-
1
-
-
33947732977
-
Angiogenesis: an organizing principle for drug discovery?
-
Folkman J. Angiogenesis: an organizing principle for drug discovery?. Nat Rev Drug Discov 2007, 6:273-286.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 273-286
-
-
Folkman, J.1
-
2
-
-
77952538743
-
Tumor angiogenesis: insights and innovations
-
Nussenbaum F., Herman I.M. Tumor angiogenesis: insights and innovations. J Oncol 2010, 2010:132641.
-
(2010)
J Oncol
, vol.2010
, pp. 132641
-
-
Nussenbaum, F.1
Herman, I.M.2
-
3
-
-
0023637601
-
New perspectives in cell adhesion: RGD and integrins
-
Ruoslahti E., Pierschbacher M.D. New perspectives in cell adhesion: RGD and integrins. Science 1987, 238:491-497.
-
(1987)
Science
, vol.238
, pp. 491-497
-
-
Ruoslahti, E.1
Pierschbacher, M.D.2
-
4
-
-
0037145037
-
Integrins: bidirectional, allosteric signaling machines
-
Hynes R.O. Integrins: bidirectional, allosteric signaling machines. Cell 2002, 110:673-687.
-
(2002)
Cell
, vol.110
, pp. 673-687
-
-
Hynes, R.O.1
-
6
-
-
0028670833
-
Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
-
Brooks P.C., Montgomery A.M., Rosenfeld M., Reisfeld R.A., Hu T., Klier G., Cheresh D.A. Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 1994, 79:1157-1164.
-
(1994)
Cell
, vol.79
, pp. 1157-1164
-
-
Brooks, P.C.1
Montgomery, A.M.2
Rosenfeld, M.3
Reisfeld, R.A.4
Hu, T.5
Klier, G.6
Cheresh, D.A.7
-
7
-
-
0028362876
-
Requirement of vascular integrin alpha v beta 3 for angiogenesis
-
Brooks P.C., Clark R.A., Cheresh D.A. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 1994, 264:569-571.
-
(1994)
Science
, vol.264
, pp. 569-571
-
-
Brooks, P.C.1
Clark, R.A.2
Cheresh, D.A.3
-
8
-
-
0028941413
-
Cell adhesion and regulatory molecules involved in tumor formation, hemostasis, and wound healing
-
Van Waes C. Cell adhesion and regulatory molecules involved in tumor formation, hemostasis, and wound healing. Head Neck 1995, 17:140-147.
-
(1995)
Head Neck
, vol.17
, pp. 140-147
-
-
Van Waes, C.1
-
9
-
-
0037318003
-
Integrin alpha v beta 3 as a therapeutic target for blocking tumor-induced angiogenesis
-
Kumar C.C. Integrin alpha v beta 3 as a therapeutic target for blocking tumor-induced angiogenesis. Curr Drug Targets 2003, 4:123-131.
-
(2003)
Curr Drug Targets
, vol.4
, pp. 123-131
-
-
Kumar, C.C.1
-
10
-
-
33746797624
-
Vascular integrins in tumor angiogenesis: mediators and therapeutic targets
-
Alghisi G.C., Ruegg C. Vascular integrins in tumor angiogenesis: mediators and therapeutic targets. Endothelium 2006, 13:113-135.
-
(2006)
Endothelium
, vol.13
, pp. 113-135
-
-
Alghisi, G.C.1
Ruegg, C.2
-
11
-
-
33748616254
-
Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism
-
Cai W., Chen X. Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism. Anticancer Agents Med Chem 2006, 6:407-428.
-
(2006)
Anticancer Agents Med Chem
, vol.6
, pp. 407-428
-
-
Cai, W.1
Chen, X.2
-
12
-
-
77952986190
-
Integrins as target: first phase III trial launches, but questions remain
-
Carter A. Integrins as target: first phase III trial launches, but questions remain. J Natl Cancer Inst 2010, 102:675-677.
-
(2010)
J Natl Cancer Inst
, vol.102
, pp. 675-677
-
-
Carter, A.1
-
13
-
-
77953658108
-
Vascular integrins: therapeutic and imaging targets of tumor angiogenesis
-
Ruegg C., Alghisi G.C. Vascular integrins: therapeutic and imaging targets of tumor angiogenesis. Recent Results Cancer Res 2010, 180:83-101.
-
(2010)
Recent Results Cancer Res
, vol.180
, pp. 83-101
-
-
Ruegg, C.1
Alghisi, G.C.2
-
14
-
-
51049108993
-
Alphavbeta3 integrin and angiogenesis: a moody integrin in a changing environment
-
Hodivala-Dilke K. alphavbeta3 integrin and angiogenesis: a moody integrin in a changing environment. Curr Opin Cell Biol 2008, 20:514-519.
-
(2008)
Curr Opin Cell Biol
, vol.20
, pp. 514-519
-
-
Hodivala-Dilke, K.1
-
15
-
-
0035851912
-
Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins
-
Stupack D.G., Puente X.S., Boutsaboualoy S., Storgard C.M., Cheresh D.A. Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J Cell Biol 2001, 155:459-470.
