A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: Synthesis and inhibitory activity

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 23, 1998, Pages 3321-3324

  Lew, Willard ^a   Wu, Huiwei ^a   Mendel, Dirk B ^a   Escarpe, Paul A ^a   Chen, Xiaowu ^a   Laver, W Graeme ^b   Graves, Bradford J ^c   Kim, Choung U ^a  

^a GILEAD SCIENCES   (United States)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^c ROCHE PRODUCTS LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; HETEROCYCLIC COMPOUND; OSELTAMIVIR; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; ENZYME INHIBITOR; SIALIDASE;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; INFLUENZA VIRUS A; NONHUMAN; VIRUS INHIBITION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; ORTHOMYXOVIRUS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTIVIRAL AGENTS; AZA COMPOUNDS; ENZYME INHIBITORS; NEURAMINIDASE; ORTHOMYXOVIRIDAE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032217040     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00587-3     Document Type: Article

References (8)

1. th International Conference on Antiviral Research, San Diego, CA, USA, April 5-10, 1998.
2. 2. Kim, C. U.; Lew, W.; Williams, M. A.; Liu, H.; Zhang, L.; Swaminathan, S.; Bischofberger, N.; Chen, M. S.; Mendel, D. B.; Tai, C. Y.; Laver, W. G.; Stevens, R. C. J. Am. Chem. Soc. 1997, 119, 681.
3. 3. (a) Williams, M.A.; Lew, W.; Mendel, D.B.; Tai, C.Y.; Escarpe, P.A.; Laver, W.G.; Stevens, R.C; Kim, C.U. Bioorg. Med. Chem. Lett. 1997, 7, 1837
4. (b) Lew, W.; Williams, M.A.; Mendel, D.B.; Escarpe, P.A.; Kim, C.U. Bioorg. Med. Chem. Lett. 1997, 7, 1843
5. (c) Kim, C. U.; Lew, W.; Williams, M. A.; Wu, H.; Zhang, L.; Chen, X.; Escarpe, P.A.; Mendel, D. B.; Laver, W. G.; Stevens, R. C. J. Med. Chem. 1998, 41, 2451.
6. 4. Murahashi, S.I.; Taniguchi, Y.; Imada, Y.; Tanigawa, Y. J. Org. Chem. 1989, 54, 3292.
7. 5 azido group of 6.
8. 6. A full protocol for the enzymatic assay is found in: Li, W.; Escarpe, P.A.; Eisenberg, E.J.; Cundy, K.C.; Sweet, C.; Jakeman, K.J.; Merson, J.; Lew, W.; Williams, M.A.; Zhang, L.; Kim, C.U.; Bischofberger, N.; Chen, M.S.; Mendel, D.B. Antimicrob. Agents Chemother. 1998, 42, 647.