Effects of chronic haloperidol and clozapine treatment on neurogenesis in the adult rat hippocampus

Neuropsychopharmacology

Volumn 29, Issue 6, 2004, Pages 1063-1069

  Halim, Nader D ^a   Weickert, Cynthia Shannon ^a   McClintock, Benjamin W ^a   Weinberger, Daniel R ^a   Lipska, Barbara K ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Antipsychotic; BrdU; Dentate gyrus; Neuroleptic; Schizophrenia

Indexed keywords

BIOCHEMICAL MARKER; BROXURIDINE; CLOZAPINE; DIZOCILPINE; DNA; HALOPERIDOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL DIVISION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DENTATE GYRUS; DNA SYNTHESIS; DOSE RESPONSE; DRUG EFFECT; HIPPOCAMPUS; LONG TERM CARE; LOW DRUG DOSE; MALE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; RAT;

ANALYSIS OF VARIANCE; ANIMALS; ANTIPSYCHOTIC AGENTS; BROMODEOXYURIDINE; CELL COUNT; CELL DIVISION; CELL SURVIVAL; CLOZAPINE; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; GLIAL FIBRILLARY ACIDIC PROTEIN; HALOPERIDOL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; PHENOTYPE; PHOSPHOPYRUVATE HYDRATASE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 2442691413     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300422     Document Type: Article

References (47)