-
(2001)
J Cell Biol
, vol.155
, pp. 459-470
-
-
Stupack, D.G.1
Puente, X.S.2
Boutsaboualoy, S.3
Storgard, C.M.4
Cheresh, D.A.5
-
16
-
-
84887212399
-
The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells
-
Alghisi G.C., Ponsonnet L., Ruegg C. The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells. PLoS ONE 2009, 4:e4449.
-
(2009)
PLoS ONE
, vol.4
-
-
Alghisi, G.C.1
Ponsonnet, L.2
Ruegg, C.3
-
18
-
-
0036152857
-
Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins
-
Reynolds L.E., Wyder L., Lively J.C., Taverna D., Robinson S.D., Huang X., Sheppard D., Hynes R.O., Hodivala-Dilke K.M. Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat Med 2002, 8:27-34.
-
(2002)
Nat Med
, vol.8
, pp. 27-34
-
-
Reynolds, L.E.1
Wyder, L.2
Lively, J.C.3
Taverna, D.4
Robinson, S.D.5
Huang, X.6
Sheppard, D.7
Hynes, R.O.8
Hodivala-Dilke, K.M.9
-
19
-
-
0028670130
-
In situ expression of beta 1, beta 3 and beta 4 integrin subunits in non-neoplastic endothelium and vascular tumours
-
Mechtersheimer G., Barth T., Hartschuh W., Lehnert T., Moller P. In situ expression of beta 1, beta 3 and beta 4 integrin subunits in non-neoplastic endothelium and vascular tumours. Virchows Arch 1994, 425:375-384.
-
(1994)
Virchows Arch
, vol.425
, pp. 375-384
-
-
Mechtersheimer, G.1
Barth, T.2
Hartschuh, W.3
Lehnert, T.4
Moller, P.5
-
20
-
-
0034744723
-
Vascular integrin beta 3 and its relation to pulmonary metastasis of colorectal carcinoma
-
Sato T., Konishi K., Kimura H., Maeda K., Yabushita K., Tsuji M., Miwa A. Vascular integrin beta 3 and its relation to pulmonary metastasis of colorectal carcinoma. Anticancer Res 2001, 21:643-647.
-
(2001)
Anticancer Res
, vol.21
, pp. 643-647
-
-
Sato, T.1
Konishi, K.2
Kimura, H.3
Maeda, K.4
Yabushita, K.5
Tsuji, M.6
Miwa, A.7
-
21
-
-
0036255249
-
Ets-1 and integrin beta3 for lung metastasis from colorectal cancer
-
Sato T., Miwa A. Ets-1 and integrin beta3 for lung metastasis from colorectal cancer. APMIS 2002, 110:347-353.
-
(2002)
APMIS
, vol.110
, pp. 347-353
-
-
Sato, T.1
Miwa, A.2
-
22
-
-
0842333243
-
Alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitro
-
Nisato R.E., Tille J.C., Jonczyk A., Goodman S.L., Pepper M.S. alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitro. Angiogenesis 2003, 6:105-119.
-
(2003)
Angiogenesis
, vol.6
, pp. 105-119
-
-
Nisato, R.E.1
Tille, J.C.2
Jonczyk, A.3
Goodman, S.L.4
Pepper, M.S.5
-
23
-
-
0037017835
-
Inhibition of the alpha-nu integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo
-
Buerkle M.A., Pahernik S.A., Sutter A., Jonczyk A., Messmer K., Dellian M. Inhibition of the alpha-nu integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo. Br J Cancer 2002, 86:788-795.
-
(2002)
Br J Cancer
, vol.86
, pp. 788-795
-
-
Buerkle, M.A.1
Pahernik, S.A.2
Sutter, A.3
Jonczyk, A.4
Messmer, K.5
Dellian, M.6
-
24
-
-
33845628019
-
Effect of the angiogenesis inhibitor Cilengitide (EMD 121974) on glioblastoma growth in nude mice
-
discussion 1312
-
Yamada S., Bu X.Y., Khankaldyyan V., Gonzales-Gomez I., McComb J.G., Laug W.E. Effect of the angiogenesis inhibitor Cilengitide (EMD 121974) on glioblastoma growth in nude mice. Neurosurgery 2006, 59:1304-1312. discussion 1312.
-
(2006)
Neurosurgery
, vol.59
, pp. 1304-1312
-
-
Yamada, S.1
Bu, X.Y.2
Khankaldyyan, V.3
Gonzales-Gomez, I.4
McComb, J.G.5
Laug, W.E.6
-
25
-
-
34247895532
-
Cilengitide inhibits proliferation and differentiation of human endothelial progenitor cells in vitro
-
Loges S., Butzal M., Otten J., Schweizer M., Fischer U., Bokemeyer C., Hossfeld D.K., Schuch G., Fiedler W. Cilengitide inhibits proliferation and differentiation of human endothelial progenitor cells in vitro. Biochem Biophys Res Commun 2007, 357:1016-1020.
