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Volumn , Issue , 2009, Pages 251-259

Evidence-Based Treatment of Thalassemia Major

Author keywords

Clinical trials on desferrioxamine (DFO); Cord blood transplantation; Desferrioxamine and deferiprone combinations; Evidence based findings on treatment of transfusion dependent thalassemia major; Grading of evidence and recommendations; Risks of splenectomy; Splenectomy in transfused patients?; Thalassemia major; Transplants from HLA identical related donors; Transplants from HLA unrelated donors

Indexed keywords


EID: 84891040211     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781444300857.ch31     Document Type: Chapter
Times cited : (1)

References (55)
  • 1
    • 33144490691 scopus 로고    scopus 로고
    • Grading strength of recommendations and quality of evidence in clinical guidelines: report from an American College of Chest Physicians Task Force
    • Guyatt G, Gutterman D, Baumann MH, Addrizzo-Harris D, Hylek EM, Phillips B, Raskob G, Lewis SZ, Schunemann H. Grading strength of recommendations and quality of evidence in clinical guidelines: report from an American College of Chest Physicians Task Force. Chest. 2006;129(1):174-81.
    • (2006) Chest , vol.129 , Issue.1 , pp. 174-181
    • Guyatt, G.1    Gutterman, D.2    Baumann, M.H.3    Addrizzo-Harris, D.4    Hylek, E.M.5    Phillips, B.6    Raskob, G.7    Lewis, S.Z.8    Schunemann, H.9
  • 2
    • 0028823093 scopus 로고
    • The management of patients with Cooley's anemia: transfusions and splenectomy
    • Piomelli S. The management of patients with Cooley's anemia: transfusions and splenectomy. Semin Hematol. 1995;32(4):262-68.
    • (1995) Semin Hematol , vol.32 , Issue.4 , pp. 262-268
    • Piomelli, S.1
  • 3
    • 0018924055 scopus 로고
    • New approaches to the transfusion management of thalassemia
    • Propper RD, Button LN, Nathan DG. New approaches to the transfusion management of thalassemia. Blood. 1980;55(1):55-60.
    • (1980) Blood , vol.55 , Issue.1 , pp. 55-60
    • Propper, R.D.1    Button, L.N.2    Nathan, D.G.3
  • 4
    • 0019982571 scopus 로고
    • Evaluation of the supertransfusion regimen in homozygous beta-thalassaemia children
    • Masera G, Terzoli S, Avanzini A, et al. Evaluation of the supertransfusion regimen in homozygous beta-thalassaemia children. Br J Haematol. 1982;52(1):111-13.
    • (1982) Br J Haematol , vol.52 , Issue.1 , pp. 111-113
    • Masera, G.1    Terzoli, S.2    Avanzini, A.3
  • 5
    • 0020050015 scopus 로고
    • Haemoglobin levels and blood requirement in thalassaemia
    • Gabutti V, Piga A, Nicola P, et al. Haemoglobin levels and blood requirement in thalassaemia. Arch Dis Child. 1982;57(2):156-58.
    • (1982) Arch Dis Child , vol.57 , Issue.2 , pp. 156-158
    • Gabutti, V.1    Piga, A.2    Nicola, P.3
  • 6
    • 0025970809 scopus 로고
    • Transfusion requirements and effects in patients with thalassaemia major Cooleycare Programme
    • Rebulla P, Modell B. Transfusion requirements and effects in patients with thalassaemia major. Cooleycare Programme. Lancet. 1991;337(8736):277-80.
    • (1991) Lancet , vol.337 , Issue.8736 , pp. 277-280
    • Rebulla, P.1    Modell, B.2
  • 7
    • 0028937612 scopus 로고
    • Relationship between transfusion regimen and suppression of erythropoiesis in beta-thalassaemia major
    • Cazzola M, De Stefano P, Ponchio L, et al. Relationship between transfusion regimen and suppression of erythropoiesis in beta-thalassaemia major. Br J Haematol. 1995;89(3):473-78.
    • (1995) Br J Haematol , vol.89 , Issue.3 , pp. 473-478
    • Cazzola, M.1    De Stefano, P.2    Ponchio, L.3
  • 8
    • 33646407268 scopus 로고    scopus 로고
    • Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major
    • Borgna-Pignatti C, Cappellini MD, De Stefano P, et al. Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major. Blood. 2006;107(9):3733-37.
