The p75 receptor mediates axon growth inhibition through an association with PIR-B

Cell Death and Disease

Volumn 2, Issue 9, 2011, Pages

  Fujita, Y ^a,b   Takashima, R ^a   Endo, S ^c   Takai, T ^c   Yamashita, T ^a,b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

Axon regeneration; MAG; P75; PIR B

Indexed keywords

MYELIN ASSOCIATED GLYCOPROTEIN; NEUROTROPHIN RECEPTOR P75; PAIRED IMMUNOGLOBULIN LIKE RECEPTOR B; PROTEIN TYROSINE PHOSPHATASE SHP; RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE MUTATION; LIGAND BINDING; MALE; MOUSE; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NONHUMAN; OPTIC NERVE INJURY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; AXONS; CERCOPITHECUS AETHIOPS; COS CELLS; MICE; MICE, INBRED C57BL; MUTATION; MYELIN-ASSOCIATED GLYCOPROTEIN; PROTEIN BINDING; PROTEIN TYROSINE PHOSPHATASES; RECEPTOR, NERVE GROWTH FACTOR; RECEPTOR, TRKB; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS;

MUS;

EID: 80053395636     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2011.85     Document Type: Article

References (22)

1. Yiu G, He Z. Glial inhibition of CNS axon regeneration. Nat Rev Neurosci 2006; 7: 617-627. (Pubitemid 44106744)
2. Yamashita T, Tohyama M. The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. Nat Neurosci 2003; 6: 461-467. (Pubitemid 36514693)
3. Takai T. Paired immunoglobulin-like receptors and their MHC class I recognition. Immunology 2005; 115: 433-440. (Pubitemid 41032431)
4. Fujita Y, Endo S, Takai T, Yamashita T. Myelin suppresses axon regeneration by PIR-B/ SHP-mediated inhibition of Trk activity. EMBO J 2011; 30: 1389-1401.
5. Kaplan DR, Miller FD. Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 2000; 10: 381-391. (Pubitemid 30389307)
6. Dechant G, Barde YA. The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system. Nat Neurosci 2002; 5: 1131-1136. (Pubitemid 35247171)
7. Lee KF, Li E, Huber LJ, Landis SC, Sharpe AH, Chao MV et al. Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 1992; 69: 737-749.
8. Lu W, Gong D, Bar-Sagi D, Cole PA. Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling. Mol Cell 2001; 8: 759-769. (Pubitemid 33030210)
9. Mohi MG, Neel BG. The role of Shp2 (PTPN11) in cancer. Curr Opin Genet Dev 2007; 17: 23-30. (Pubitemid 46131442)
10. Lee JK, Geoffroy CG, Chan AF, Tolentino KE, Crawford MJ, Leal MA et al. Assessing spinal axon regeneration and sprouting in Nogo-, MAG-, and OMgp-deficient mice. Neuron 2010; 66: 663-670.
11. Song XY, Zhong JH, Wang X, Zhou XF. Suppression of p75NTR does not promote regeneration of injured spinal cord in mice. J Neurosci 2004; 24: 542-546. (Pubitemid 38112387)
12. Zheng B, Atwal J, Ho C, Case L, He XL, Garcia KC et al. Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci USA 2005; 102: 1205-1210. (Pubitemid 40170750)
13. Ben-Zvi A, Ben-Gigi L, Klein H, Behar O. Modulation of semaphorin3A activity by p75 neurotrophin receptor influences peripheral axon patterning. J Neurosci 2007; 27: 13000-13011. (Pubitemid 350159582)
14. Togashi H, Schmidt EF, Strittmatter SM. RanBPM contributes to Semaphorin3A signaling through plexin-A receptors. J Neurosci 2006; 26: 4961-4969. (Pubitemid 44315339)
15. Yamashita T, Higuchi H, Tohyama M. The p75 receptor transduces the signal from myelinassociated glycoprotein to Rho. J Cell Biol 2002; 157: 565-570. (Pubitemid 34839785)
16. Endo S, Sakamoto Y, Kobayashi E, Nakamura A, Takai T. Regulation of cytotoxic T lymphocyte triggering by PIR-B on dendritic cells. Proc Natl Acad Sci USA 2008; 105: 14515-14520.
17. Bibel M, Hoppe E, Barde YA. Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR. Embo J 1999; 18: 616-622. (Pubitemid 29057246)
18. Yano H, Lee FS, Kong H, Chuang J, Arevalo J, Perez P et al. Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor. J Neurosci 2001; 21: RC125.
19. Hata K, Kaibuchi K, Inagaki S, Yamashita T. Unc5B associates with LARG to mediate the action of repulsive guidance molecule. J Cell Biol 2009; 184: 737-750.
20. Chen L, Sung SS, Yip ML, Lawrence HR, Ren Y, Guida WC et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol 2006; 70: 562-570. (Pubitemid 44092317)
21. Nakamura K, Harada C, Okumura A, Namekata K, Mitamura Y, Yoshida K et al. Effect of p75NTR on the regulation of photoreceptor apoptosis in the rd mouse. Mol Vis 2005; 11: 1229-1235. (Pubitemid 43040698)
22. Smith PD, Sun F, Park KK, Cai B, Wang C, Kuwako K et al. SOCS3 deletion promotes optic nerve regeneration in vivo. Neuron 2009; 64: 617-623.