-
(2007)
Biochem Biophys Res Commun
, vol.357
, pp. 1016-1020
-
-
Loges, S.1
Butzal, M.2
Otten, J.3
Schweizer, M.4
Fischer, U.5
Bokemeyer, C.6
Hossfeld, D.K.7
Schuch, G.8
Fiedler, W.9
-
26
-
-
34249113455
-
Integrin inhibitors reaching the clinic
-
Stupp R., Ruegg C. Integrin inhibitors reaching the clinic. J Clin Oncol 2007, 25:1637-1638.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1637-1638
-
-
Stupp, R.1
Ruegg, C.2
-
27
-
-
65349121788
-
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
-
Stupp R., Hegi M.E., Mason W.P., van den Bent M.J., Taphoorn M.J., Janzer R.C., Ludwin S.K., Allgeier A., Fisher B., Belanger K., et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 2009, 10:459-466.
-
(2009)
Lancet Oncol
, vol.10
, pp. 459-466
-
-
Stupp, R.1
Hegi, M.E.2
Mason, W.P.3
van den Bent, M.J.4
Taphoorn, M.J.5
Janzer, R.C.6
Ludwin, S.K.7
Allgeier, A.8
Fisher, B.9
Belanger, K.10
-
28
-
-
64149106522
-
Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
-
Reynolds A.R., Hart I.R., Watson A.R., Welti J.C., Silva R.G., Robinson S.D., Da Violante G., Gourlaouen M., Salih M., Jones M.C., et al. Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nat Med 2009, 15:392-400.
-
(2009)
Nat Med
, vol.15
, pp. 392-400
-
-
Reynolds, A.R.1
Hart, I.R.2
Watson, A.R.3
Welti, J.C.4
Silva, R.G.5
Robinson, S.D.6
Da Violante, G.7
Gourlaouen, M.8
Salih, M.9
Jones, M.C.10
-
29
-
-
0037699955
-
Angiogenesis in health and disease
-
Carmeliet P. Angiogenesis in health and disease. Nat Med 2003, 9:653-660.
-
(2003)
Nat Med
, vol.9
, pp. 653-660
-
-
Carmeliet, P.1
-
30
-
-
0038476608
-
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
-
Bergers G., Song S., Meyer-Morse N., Bergsland E., Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003, 111:1287-1295.
-
(2003)
J Clin Invest
, vol.111
, pp. 1287-1295
-
-
Bergers, G.1
Song, S.2
Meyer-Morse, N.3
Bergsland, E.4
Hanahan, D.5
-
31
-
-
18844428327
-
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
-
Orimo A., Gupta P.B., Sgroi D.C., Arenzana-Seisdedos F., Delaunay T., Naeem R., Carey V.J., Richardson A.L., Weinberg R.A. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005, 121:335-348.
-
(2005)
Cell
, vol.121
, pp. 335-348
-
-
Orimo, A.1
Gupta, P.B.2
Sgroi, D.C.3
Arenzana-Seisdedos, F.4
Delaunay, T.5
Naeem, R.6
Carey, V.J.7
Richardson, A.L.8
Weinberg, R.A.9
-
32
-
-
5444225991
-
Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis
-
Yang L., DeBusk L.M., Fukuda K., Fingleton B., Green-Jarvis B., Shyr Y., Matrisian L.M., Carbone D.P., Lin P.C. Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell 2004, 6:409-421.
-
(2004)
Cancer Cell
, vol.6
, pp. 409-421
-
-
Yang, L.1
DeBusk, L.M.2
Fukuda, K.3
Fingleton, B.4
Green-Jarvis, B.5
Shyr, Y.6
Matrisian, L.M.7
Carbone, D.P.8
Lin, P.C.9
-
33
-
-
14544282964
-
Endothelial progenitor cells
-
Khakoo A.Y., Finkel T. Endothelial progenitor cells. Annu Rev Med 2005, 56:79-101.
-
(2005)
Annu Rev Med
, vol.56
, pp. 79-101
-
-
Khakoo, A.Y.1
Finkel, T.2
-
34
-
-
20144386931
-
Contribution of bone marrow-derived endothelial cells to human tumor vasculature
-
Peters B.A., Diaz L.A., Polyak K., Meszler L., Romans K., Guinan E.C., Antin J.H., Myerson D., Hamilton S.R., Vogelstein B., et al. Contribution of bone marrow-derived endothelial cells to human tumor vasculature. Nat Med 2005, 11:261-262.
-
(2005)
Nat Med
, vol.11
, pp. 261-262
-
-
Peters, B.A.1
Diaz, L.A.2
Polyak, K.3
Meszler, L.4
Romans, K.5
Guinan, E.C.6
Antin, J.H.7
Myerson, D.8
Hamilton, S.R.9
Vogelstein, B.10
-
35
-
-
30344437303
-
VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells
-
Grunewald M., Avraham I., Dor Y., Bachar-Lustig E., Itin A., Jung S., Chimenti S., Landsman L., Abramovitch R., Keshet E. VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell 2006, 124:175-189.
