The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase

Biochemical Journal

Volumn 354, Issue 1, 2001, Pages 131-139

  Olivares, C ^a   Jimenez Cervantes C ^a   Lozano, J A ^a   Solano, F ^a   Garcia Borron J C ^a  

^a UNIVERSITY OF MURCIA   (Spain)

Author keywords

Melanin; Melanocyte; Melanogenesis; Tyrosinase related protein 1

Indexed keywords

5,6 DIHYDROXYINDOLE 2 CARBOXYLIC ACID OXIDASE; MELANIN; MONOPHENOL MONOOXYGENASE; OXIDOREDUCTASE; TYROSINASE RELATED PROTEIN 1; TYROSINASE RELATED PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE EXPRESSION; HUMAN; MELANOCYTE; MELANOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL EXTRACTS; COS CELLS; DNA PRIMERS; HUMANS; MELANINS; MELANOMA; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; MONOPHENOL MONOOXYGENASE; OXIDATION-REDUCTION; OXIDOREDUCTASES; PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR CELLS, CULTURED;

ANIMALIA; MAMMALIA;

EID: 0035865591     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3540131     Document Type: Article

References (47)

1. Functional analysis of alternatively spliced tyrosinase gene transcript
2. Sequence analysis of mouse tyrosinase cDNA and the effect of melanotropin on its gene expression
3. Cloning and expression of cDNA encoding mouse tyrosinase
4. A cDNA encoding tyrosinase-related protein maps to the brown locus in mice
5. A second tyrosinase related protein (TRP-2) is a melanogenic enzyme termed dopachrome tautomerase
6. A second tyrosinase related protein, TRP-2 maps to and is mutated at the mouse slaty locus
7. Evidence of the indirect formation of the catecholic intermediate substrate responsible for the autoactivation kinetics of tyrosinase
8. An introduction to melanin research
9. Regulation of distal mammalian melanogenesis. 1. Partial purification and characterization of a dopachrome converting factor: Dopachrome tautomerase
10. Comparative actions of dopachrome tautomerase and metal ions on the rearrangement of dopachrome
11. Tyrosinase isoenzymes in mammalian melanocytes. 1. Biochemical characterization of two melanosomal tyrosinases from B16 mouse melanoma
12. Tyrosinases from two different loci are expressed by normal and by transformed melanocytes
13. A new enzymatic function in the melanogenic pathway: The DHICA oxidase activity of tyrosinase related protein-1 (TRP1)
14. Tyrosinase-related protein 1 (TRP1) functions as a DHICA oxidase in melanin byosinthesis
15. Conversion of particulate tyrosinase to soluble form and to desialytated tyrosinase in human malignant melanoma
16. Dopa oxidation and tyrosine oxygenation by human melanoma tyrosinase
17. Tyrosinase isozyme heterogeneity in differentiating B16/c3 melanoma
18. Human TRP-1 has tyrosine hydroxylase but no dopa oxidase activity
19. Human tyrosinase related protein-1 (TYRP1) does not function as a DHICA oxidase activity in contrast to routine TYRP1
20. Composition of mammalian eumelanins: Analyses of DHICA-derived units in pigments from hair and melanoma cells
21. Eumelanin and phaeomelanin contents of human epidermis and cultured melanocytes
22. Inhibitory effects of melanin monomers, dihydroxyindole-2-carboxylic acid (DHICA) and dihydroxyindole (DHI) on mammalian tyrosinase, with a special reference to the role of DHICA/DHI ratio in melanogenesis
23. TRP-1 expression correlates with eumelanogenesis in human pigment cells in culture
24. Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells
25. Incomplete expression of the tyrosinase gene family (tyrosinase, TYRP1 and TYRP-2) in human malignant melanoma cells in vitro
26. Transforming growth factor-β1 inhibits basal melanogenesis in B16/F10 mouse melanoma cells by increasing the rate of degradation of tyrosinase and tyrosinase-related protein-1
27. Assays for mammalian tyrosinase: A comparative study
28. New assays for tyrosine hydroxylase and dopa oxidase activities of tyrosinase
29. Improved tyrosinase activity stains in polyacrylamide electrophoresis gels
30. Expression of the MC1 receptor gene in normal and malignant human melanocytes. A semiquantitative RT-PCR study
31. Cloning and sequencing of mouse tyrosinase cDNA
32. Qualitative and quantitative catalog of tyrosinase alternative transcripts in normal murine skin melanocytes as a basis for detecting melanoma-specific changes
33. Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus
34. RFLP for Mbo 1 in the human tyrosinase (TYROSINASE) gene detected by PCR
35. Intermediates of melanin formation
36. The great DOPA mistery: The source and significance of DOPA in phase 1 melanogenesis
37. Polymerization of 5,6-dihydroxyindole-2-carboxylic acid to melanin by the pmel17/silver locus protein
38. Characterization and subcellular localization of human Pmel17/silver, a 100 kDa (pre)melanosomal membrane protein associated with 5,6-dihydroxyindole-2-carboxylic acid (DHICA) converting activity
39. Melanin chemistry and melanin precursors in melanoma
40. Chemical characterization of hair melanins in various coat-color mutants of mice
41. Tyrosinase-promoted oxidation of 5,6-dihydroxyindole-2-carboxylic acid to melanin. Isolation and characterization of oligomer intermediates
42. Regulation of the final phase of mammalian melanogenesis. The role of dopachrome tautomerase and the ratio between 5,6-dihydroxyindole-2-carboxylic acid and 5,6-dihydroxyindole
43. Synthesis and characterization of melanins from dihydroxyindole-2-carboxylic acid and dihydroxyindole
44. Levels of dopachrome tautomerase in human melanocytes cultured in vitro
45. Molecular interactions within the melanogenic complex: Formation of heterodimers of tyrosinase and TRP1 from B16 mouse melanoma
46. Tyrosinase stabilization by tyrp1 (the brown locus protein)
47. Electronic structure contributions to function in bioinorganic chemistry