Prenatal exclusion of β thalassaemia major by examination of maternal plasma

Lancet

Volumn 360, Issue 9338, 2002, Pages 998-1000

  Chiu, Rossa W K ^a   Lau, Tze K ^a   Leung, Tse N ^a   Chow, Katherine C K ^a   Chui, David H K ^b   Dennis Lo, Y M ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; DNA; FLUORESCENT DYE; PRIMER DNA;

ACCURACY; ALLELE; AMNIOCENTESIS; AMNION FLUID ANALYSIS; ARTICLE; CODON; CONTROLLED STUDY; DNA DETERMINATION; DNA SEQUENCE; FEMALE; FETUS; GENE IDENTIFICATION; GENE MUTATION; GENETIC COUNSELING; GENETIC SCREENING; HERITABILITY; HETEROZYGOTE; HIGH RISK POPULATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MATERNAL PLASMA; PLASMA; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THALASSEMIA MAJOR;

EID: 0037190608     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(02)11086-5     Document Type: Article

References (5)

1. Weatherall D.J. The thalassaemias. BMJ. 314:1997;1675-1678.
2. Lo Y.M.D., Corbetta N., Chamberlain P.F., et al. Presence of fetal DNA in maternal plasma and serum. Lancet. 350:1997;485-487.
3. Costa J.M., Benachi A., Gautier E. New strategy for prenatal diagnosis of X-linked disorders. N Engl J Med. 346:2002;1502.
4. Lo Y.M.D., Hjelm N.M., Fidler C., et al. Prenatal diagnosis of fetal RhD status by molecular analysis of maternal plasma. N Engl J Med. 339:1998;1734-1738.
5. Lau Y.L., Chan L.C., Chan Y.Y., et al. Prevalence and genotypes of alpha- and beta-thalassemia carriers in Hong Kong: implications for population screening. N Engl J Med. 336:1997;1298-1301.