-
(2006)
Cell
, vol.124
, pp. 175-189
-
-
Grunewald, M.1
Avraham, I.2
Dor, Y.3
Bachar-Lustig, E.4
Itin, A.5
Jung, S.6
Chimenti, S.7
Landsman, L.8
Abramovitch, R.9
Keshet, E.10
-
36
-
-
33646581046
-
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes
-
Jin D.K., Shido K., Kopp H.G., Petit I., Shmelkov S.V., Young L.M., Hooper A.T., Amano H., Avecilla S.T., Heissig B., et al. Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nat Med 2006, 12:557-567.
-
(2006)
Nat Med
, vol.12
, pp. 557-567
-
-
Jin, D.K.1
Shido, K.2
Kopp, H.G.3
Petit, I.4
Shmelkov, S.V.5
Young, L.M.6
Hooper, A.T.7
Amano, H.8
Avecilla, S.T.9
Heissig, B.10
-
37
-
-
0037180757
-
Inflammation and cancer
-
Coussens L.M., Werb Z. Inflammation and cancer. Nature 2002, 420:860-867.
-
(2002)
Nature
, vol.420
, pp. 860-867
-
-
Coussens, L.M.1
Werb, Z.2
-
38
-
-
31044433663
-
Macrophages: obligate partners for tumor cell migration, invasion, and metastasis
-
Condeelis J., Pollard J.W. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 2006, 124:263-266.
-
(2006)
Cell
, vol.124
, pp. 263-266
-
-
Condeelis, J.1
Pollard, J.W.2
-
39
-
-
38949178835
-
Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released
-
Italiano J.E., Richardson J.L., Patel-Hett S., Battinelli E., Zaslavsky A., Short S., Ryeom S., Folkman J., Klement G.L. Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood 2008, 111:1227-1233.
-
(2008)
Blood
, vol.111
, pp. 1227-1233
-
-
Italiano, J.E.1
Richardson, J.L.2
Patel-Hett, S.3
Battinelli, E.4
Zaslavsky, A.5
Short, S.6
Ryeom, S.7
Folkman, J.8
Klement, G.L.9
-
40
-
-
38549154715
-
Regulation of vasculogenesis by platelet-mediated recruitment of bone marrow-derived cells
-
Rafii D.C., Psaila B., Butler J., Jin D.K., Lyden D. Regulation of vasculogenesis by platelet-mediated recruitment of bone marrow-derived cells. Arterioscler Thromb Vasc Biol 2008, 28:217-222.
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 217-222
-
-
Rafii, D.C.1
Psaila, B.2
Butler, J.3
Jin, D.K.4
Lyden, D.5
-
41
-
-
58149388333
-
A dual role for integrin-linked kinase in platelets: regulating integrin function and alpha-granule secretion
-
Tucker K.L., Sage T., Stevens J.M., Jordan P.A., Jones S., Barrett N.E., St-Arnaud R., Frampton J., Dedhar S., Gibbins J.M. A dual role for integrin-linked kinase in platelets: regulating integrin function and alpha-granule secretion. Blood 2008, 112:4523-4531.
-
(2008)
Blood
, vol.112
, pp. 4523-4531
-
-
Tucker, K.L.1
Sage, T.2
Stevens, J.M.3
Jordan, P.A.4
Jones, S.5
Barrett, N.E.6
St-Arnaud, R.7
Frampton, J.8
Dedhar, S.9
Gibbins, J.M.10
-
42
-
-
0031417471
-
Expression of alpha IIb beta 3 integrin (GPIIb-IIIa) in myeloid cell lines and normal CD34+/CD33+ bone marrow cells
-
Wall C.D., Conley P.B., Armendariz-Borunda J., Sudarshan C., Wagner J.E., Raghow R., Jennings L.K. Expression of alpha IIb beta 3 integrin (GPIIb-IIIa) in myeloid cell lines and normal CD34+/CD33+ bone marrow cells. Blood Cells Mol Dis 1997, 23:361-376.
-
(1997)
Blood Cells Mol Dis
, vol.23
, pp. 361-376
-
-
Wall, C.D.1
Conley, P.B.2
Armendariz-Borunda, J.3
Sudarshan, C.4
Wagner, J.E.5
Raghow, R.6
Jennings, L.K.7
-
43
-
-
33751558109
-
Expression of Integrin beta3 is correlated to the properties of quiescent hemopoietic stem cells possessing the side population phenotype
-
Umemoto T., Yamato M., Shiratsuchi Y., Terasawa M., Yang J., Nishida K., Kobayashi Y., Okano T. Expression of Integrin beta3 is correlated to the properties of quiescent hemopoietic stem cells possessing the side population phenotype. J Immunol 2006, 177:7733-7739.
-
(2006)
J Immunol
, vol.177
, pp. 7733-7739
-
-
Umemoto, T.1
Yamato, M.2
Shiratsuchi, Y.3
Terasawa, M.4
Yang, J.5
Nishida, K.6
Kobayashi, Y.7
Okano, T.8
-
44
-
-
0025224552
-
Platelet membrane glycoproteins: functions in cellular interactions
-
Kieffer N., Phillips D.R. Platelet membrane glycoproteins: functions in cellular interactions. Annu Rev Cell Biol 1990, 6:329-357.
