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Volumn 23, Issue 5, 2011, Pages 630-637

The role of β3-integrins in tumor angiogenesis: Context is everything

Author keywords

[No Author keywords available]

Indexed keywords

BETA3 INTEGRIN; CILENGITIDE; GROWTH FACTOR RECEPTOR; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN RECEPTOR 2; VITRONECTIN RECEPTOR;

EID: 80053374576     PISSN: 09550674     EISSN: 18790410     Source Type: Journal    
DOI: 10.1016/j.ceb.2011.03.014     Document Type: Review
Times cited : (112)

References (89)
  • 1
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: an organizing principle for drug discovery?
    • Folkman J. Angiogenesis: an organizing principle for drug discovery?. Nat Rev Drug Discov 2007, 6:273-286.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 273-286
    • Folkman, J.1
  • 2
    • 77952538743 scopus 로고    scopus 로고
    • Tumor angiogenesis: insights and innovations
    • Nussenbaum F., Herman I.M. Tumor angiogenesis: insights and innovations. J Oncol 2010, 2010:132641.
    • (2010) J Oncol , vol.2010 , pp. 132641
    • Nussenbaum, F.1    Herman, I.M.2
  • 3
    • 0023637601 scopus 로고
    • New perspectives in cell adhesion: RGD and integrins
    • Ruoslahti E., Pierschbacher M.D. New perspectives in cell adhesion: RGD and integrins. Science 1987, 238:491-497.
    • (1987) Science , vol.238 , pp. 491-497
    • Ruoslahti, E.1    Pierschbacher, M.D.2
  • 4
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: bidirectional, allosteric signaling machines
    • Hynes R.O. Integrins: bidirectional, allosteric signaling machines. Cell 2002, 110:673-687.
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 6
    • 0028670833 scopus 로고
    • Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
    • Brooks P.C., Montgomery A.M., Rosenfeld M., Reisfeld R.A., Hu T., Klier G., Cheresh D.A. Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 1994, 79:1157-1164.
    • (1994) Cell , vol.79 , pp. 1157-1164
    • Brooks, P.C.1    Montgomery, A.M.2    Rosenfeld, M.3    Reisfeld, R.A.4    Hu, T.5    Klier, G.6    Cheresh, D.A.7
  • 7
    • 0028362876 scopus 로고
    • Requirement of vascular integrin alpha v beta 3 for angiogenesis
    • Brooks P.C., Clark R.A., Cheresh D.A. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 1994, 264:569-571.
    • (1994) Science , vol.264 , pp. 569-571
    • Brooks, P.C.1    Clark, R.A.2    Cheresh, D.A.3
  • 8
    • 0028941413 scopus 로고
    • Cell adhesion and regulatory molecules involved in tumor formation, hemostasis, and wound healing
    • Van Waes C. Cell adhesion and regulatory molecules involved in tumor formation, hemostasis, and wound healing. Head Neck 1995, 17:140-147.
    • (1995) Head Neck , vol.17 , pp. 140-147
    • Van Waes, C.1
  • 9
    • 0037318003 scopus 로고    scopus 로고
    • Integrin alpha v beta 3 as a therapeutic target for blocking tumor-induced angiogenesis
    • Kumar C.C. Integrin alpha v beta 3 as a therapeutic target for blocking tumor-induced angiogenesis. Curr Drug Targets 2003, 4:123-131.
    • (2003) Curr Drug Targets , vol.4 , pp. 123-131
    • Kumar, C.C.1
  • 10
    • 33746797624 scopus 로고    scopus 로고
    • Vascular integrins in tumor angiogenesis: mediators and therapeutic targets
    • Alghisi G.C., Ruegg C. Vascular integrins in tumor angiogenesis: mediators and therapeutic targets. Endothelium 2006, 13:113-135.
