Apoptosis-inducing antifungal peptides and proteins

Biochemical Society Transactions

Volumn 39, Issue 5, 2011, Pages 1527-1532

  De Brucker, Katrijn ^a   Cammue, Bruno P A ^a   Thevissen, Karin ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Antifungal agent; Antimicrobial peptide; Apoptosis; Candida; Plant defensin

Indexed keywords

ACTIN; ANTIFUNGAL AGENT; APOPTOSIS INDUCING FACTOR; APOPTOSIS INDUCING FACTOR 1; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHROME C; DEFENSIN AFP1; DEFENSIN AFP2; DERMASEPTIN S3; GLUCAN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; LACTOFERRICIN B; LACTOFERRIN; MELITTIN; MITOGEN ACTIVATED PROTEIN KINASE; OSMOTIN; PENICILLIUM CHRYSOGENUM ANTIFUNGAL PROTEIN; PLANT EXTRACT; PROTEIN KINASE C; PSACOTHEACIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; WH1 FUNGIN;

ANTIFUNGAL ACTIVITY; APOPTOSIS; ASPERGILLUS FLAVUS; ASPERGILLUS NIDULANS; BOTRYTIS CINEREA; CANDIDA ALBICANS; CANDIDA KRUSEI; CANDIDA TROPICALIS; CANDIDIASIS; CELL WALL; CONFERENCE PAPER; ENZYME ACTIVITY; FROG; FUNGAL CELL; FUSARIUM CULMORUM; FUSARIUM GRAMINEARUM; FUSARIUM OXYSPORUM; FUSARIUM SOLANI; GROWTH INHIBITION; HEUCHERA; HEUCHERA SANGUINEA; HUMAN; HYPHOMYCETES; INTERNALIZATION; MICROFILAMENT; MITOCHONDRION; NEUROSPORA CRASSA; NONHUMAN; PENICILLIUM CHRYSOGENUM; PHYLLOMEDUSA SAUVAGII; PRIORITY JOURNAL; RADISH; RHIZOCTONIA SOLANI; RODENT DISEASE; SACCHAROMYCES CEREVISIAE; THRUSH;

ANIMALS; ANTIFUNGAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; APOPTOSIS; BIOLOGICAL AGENTS; FUNGI; HUMANS; PROTEINS;

AMPHIBIA; CANDIDA; HEXAPODA; MAMMALIA;

EID: 80053373919     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0391527     Document Type: Conference Paper

References (53)