    • (2006) Blood , vol.107 , Issue.9 , pp. 3733-3737
    • Borgna-Pignatti, C.1    Cappellini, M.D.2    De Stefano, P.3
  • 9
    • 33644874106 scopus 로고    scopus 로고
    • Desferrioxamine mesylate for managing transfusional iron overload in people with transfusion-dependent thalassaemia
    • Roberts DJ, Rees D, Howard J. Desferrioxamine mesylate for managing transfusional iron overload in people with transfusion-dependent thalassaemia. Cochrane Database Syst Rev. 2005;4:CD004450.
    • (2005) Cochrane Database Syst Rev , vol.4
    • Roberts, D.J.1    Rees, D.2    Howard, J.3
  • 10
    • 33646391919 scopus 로고    scopus 로고
    • Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: new data, new questions
    • Neufeld EJ. Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: new data, new questions. Blood. 2006;107(9):3436-41.
    • (2006) Blood , vol.107 , Issue.9 , pp. 3436-3441
    • Neufeld, E.J.1
  • 12
    • 0021833690 scopus 로고
    • Prevention of cardiac disease by subcutaneous deferoxamine in patients with thalassemia major
    • Wolfe L, Olivieri N, Sallan D, et al. Prevention of cardiac disease by subcutaneous deferoxamine in patients with thalassemia major. N Engl J Med. 1985;312(25):1600-603.
    • (1985) N Engl J Med , vol.312 , Issue.25 , pp. 1600-1603
    • Wolfe, L.1    Olivieri, N.2    Sallan, D.3
  • 13
    • 0036068230 scopus 로고    scopus 로고
    • The safety and effectiveness of deferiprone in a large-scale, 3-year study in Italian patients
    • Ceci A, Baiardi P, Felisi M, et al. The safety and effectiveness of deferiprone in a large-scale, 3-year study in Italian patients. Br J Haematol. 2002;118(1):330-36.
    • (2002) Br J Haematol , vol.118 , Issue.1 , pp. 330-336
    • Ceci, A.1    Baiardi, P.2    Felisi, M.3
  • 14
    • 14544288577 scopus 로고    scopus 로고
    • Deferiprone therapy for transfusional iron overload
    • VictorHoffbrand A. Deferiprone therapy for transfusional iron overload. Best Pract Res Clin Haematol. 2005;18(2):299-317.
    • (2005) Best Pract Res Clin Haematol , vol.18 , Issue.2 , pp. 299-317
    • VictorHoffbrand, A.1
  • 15
    • 10744230223 scopus 로고    scopus 로고
    • Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial
    • Nisbet-Brown E, Olivieri NF, Giardina PJ, et al. Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet. 2003;361(9369):1597-602.
    • (2003) Lancet , vol.361 , Issue.9369 , pp. 1597-1602
    • Nisbet-Brown, E.1    Olivieri, N.F.2    Giardina, P.J.3
  • 16
    • 33745774771 scopus 로고    scopus 로고
    • Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload
    • Piga A, Galanello R, Forni GL, et al. Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload. Haematologica. 2006;91(7):873-80.
    • (2006) Haematologica , vol.91 , Issue.7 , pp. 873-880
    • Piga, A.1    Galanello, R.2    Forni, G.L.3
  • 17
    • 33646414765 scopus 로고    scopus 로고
    • A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with betathalassemia
    • Cappellini MD, Cohen A, Piga A, et al. A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with betathalassemia. Blood. 2006;107(9):3455-62.
    • (2006) Blood , vol.107 , Issue.9 , pp. 3455-3462
    • Cappellini, M.D.1    Cohen, A.2    Piga, A.3
  • 18
    • 0034783438 scopus 로고    scopus 로고
    • Chelation therapy in beta-thalassemia: an optimistic update
    • Giardina PJ, Grady RW. Chelation therapy in beta-thalassemia: an optimistic update. Semin Hematol. 2001;38(4):360-66.
    • (2001) Semin Hematol , vol.38 , Issue.4 , pp. 360-366
    • Giardina, P.J.1    Grady, R.W.2
  • 19
    • 0034928342 scopus 로고    scopus 로고
    • Exploring the "iron shuttle" hypothesis in chelation therapy: effects of combined deferoxamine and deferiprone treatment in hypertransfused rats with labeled iron stores and in iron-loaded rat heart cells in culture
    • Link G, Konijn AM, Breuer W, et al. Exploring the "iron shuttle" hypothesis in chelation therapy: effects of combined deferoxamine and deferiprone treatment in hypertransfused rats with labeled iron stores and in iron-loaded rat heart cells in culture. J Lab ClinMed. 2001;138(2):130-38.