    • (2006) Endothelium , vol.13 , pp. 113-135
    • Alghisi, G.C.1    Ruegg, C.2
  • 11
    • 33748616254 scopus 로고    scopus 로고
    • Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism
    • Cai W., Chen X. Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism. Anticancer Agents Med Chem 2006, 6:407-428.
    • (2006) Anticancer Agents Med Chem , vol.6 , pp. 407-428
    • Cai, W.1    Chen, X.2
  • 12
    • 77952986190 scopus 로고    scopus 로고
    • Integrins as target: first phase III trial launches, but questions remain
    • Carter A. Integrins as target: first phase III trial launches, but questions remain. J Natl Cancer Inst 2010, 102:675-677.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 675-677
    • Carter, A.1
  • 13
    • 77953658108 scopus 로고    scopus 로고
    • Vascular integrins: therapeutic and imaging targets of tumor angiogenesis
    • Ruegg C., Alghisi G.C. Vascular integrins: therapeutic and imaging targets of tumor angiogenesis. Recent Results Cancer Res 2010, 180:83-101.
    • (2010) Recent Results Cancer Res , vol.180 , pp. 83-101
    • Ruegg, C.1    Alghisi, G.C.2
  • 14
    • 51049108993 scopus 로고    scopus 로고
    • Alphavbeta3 integrin and angiogenesis: a moody integrin in a changing environment
    • Hodivala-Dilke K. alphavbeta3 integrin and angiogenesis: a moody integrin in a changing environment. Curr Opin Cell Biol 2008, 20:514-519.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 514-519
    • Hodivala-Dilke, K.1
  • 16
    • 84887212399 scopus 로고    scopus 로고
    • The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells
    • Alghisi G.C., Ponsonnet L., Ruegg C. The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells. PLoS ONE 2009, 4:e4449.
    • (2009) PLoS ONE , vol.4
    • Alghisi, G.C.1    Ponsonnet, L.2    Ruegg, C.3
  • 19
    • 0028670130 scopus 로고
    • In situ expression of beta 1, beta 3 and beta 4 integrin subunits in non-neoplastic endothelium and vascular tumours
    • Mechtersheimer G., Barth T., Hartschuh W., Lehnert T., Moller P. In situ expression of beta 1, beta 3 and beta 4 integrin subunits in non-neoplastic endothelium and vascular tumours. Virchows Arch 1994, 425:375-384.
    • (1994) Virchows Arch , vol.425 , pp. 375-384
    • Mechtersheimer, G.1    Barth, T.2    Hartschuh, W.3    Lehnert, T.4    Moller, P.5
  • 20
    • 0034744723 scopus 로고    scopus 로고
    • Vascular integrin beta 3 and its relation to pulmonary metastasis of colorectal carcinoma
    • Sato T., Konishi K., Kimura H., Maeda K., Yabushita K., Tsuji M., Miwa A. Vascular integrin beta 3 and its relation to pulmonary metastasis of colorectal carcinoma. Anticancer Res 2001, 21:643-647.
    • (2001) Anticancer Res , vol.21 , pp. 643-647
    • Sato, T.1    Konishi, K.2    Kimura, H.3    Maeda, K.4    Yabushita, K.5    Tsuji, M.6    Miwa, A.7
  • 21
    • 0036255249 scopus 로고    scopus 로고
    • Ets-1 and integrin beta3 for lung metastasis from colorectal cancer
    • Sato T., Miwa A. Ets-1 and integrin beta3 for lung metastasis from colorectal cancer. APMIS 2002, 110:347-353.
    • (2002) APMIS , vol.110 , pp. 347-353
    • Sato, T.1    Miwa, A.2
  • 22
    • 0842333243 scopus 로고    scopus 로고
    • Alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitro
    • Nisato R.E., Tille J.C., Jonczyk A., Goodman S.L., Pepper M.S. alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitro. Angiogenesis 2003, 6:105-119.