-
(1990)
Annu Rev Cell Biol
, vol.6
, pp. 329-357
-
-
Kieffer, N.1
Phillips, D.R.2
-
45
-
-
0029087897
-
Function and regulation of the beta 3 integrins in hemostasis and vascular biology
-
Shattil S.J. Function and regulation of the beta 3 integrins in hemostasis and vascular biology. Thromb Haemost 1995, 74:149-155.
-
(1995)
Thromb Haemost
, vol.74
, pp. 149-155
-
-
Shattil, S.J.1
-
46
-
-
0030873859
-
The alpha v beta 3 integrin 'vitronectin receptor'
-
Horton M.A. The alpha v beta 3 integrin 'vitronectin receptor'. Int J Biochem Cell Biol 1997, 29:721-725.
-
(1997)
Int J Biochem Cell Biol
, vol.29
, pp. 721-725
-
-
Horton, M.A.1
-
47
-
-
0033121275
-
The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development
-
Eliceiri B.P., Cheresh D.A. The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development. J Clin Invest 1999, 103:1227-1230.
-
(1999)
J Clin Invest
, vol.103
, pp. 1227-1230
-
-
Eliceiri, B.P.1
Cheresh, D.A.2
-
49
-
-
1642433233
-
Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins
-
Taverna D., Moher H., Crowley D., Borsig L., Varki A., Hynes R.O. Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins. Proc Natl Acad Sci U S A 2004, 101:763-768.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 763-768
-
-
Taverna, D.1
Moher, H.2
Crowley, D.3
Borsig, L.4
Varki, A.5
Hynes, R.O.6
-
50
-
-
33750499985
-
Integrin signaling is critical for pathological angiogenesis
-
Mahabeleshwar G.H., Feng W., Phillips D.R., Byzova T.V. Integrin signaling is critical for pathological angiogenesis. J Exp Med 2006, 203:2495-2507.
-
(2006)
J Exp Med
, vol.203
, pp. 2495-2507
-
-
Mahabeleshwar, G.H.1
Feng, W.2
Phillips, D.R.3
Byzova, T.V.4
-
51
-
-
33847350777
-
Cooperation between VEGF and beta3 integrin during cardiac vascular development
-
Weis S.M., Lindquist J.N., Barnes L.A., Lutu-Fuga K.M., Cui J., Wood M.R., Cheresh D.A. Cooperation between VEGF and beta3 integrin during cardiac vascular development. Blood 2007, 109:1962-1970.
-
(2007)
Blood
, vol.109
, pp. 1962-1970
-
-
Weis, S.M.1
Lindquist, J.N.2
Barnes, L.A.3
Lutu-Fuga, K.M.4
Cui, J.5
Wood, M.R.6
Cheresh, D.A.7
-
52
-
-
76749103879
-
Deficiency of bone marrow beta3-integrin enhances non-functional neovascularization
-
Watson A.R., Pitchford S.C., Reynolds L.E., Direkze N., Brittan M., Alison M.R., Rankin S., Wright N.A., Hodivala-Dilke K.M. Deficiency of bone marrow beta3-integrin enhances non-functional neovascularization. J Pathol 2010, 220:435-445.
-
(2010)
J Pathol
, vol.220
, pp. 435-445
-
-
Watson, A.R.1
Pitchford, S.C.2
Reynolds, L.E.3
Direkze, N.4
Brittan, M.5
Alison, M.R.6
Rankin, S.7
Wright, N.A.8
Hodivala-Dilke, K.M.9
-
53
-
-
58249085553
-
The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells
-
Feng W., McCabe N.P., Mahabeleshwar G.H., Somanath P.R., Phillips D.R., Byzova T.V. The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells. J Cell Biol 2008, 183:1145-1157.
-
(2008)
J Cell Biol
, vol.183
, pp. 1145-1157
-
-
Feng, W.1
McCabe, N.P.2
Mahabeleshwar, G.H.3
Somanath, P.R.4
Phillips, D.R.5
Byzova, T.V.6
-
54
-
-
3142613029
-
Differential role of platelet granular mediators in angiogenesis
-
Brill A., Elinav H., Varon D. Differential role of platelet granular mediators in angiogenesis. Cardiovasc Res 2004, 63:226-235.
-
(2004)
Cardiovasc Res
, vol.63
, pp. 226-235
-
-
Brill, A.1
Elinav, H.2
Varon, D.3
-
55
-
-
77951625288
-
Dissection of platelet and myeloid cell defects by conditional targeting of the beta3-integrin subunit
-
Morgan E.A., Schneider J.G., Baroni T.E., Uluckan O., Heller E., Hurchla M.A., Deng H., Floyd D., Berdy A., Prior J.L., et al. Dissection of platelet and myeloid cell defects by conditional targeting of the beta3-integrin subunit. FASEB J 2010, 24:1117-1127.