1. Martin, G.S., Mannino, D.M., Eaton, S. and Moss, M. (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N. Engl. J. Med. 348, 1546-1554 (Pubitemid 36437931)
2. Gudlaugsson, O., Gillespie, S., Lee, K., vande, B.J., Hu, J., Messer, S., Herwaldt, L., Pfaller, M. and Diekema, D. (2003) Attributable mortality of nosocomial candidemia, revisited. Clin. Infect. Dis. 37, 1172-1177 (Pubitemid 37372504)
3. Vonberg, R.P. and Gastmeier, P. (2006) Nosocomial aspergillosis in outbreak settings. J. Hosp. Infect. 63, 246-254
4. Como, J.A. and Dismukes, W.E. (1994) Oral azole drugs as systemic antifungal therapy. N. Engl. J. Med. 330, 263-272 (Pubitemid 24034139)
5. Mathew, B.P. and Nath, M. (2009) Recent approaches to antifungal therapy for invasive mycoses. Chem. Med. Chem. 4, 310-323
6. Aerts, A.M., Carmona-Gutierrez, D., Lefevre, S., Govaert, G., Francois, I.E., Madeo, F., Santos, R., Cammue, B.P. and Thevissen, K. (2009) The antifungal plant defensin RsAFP2 from radish induces apoptosis in a metacaspase independent way in Candida albicans. FEBS Lett. 583, 2513-2516
7. Aerts, A.M., Bammens, L., Govaert, G., Carmona-Gutierrez, D., Madeo, F., Cammue, B.P.A. and Thevissen, K. (2011) The antifungal plant defensin HsAFP1 from Heuchera sanguinea induces apoptosis in Candida albicans. Front. Microbiol. 2, 47
8. Buttner, S., Eisenberg, T., Herker, E., Carmona-Gutierrez, D., Kroemer, G. and Madeo, F. (2006) Why yeast cells can undergo apoptosis: death in times of peace, love, and war? J. Cell Biol. 175, 521-525 (Pubitemid 44790604)
9. Severin, F.F. and Hyman, A.A. (2002) Pheromone induces programmed cell death in S. cerevisiae. Curr. Biol. 12, R233-R235 (Pubitemid 34271353)
10. Váchová, L. and Palková, Z. (2005) Physiological regulation of yeast cell death in multicellular colonies is triggered by ammonia. J. Cell Biol. 169, 711-717
11. Eisenberg, T., Carmona-Gutierrez, D., Buttner, S., Tavernarakis, N. and Madeo, F. (2010) Necrosis in yeast. Apoptosis 15, 257-268
12. Carmona-Gutierrez, D., Eisenberg, T., Buttner, S., Meisinger, C., Kroemer, G. and Madeo, F. (2010) Apoptosis in yeast: triggers, pathways, subroutines. Cell Death Differ. 17, 763-773
13. Qi, G., Zhu, F., Du, P., Yang, X., Qiu, D., Yu, Z., Chen, J. and Zhao, X. (2010) Lipopeptide induces apoptosis in fungal cells by a mitochondriadependent pathway. Peptides 31, 1978-1986
14. Marx, F., Binder, U., Leiter, E. and Pocsi, I. (2008) The Penicillium chrysogenum antifungal protein PAF, a promising tool for the development of new antifungal therapies and fungal cell biology studies. Cell. Mol. Life Sci. 65, 445-454 (Pubitemid 351214653)
15. Szappanos, H., Szigeti, G.P., Pal, B., Rusznak, Z., Szucs, G., Rajnavolgyi, E., Balla, J., Balla, G., Nagy, E., Leiter, E. et al. (2005) The Penicillium chrysogenum-derived antifungal peptide shows no toxic effects on mammalian cells in the intended therapeutic concentration. Naunyn-Schmiedeberg's Arch. Pharmacol. 371, 122-132 (Pubitemid 40487417)
16. Oberparleiter, C., Kaiserer, L., Haas, H., Ladurner, P., Andratsch, M. and Marx, F. (2003) Active internalization of the Penicillium chrysogenum antifungal protein PAF in sensitive aspergilli. Antimicrob. Agents Chemother. 47, 3598-3601 (Pubitemid 37345726)
17. Leiter, E., Szappanos, H., Oberparleiter, C., Kaiserer, L., Csernoch, L., Pusztahelyi, T., Emri, T., Pocsi, I., Salvenmoser, W. and Marx, F. (2005) Antifungal protein PAF severely affects the integrity of the plasma membrane of Aspergillus nidulans and induces an apoptosis-like phenotype. Antimicrob. Agents Chemother. 49, 2445-2453 (Pubitemid 40734478)
18. Binder, U., Oberparleiter, C., Meyer, V. and Marx, F. (2010) The antifungal protein PAF interferes with PKC/MPK and cAMP/PKA signalling of Aspergillus nidulans. Mol. Microbiol. 75, 294-307
19. Thevissen, K., Kristensen, H.H., Thomma, B.P., Cammue, B.P. and Francois, I.E. (2007) Therapeutic potential of antifungal plant and insect defensins. Drug Discovery Today 12, 966-971 (Pubitemid 350052668)
