-
1
-
-
0037425564
-
Mortality associated with influenza and respiratory syncytial virus in the United States
-
Thompson, W. W.; Shay, D. K.; Weintraub, E.; Brammer, L.; Cox, N.; Anderson, L. J.; Fukuda, K. Mortality associated with influenza and respiratory syncytial virus in the United States. J. Am. Med. Assoc. 2003, 289, 179-186.
-
(2003)
J. Am. Med. Assoc
, vol.289
, pp. 179-186
-
-
Thompson, W.W.1
Shay, D.K.2
Weintraub, E.3
Brammer, L.4
Cox, N.5
Anderson, L.J.6
Fukuda, K.7
-
2
-
-
27744437942
-
Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection
-
Carey, M. A.; Bradbury, J. A.; Seubert, J. M.; Langenbach, R.; Zeldin, D. C.; Germolec, D. R. Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection. J. Immunol. 2005, 175, 6878-6884.
-
(2005)
J. Immunol
, vol.175
, pp. 6878-6884
-
-
Carey, M.A.1
Bradbury, J.A.2
Seubert, J.M.3
Langenbach, R.4
Zeldin, D.C.5
Germolec, D.R.6
-
3
-
-
0344983434
-
Influenza
-
Nicholson, K. G.; Wood, J. M.; Zambon, M. Influenza. Lancet 2003, 362, 1733-1745.
-
(2003)
Lancet
, vol.362
, pp. 1733-1745
-
-
Nicholson, K.G.1
Wood, J.M.2
Zambon, M.3
-
4
-
-
0031048319
-
Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogs with potent anti-influenza activity
-
Kim, C. U.; Lew, W.; Williams, M. A.; Zhang, L.; Liu, H.; Swaminathan, S.; Bischofberger, N.; Chen, M. S.; Tai, C. Y.; Mendel, D. B.; Laver, W. G.; Stevens, R. C. Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogs with potent anti-influenza activity. J. Am. Chem. Soc. 1997, 119, 681-690.
-
(1997)
J. Am. Chem. Soc
, vol.119
, pp. 681-690
-
-
Kim, C.U.1
Lew, W.2
Williams, M.A.3
Zhang, L.4
Liu, H.5
Swaminathan, S.6
Bischofberger, N.7
Chen, M.S.8
Tai, C.Y.9
Mendel, D.B.10
Laver, W.G.11
Stevens, R.C.12
-
5
-
-
15644379365
-
Dihydropyrancarboxamides related to zanami-vir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-gua-nidino-and 4-amino-4#-pyran-6-carboxamides
-
Smith, P. W.; Sollis, S. L.; Howes, P. D.; Cherry, P. C.; Starkey, I. D.; Cobley, K. N.; Weston, H.; Scicinski, J.; Merritt, A.; Whittington, A.; Wyatt, P.; Taylor, N.; Green, D.; Bethell, R.; Madar, S.; Fenton, R. J.; Morley, P. J.; Pateman, T.; Beresford, A. Dihydropyrancarboxamides related to zanami-vir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-gua-nidino-and 4-amino-4#-pyran-6-carboxamides. J. Med. Chem. 1998, 41, 787-797.
-
(1998)
J. Med. Chem
, vol.41
, pp. 787-797
-
-
Smith, P.W.1
Sollis, S.L.2
Howes, P.D.3
Cherry, P.C.4
Starkey, I.D.5
Cobley, K.N.6
Weston, H.7
Scicinski, J.8
Merritt, A.9
Whittington, A.10
Wyatt, P.11
Taylor, N.12
Green, D.13
Bethell, R.14
Madar, S.15
Fenton, R.J.16
Morley, P.J.17
Pateman, T.18
Beresford, A.19
-
6
-
-
11144353776
-
Syntheses and neuraminidase inhibitory activity of multisubstituted cyclopentane amide derivatives
-
Chand, P.; Babu, Y. S.; Bantia, S.; Rowland, S.; Dehghani, A.; Kotian, P. L.; Hutchison, T. L.; Ali, S.; Brouillette, W.; El-Kattan, Y.; Lin, T.-H. Syntheses and neuraminidase inhibitory activity of multisubstituted cyclopentane amide derivatives. J. Med. Chem. 2004, 47, 1919-1929.
-
(2004)
J. Med. Chem
, vol.47
, pp. 1919-1929
-
-
Chand, P.1
Babu, Y.S.2
Bantia, S.3
Rowland, S.4
Dehghani, A.5
Kotian, P.L.6
Hutchison, T.L.7
Ali, S.8
Brouillette, W.9
El-Kattan, Y.10
Lin, T.-H.11
-
7
-
-
30344438548
-
A QSAR study on influenza neuraminidase inhibitors
-
Verma, R. P.; Hansch, C. A QSAR study on influenza neuraminidase inhibitors. Bioorg. Med. Chem. 2006, 14, 982-996.