    • (2001) J Lab ClinMed , vol.138 , Issue.2 , pp. 130-138
    • Link, G.1    Konijn, A.M.2    Breuer, W.3
  • 20
    • 33646387405 scopus 로고    scopus 로고
    • Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis
    • Pennell DJ, Berdoukas V, Karagiorga M, et al. Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis. Blood. 2006;107(9): 3738-44.
    • (2006) Blood , vol.107 , Issue.9 , pp. 3738-3744
    • Pennell, D.J.1    Berdoukas, V.2    Karagiorga, M.3
  • 21
    • 0031784438 scopus 로고    scopus 로고
    • Combined therapy with deferiprone and desferrioxamine
    • Wonke B, Wright C, Hoffbrand AV. Combined therapy with deferiprone and desferrioxamine. Br J Haematol. 1998;103(2):361-64.
    • (1998) Br J Haematol , vol.103 , Issue.2 , pp. 361-364
    • Wonke, B.1    Wright, C.2    Hoffbrand, A.V.3
  • 22
    • 0242584372 scopus 로고    scopus 로고
    • Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients
    • Mourad FH, Hoffbrand AV, Sheikh-Taha M, et al. Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients. Br J Haematol. 2003;121(1):187-89.
    • (2003) Br J Haematol , vol.121 , Issue.1 , pp. 187-189
    • Mourad, F.H.1    Hoffbrand, A.V.2    Sheikh-Taha, M.3
  • 23
    • 11044238013 scopus 로고    scopus 로고
    • Effectiveness and safety of combined iron-chelation therapy with deferoxamine and deferiprone
    • Alymara V, Bourantas D, Chaidos A, et al. Effectiveness and safety of combined iron-chelation therapy with deferoxamine and deferiprone. Hematol J. 2004;5(6):475-79.
    • (2004) Hematol J , vol.5 , Issue.6 , pp. 475-479
    • Alymara, V.1    Bourantas, D.2    Chaidos, A.3
  • 24
    • 27144560152 scopus 로고    scopus 로고
    • Combined therapy with deferiprone and desferrioxamine in thalassemia major
    • Origa R, Bina P, Agus A, Crobu G, et al. Combined therapy with deferiprone and desferrioxamine in thalassemia major. Haematologica. 2005;90(10):1309-14.
    • (2005) Haematologica , vol.90 , Issue.10 , pp. 1309-1314
    • Origa, R.1    Bina, P.2    Agus, A.3    Crobu, G.4
  • 25
    • 33748783066 scopus 로고    scopus 로고
    • A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patientswith thalassemia major
    • Galanello R, Kattamis A, Piga A, et al. A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patientswith thalassemia major. Haematologica 2005;91(9):1241-43.
    • (2005) Haematologica , vol.91 , Issue.9 , pp. 1241-1243
    • Galanello, R.1    Kattamis, A.2    Piga, A.3
  • 26
    • 30344471110 scopus 로고    scopus 로고
    • Iron chelation treatment with combined therapywith deferiprone and deferioxamine: a 12-month trial
    • Kattamis A, Ladis V, Berdousi H, et al. Iron chelation treatment with combined therapywith deferiprone and deferioxamine: a 12-month trial. Blood Cells Mol Dis. 2006;36(1):21-25.
    • (2006) Blood Cells Mol Dis , vol.36 , Issue.1 , pp. 21-25
    • Kattamis, A.1    Ladis, V.2    Berdousi, H.3
  • 27
    • 0017713378 scopus 로고
    • Total management of thalassaemia major
    • Modell B. Total management of thalassaemia major. Arch Dis Child. 1977;52:489-500.
    • (1977) Arch Dis Child , vol.52 , pp. 489-500
    • Modell, B.1
  • 28
    • 0019307262 scopus 로고
    • Transfusion requirements and splenectomy in thalassemia major
    • Cohen A, Markenson AL, Schwartz E. Transfusion requirements and splenectomy in thalassemia major. J Pediatr. 1980;97(1):100-102.