    • (2003) Angiogenesis , vol.6 , pp. 105-119
    • Nisato, R.E.1    Tille, J.C.2    Jonczyk, A.3    Goodman, S.L.4    Pepper, M.S.5
  • 23
    • 0037017835 scopus 로고    scopus 로고
    • Inhibition of the alpha-nu integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo
    • Buerkle M.A., Pahernik S.A., Sutter A., Jonczyk A., Messmer K., Dellian M. Inhibition of the alpha-nu integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo. Br J Cancer 2002, 86:788-795.
    • (2002) Br J Cancer , vol.86 , pp. 788-795
    • Buerkle, M.A.1    Pahernik, S.A.2    Sutter, A.3    Jonczyk, A.4    Messmer, K.5    Dellian, M.6
  • 24
    • 33845628019 scopus 로고    scopus 로고
    • Effect of the angiogenesis inhibitor Cilengitide (EMD 121974) on glioblastoma growth in nude mice
    • discussion 1312
    • Yamada S., Bu X.Y., Khankaldyyan V., Gonzales-Gomez I., McComb J.G., Laug W.E. Effect of the angiogenesis inhibitor Cilengitide (EMD 121974) on glioblastoma growth in nude mice. Neurosurgery 2006, 59:1304-1312. discussion 1312.
    • (2006) Neurosurgery , vol.59 , pp. 1304-1312
    • Yamada, S.1    Bu, X.Y.2    Khankaldyyan, V.3    Gonzales-Gomez, I.4    McComb, J.G.5    Laug, W.E.6
  • 26
    • 34249113455 scopus 로고    scopus 로고
    • Integrin inhibitors reaching the clinic
    • Stupp R., Ruegg C. Integrin inhibitors reaching the clinic. J Clin Oncol 2007, 25:1637-1638.
    • (2007) J Clin Oncol , vol.25 , pp. 1637-1638
    • Stupp, R.1    Ruegg, C.2
  • 27
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    • Stupp R., Hegi M.E., Mason W.P., van den Bent M.J., Taphoorn M.J., Janzer R.C., Ludwin S.K., Allgeier A., Fisher B., Belanger K., et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 2009, 10:459-466.
    • (2009) Lancet Oncol , vol.10 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3    van den Bent, M.J.4    Taphoorn, M.J.5    Janzer, R.C.6    Ludwin, S.K.7    Allgeier, A.8    Fisher, B.9    Belanger, K.10
  • 29
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. Angiogenesis in health and disease. Nat Med 2003, 9:653-660.
    • (2003) Nat Med , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 30
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G., Song S., Meyer-Morse N., Bergsland E., Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003, 111:1287-1295.
    • (2003) J Clin Invest , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 31
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo A., Gupta P.B., Sgroi D.C., Arenzana-Seisdedos F., Delaunay T., Naeem R., Carey V.J., Richardson A.L., Weinberg R.A. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005, 121:335-348.
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3    Arenzana-Seisdedos, F.4    Delaunay, T.5    Naeem, R.6    Carey, V.J.7    Richardson, A.L.8    Weinberg, R.A.9
  • 33
    • 14544282964 scopus 로고    scopus 로고
    • Endothelial progenitor cells
    • Khakoo A.Y., Finkel T. Endothelial progenitor cells. Annu Rev Med 2005, 56:79-101.
    • (2005) Annu Rev Med , vol.56 , pp. 79-101
    • Khakoo, A.Y.1    Finkel, T.2
  • 37
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens L.M., Werb Z. Inflammation and cancer. Nature 2002, 420:860-867.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 38
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis J., Pollard J.W. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 2006, 124:263-266.
    • (2006) Cell , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 39
    • 38949178835 scopus 로고    scopus 로고
    • Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released
    • Italiano J.E., Richardson J.L., Patel-Hett S., Battinelli E., Zaslavsky A., Short S., Ryeom S., Folkman J., Klement G.L. Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood 2008, 111:1227-1233.
