Nitisinone improves eye and skin pigmentation defects in a mouse model of oculocutaneous albinism

Journal of Clinical Investigation

Volumn 121, Issue 10, 2011, Pages 3914-3923

  Onojafe, Ighovie F ^a   Adams, David R ^b   Simeonov, Dimitre R ^b   Zhang, Jun ^a   Chan, Chi Chao ^a   Bernardini, Isa M ^b   Sergeev, Yuri V ^a   Dolinska, Monika B ^a   Alur, Ramakrishna P ^a   Brilliant, Murray H ^c   Gahl, William A ^b   Brooks, Brian P ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c MARSHFIELD CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MELANIN; NITISINONE; PLACEBO; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; MELANOSOME; MOUSE; NONHUMAN; NULL ALLELE; OCULOCUTANEOUS ALBINISM; OCULOCUTANEOUS ALBINISM TYPE 1B; PIGMENT DISORDER; PRIORITY JOURNAL; SKIN PIGMENTATION; TREATMENT RESPONSE;

ALBINISM, OCULOCUTANEOUS; ANIMALS; CYCLOHEXANONES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; ENZYME STABILITY; EYE COLOR; FEMALE; HUMANS; MELANINS; MELANOCYTES; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, MOLECULAR; MONOPHENOL MONOOXYGENASE; MUTATION; NITROBENZOATES; PREGNANCY; SKIN PIGMENTATION; TYROSINE;

EID: 80053406581     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI59372     Document Type: Article

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