    • (1980) J Pediatr , vol.97 , Issue.1 , pp. 100-102
    • Cohen, A.1    Markenson, A.L.2    Schwartz, E.3
  • 29
    • 0019813175 scopus 로고
    • Chelation therapy in ß- thalassemia major: the role of splenectomy in achieving iron balance
    • Graziano JH, Piomelli S, Hilgartner M, et al. Chelation therapy in ß- thalassemia major: the role of splenectomy in achieving iron balance. J Pediatr. 1981;99(5):695-99.
    • (1981) J Pediatr , vol.99 , Issue.5 , pp. 695-699
    • Graziano, J.H.1    Piomelli, S.2    Hilgartner, M.3
  • 30
    • 0024596864 scopus 로고
    • Long-termeffect of splenectomy on transfusion requirements in thalassemia major
    • Cohen A, Gayer R, Mizanin J. Long-termeffect of splenectomy on transfusion requirements in thalassemia major. Am J Hematol. 1989;30:254-56.
    • (1989) Am J Hematol , vol.30 , pp. 254-256
    • Cohen, A.1    Gayer, R.2    Mizanin, J.3
  • 31
    • 0035725754 scopus 로고    scopus 로고
    • Risk of infection and death among post-splenectomy patients
    • Bisharat N, Omari H, Lavi I, et al. Risk of infection and death among post-splenectomy patients. J Infect. 2001;43:182-86.
    • (2001) J Infect , vol.43 , pp. 182-186
    • Bisharat, N.1    Omari, H.2    Lavi, I.3
  • 32
    • 0036760048 scopus 로고    scopus 로고
    • Update on guidelines for the prevention and treatment of infection in patients with absent or dysfunctional spleen
    • Davies JM, Barnes R, Milligan D. Update on guidelines for the prevention and treatment of infection in patients with absent or dysfunctional spleen. Clin Med. 2002;2(5):440-43.
    • (2002) Clin Med , vol.2 , Issue.5 , pp. 440-443
    • Davies, J.M.1    Barnes, R.2    Milligan, D.3
  • 34
    • 0025070260 scopus 로고
    • Bone marrow transplantation in patients with thalassemia
    • Lucarelli G, Galimberti M, Polchi P, et al. Bone marrow transplantation in patients with thalassemia. N Engl J Med. 1990;322:417-21.
    • (1990) N Engl J Med , vol.322 , pp. 417-421
    • Lucarelli, G.1    Galimberti, M.2    Polchi, P.3
  • 35
    • 0027184519 scopus 로고
    • Marrow transplantation in patients with thalassemia responsive to iron chelation
    • Lucarelli G, Galimberti M, Polchi P, et al. Marrow transplantation in patients with thalassemia responsive to iron chelation. N Engl J Med. 1993;329:840-44.
    • (1993) N Engl J Med , vol.329 , pp. 840-844
    • Lucarelli, G.1    Galimberti, M.2    Polchi, P.3
  • 36
    • 0030954991 scopus 로고    scopus 로고
    • Bone marrow transplantation in thalassemia: the experience of Pesaro
    • Galimberti M, Polchi P, Angelucci E, et al. Bone marrow transplantation in thalassemia: the experience of Pesaro. Bone Marrow Transplant. 1997;19:45-47.
    • (1997) Bone Marrow Transplant , vol.19 , pp. 45-47
    • Galimberti, M.1    Polchi, P.2    Angelucci, E.3
  • 37
    • 0028147444 scopus 로고
    • Bone marrow transplant for thalassemia: the USA experience
    • Walters MC, Sullivan KM, O'Reilly RJ, et al. Bone marrow transplant for thalassemia: the USA experience. Am J Pediatr Oncol. 1994;16: 11-17.
    • (1994) Am J Pediatr Oncol , vol.16 , pp. 11-17
    • Walters, M.C.1    Sullivan, K.M.2    O'Reilly, R.J.3
  • 38
    • 0037275448 scopus 로고    scopus 로고
    • Bone marrow transplantation for ß-thalassaemia major: the UK experience in two pediatric centers
    • Lawson SE, Roberts IAG, Amrolia P, et al. Bone marrow transplantation for ß-thalassaemia major: the UK experience in two pediatric centers. Br J Haematol. 2003;120:289-95.