    • (2008) Blood , vol.111 , pp. 1227-1233
    • Italiano, J.E.1    Richardson, J.L.2    Patel-Hett, S.3    Battinelli, E.4    Zaslavsky, A.5    Short, S.6    Ryeom, S.7    Folkman, J.8    Klement, G.L.9
  • 40
    • 38549154715 scopus 로고    scopus 로고
    • Regulation of vasculogenesis by platelet-mediated recruitment of bone marrow-derived cells
    • Rafii D.C., Psaila B., Butler J., Jin D.K., Lyden D. Regulation of vasculogenesis by platelet-mediated recruitment of bone marrow-derived cells. Arterioscler Thromb Vasc Biol 2008, 28:217-222.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 217-222
    • Rafii, D.C.1    Psaila, B.2    Butler, J.3    Jin, D.K.4    Lyden, D.5
  • 43
    • 33751558109 scopus 로고    scopus 로고
    • Expression of Integrin beta3 is correlated to the properties of quiescent hemopoietic stem cells possessing the side population phenotype
    • Umemoto T., Yamato M., Shiratsuchi Y., Terasawa M., Yang J., Nishida K., Kobayashi Y., Okano T. Expression of Integrin beta3 is correlated to the properties of quiescent hemopoietic stem cells possessing the side population phenotype. J Immunol 2006, 177:7733-7739.
    • (2006) J Immunol , vol.177 , pp. 7733-7739
    • Umemoto, T.1    Yamato, M.2    Shiratsuchi, Y.3    Terasawa, M.4    Yang, J.5    Nishida, K.6    Kobayashi, Y.7    Okano, T.8
  • 44
    • 0025224552 scopus 로고
    • Platelet membrane glycoproteins: functions in cellular interactions
    • Kieffer N., Phillips D.R. Platelet membrane glycoproteins: functions in cellular interactions. Annu Rev Cell Biol 1990, 6:329-357.
    • (1990) Annu Rev Cell Biol , vol.6 , pp. 329-357
    • Kieffer, N.1    Phillips, D.R.2
  • 45
    • 0029087897 scopus 로고
    • Function and regulation of the beta 3 integrins in hemostasis and vascular biology
    • Shattil S.J. Function and regulation of the beta 3 integrins in hemostasis and vascular biology. Thromb Haemost 1995, 74:149-155.
    • (1995) Thromb Haemost , vol.74 , pp. 149-155
    • Shattil, S.J.1
  • 46
    • 0030873859 scopus 로고    scopus 로고
    • The alpha v beta 3 integrin 'vitronectin receptor'
    • Horton M.A. The alpha v beta 3 integrin 'vitronectin receptor'. Int J Biochem Cell Biol 1997, 29:721-725.
    • (1997) Int J Biochem Cell Biol , vol.29 , pp. 721-725
    • Horton, M.A.1
  • 47
    • 0033121275 scopus 로고    scopus 로고
    • The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development
    • Eliceiri B.P., Cheresh D.A. The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development. J Clin Invest 1999, 103:1227-1230.
    • (1999) J Clin Invest , vol.103 , pp. 1227-1230
    • Eliceiri, B.P.1    Cheresh, D.A.2
  • 49
    • 1642433233 scopus 로고    scopus 로고
    • Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins
    • Taverna D., Moher H., Crowley D., Borsig L., Varki A., Hynes R.O. Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins. Proc Natl Acad Sci U S A 2004, 101:763-768.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 763-768
    • Taverna, D.1    Moher, H.2    Crowley, D.3    Borsig, L.4    Varki, A.5    Hynes, R.O.6
  • 50
    • 33750499985 scopus 로고    scopus 로고
    • Integrin signaling is critical for pathological angiogenesis
    • Mahabeleshwar G.H., Feng W., Phillips D.R., Byzova T.V. Integrin signaling is critical for pathological angiogenesis. J Exp Med 2006, 203:2495-2507.