-
(2010)
FASEB J
, vol.24
, pp. 1117-1127
-
-
Morgan, E.A.1
Schneider, J.G.2
Baroni, T.E.3
Uluckan, O.4
Heller, E.5
Hurchla, M.A.6
Deng, H.7
Floyd, D.8
Berdy, A.9
Prior, J.L.10
-
56
-
-
45149134605
-
Re-educating" tumor-associated macrophages by targeting NF-kappaB
-
Hagemann T., Lawrence T., McNeish I., Charles K.A., Kulbe H., Thompson R.G., Robinson S.C., Balkwill F.R. Re-educating" tumor-associated macrophages by targeting NF-kappaB. J Exp Med 2008, 205:1261-1268.
-
(2008)
J Exp Med
, vol.205
, pp. 1261-1268
-
-
Hagemann, T.1
Lawrence, T.2
McNeish, I.3
Charles, K.A.4
Kulbe, H.5
Thompson, R.G.6
Robinson, S.C.7
Balkwill, F.R.8
-
57
-
-
72249096591
-
{beta}3-Integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer
-
Kaur S., Kenny H.A., Jagadeeswaran S., Zillhardt M.R., Montag A.G., Kistner E., Yamada S.D., Mitra A.K., Lengyel E. {beta}3-Integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer. Am J Pathol 2009, 175:2184-2196.
-
(2009)
Am J Pathol
, vol.175
, pp. 2184-2196
-
-
Kaur, S.1
Kenny, H.A.2
Jagadeeswaran, S.3
Zillhardt, M.R.4
Montag, A.G.5
Kistner, E.6
Yamada, S.D.7
Mitra, A.K.8
Lengyel, E.9
-
58
-
-
0030221156
-
Expression and localization of alpha v integrins and their ligand vitronectin in normal ovarian epithelium and in ovarian carcinoma
-
Carreiras F., Denoux Y., Staidly C., Lehmann M., Sichel F., Gauduchon P. Expression and localization of alpha v integrins and their ligand vitronectin in normal ovarian epithelium and in ovarian carcinoma. Gynecol Oncol 1996, 62:260-267.
-
(1996)
Gynecol Oncol
, vol.62
, pp. 260-267
-
-
Carreiras, F.1
Denoux, Y.2
Staidly, C.3
Lehmann, M.4
Sichel, F.5
Gauduchon, P.6
-
59
-
-
18144404647
-
Expression of alpha V-associated integrin beta subunits in epithelial ovarian cancer and its relation to prognosis in patients treated with platinum-based regimens
-
Maubant S., Cruet-Hennequart S., Dutoit S., Denoux Y., Crouet H., Henry-Amar M., Gauduchon P. Expression of alpha V-associated integrin beta subunits in epithelial ovarian cancer and its relation to prognosis in patients treated with platinum-based regimens. J Mol Histol 2005, 36:119-129.
-
(2005)
J Mol Histol
, vol.36
, pp. 119-129
-
-
Maubant, S.1
Cruet-Hennequart, S.2
Dutoit, S.3
Denoux, Y.4
Crouet, H.5
Henry-Amar, M.6
Gauduchon, P.7
-
60
-
-
67649811051
-
Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain
-
Lorger M., Krueger J.S., O'Neal M., Staflin K., Felding-Habermann B. Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain. Proc Natl Acad Sci U S A 2009, 106:10666-10671.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 10666-10671
-
-
Lorger, M.1
Krueger, J.S.2
O'Neal, M.3
Staflin, K.4
Felding-Habermann, B.5
-
61
-
-
65649146880
-
Integrin signalling at a glance
-
Harburger D.S., Calderwood D.A. Integrin signalling at a glance. J Cell Sci 2009, 122:159-163.
-
(2009)
J Cell Sci
, vol.122
, pp. 159-163
-
-
Harburger, D.S.1
Calderwood, D.A.2
-
63
-
-
33645889655
-
Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways
-
Giannone G., Sheetz M.P. Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways. Trends Cell Biol 2006, 16:213-223.
-
(2006)
Trends Cell Biol
, vol.16
, pp. 213-223
-
-
Giannone, G.1
Sheetz, M.P.2
-
65
-
-
33644848599
-
PINCH and parvin: the tIPP of integrin signalling
-
Legate K.R., Montanez E., Kudlacek O., Fassler R: I.L.K. PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol 2006, 7:20-31.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 20-31
-
-
Legate, K.R.1
Montanez, E.2
Kudlacek, O.3
Fassler, R.4
-
66
-
-
50249107474
-
Paxillin comes of age
-
Deakin N.O., Turner C.E. Paxillin comes of age. J Cell Sci 2008, 121:2435-2444.
-
(2008)
J Cell Sci
, vol.121
, pp. 2435-2444
-
-
Deakin, N.O.1
Turner, C.E.2
-
68
-
-
0033731119
-
Integrin cytoplasmic domain-binding proteins
-
Liu S., Calderwood D.A., Ginsberg M.H. Integrin cytoplasmic domain-binding proteins. J Cell Sci 2000, 113(Pt 20):3563-3571.