1. Al-Amin HA, Weinberger DR, Lipska BK (2000). Exaggerated MK-801-induced motor hyperactivity in rats with the neonatal lesion of the ventral hippocampus. Behav Pharmacol 11: 269-278.
2. Altman J, Das GD (1965). Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Comp Neurol 124: 319-335.
3. Backhouse B, Barochovsky O, Malik C, Pate AJ, Lewis PD (1982). Effects of haloperidol on cell proliferation in the early postnatal rat brain. Neuropathol Appl Neurobiol 8: 109-116.
4. Benes FM, Kwok EW, Vincent SL, Todtenkopf MS (1998). A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives. Biol Psychiatry 44: 88-97.
5. Cameron HA, McEwen BS, Gould E (1995). Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus. J Neurosci 15: 4687-4692.
6. Cameron HA, McKay RD (2001). Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J Comp Neurol 435: 406-417.
7. Chen B, Dowlatshahi D, MacQueen GM, Wang JF, Young LT (2001). Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol Psychiatry 50: 260-265.
8. Chen G, Rajkowska G, Du F, Seraji-Bozorgzad N, Manji HK (2000). Enhancement of hippocampal neurogenesis by lithium. J Neurochem 75: 1729-1734.
9. Chlan-Fourney J, Ashe P, Nylen K, Juorio AV, Li XM (2002). Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration. Brain Res 954: 11-20.
10. Cooper-Kuhn CM, Kuhn HG (2002). Is it all DNA repair? Methodological considerations for detecting neurogenesis in the adult brain. Brain Res Dev Brain Res 134: 13-21.
11. Dawirs RR, Hildebrandt K, Teuchert-Noodt G (1998). Adult treatment with haloperidol increases dentate granule cell proliferation in the gerbil hippocampus. J Neural Transm 107: 317-327.
12. Dawson NM, Hamid EH, Egan MF, Meredith GE (2001). Changes in the pattern of brain-derived neurotrophic factor immunoreactivity in the rat brain after acute and subchronic haloperidol treatment. Synapse 39: 70-81.
13. Duman RS (2002). Synaptic plasticity and mood disorders. Mol Psychiatry 7(Suppl 1): S29-S34.
14. Duman RS, Heninger GR, Nestler EJ (1997). A molecular and cellular theory of depression. Arch Gen Psychiatry 54: 597-606.
15. Eisch AJ, Barrot M, Schad CA, Self DW, Nestler EJ (2000). Opiates inhibit neurogenesis in the adult rat hippocampus. Proc Natl Acad Sci USA 97: 7579-7584.
16. Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn AM, Nordborg C, Peterson DA et al (1998). Neurogenesis in the adult human hippocampus. Nat Med 4: 1313-1317.
17. Gould E, Beylin A, Tanapat P, Reeves A, Shors TJ (1999). Learning enhances adult neurogenesis in the hippocampal formation. Nat Neurosci 2: 260-265.
18. Gould E, Tanapat P, McEwen BS, Flugge G, Fuchs E (1998). Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc Natl Acad Sci USA 95: 3168-3171.
19. Guillery RW, Herrup K (1997). Quantification without pontification: choosing a method for counting objects in sectioned tissues. J Comp Neurol 386: 2-7.
20. Hastings NB, Gould E (1999). Rapid extension of axons into the CA3 region by adult-generated granule cells. J Comp Neurol 415: 146-154.
21. Kaplan MS, Hinds JW (1982). Proliferation of subependymal cells in the adult primate CNS: differential uptake of DNA labeled precursors. J Hirnforsch 23: 23-33.
22. Kapur S, Wadenberg ML, Remington G (2000). Are animal studies of antipsychotics appropriately dosed? Lessons from the bedside to the bench. Can J Psychiatry 45: 241-246.
23. Kippin TE, Kapur S, van der Kooy D (2002). Chronic haloperidol, but not clozapine, increases the proliferation of neural stem and progenitor cells and alters lateral ventricle morphology in the adult rat. Abstract Viewer/Itinerary Planner. Society for Neuroscience: Washington, DC. Program No. 895.3.
24. Kornack DR, Rakic P (1999). Continuation of neurogenesis in the hippocampus of the adult macaque monkey. Proc Natl Acad Sci USA 96: 5768-5773.
25. Kornack DR, Rakic P (2001). Cell proliferation without neurogenesis in adult primate neocortex. Science 294: 2127-2130.
26. Levin ED (1997). Chronic haloperidol administration does not block acute nicotine-induced improvements in radial-arm maze performance in the rat. Pharmacol Biochem Behav 58: 899-902.
27. Levin ED, Kim P, Meray R (1996). Chronic nicotine working and reference memory effects in the 16-arm radial maze: interactions with D1 agonist and antagonist drugs. Psychopharmacology (Berl) 127: 25-30.
28. Lipska BK, Khaing ZZ, Weickert CS, Weinberger DR (2001). BDNF mRNA expression in rat hippocampus and prefrontal cortex: effects of neonatal ventral hippocampal damage and antipsychotic drugs. Eur J Neurosci 14: 135-144.
29. Lipska BK, Lerman D, Khaing ZZ, Weickert CS, Weinberger DR (2003). Gene expression in dopamine and GABA systems in an animal model of schizophrenia: effects of antipsychotic drugs. Eur J Neurosci 18: 391-402.
30. Liu J, Solway K, Messing RO, Sharp FR (1998). Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J Neurosci 18: 7768-7778.
31. Malberg JE, Eisch AJ, Nestler EJ, Duman RS (2000). Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 24: 9104-9110.
32. Manev H, Uz T, Smalheiser NR, Manev R (2001). Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro. Eur J Pharmacol 411: 67-70.
33. Markakis E, Gage FH (1999). Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles. J Comp Neurol 406: 449-460.
34. Nibuya M, Morinobu S, Duman RS (1995). Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 15: 7539-7547.
35. Palmer TD, Willhoite AR, Gage FH (2000). Vascular niche for adult hippocampal neurogenesis. J Comp Neurol 425: 479-494.
36. Paxinos G, Watson C (1997). The Rat Brain in Stereotaxic Coordinates, compact 3rd edition Academic Press: San Diego, CA.
37. Prickaerts J, Koopmans G, Blokland A, Scheepens A (2004). Learning and adult neurogenesis. Survival with or without proliferation. Neurobiol Learn Mem 81: 1-11.
38. Seaberg RM, van der Kooy D (2002). Adult rodent neurogenic regions: the ventricular subependyma contains neural stem cells, but the dentate gyrus contains restricted progenitors. J Neurosci 22: 1784-1793.
39. Seki T (2002). Expression patterns of immature neuronal markers PSA-NCAM, CRMP-4 and NeuroD in the hippocampus of young adult and aged rodents. J Neurosci Res 70: 327-334.
40. Sheline Y, Wany P, Gado M, Csernansky J, Vannier M (1996). Hippocampal atrophy in recurrent major depression. Proc Natl Acad Sci USA 12: 3908-3913.
41. Shors TJ, Miesegaes G, Beylin A, Zhao M, Rydel T, Gould E et al (2001). Neurogenesis in the adult is involved in the formation of trace memories. Nature 410: 372-376.
42. van Praag H, Christie BR, Sejnowski TJ, Gage FH (1999b). Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci USA 96: 13427-13431.
43. van Praag H, Kempermann G, Gage FH (1999a). Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 2: 266-270.
44. van Praag H, Schinder AF, Christie BR, Toni N, Palmer TD, Gage FH et al (2002). Functional neurogenesis in the adult hippocampus. Nature 415: 1030-1034.
45. Wakade CG, Mahadik SP, Waller JL, Chiu FC (2002). Atypical neuroleptics stimulate neurogenesis in adult rat brain. J Neurosci Res 69: 72-79.
46. Weinberger DR (1999). Cell biology of the hippocampal formation in schizophrenia. Biol Psychiatry 45: 395-402.
47. Zigova T, Pencea V, Wiegand SJ, Luskin MB (1998). Intraven tricular administration of BDNF increases the number of newly generated neurons in the adult olfactory bulb. Mol Cell Neurosci 11: 234-245.