C-terminal domain of Chk1 regulates its subcellular location and kinase activity for DNA repair

Chinese Science Bulletin

Volumn 56, Issue 30, 2011, Pages 3138-3147

  Ning, LiFeng ^a,b   Wang, HuiPing ^b   San, Dan ^a   Sang, JianLi ^a  

^a BEIJING NORMAL UNIVERSITY   (China)

^b NATIONAL RESEARCH INSTITUTE FOR FAMILY PLANNING   (China)

Author keywords

cell cycle; Chk1; DNA damage; domain; nuclear accumulation; repair

Indexed keywords

EID: 80053455134     PISSN: 10016538     EISSN: 18619541     Source Type: Journal    
DOI: 10.1007/s11434-011-4538-4     Document Type: Article

References (28)

1. Zhou B B, Elledge S J. The DNA damage response: Putting checkpoints in perspective. Nature, 2000, 408: 433-439.
2. Zachos G, Rainey M D, Gillespie D A. Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects. EMBO J, 2003, 22: 713-723.
3. Merry C, Fu K, Wang J, et al. Targeting the checkpoint kinase Chk1 in cancer therapy. Cell Cycle, 2010, 9: 279-283.
4. Li X F, Ward T, Yao X B, et al. Chk1 prevents abnormal mitosis of S-phase HeLa cells containing DNA damage. Chinese Sci Bull, 2009, 54: 4205-4213.
5. Ng C P, Lee H C, Ho C W, et al. Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains. J Biol Chem, 2004, 279: 8808-8819.
6. Sweeney G. Leptin signalling. Cell Signal, 2002, 14: 655-663.
7. Bolderson E, Richard D J, Zhou B B, et al. Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair. Clin Cancer Res, 2009, 15: 6314-6320.
8. Carrassa L, Sanchez Y, Erba E, et al. U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle check-point. J Cell Mol Med, 2009, 13: 1565-1576.
9. Karlsson-Rosenthal C, Millar J B. Cdc25: Mechanisms of checkpoint inhibition and recovery. Trends Cell Biol, 2006, 16: 285-292.
10. Pan Y, Ren K H, He H W, et al. Knockdown of Chk1 sensitizes human colon carcinoma HCT116 cells in a p53-dependent manner to lidamycin through abrogation of a G2/M checkpoint and induct ion of apoptosis. Cancer Biol Ther, 2009, 8: 1559-1566.
11. McNeely S, Conti C, Sheikh T, et al. Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase. Cell Cycle, 2010, 9: 995-1004.
12. Xiao Z, Xue J, Gu W Z, et al. Cyclin B1 is an efficacy-predicting biomarker for Chk1 inhibitors. Biomarkers, 2008, 13: 579-596.
13. Nigg E A. Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol, 2001, 2: 21-32.
14. Ling H, Wen L, Ji X X, et al. Growth inhibitory effect and Chk1-dependent signaling involved in G2/M arrest on human gastric cancer cells induced by diallyl disulfide. Braz J Med Biol Res, 2010, 43: 271-278.
15. Wilsker D, Petermann E, Helleday T, et al. Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control. Proc Natl Acad Sci USA, 2008, 105: 20752-20757.
16. Liu Q, Guntuku S, Cui X S, et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev, 2000, 14: 1448-1459.
17. Zhao H, Watkins J L, Piwnica-Worms H. Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Proc Natl Acad Sci USA, 2002, 99: 14795-14800.
18. Lopez-Girona A, Tanaka K, Chen X B, et al. Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast. Proc Natl Acad Sci USA, 2001, 98: 11289-11294.
19. Guo Z, Kumagai A, Wang S X, et al. Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev, 2000, 14: 2745-2756.
20. Gatei M, Sloper K, Sorensen C, et al. Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J Biol Chem, 2003, 278: 14806-14811.
21. Jiang K, Pereira E, Maxfield M, et al. Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345. J Biol Chem, 2003, 278: 25207-25217.
22. Dunaway S, Liu H Y, Walworth N C. Interaction of 14-3-3 protein with Chk1 affects localization and checkpoint function. J Cell Sci, 2004, 118: 39-50.
23. Kim E M, Burke D J. DNA damage activates the SAC in an ATM/ATR-dependent manner, independently of the kinetochore. PLoS Genet, 2008, 4: e1000015.
24. Chen L, Liu T H, Walworth N C. Association of Chk1 with 14-3-3 proteins is stimulated by DNA damage. Genes Dev, 1999, 13: 675-685.
25. Seimiya H, Sawada H, Muramatsu Y, et al. Involvement of 14-3-3 proteins in nuclear localization of telomerase. EMBO J, 2000, 19: 2652-2661.
26. Muslin A J, Tanner J W, Allen P M, et al. Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell, 1996, 84: 889-897.
27. Zeng Y, Piwnica-Worms H. DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding. Mol Cell Biol, 1999, 19: 7410-7419.
28. Atanassov B S, Ninova P D, Anachkova B B, et al. Relationship between DNA repair capacity and resistance to genotoxins in four human cell lines. Cancer Detect Prev, 2003, 27: 24-29.