-
(2000)
J Cell Sci
, vol.113
, Issue.PART 20
, pp. 3563-3571
-
-
Liu, S.1
Calderwood, D.A.2
Ginsberg, M.H.3
-
69
-
-
34547606042
-
Functional atlas of the integrin adhesome
-
Zaidel-Bar R., Itzkovitz S., Ma'ayan A., Iyengar R., Geiger B. Functional atlas of the integrin adhesome. Nat Cell Biol 2007, 9:858-867.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 858-867
-
-
Zaidel-Bar, R.1
Itzkovitz, S.2
Ma'ayan, A.3
Iyengar, R.4
Geiger, B.5
-
70
-
-
63149169947
-
Integrin and growth factor receptor alliance in angiogenesis
-
Somanath P.R., Ciocea A., Byzova T.V. Integrin and growth factor receptor alliance in angiogenesis. Cell Biochem Biophys 2009, 53:53-64.
-
(2009)
Cell Biochem Biophys
, vol.53
, pp. 53-64
-
-
Somanath, P.R.1
Ciocea, A.2
Byzova, T.V.3
-
71
-
-
0030860609
-
Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth
-
Jones P.L., Crack J., Rabinovitch M. Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth. J Cell Biol 1997, 139:279-293.
-
(1997)
J Cell Biol
, vol.139
, pp. 279-293
-
-
Jones, P.L.1
Crack, J.2
Rabinovitch, M.3
-
72
-
-
0034704174
-
Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain
-
Borges E., Jan Y., Ruoslahti E. Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain. J Biol Chem 2000, 275:39867-39873.
-
(2000)
J Biol Chem
, vol.275
, pp. 39867-39873
-
-
Borges, E.1
Jan, Y.2
Ruoslahti, E.3
-
73
-
-
0032563606
-
Growth factor-dependent activation of alphavbeta3 integrin in normal epithelial cells: implications for tumor invasion
-
Trusolino L., Serini G., Cecchini G., Besati C., Ambesi-Impiombato F.S., Marchisio P.C., De Filippi R. Growth factor-dependent activation of alphavbeta3 integrin in normal epithelial cells: implications for tumor invasion. J Cell Biol 1998, 142:1145-1156.
-
(1998)
J Cell Biol
, vol.142
, pp. 1145-1156
-
-
Trusolino, L.1
Serini, G.2
Cecchini, G.3
Besati, C.4
Ambesi-Impiombato, F.S.5
Marchisio, P.C.6
De Filippi, R.7
-
74
-
-
25444495268
-
Novel hepatocyte growth factor (HGF) binding domains on fibronectin and vitronectin coordinate a distinct and amplified Met-integrin induced signalling pathway in endothelial cells
-
Rahman S., Patel Y., Murray J., Patel K.V., Sumathipala R., Sobel M., Wijelath E.S. Novel hepatocyte growth factor (HGF) binding domains on fibronectin and vitronectin coordinate a distinct and amplified Met-integrin induced signalling pathway in endothelial cells. BMC Cell Biol 2005, 6:8.
-
(2005)
BMC Cell Biol
, vol.6
, pp. 8
-
-
Rahman, S.1
Patel, Y.2
Murray, J.3
Patel, K.V.4
Sumathipala, R.5
Sobel, M.6
Wijelath, E.S.7
-
75
-
-
0028641601
-
Association of insulin receptor substrate-1 with integrins
-
Vuori K., Ruoslahti E. Association of insulin receptor substrate-1 with integrins. Science 1994, 266:1576-1578.
-
(1994)
Science
, vol.266
, pp. 1576-1578
-
-
Vuori, K.1
Ruoslahti, E.2
-
76
-
-
1542344006
-
Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels
-
Delafontaine P., Song Y.H., Li Y. Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler Thromb Vasc Biol 2004, 24:435-444.
-
(2004)
Arterioscler Thromb Vasc Biol
, vol.24
, pp. 435-444
-
-
Delafontaine, P.1
Song, Y.H.2
Li, Y.3
-
77
-
-
25144496041
-
The IGF-1 receptor and its contributions to metastatic tumor growth-novel approaches to the inhibition of IGF-1R function
-
Bahr C., Groner B. The IGF-1 receptor and its contributions to metastatic tumor growth-novel approaches to the inhibition of IGF-1R function. Growth Factors 2005, 23:1-14.
-
(2005)
Growth Factors
, vol.23
, pp. 1-14
-
-
Bahr, C.1
Groner, B.2
-
78
-
-
34547164352
-
Role of the integrin alphaVbeta3 in mediating increased smooth muscle cell responsiveness to IGF-I in response to hyperglycemic stress
-
Clemmons D.R., Maile L.A., Ling Y., Yarber J., Busby W.H. Role of the integrin alphaVbeta3 in mediating increased smooth muscle cell responsiveness to IGF-I in response to hyperglycemic stress. Growth Horm IGF Res 2007, 17:265-270.
-
(2007)
Growth Horm IGF Res
, vol.17
, pp. 265-270
-
-
Clemmons, D.R.1
Maile, L.A.2
Ling, Y.3
Yarber, J.4
Busby, W.H.5
-
79
-
-
63449129028
-
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor
-
Beauvais D.M., Ell B.J., McWhorter A.R., Rapraeger A.C. Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor. J Exp Med 2009, 206:691-705.
