L-DOPA is an endogenous ligand for OA1

PLoS Biology

Volumn 6, Issue 9, 2008, Pages 1861-1869

  Lopez, Vanessa M ^a   Decatur, Christina L ^a   Stamer, W Daniel ^a   Lynch, Ronald M ^a   McKay, Brian S ^a,b  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN; CALCIUM; DOPAMINE RECEPTOR; G PROTEIN COUPLED RECEPTOR; LEVODOPA; MELANIN; MONOPHENOL MONOOXYGENASE; PIGMENT EPITHELIUM DERIVED FACTOR; PROTEIN OA1; TYROSINE; UNCLASSIFIED DRUG; DOPAMINE; DOPAMINE RECEPTOR STIMULATING AGENT; EYE PROTEIN; GPR143 PROTEIN, HUMAN; LIGAND; MEMBRANE PROTEIN; NERVE GROWTH FACTOR; PIGMENT EPITHELIUM-DERIVED FACTOR; PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR;

ALBINISM; ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; BINDING SITE; CALCIUM TRANSPORT; CELL SURFACE; CONTROLLED STUDY; EYE DISEASE; GENE EXPRESSION; ISOTOPE LABELING; NONHUMAN; OCULAR CUTANEOUS ALBINISM; PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION; SYNTHESIS; ANIMAL; CELL LINE; CYTOLOGY; DRUG POTENTIATION; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY;

ALBINISM; ANIMALS; AUTOCRINE COMMUNICATION; CALCIUM; CELL LINE; DOPAMINE; DOPAMINE AGENTS; EYE PROTEINS; HUMANS; LEVODOPA; LIGANDS; MEMBRANE GLYCOPROTEINS; MONOPHENOL MONOOXYGENASE; NERVE GROWTH FACTORS; PIGMENT EPITHELIUM OF EYE; PROTEASE INHIBITORS; RECEPTORS, DOPAMINE; SERPINS; SIGNAL TRANSDUCTION; TYROSINE;

EID: 54749153292     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.0060236     Document Type: Article

References (47)