-
(2006)
Bioorg. Med. Chem
, vol.14
, pp. 982-996
-
-
Verma, R.P.1
Hansch, C.2
-
8
-
-
34447521097
-
Correlation of biological activity of phenoxyacetic acids with Hammett substituent constants and partition coefficients
-
Hansch, C.; Maloney, P. P.; Fujita, T.; Muir, R. M. Correlation of biological activity of phenoxyacetic acids with Hammett substituent constants and partition coefficients. Nature 1962, 194, 178-180.
-
(1962)
Nature
, vol.194
, pp. 178-180
-
-
Hansch, C.1
Maloney, P.P.2
Fujita, T.3
Muir, R.M.4
-
9
-
-
0003955925
-
Exploring QSAR: Fundamentals and Applications in Chemistry and Biology
-
In, American Chemical Society, Washington, D.C.,
-
Hansch, C.; Leo, A. In Exploring QSAR: Fundamentals and Applications in Chemistry and Biology, American Chemical Society, Washington, D.C., 1995.
-
(1995)
-
-
Hansch, C.1
Leo, A.2
-
10
-
-
0036628559
-
Comparative QSAR and the radical toxicity of various functional groups
-
Selassie, C.D.; Garg, R.; Kapur, S.; Kurup, A.; Verma, R. P.; Mekapati, S. B.; Hansch, C. Comparative QSAR and the radical toxicity of various functional groups. Chem. Rev. 2002, 102, 2585-2605.
-
(2002)
Chem. Rev
, vol.102
, pp. 2585-2605
-
-
Selassie, C.D.1
Garg, R.2
Kapur, S.3
Kurup, A.4
Verma, R.P.5
Mekapati, S.B.6
Hansch, C.7
-
11
-
-
12844254457
-
Chemical-biological interactions in human
-
Verma, R. P.; Kurup, A.; Mekapati, S. B.; Hansch, C. Chemical-biological interactions in human. Bioorg. Med. Chem. 2005, 13, 933-948.
-
(2005)
Bioorg. Med. Chem
, vol.13
, pp. 933-948
-
-
Verma, R.P.1
Kurup, A.2
Mekapati, S.B.3
Hansch, C.4
-
12
-
-
2542507358
-
QSAR and AD ME
-
Hansch, C.; Leo, A.; Mekapati, S. B.; Kurup, A. QSAR and AD ME. Bioorg. Med. Chem. 2004, 12, 3391-3400.
-
(2004)
Bioorg. Med. Chem
, vol.12
, pp. 3391-3400
-
-
Hansch, C.1
Leo, A.2
Mekapati, S.B.3
Kurup, A.4
-
13
-
-
0043035746
-
QSAR: Then and now
-
Selassie, C. D.; Mekapati, S. B.; Verma, R. P. QSAR: Then and now. Curr. Top. Med. Chem. 2002, 2, 1357-1379.
-
(2002)
Curr. Top. Med. Chem
, vol.2
, pp. 1357-1379
-
-
Selassie, C.D.1
Mekapati, S.B.2
Verma, R.P.3
-
14
-
-
84889771349
-
-
C-QSAR Program, BioByte Corp., 201W. 4th Street, Suite 204, Claremont, CA 91711, USA
-
C-QSAR Program, BioByte Corp., 201W. 4th Street, Suite 204, Claremont, CA 91711, USA, www.biobyte.com.
-
-
-
-
15
-
-
84987100711
-
Cross validation, Bootstrapping and partial least squares compared with multiple regression in conventional QSAR studies
-
Cramer, R. D., III; Bunce, J. D.; Patterson, D. E.; Frank, I. E. Cross validation, Bootstrapping and partial least squares compared with multiple regression in conventional QSAR studies. Quant. Struct.-Act. Relat. 1988, 7, 18-25.
-
(1988)
Quant. Struct.-Act. Relat
, vol.7
, pp. 18-25
-
-
Cramer III, R.D.1
Bunce, J.D.2
Patterson, D.E.3
Frank, I.E.4
-
16
-
-
0000998706
-
Modeling with special descriptors derived from a mediumsized set of connectivity indices
-
Pogliani, L. Modeling with special descriptors derived from a mediumsized set of connectivity indices. J. Phys. Chem. 1996, 100, 18065-18077.