    • (2006) J Exp Med , vol.203 , pp. 2495-2507
    • Mahabeleshwar, G.H.1    Feng, W.2    Phillips, D.R.3    Byzova, T.V.4
  • 54
    • 3142613029 scopus 로고    scopus 로고
    • Differential role of platelet granular mediators in angiogenesis
    • Brill A., Elinav H., Varon D. Differential role of platelet granular mediators in angiogenesis. Cardiovasc Res 2004, 63:226-235.
    • (2004) Cardiovasc Res , vol.63 , pp. 226-235
    • Brill, A.1    Elinav, H.2    Varon, D.3
  • 57
    • 72249096591 scopus 로고    scopus 로고
    • {beta}3-Integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer
    • Kaur S., Kenny H.A., Jagadeeswaran S., Zillhardt M.R., Montag A.G., Kistner E., Yamada S.D., Mitra A.K., Lengyel E. {beta}3-Integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer. Am J Pathol 2009, 175:2184-2196.
    • (2009) Am J Pathol , vol.175 , pp. 2184-2196
    • Kaur, S.1    Kenny, H.A.2    Jagadeeswaran, S.3    Zillhardt, M.R.4    Montag, A.G.5    Kistner, E.6    Yamada, S.D.7    Mitra, A.K.8    Lengyel, E.9
  • 58
    • 0030221156 scopus 로고    scopus 로고
    • Expression and localization of alpha v integrins and their ligand vitronectin in normal ovarian epithelium and in ovarian carcinoma
    • Carreiras F., Denoux Y., Staidly C., Lehmann M., Sichel F., Gauduchon P. Expression and localization of alpha v integrins and their ligand vitronectin in normal ovarian epithelium and in ovarian carcinoma. Gynecol Oncol 1996, 62:260-267.
    • (1996) Gynecol Oncol , vol.62 , pp. 260-267
    • Carreiras, F.1    Denoux, Y.2    Staidly, C.3    Lehmann, M.4    Sichel, F.5    Gauduchon, P.6
  • 59
    • 18144404647 scopus 로고    scopus 로고
    • Expression of alpha V-associated integrin beta subunits in epithelial ovarian cancer and its relation to prognosis in patients treated with platinum-based regimens
    • Maubant S., Cruet-Hennequart S., Dutoit S., Denoux Y., Crouet H., Henry-Amar M., Gauduchon P. Expression of alpha V-associated integrin beta subunits in epithelial ovarian cancer and its relation to prognosis in patients treated with platinum-based regimens. J Mol Histol 2005, 36:119-129.
    • (2005) J Mol Histol , vol.36 , pp. 119-129
    • Maubant, S.1    Cruet-Hennequart, S.2    Dutoit, S.3    Denoux, Y.4    Crouet, H.5    Henry-Amar, M.6    Gauduchon, P.7
  • 60
    • 67649811051 scopus 로고    scopus 로고
    • Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain
    • Lorger M., Krueger J.S., O'Neal M., Staflin K., Felding-Habermann B. Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain. Proc Natl Acad Sci U S A 2009, 106:10666-10671.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 10666-10671
    • Lorger, M.1    Krueger, J.S.2    O'Neal, M.3    Staflin, K.4    Felding-Habermann, B.5
  • 61
    • 65649146880 scopus 로고    scopus 로고
    • Integrin signalling at a glance
    • Harburger D.S., Calderwood D.A. Integrin signalling at a glance. J Cell Sci 2009, 122:159-163.
    • (2009) J Cell Sci , vol.122 , pp. 159-163
    • Harburger, D.S.1    Calderwood, D.A.2
  • 62
    • 11244258882 scopus 로고    scopus 로고
    • Focal adhesion kinase: in command and control of cell motility
    • Mitra S.K., Hanson D.A., Schlaepfer D.D. Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol 2005, 6:56-68.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 56-68
    • Mitra, S.K.1    Hanson, D.A.2    Schlaepfer, D.D.3
  • 63
    • 33645889655 scopus 로고    scopus 로고
    • Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways
    • Giannone G., Sheetz M.P. Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways. Trends Cell Biol 2006, 16:213-223.