    • (2003) Br J Haematol , vol.120 , pp. 289-295
    • Lawson, S.E.1    Roberts, I.A.G.2    Amrolia, P.3
  • 39
    • 19244366141 scopus 로고    scopus 로고
    • New approach to bone marrow transplantation inpatientswith class 3 thalassemia aged younger than 17 years
    • Sodani P, Gaziev D, Polchi P, et al. New approach to bone marrow transplantation inpatientswith class 3 thalassemia aged younger than 17 years. Blood. 2004;104:1201-3.
    • (2004) Blood , vol.104 , pp. 1201-1203
    • Sodani, P.1    Gaziev, D.2    Polchi, P.3
  • 40
    • 29744438595 scopus 로고    scopus 로고
    • Bone marrowtransplantation in adults with thalassemia Treatment and long-termfollow-up
    • Graziev J, Sodani P, Polchi P, et al. Bone marrowtransplantation in adults with thalassemia. Treatment and long-termfollow-up. Ann NY Acad Sci. 2005;1054:196-205.
    • (2005) Ann NY Acad Sci , vol.1054 , pp. 196-205
    • Graziev, J.1    Sodani, P.2    Polchi, P.3
  • 41
    • 0037097807 scopus 로고    scopus 로고
    • Unrelated donor bone marrow transplantation for thalassemia: the effect of extended haplotypes
    • La Nasa G, Giardini C, Argiolu F, et al. Unrelated donor bone marrow transplantation for thalassemia: the effect of extended haplotypes. Blood. 2002;99:4350-56.
    • (2002) Blood , vol.99 , pp. 4350-4356
    • La Nasa, G.1    Giardini, C.2    Argiolu, F.3
  • 42
    • 33746874867 scopus 로고    scopus 로고
    • Outcomes of transplantation with related- and unrelated-donor stem cells in children with severe thalassemia
    • Hongeng S, Pakakasama S, Chuansumrit A, et al. Outcomes of transplantation with related- and unrelated-donor stem cells in children with severe thalassemia. Biol Blood Marrow Transplant. 2006;12:683-87.
    • (2006) Biol Blood Marrow Transplant , vol.12 , pp. 683-687
    • Hongeng, S.1    Pakakasama, S.2    Chuansumrit, A.3
  • 43
    • 0037443543 scopus 로고    scopus 로고
    • Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease
    • Locatelli F, Rocha V, Reed W, et al. Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease. Blood. 2003;101:2137-43.
    • (2003) Blood , vol.101 , pp. 2137-2143
    • Locatelli, F.1    Rocha, V.2    Reed, W.3
  • 44
    • 29244489771 scopus 로고    scopus 로고
    • Innovative approaches to hemopoietic stem cell transplantation for patients with thalassemia
    • Locatelli F, De Stefano P. Innovative approaches to hemopoietic stem cell transplantation for patients with thalassemia. Haematologica. 2005;90(12):1592-94.
    • (2005) Haematologica , vol.90 , Issue.12 , pp. 1592-1594
    • Locatelli, F.1    De Stefano, P.2
  • 45
    • 0034820416 scopus 로고    scopus 로고
    • Pharmacological modulation of fetal hemoglobin
    • Steinberg MH, Rogers GP. Pharmacological modulation of fetal hemoglobin. Medicine. 2001;80:328-44.
    • (2001) Medicine , vol.80 , pp. 328-344
    • Steinberg, M.H.1    Rogers, G.P.2
  • 46
    • 0034772589 scopus 로고    scopus 로고
    • Pharmacological induction of fetal hemoglobin in sickle cell disease and ß-thalassemia
    • Atweh GF, Loukopoulos D. Pharmacological induction of fetal hemoglobin in sickle cell disease and ß-thalassemia. Semin Hematol. 2001;38:367-73.
    • (2001) Semin Hematol , vol.38 , pp. 367-373
    • Atweh, G.F.1    Loukopoulos, D.2
  • 47
    • 0000206049 scopus 로고
    • 5-azacytidine stimulates fetal hemoglobin synthesis in anemic baboons
    • DeSimone J, Heller P, Hall L, et al. 5-azacytidine stimulates fetal hemoglobin synthesis in anemic baboons. Proc Natl Acad Sci U S A. 1982;79:4428-31.