-
(1996)
J. Phys. Chem
, vol.100
, pp. 18065-18077
-
-
Pogliani, L.1
-
17
-
-
0034299377
-
From molecular connectivity indices to semiempirical connectivity terms: Recent trends in graph theoretical descriptors
-
Pogliani, L. From molecular connectivity indices to semiempirical connectivity terms: Recent trends in graph theoretical descriptors. Chem. Rev. 2000, 100, 3827-3858.
-
(2000)
Chem. Rev
, vol.100
, pp. 3827-3858
-
-
Pogliani, L.1
-
18
-
-
33144483831
-
QSAR study on topically acting sulfonamides incorporating GABA moieties: A molecular connectivity approach
-
Agrawal, V.; Singh, J.; Khadikar, P. V.; Supuran, C. T. QSAR study on topically acting sulfonamides incorporating GABA moieties: A molecular connectivity approach. Bioorg. Med. Chem. Lett. 2006, 16, 2044-2051.
-
(2006)
Bioorg. Med. Chem. Lett
, vol.16
, pp. 2044-2051
-
-
Agrawal, V.1
Singh, J.2
Khadikar, P.V.3
Supuran, C.T.4
-
19
-
-
28544441042
-
Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study
-
Selassie, C. D.; Kapur, S.; Verma, R. P.; Rosario, M. Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study. J. Med. Chem. 2005, 48, 7234-7242.
-
(2005)
J. Med. Chem
, vol.48
, pp. 7234-7242
-
-
Selassie, C.D.1
Kapur, S.2
Verma, R.P.3
Rosario, M.4
-
20
-
-
33748458813
-
Cytotoxicity of organic compounds against ovarian cancer cells: A quantitative structure-activity relationship study
-
Verma, R. P.; Hansch, C. Cytotoxicity of organic compounds against ovarian cancer cells: A quantitative structure-activity relationship study. Mol. Pharm. 2006, 3, 441-450.
-
(2006)
Mol. Pharm
, vol.3
, pp. 441-450
-
-
Verma, R.P.1
Hansch, C.2
-
21
-
-
33846833802
-
Understanding human rhinovirus infections in terms of QSAR
-
Verma, R. P.; Hansch, C. Understanding human rhinovirus infections in terms of QSAR. Virology 2007, 359, 152-161.
-
(2007)
Virology
, vol.359
, pp. 152-161
-
-
Verma, R.P.1
Hansch, C.2
-
22
-
-
0034608462
-
Carbocyclic influenza neuraminidase inhibitors possessing a C_inf_3_/inf_-cyclic amine side chain: Synthesis and inhibitory activity
-
Lew, W.; Wu, H.; Chen, X.; Graves, B. J.; Escarpe, P. A.; MacArthur, H. L.; Mendel, D. B.; Kim, C. U. Carbocyclic influenza neuraminidase inhibitors possessing a C_inf_3_/inf_-cyclic amine side chain: Synthesis and inhibitory activity. Bioorg. Med. Chem. Lett. 2000, 10, 1257-1260.
-
(2000)
Bioorg. Med. Chem. Lett
, vol.10
, pp. 1257-1260
-
-
Lew, W.1
Wu, H.2
Chen, X.3
Graves, B.J.4
Escarpe, P.A.5
MacArthur, H.L.6
Mendel, D.B.7
Kim, C.U.8
-
23
-
-
15444353753
-
Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors
-
Kim, C. U.; Lew, W.; Williams, M. A.; Wu, H.; Zhang, L.; Chen, X.; Escarpe, P. A.; Mendel, D. B.; Laver, W. G.; Stevens, R. C. Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors. J. Med. Chem. 1998, 41, 2451-2460.
-
(1998)
J. Med. Chem
, vol.41
, pp. 2451-2460
-
-
Kim, C.U.1
Lew, W.2
Williams, M.A.3
Wu, H.4
Zhang, L.5
Chen, X.6
Escarpe, P.A.7
Mendel, D.B.8
Laver, W.G.9
Stevens, R.C.10
-
24
-
-
0032217040
-
A new series of C_inf_3_/inf_-aza carbocyclic influenza neuraminidase inhibitors: Synthesis and inhibitory activity
-
Lew, W.; Wu, H.; Mendel, D. B.; Escarpe, P. A.; Chen, X.; Laver, W. G.; Graves, B. J.; Kim, C. U. A new series of C_inf_3_/inf_-aza carbocyclic influenza neuraminidase inhibitors: Synthesis and inhibitory activity. Bioorg. Med. Chem. Lett. 1998, 8, 3321-3324.