    • (2006) Trends Cell Biol , vol.16 , pp. 213-223
    • Giannone, G.1    Sheetz, M.P.2
  • 66
    • 50249107474 scopus 로고    scopus 로고
    • Paxillin comes of age
    • Deakin N.O., Turner C.E. Paxillin comes of age. J Cell Sci 2008, 121:2435-2444.
    • (2008) J Cell Sci , vol.121 , pp. 2435-2444
    • Deakin, N.O.1    Turner, C.E.2
  • 68
    • 0033731119 scopus 로고    scopus 로고
    • Integrin cytoplasmic domain-binding proteins
    • Liu S., Calderwood D.A., Ginsberg M.H. Integrin cytoplasmic domain-binding proteins. J Cell Sci 2000, 113(Pt 20):3563-3571.
    • (2000) J Cell Sci , vol.113 , Issue.PART 20 , pp. 3563-3571
    • Liu, S.1    Calderwood, D.A.2    Ginsberg, M.H.3
  • 70
    • 63149169947 scopus 로고    scopus 로고
    • Integrin and growth factor receptor alliance in angiogenesis
    • Somanath P.R., Ciocea A., Byzova T.V. Integrin and growth factor receptor alliance in angiogenesis. Cell Biochem Biophys 2009, 53:53-64.
    • (2009) Cell Biochem Biophys , vol.53 , pp. 53-64
    • Somanath, P.R.1    Ciocea, A.2    Byzova, T.V.3
  • 71
    • 0030860609 scopus 로고    scopus 로고
    • Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth
    • Jones P.L., Crack J., Rabinovitch M. Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth. J Cell Biol 1997, 139:279-293.
    • (1997) J Cell Biol , vol.139 , pp. 279-293
    • Jones, P.L.1    Crack, J.2    Rabinovitch, M.3
  • 72
    • 0034704174 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain
    • Borges E., Jan Y., Ruoslahti E. Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain. J Biol Chem 2000, 275:39867-39873.
    • (2000) J Biol Chem , vol.275 , pp. 39867-39873
    • Borges, E.1    Jan, Y.2    Ruoslahti, E.3
  • 74
    • 25444495268 scopus 로고    scopus 로고
    • Novel hepatocyte growth factor (HGF) binding domains on fibronectin and vitronectin coordinate a distinct and amplified Met-integrin induced signalling pathway in endothelial cells
    • Rahman S., Patel Y., Murray J., Patel K.V., Sumathipala R., Sobel M., Wijelath E.S. Novel hepatocyte growth factor (HGF) binding domains on fibronectin and vitronectin coordinate a distinct and amplified Met-integrin induced signalling pathway in endothelial cells. BMC Cell Biol 2005, 6:8.
    • (2005) BMC Cell Biol , vol.6 , pp. 8
    • Rahman, S.1    Patel, Y.2    Murray, J.3    Patel, K.V.4    Sumathipala, R.5    Sobel, M.6    Wijelath, E.S.7
  • 75
    • 0028641601 scopus 로고
    • Association of insulin receptor substrate-1 with integrins
    • Vuori K., Ruoslahti E. Association of insulin receptor substrate-1 with integrins. Science 1994, 266:1576-1578.
    • (1994) Science , vol.266 , pp. 1576-1578
    • Vuori, K.1    Ruoslahti, E.2
  • 76
    • 1542344006 scopus 로고    scopus 로고
    • Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels
    • Delafontaine P., Song Y.H., Li Y. Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler Thromb Vasc Biol 2004, 24:435-444.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 435-444
    • Delafontaine, P.1    Song, Y.H.2    Li, Y.3
  • 77
    • 25144496041 scopus 로고    scopus 로고
    • The IGF-1 receptor and its contributions to metastatic tumor growth-novel approaches to the inhibition of IGF-1R function
    • Bahr C., Groner B. The IGF-1 receptor and its contributions to metastatic tumor growth-novel approaches to the inhibition of IGF-1R function. Growth Factors 2005, 23:1-14.