20. Tavares, P.M., Thevissen, K., Cammue, B.P., Francois, I.E., Barreto-Bergter, E., Taborda, C.P., Marques, A.F., Rodrigues, M.L. and Nimrichter, L. (2008) In vitro activity of the antifungal plant defensin RsAFP2 against Candida isolates and its in vivo efficacy in prophylactic murine models of candidiasis. Antimicrob. Agents Chemother. 52, 4522-4525
21. Thevissen, K., Warnecke, D.C., Francois, I.E., Leipelt, M., Heinz, E., Ott, C., Zahringer, U., Thomma, B.P., Ferket, K.K. and Cammue, B.P. (2004) Defensins from insects and plants interact with fungal glucosylceramides. J. Biol. Chem. 279, 3900-3905 (Pubitemid 38198972)
22. Saito, K., Takakuwa, N., Ohnishi, M. and Oda, Y. (2006) Presence of glucosylceramide in yeast and its relation to alkali tolerance of yeast. Appl. Microbiol. Biotechnol. 71, 515-521 (Pubitemid 44060955)
23. Thevissen, K., Terras, F.R. and Broekaert, W.F. (1999) Permeabilization of fungal membranes by plant defensins inhibits fungal growth. Appl. Environ. Microbiol. 65, 5451-5458 (Pubitemid 129520636)
24. Ramamoorthy, V., Zhao, X., Snyder, A.K., Xu, J.R. and Shah, D.M. (2007) Two mitogen-activated protein kinase signalling cascades mediate basal resistance to antifungal plant defensins in Fusarium graminearum. Cell. Microbiol. 9, 1491-1506 (Pubitemid 46774020)
25. Osborn, R.W., De Samblanx, G.W., Thevissen, K., Goderis, I., Torrekens, S., van, L.F., Attenborough, S., Rees, S.B. and Broekaert, W.F. (1995) Isolation and characterisation of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanaceae and Saxifragaceae. FEBS Lett. 368, 257-262
26. Singh, N.K., Bracker, C.A., Hasegawa, P.M., Handa, A.K., Buckel, S., Hermodson, M.A., Pfankoch, E., Regnier, F.E. and Bressan, R.A. (1987) Characterization of osmotin: a thaumatin-like protein associated with osmotic adaptation in plant cells. Plant Physiol. 85, 529-536
27. Woloshuk, C.P., Meulenhoff, J.S., Sela-Buurlage, M., van den Elzen, P.J. and Cornelissen, B.J. (1991) Pathogen-induced proteins with inhibitory activity toward Phytophthora infestans. Plant Cell 3, 619-628 (Pubitemid 21913726)
28. Narasimhan, M.L., Lee, H., Damsz, B., Singh, N.K., Ibeas, J.I., Matsumoto, T.K., Woloshuk, C.P. and Bressan, R.A. (2003) Overexpression of a cell wall glycoprotein in Fusarium oxysporum increases virulence and resistance to a plant PR-5 protein. Plant J. 36, 390-400 (Pubitemid 37436061)
29. Yun, D.J., Zhao, Y., Pardo, J.M., Narasimhan, M.L., Damsz, B., Lee, H., Abad, L.R., D'Urzo, M.P., Hasegawa, P.M. and Bressan, R.A. (1997) Stress proteins on the yeast cell surface determine resistance to osmotin, a plant antifungal protein. Proc. Natl. Acad. Sci. U.S.A. 94, 7082-7087 (Pubitemid 27281994)
30. Ibeas, J.I., Yun, D.J., Damsz, B., Narasimhan, M.L., Uesono, Y., Ribas, J.C., Lee, H., Hasegawa, P.M., Bressan, R.A. and Pardo, J.M. (2001) Resistance to the plant PR-5 protein osmotin in the model fungus Saccharomyces cerevisiae is mediated by the regulatory effects of SSD1 on cell wall composition. Plant J. 25, 271-280 (Pubitemid 32192090)
31. Ibeas, J.I., Lee, H., Damsz, B., Prasad, D.T., Pardo, J.M., Hasegawa, P.M., Bressan, R.A. and Narasimhan, M.L. (2000) Fungal cell wall phosphomannans facilitate the toxic activity of a plant PR-5 protein. Plant J. 23, 375-383 (Pubitemid 30620844)
32. Yun, D.J., Ibeas, J.I., Lee, H., Coca, M.A., Narasimhan, M.L., Uesono, Y., Hasegawa, P.M., Pardo, J.M. and Bressan, R.A. (1998) Osmotin, a plant antifungal protein, subverts signal transduction to enhance fungal cell susceptibility. Mol. Cell 1, 807-817 (Pubitemid 128379065)
33. Narasimhan, M.L., Damsz, B., Coca, M.A., Ibeas, J.I., Yun, D.J., Pardo, J.M., Hasegawa, P.M. and Bressan, R.A. (2001) A plant defense response effector induces microbial apoptosis. Mol. Cell 8, 921-930 (Pubitemid 33030224)
34. Narasimhan, M.L., Coca, M.A., Jin, J., Yamauchi, T., Ito, Y., Kadowaki, T., Kim, K.K., Pardo, J.M., Damsz, B., Hasegawa, P.M. et al. (2005) Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor. Mol. Cell 17, 171-180 (Pubitemid 40138613)