-
(2009)
J Exp Med
, vol.206
, pp. 691-705
-
-
Beauvais, D.M.1
Ell, B.J.2
McWhorter, A.R.3
Rapraeger, A.C.4
-
80
-
-
78149325327
-
Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation
-
Beauvais D.M., Rapraeger A.C. Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation. J Cell Sci 2010, 123:3796-3807.
-
(2010)
J Cell Sci
, vol.123
, pp. 3796-3807
-
-
Beauvais, D.M.1
Rapraeger, A.C.2
-
81
-
-
0033558087
-
Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2
-
Soldi R., Mitola S., Strasly M., Defilippi P., Tarone G., Bussolino F. Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J 1999, 18:882-892.
-
(1999)
EMBO J
, vol.18
, pp. 882-892
-
-
Soldi, R.1
Mitola, S.2
Strasly, M.3
Defilippi, P.4
Tarone, G.5
Bussolino, F.6
-
82
-
-
0037358192
-
Integrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF
-
Masson-Gadais B., Houle F., Laferriere J., Huot J. Integrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF. Cell Stress Chaperones 2003, 8:37-52.
-
(2003)
Cell Stress Chaperones
, vol.8
, pp. 37-52
-
-
Masson-Gadais, B.1
Houle, F.2
Laferriere, J.3
Huot, J.4
-
83
-
-
40549105078
-
Integrin affinity modulation in angiogenesis
-
Mahabeleshwar G.H., Chen J., Feng W., Somanath P.R., Razorenova O.V., Byzova T.V. Integrin affinity modulation in angiogenesis. Cell Cycle 2008, 7:335-347.
-
(2008)
Cell Cycle
, vol.7
, pp. 335-347
-
-
Mahabeleshwar, G.H.1
Chen, J.2
Feng, W.3
Somanath, P.R.4
Razorenova, O.V.5
Byzova, T.V.6
-
84
-
-
34748863572
-
Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis
-
Mahabeleshwar G.H., Feng W., Reddy K., Plow E.F., Byzova T.V. Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis. Circ Res 2007, 101:570-580.
-
(2007)
Circ Res
, vol.101
, pp. 570-580
-
-
Mahabeleshwar, G.H.1
Feng, W.2
Reddy, K.3
Plow, E.F.4
Byzova, T.V.5
-
85
-
-
9244231286
-
Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in beta3-integrin-deficient mice
-
Reynolds A.R., Reynolds L.E., Nagel T.E., Lively J.C., Robinson S.D., Hicklin D.J., Bodary S.C., Hodivala-Dilke K.M. Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in beta3-integrin-deficient mice. Cancer Res 2004, 64:8643-8650.
-
(2004)
Cancer Res
, vol.64
, pp. 8643-8650
-
-
Reynolds, A.R.1
Reynolds, L.E.2
Nagel, T.E.3
Lively, J.C.4
Robinson, S.D.5
Hicklin, D.J.6
Bodary, S.C.7
Hodivala-Dilke, K.M.8
-
86
-
-
8344265218
-
Beta3-integrin regulates vascular endothelial growth factor-A-dependent permeability
-
Robinson S.D., Reynolds L.E., Wyder L., Hicklin D.J., Hodivala-Dilke K.M. Beta3-integrin regulates vascular endothelial growth factor-A-dependent permeability. Arterioscler Thromb Vasc Biol 2004, 24:2108-2114.
-
(2004)
Arterioscler Thromb Vasc Biol
, vol.24
, pp. 2108-2114
-
-
Robinson, S.D.1
Reynolds, L.E.2
Wyder, L.3
Hicklin, D.J.4
Hodivala-Dilke, K.M.5
-
87
-
-
71749099202
-
Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis
-
Robinson S.D., Reynolds L.E., Kostourou V., Reynolds A.R., da Silva R.G., Tavora B., Baker M., Marshall J.F., Hodivala-Dilke K.M. Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis. J Biol Chem 2009, 284:33966-33981.
-
(2009)
J Biol Chem
, vol.284
, pp. 33966-33981
-
-
Robinson, S.D.1
Reynolds, L.E.2
Kostourou, V.3
Reynolds, A.R.4
da Silva, R.G.5
Tavora, B.6
Baker, M.7
Marshall, J.F.8
Hodivala-Dilke, K.M.9
-
88
-
-
0032549799
-
Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
-
Soker S., Takashima S., Miao H.Q., Neufeld G., Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 1998, 92:735-745.
-
(1998)
Cell
, vol.92
, pp. 735-745
-
-
Soker, S.1
Takashima, S.2
Miao, H.Q.3
Neufeld, G.4
Klagsbrun, M.5
-
89
-
-
0035895711
-
Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family
-
Zachary I., Gliki G. Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc Res 2001, 49:568-581.
-
(2001)
Cardiovasc Res
, vol.49
, pp. 568-581
-
-
Zachary, I.1
Gliki, G.2
|