    • (2005) Growth Factors , vol.23 , pp. 1-14
    • Bahr, C.1    Groner, B.2
  • 78
    • 34547164352 scopus 로고    scopus 로고
    • Role of the integrin alphaVbeta3 in mediating increased smooth muscle cell responsiveness to IGF-I in response to hyperglycemic stress
    • Clemmons D.R., Maile L.A., Ling Y., Yarber J., Busby W.H. Role of the integrin alphaVbeta3 in mediating increased smooth muscle cell responsiveness to IGF-I in response to hyperglycemic stress. Growth Horm IGF Res 2007, 17:265-270.
    • (2007) Growth Horm IGF Res , vol.17 , pp. 265-270
    • Clemmons, D.R.1    Maile, L.A.2    Ling, Y.3    Yarber, J.4    Busby, W.H.5
  • 79
    • 63449129028 scopus 로고    scopus 로고
    • Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor
    • Beauvais D.M., Ell B.J., McWhorter A.R., Rapraeger A.C. Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor. J Exp Med 2009, 206:691-705.
    • (2009) J Exp Med , vol.206 , pp. 691-705
    • Beauvais, D.M.1    Ell, B.J.2    McWhorter, A.R.3    Rapraeger, A.C.4
  • 80
    • 78149325327 scopus 로고    scopus 로고
    • Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation
    • Beauvais D.M., Rapraeger A.C. Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation. J Cell Sci 2010, 123:3796-3807.
    • (2010) J Cell Sci , vol.123 , pp. 3796-3807
    • Beauvais, D.M.1    Rapraeger, A.C.2
  • 81
    • 0033558087 scopus 로고    scopus 로고
    • Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2
    • Soldi R., Mitola S., Strasly M., Defilippi P., Tarone G., Bussolino F. Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J 1999, 18:882-892.
    • (1999) EMBO J , vol.18 , pp. 882-892
    • Soldi, R.1    Mitola, S.2    Strasly, M.3    Defilippi, P.4    Tarone, G.5    Bussolino, F.6
  • 82
    • 0037358192 scopus 로고    scopus 로고
    • Integrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF
    • Masson-Gadais B., Houle F., Laferriere J., Huot J. Integrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF. Cell Stress Chaperones 2003, 8:37-52.
    • (2003) Cell Stress Chaperones , vol.8 , pp. 37-52
    • Masson-Gadais, B.1    Houle, F.2    Laferriere, J.3    Huot, J.4
  • 84
    • 34748863572 scopus 로고    scopus 로고
    • Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis
    • Mahabeleshwar G.H., Feng W., Reddy K., Plow E.F., Byzova T.V. Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis. Circ Res 2007, 101:570-580.
    • (2007) Circ Res , vol.101 , pp. 570-580
    • Mahabeleshwar, G.H.1    Feng, W.2    Reddy, K.3    Plow, E.F.4    Byzova, T.V.5
  • 88
    • 0032549799 scopus 로고    scopus 로고
    • Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
    • Soker S., Takashima S., Miao H.Q., Neufeld G., Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 1998, 92:735-745.
    • (1998) Cell , vol.92 , pp. 735-745
    • Soker, S.1    Takashima, S.2    Miao, H.Q.3    Neufeld, G.4    Klagsbrun, M.5
  • 89
    • 0035895711 scopus 로고    scopus 로고
    • Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family
    • Zachary I., Gliki G. Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc Res 2001, 49:568-581.
    • (2001) Cardiovasc Res , vol.49 , pp. 568-581
    • Zachary, I.1    Gliki, G.2


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