Multidrug efflux pumps: The structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues

FEBS Journal

Volumn 277, Issue 3, 2010, Pages 550-563

  Kerr, Ian D ^a   Jones, Peter M ^b   George, Anthony M ^b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

Author keywords

ABC transporter; ABCC1; ABCG2; Homology modelling; MsbA; Multidrug pump; P glycoprotein; Sav1866; Structure; Transport mechanism

Indexed keywords

ABC TRANSPORTER; ADENOSINE DIPHOSPHATE; BREAST CANCER RESISTANCE PROTEIN; GLYCOPROTEIN P; MEMBRANE PROTEIN; MSBA PROTEIN; MULTIDRUG EFFLUX PUMP; MULTIDRUG RESISTANCE PROTEIN 1; UNCLASSIFIED DRUG;

CANCER RESISTANCE; CRYSTALLIZATION; DRUG BINDING; ELECTRON SPIN RESONANCE; ESCHERICHIA COLI; EUKARYOTIC CELL; HUMAN; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROKARYOTIC CELL; PROTEIN FUNCTION; SALMONELLA TYPHI; SHORT SURVEY; STAPHYLOCOCCUS AUREUS; STRUCTURAL HOMOLOGY; STRUCTURAL PROTEOMICS; VIBRIO CHOLERAE;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; DRUG RESISTANCE, MULTIPLE; EVOLUTION, MOLECULAR; HUMANS; MODELS, MOLECULAR; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; P-GLYCOPROTEINS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

EUKARYOTA; PROKARYOTA;

EID: 75149135645     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2009.07486.x     Document Type: Short Survey

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