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ChemMedChem

Volumn 6, Issue 10, 2011, Pages 1792-1795

Two Distinct Conformations of GABA Locked by Embedding in the Bicyclo[3.1.0]hexane Core Structure

(5) Jimeno, Ciril a Pericàs, Miquel A a Wessel, Hans Peter b Alker, André b Müller, Klaus b

a INSTITUTE OF CHEMICAL RESEARCH OF CATALONIA ICIQ (Spain)

b F HOFFMANN LA ROCHE LTD (Switzerland)

Author keywords

Analogues; Bicyclohexane; Conformation; GABA; Structure

Indexed keywords

2 AMINOBICYCLO[3.1.0]HEXANE; 2 AMINOBICYCLO[3.1.0]HEXANE 6 CARBOXYLIC ACID; 3 AZABICYCLO[3.1.0]HEX 6 YLAMINE; 4 AMINOBUTYRIC ACID; 4 METHOXYBENZYLAMINE; AMINO ACID DERIVATIVE; BICYCLO[3.1.0]HEXANE; BIOMATERIAL; CARBOXYLIC ACID DERIVATIVE; GLUTAMIC ACID; HEXANE; METHANOPROLINE 1; PROLINE; UNCLASSIFIED DRUG;

AMINATION; ARTICLE; BIOLOGICAL ACTIVITY; CATALYST; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONFORMATION; EMBEDDING; EPIMER; HYDROGENATION; ONE POT SYNTHESIS; PHARMACOPHORE; PRIORITY JOURNAL; REDUCTION; SYNTHESIS;

BICYCLO COMPOUNDS; CRYSTALLOGRAPHY, X-RAY; DATABASES, FACTUAL; GAMMA-AMINOBUTYRIC ACID; ISOMERISM; MOLECULAR CONFORMATION;

EID: 80053402732 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201100220 Document Type: Article

Times cited : (6)

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- Data were collected on a STOE imaging plate diffraction system (STOE, Darmstadt, Germany) with Mo radiation (0.71073Å) and processed with STOE IPDS software. The crystal structures were solved and refined with ShelXTL software (Bruker AXS, Karlsruhe, Germany). CCDC 635509 (for rac-7b) and 635510 (for rac-8b) contain the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via .

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