and dusmethylselegiline in the rat
    • Borbe H, Niehch G, Nickel B. Kinetic evaluation of MAO-B activity following oral administration of selegiline and dusmethylselegiline in the rat. J Neural Transm 1990; 32 Suppl.: 131-7
    • (1990) J Neural Transm , vol.32 , Issue.SUPPL. , pp. 131-137
    • Borbe, H.1    Niehch, G.2    Nickel, B.3


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