The Penicillium chrysogenum-derived antifungal peptide shows no toxic effects on mammalian cells in the intended therapeutic concentration

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 371, Issue 2, 2005, Pages 122-132

  Szappanos, Henrietta ^a   Szigeti, Gyula Péter ^a   Pál, Balázs ^a   Rusznák, Zoltán ^a   Szucs, Géza ^a   Rajnavölgyi, Éva ^a   Balla, József ^b   Balla, György ^a   Nagy, Emoke ^a   Leiter, Éva ^c   Pócsi, István ^c   Marx, Florentine ^d   Csernoch, László ^a,b  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c UNIVERSITY OF DEBRECEN   (Hungary)

^d INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Antifungal proteins; Calcium current; Cytotoxicity; Inflammatory action; Patch clamp; Potassium current

Indexed keywords

ANTIFUNGAL AGENT; CALCIUM CHANNEL L TYPE; CYSTEINE; FUNGAL PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CALCIUM CURRENT; CELL ACTIVATION; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DRUG EFFECT; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERPOLARIZATION; IMMUNE SYSTEM; IMMUNOSTIMULATION; ION CURRENT; MAMMAL CELL; MEMBRANE CURRENT; NERVE CELL; NONHUMAN; PENICILLIUM CHRYSOGENUM; RAT; SKELETAL MUSCLE; TOXICITY TESTING; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIFUNGAL AGENTS; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; HIPPOCAMPUS; HUMANS; INTERLEUKINS; MUSCLE, SKELETAL; MUSCLE, SMOOTH, VASCULAR; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PENICILLIUM CHRYSOGENUM; POTASSIUM; RATS; RATS, WISTAR; TISSUE CULTURE TECHNIQUES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 20144386855     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-004-1013-7     Document Type: Article

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