-
(1998)
Bioorg. Med. Chem. Lett
, vol.8
, pp. 3321-3324
-
-
Lew, W.1
Wu, H.2
Mendel, D.B.3
Escarpe, P.A.4
Chen, X.5
Laver, W.G.6
Graves, B.J.7
Kim, C.U.8
-
25
-
-
0030800108
-
Structure-activity relationships of carbocyclic influenza neuraminidase inhibitors
-
Williams, M.A.; Lew, W.; Mendel, D.B.; Tai, C. Y.; Escarpe, P. A.; Laver, W. G.; Stevens, R. C.; Kim, C. U. Structure-activity relationships of carbocyclic influenza neuraminidase inhibitors. Bioorg. Med. Chem. Lett. 1997, 7, 1837-1842.
-
(1997)
Bioorg. Med. Chem. Lett
, vol.7
, pp. 1837-1842
-
-
Williams, M.A.1
Lew, W.2
Mendel, D.B.3
Tai, C.Y.4
Escarpe, P.A.5
Laver, W.G.6
Stevens, R.C.7
Kim, C.U.8
-
26
-
-
0030739707
-
C_inf_3_/inf_-thia and C3-carba isosteres of a carbocyclic influenza neuraminidase inhibitor, (3R, 4R, 5S)-4-acetamido-5-amino-3-propoxy-1-cyclohexene-1-carboxylic acid
-
Lew, W; Williams, M. A.; Mendel, D. B.; Escarpe, P. A., Kim, C. U. C_inf_3_/inf_-thia and C3-carba isosteres of a carbocyclic influenza neuraminidase inhibitor, (3R, 4R, 5S)-4-acetamido-5-amino-3-propoxy-1-cyclohexene-1-carboxylic acid. Bioorg. Med. Chem. Lett. 1997, 7, 1843-1846.
-
(1997)
Bioorg. Med. Chem. Lett
, vol.7
, pp. 1843-1846
-
-
Lew, W.1
Williams, M.A.2
Mendel, D.B.3
Escarpe, P.A.4
Kim, C.U.5
-
27
-
-
0036006911
-
Beware of q_sup_2_/sup_!
-
Golbraikh, A.; Tropsha, A.
-
Golbraikh, A.; Tropsha, A. Beware of q_sup_2_/sup_! J. Mol. Graph. Modl. 2002, 20, 269-276.
-
(2002)
J. Mol. Graph. Modl
, vol.20
, pp. 269-276
-
-
-
28
-
-
0038724207
-
The importance of being earnest: Validation is the absolute essential for successful application and interpretation of QSPR models
-
Tropsha, A.; Gramatica, P.; Gombar, V. K. The importance of being earnest: Validation is the absolute essential for successful application and interpretation of QSPR models. QSAR Comb. Sci. 2003, 22, 69-77.
-
(2003)
QSAR Comb. Sci
, vol.22
, pp. 69-77
-
-
Tropsha, A.1
Gramatica, P.2
Gombar, V.K.3
-
29
-
-
84889768103
-
-
Spartan'06Program, Wavefunction, Inc., 18401 VonKarmanAvenue, Suite 370, Irvine, CA 92612, USA.
-
Spartan'06Program, Wavefunction, Inc., 18401 VonKarmanAvenue, Suite 370, Irvine, CA 92612, USA. www.wavefun.com.
-
-
-
-
30
-
-
33644896260
-
MIA-QSAR modelling of anti-HIV-1 acvtivities of some 2-amino-6-arylsulfonylbenzonitriles and their thio and sulfinyl congeners
-
Freitas, M. P. MIA-QSAR modelling of anti-HIV-1 acvtivities of some 2-amino-6-arylsulfonylbenzonitriles and their thio and sulfinyl congeners. Org. Biomol. Chem. 2006, 4, 1154-1159.
-
(2006)
Org. Biomol. Chem
, vol.4
, pp. 1154-1159
-
-
Freitas, M.P.1
-
31
-
-
0031024171
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski, C. A.; Lombardo, F.; Dominy, B. W.; Feeney, P. J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug. Delivery Rev. 1997, 23, 3-25.
-
(1997)
Adv. Drug. Delivery Rev
, vol.23
, pp. 3-25
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
32
-
-
0043069489
-
Drug research: Myths, hype and reality
-
Kubinyi, H. Drug research: Myths, hype and reality. Nature Rev. 2003, 2, 665-668.
-
(2003)
Nature Rev
, vol.2
, pp. 665-668
-
-
Kubinyi, H.1
-
33
-
-
0032795192
-
Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption
-
Clark, D. E. Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption. J. Pharm. Sci. 1999, 88, 807-814.
-
(1999)
J. Pharm. Sci
, vol.88
, pp. 807-814
-
-
Clark, D.E.1
|