1. Akeo K, Shirai S, Okisaka S, Shimizu H, Miyata H, et al. (1996) Histology of fetal eyes with oculocutaneous albinism. Arch Ophthalmol 114: 613-616.
2. Gregor Z (1978) The perifoveal vasculature in albinism. Br J Ophthalmol 62: 554-557.
3. Schraermeyer U, Heimann K (1999) Current understanding on the role of retinal pigment epithelium and its pigmentation. Pigment Cell Res 12: 219-236.
4. Rachel RA, Mason CA, Beermann F (2002) Influence of tyrosinase levels on pigment accumulation in the retinal pigment epithelium and on the uncrossed retinal projection. Pigment Cell Res 15: 273-281.
5. Okulicz JF, Shah RS, Schwartz RA, Janniger CK (2003) Oculocutaneous albinism. J Eur Acad Dermatol Venereol 17: 251-256.
6. Donatien P, Jeffery G (2002) Correlation between rod photoreceptor numbers and levels of ocular pigmentation. Invest Ophthalmol Vis Sci 43: 1198-1203.
7. Russell-Eggitt I (2001) Albinism. Ophthalmol Clin North Am 14: 533-546.
8. Oetting WS (1999) Albinism. Curr Opin Pediatr 11: 565-571.
9. Oetting WS, King RA (1999) Molecular basis of albinism: mutations and polymorphisms of pigmentation genes associated with albinism. Hum Mutat 13: 99-115.
10. Shen B, Samaraweera P, Rosenberg B, Orlow SJ (2001) Ocular albinism type 1: more than meets the eye. Pigment Cell Res 14: 243-248.
11. Incerti B, Cortese K, Pizzigoni A, Surace EM, Varani S, et al. (2000) Oa1 knock-out: new insights on the pathogenesis of ocular albinism type 1. Hum Mol Genet 9: 2781-2788.
12. Bassi MT, Schiaffino MV, Renieri A, De Nigris F, Galli L, et al. (1995) Cloning of the gene for ocular albinism type 1 from the distal short arm of the X chromosome. Nat Genet 10: 13-19.
13. Schiaffino MV, Bassi MT, Galli L, Renieri A, Bruttini M, et al. (1995) Analysis of the OA1 gene reveals mutations in only one-third of patients with X-linked ocular albinism. Hum Mol Genet 4: 2319-2325.
14. Schiaffino MV, d'Addio M, Alloni A, Baschirotto C, Valetti C, et al. (1999) Ocular albinism: evidence for a defect in an intracellular signal transduction system. Nat Genet 23: 108-112.
15. Schiaffino MV, Tacchetti C (2005) The ocular albinism type 1 (OA1) protein and the evidence for an intracellular signal transduction system involved in melanosome biogenesis. Pigment Cell Res 18: 227-233.
16. Innamorati G, Piccirillo R, Bagnato P, Palmisano I, Schiaffino MV (2006) The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor. Pigment Cell Res 19: 125-135.
17. Staleva L, Orlow SJ (2006) Ocular albinism 1 protein: trafficking and function when expressed in Saccharomyces cerevisiae. Exp Eye Res 82: 311-318.
18. Shen B, Orlow SJ (2001) The ocular albinism type 1 gene product is an N-glycoprotein but glycosylation is not required for its subcellular distribution. Pigment Cell Res 14: 485-490.
19. d'Addio M, Pizzigoni A, Bassi MT, Baschirotto C, Valetti C, et al. (2000) Defective intracellular transport and processing of OA1 is a major cause of ocular albinism type 1. Hum Mol Genet 9: 3011-3018.
20. Shen B, Rosenberg B, Orlow SJ (2001) Intracellular distribution and late endosomal effects of the ocular albinism type 1 gene product: consequences of disease-causing mutations and implications for melanosome biogenesis. Traffic 2: 202-211.
21. Samaraweera P, Shen B, Newton JM, Barsh GS, Orlow SJ (2001) The mouse ocular albinism 1 gene product is an endolysosomal protein. Exp Eye Res 72: 319-329.
22. Schiaffino MV, Baschirotto C, Pellegrini G, Montalti S, Tacchetti C, et al. (1996) The ocular albinism type 1 gene product is a membrane glycoprotein localized to melanosomes. Proc Natl Acad Sci U S A 93: 9055-9060.
23. Ilia M, Jeffery G (2000) Retinal cell addition and rod production depend on early stages of ocular melanin synthesis. J Comp Neurol 420: 437-444.
24. Ilia M, Jeffery G (1999) Retinal mitosis is regulated by dopa, a melanin precursor that may influence the time at which cells exit the cell cycle: analysis of patterns of cell production in pigmented and albino retinae. J Comp Neurol 405: 394-405.
25. Ito S (2003) The IFPCS presidential lecture: a chemist's view of melanogenesis. Pigment Cell Res 16: 230-236.
26. Martinez-Zaguilan R, Tompkins LS, Gillies RJ, Lynch RM (2006) Simultaneous analysis of intracellular pH and Ca2+ from cell populations. Methods Mol Biol 312: 269-287.
27. Ferguson SS, Caron MG (2004) Green fluorescent protein-tagged beta-arrestin translocation as a measure of G protein-coupled receptor activation. Methods Mol Biol 237: 121-126.
28. Barak LS, Warabi K, Feng X, Caron MG, Kwatra MM (1999) Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor. J Biol Chem 274: 7565-7569.
29. Zhang J, Barak LS, Anborgh PH, Laporte SA, Caron MG, et al. (1999) Cellular trafficking of G protein-coupled receptor/beta-arrestin endocytic complexes. J Biol Chem 274: 10999-11006.
30. Tohgo A, Choy EW, Gesty-Palmer D, Pierce KL, Laporte S, et al. (2003) The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation. J Biol Chem 278: 6258-6267.
31. Ferguson SS, Zhang J, Barak LS, Caron MG (1998) Molecular mechanisms of G protein-coupled receptor desensitization and resensitization. Life Sci 62: 1561-1565.
32. Barak LS, Ferguson SS, Zhang J, Caron MG (1997) A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation. J Biol Chem 272: 27497-27500.
33. Barak LS, Ferguson SS, Zhang J, Martenson C, Meyer T, et al. (1997) Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate. Mol Pharmacol 51: 177-184.
34. McKay BS, Goodman B, Falk T, Sherman SJ (2006) Retinal pigment epithelial cell transplantation could provide trophic support in Parkinson's disease: results from an in vitro model system. Exp Neurol 201: 234-243.
35. Tombran-Tink J, Shivaram SM, Chader GJ, Johnson LV, Bok D (1995) Expression, secretion, and age-related downregulation of pigment epithelium-derived factor, a serpin with neurotrophic activity. J Neurosci 15: 4992-5003.
36. Malchiodi-Albedi F, Feher J, Caiazza S, Formisano G, Perilli R, et al. (1998) PEDF (pigment epithelium-derived factor) promotes increase and maturation of pigment granules in pigment epithelial cells in neonatal albino rat retinal cultures. Int J Dev Neurosci 16: 423-432.
37. Behling KC, Surace EM, Bennett J (2002) Pigment epithelium-derived factor expression in the developing mouse eye. Mol Vis 8: 449-454.
38. Aymerich MS, Alberdi EM, Martinez A, Becerra SP (2001) Evidence for pigment epithelium-derived factor receptors in the neural retina. Invest Ophthalmol Vis Sci 42: 3287-3293.
39. Tombran-Tink J, Chader GG, Johnson LV (1991) PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity. Exp Eye Res 53: 411-414.
40. Jablonski MM, Tombran-Tink J, Mrazek DA, Iannaccone A (2001) Pigment epithelium-derived factor supports normal Muller cell development and glutamine synthetase expression after removal of the retinal pigment epithelium. Glia 35: 14-25.
41. Jablonski MM, Tombran-Tink J, Mrazek DA, Iannaccone A (2000) Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal. J Neurosci 20: 7149-7157.
42. Jeffery G (1998) The retinal pigment epithelium as a developmental regulator of the neural retina. Eye 12: 499-503.
43. Piccirillo R, Palmisano I, Innamorati G, Bagnato P, Altimare D, et al. (2003) An unconventional dileucine-based motif and a novel cytosolic motif are required for the lysosomal and melanosomal targeting of OA1. J Cell Sci 119: 2003-2014.
44. Van Raamsdonk CD, Fitch KR, Fuchs H, de Angelis MH, Barsh GS (2004) Effects of G-protein mutations on skin color. Nat Genet 36: 961-968.
45. Young A, Powelson EB, Whitney IE, Raven MA, Nusinowitz S, et al. (2008) Involvement of OA1, an intracellular GPCR, and G alpha i3, its binding protein, in melanosomal biogenesis and optic pathway formation. Invest Ophthalmol Vis Sci 49: 3245-3252.
46. Hu J, Bok D (2001) A cell culture medium that supports the differentiation of human retinal pigment epithelium into functionally polarized monolayers. Mol Vis 7: 14-19.
47. Stamer WD, Golightly SF, Hosohata Y, Ryan EP, Porter AC, et al. (2001) Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues. Eur J Pharmacol 431: 277-286.