35. Han, S., Yeo, J., Baek, H., Lin, S.M., Meyer, S. and Molan, P. (2009) Postantibiotic effect of purified melittin from honeybee (Apis mellifera) venom against Escherichia coli and Staphylococcus aureus. J. Asian Nat. Prod. Res. 11, 796-804
36. Hwang, B., Hwang, J.S., Lee, J. and Lee, D.G. (2010) Antifungal properties and mode of action of psacotheasin, a novel knottin-type peptide derived from Psacothea hilaris. Biochem. Biophys. Res. Commun. 400, 352-357
37. Park, C. and Lee, D.G. (2010) Melittin induces apoptotic features in Candida albicans. Biochem. Biophys. Res. Commun. 394, 170-172
38. Raghuraman, H. and Chattopadhyay, A. (2007) Melittin: a membrane-active peptide with diverse functions. Biosci. Rep. 27, 189-223 (Pubitemid 47222897)
39. Asthana, N., Yadav, S.P. and Ghosh, J.K. (2004) Dissection of antibacterial and toxic activity of melittin: a leucine zipper motif plays a crucial role in determining its hemolytic activity but not antibacterial activity. J. Biol. Chem. 279, 55042-55050 (Pubitemid 40066496)
40. Hwang, B., Hwang, J.S., Lee, J. and Lee, D.G. (2011) The antimicrobial peptide, psacotheasin induces reactive oxygen species and triggers apoptosis in Candida albicans. Biochem. Biophys. Res. Commun. 405, 267-271
41. Ghosh, J.K., Shaool, D., Guillaud, P., Ciceron, L., Mazier, D., Kustanovich, I., Shai, Y. and Mor, A. (1997) Selective cytotoxicity of dermaseptin S3 toward intraerythrocytic Plasmodium falciparum and the underlying molecular basis. J. Biol. Chem. 272, 31609-31616 (Pubitemid 28013305)
42. Morton, C.O., Dos Santos, S.C. and Coote, P. (2007) An amphibian-derived, cationic, α-helical antimicrobial peptide kills yeast by caspase-independent but AIF-dependent programmed cell death. Mol. Microbiol. 65, 494-507 (Pubitemid 47052730)
43. Legrand, D., Pierce, A., Elass, E., Carpentier, M., Mariller, C. and Mazurier, J. (2008) Lactoferrin structure and functions. Adv. Exp. Med. Biol. 606, 163-194
44. Xu, Y.Y., Samaranayake, Y.H., Samaranayake, L.P. and Nikawa, H. (1999) In vitro susceptibility of Candida species to lactoferrin. Med. Mycol. 37, 35-41 (Pubitemid 29110242)
45. Kirkpatrick, C.H., Green, I., Rich, R.R. and Schade, A.L. (1971) Inhibition of growth of Candida albicans by iron-unsaturated lactoferrin: relation to host-defense mechanisms in chronic mucocutaneous candidiasis. J. Infect. Dis. 124, 539-544
46. Bellamy, W., Wakabayashi, H., Takase, M., Kawase, K., Shimamura, S. and Tomita, M. (1993) Killing of Candida albicans by lactoferricin B, a potent antimicrobial peptide derived from the N-terminal region of bovine lactoferrin. Med. Microbiol. Immunol. 182, 97-105 (Pubitemid 23160081)
47. Viejo-Diaz, M., Andres, M.T. and Fierro, J.F. (2004) Effects of human lactoferrin on the cytoplasmic membrane of Candida albicans cells related with its candidacidal activity. FEMS Immunol. Med. Microbiol. 42, 181-185 (Pubitemid 39208545)
48. + efflux. Antimicrob. Agents Chemother. 52, 4081-4088
49. Takakura, N., Wakabayashi, H., Ishibashi, H., Teraguchi, S., Tamura, Y., Yamaguchi, H. and Abe, S. (2003) Oral lactoferrin treatment of experimental oral candidiasis in mice. Antimicrob. Agents Chemother. 47, 2619-2623 (Pubitemid 36919468)
50. Wunder, D., Dong, J., Baev, D. and Edgerton, M. (2004) Human salivary histatin 5 fungicidal action does not induce programmed cell death pathways in Candida albicans. Antimicrob. Agents Chemother. 48, 110-115 (Pubitemid 38040185)
51. Killion, J.J. and Dunn, J.D. (1986) Differential cytolysis of murine spleen, bone-marrow and leukemia cells by melittin reveals differences in membrane topography. Biochem. Biophys. Res. Commun. 139, 222-227 (Pubitemid 16007266)
52. van Zoggel, H., Hamma-Kourbali, Y., Galanth, C., Ladram, A., Nicolas, P., Courty, J., Amiche, M. and Delbe, J. (2010) Antitumor and angiostatic peptides from frog skin secretions. Amino Acids, doi:10.1007/ s00726-010-0815-9
53. Kazemzadeh-Narbat, M., Kindrachuk, J., Duan, K., Jenssen, H., Hancock, R.E. and Wang, R. (2010) Antimicrobial peptides on calcium phosphate-coated titanium for the prevention of implant-associated infections. Biomaterials 31, 9519-9526