    • (1982) Proc Natl Acad Sci U S A , vol.79 , pp. 4428-4431
    • DeSimone, J.1    Heller, P.2    Hall, L.3
  • 48
    • 0034307656 scopus 로고    scopus 로고
    • 2-Deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia
    • Koshy M, Dorn L, Bresller L, et al. 2-Deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia. Blood. 2000;96:2379-84.
    • (2000) Blood , vol.96 , pp. 2379-2384
    • Koshy, M.1    Dorn, L.2    Bresller, L.3
  • 49
    • 0029025475 scopus 로고
    • Effect of hydroxyurea on the frequency of painful crisis in sickle cell anemia Investigators of theMulticenter Study of Hydroxyurea in Sickle Cell Anemia
    • Charache S, Terrin ML, Moore RD, et al. Effect of hydroxyurea on the frequency of painful crisis in sickle cell anemia. Investigators of theMulticenter Study of Hydroxyurea in Sickle Cell Anemia. N Engl J Med. 1995;332:1317-22.
    • (1995) N Engl J Med , vol.332 , pp. 1317-1322
    • Charache, S.1    Terrin, M.L.2    Moore, R.D.3
  • 50
    • 3042772793 scopus 로고    scopus 로고
    • Hydroxyurea in the treatment of major ß-thalassemia and importance of genetic screening
    • Alebouyeh M, Moussavi F, Haddad-Deylami H, et al. Hydroxyurea in the treatment of major ß-thalassemia and importance of genetic screening. Ann Hematol. 2004;83:430-33.
    • (2004) Ann Hematol , vol.83 , pp. 430-433
    • Alebouyeh, M.1    Moussavi, F.2    Haddad-Deylami, H.3
  • 51
    • 6344240976 scopus 로고    scopus 로고
    • Response to hydroxyurea treatment in Iranian transfusion-dependent ß-thalassemia patients
    • Yavarian M, Karimi M, Bakker E, et al. Response to hydroxyurea treatment in Iranian transfusion-dependent ß-thalassemia patients. Haematologica. 2004;89(10):1172-78.
    • (2004) Haematologica , vol.89 , Issue.10 , pp. 1172-1178
    • Yavarian, M.1    Karimi, M.2    Bakker, E.3
  • 52
    • 13344259315 scopus 로고    scopus 로고
    • Hydroxyurea increasesHemoglobin F levels and improves effectiveness of erythropoiesis in ß-thalassemia/hemoglobin E disease
    • Fucharoen S, Siritanaratkul N, Winichagoon P, et al. Hydroxyurea increasesHemoglobin F levels and improves effectiveness of erythropoiesis in ß-thalassemia/hemoglobin E disease. Blood. 1996;87(3):887-92.
    • (1996) Blood , vol.87 , Issue.3 , pp. 887-892
    • Fucharoen, S.1    Siritanaratkul, N.2    Winichagoon, P.3
  • 53
    • 33644649454 scopus 로고    scopus 로고
    • Fetal haemoglobin augmentation in E/ß0 thalassaemia: clinical and haematological outcome
    • Singer S, Kuypers F, Olivieri N, et al. Fetal haemoglobin augmentation in E/ß0 thalassaemia: clinical and haematological outcome. Br J Haematol. 2005;131:378-88.
    • (2005) Br J Haematol , vol.131 , pp. 378-388
    • Singer, S.1    Kuypers, F.2    Olivieri, N.3
  • 54
    • 29744433240 scopus 로고    scopus 로고
    • Induction of fetal globin in ß-thalassemia: cellular obstacles and molecular progress
    • Perrine SP, Castaneda SA, Boosalis MS, et al. Induction of fetal globin in ß-thalassemia: cellular obstacles and molecular progress. Ann NY Acad Sci. 2005;1054:257-65.
    • (2005) Ann NY Acad Sci , vol.1054 , pp. 257-265
    • Perrine, S.P.1    Castaneda, S.A.2    Boosalis, M.S.3
  • 55
    • 29744453274 scopus 로고    scopus 로고
    • Pharmacological induction of fetal hemoglobin: why havent we been more successful in thalassemia?
    • Fathallah H, Sutton M, Atweh GF. Pharmacological induction of fetal hemoglobin: why havent we been more successful in thalassemia?. Ann NY Acad Sci. 2005;1054:228-37.
    • (2005) Ann NY Acad Sci , vol.1054 , pp. 228-237
    • Fathallah, H.1    Sutton, M.2    Atweh, G.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.