In-vivo platelet activation correlates with red cell anionic phospholipid exposure in patients with β-thalassaemia major

British Journal of Haematology

Volumn 98, Issue 1, 1997, Pages 51-56

  Ruf, Andreas ^a   Pick, Marjorie ^a   Deutsch, Varda ^a   Patschkek, Heinrich ^b   Goldfarb, Ada ^c   Rachmilewitz, Eliezer A ^c   Guillin, Marie C ^d   Eldor, Amiram ^a,e  

^a TEL AVIV UNIVERSITY   (Israel)

^b UNIVERSITY OF FREIBURG   (Germany)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^d Department of Infectious and Tropical Diseases   (France)

^e TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

Annexin V; Hypercoagulability; P selectin; Platelet activation; thalassaemia major

Indexed keywords

LIPOCORTIN 5; PADGEM PROTEIN; PHOSPHOLIPID;

ADOLESCENT; ADULT; ARTICLE; BETA THALASSEMIA; CHILD; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; HUMAN; HYPERCOAGULABILITY; MALE; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; PROTEIN BINDING; THALASSEMIA; THROMBOCYTE ACTIVATION; THROMBOEMBOLISM; THROMBOGENESIS;

EID: 0030751208     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.1502965.x     Document Type: Article

References (36)

1. Bitbol, M., Fellman, P., Zachowski, A. & Devaux, P.F. (1987) Ion regulation of phosphatidylserine and phosphatidylethanolamine outside-inside translocation in human erythrocytes. Biochimica et Biophysica Acta, 904, 268-282.
2. Borenstein, V., Barenholtz, Y., Hy-Am, K., Rachmilewitz, E.A. & Eldor, A. (1993) Phosphatidylserine in the outer leaflet of red blood cells from β-thalassemia patients may explain the chronic hypercoagulable state and thrombotic episodes. American Journal of Hematology, 44, 33-35.
3. Cappellini, M.D., Coppola, R., Bottasso, B., Graziadei, G., Fargion, S. & Mannucci, P.M. (1995) Hypercoagulability in patients with thalassemia intermedia. Blood, 86, (Suppl. 1), 643a.
4. Cappellini, M.D., Coppola, R., Robbiolo, L., Graziadei, G., Valentini, M., Ariens, R.A.S., Fiorelli, G. & Mannucci, P.M. (1996) Procoagulant activity of erythrocytes in thalassemia intermedia. Blood, 88. (Suppl. 1). 38a.
5. Chen, S., Eldor, A., Rarshtein, G., Zhang, S., Goldfarb, A., Rachmilewitz, K. & Yedgar, S. (1996) Enhanced aggregability of red cells of β-thalassemia major patients. American Journal of Physiology, 270, H1951-H1956.
6. Connor, J., Pak, C.C. & Schroit, A.J. (1994) Exposure of phosphatidylserine in the outer leaflet of human red blood cells: relationship to cell density, cell age and clearance by mononuclear cells. Journal of Biological Chemistry, 269, 2339-2345.
7. Cooper, D.M., Mansell, A.L. & Weiner, M.A. (1980) Low lung capacity and hypoxemia in children with thalassemia major. Annual Review of Respiratory Disease, 121, 639-642.
8. Del-Principe, D., Menidhelli, A., Di Giulio, S., De Matteis, W., Cianciulli, P. & Papa. G, (1995) PADGEM/GMP-140 expression on platelet membrane from homozygous β-thalassaemia patients. British Journal of Haematology, 84, 111-117.
9. Eldor, A. (1978) Abnormal platelet function in β-thalassaemia. Scandinavian Journal of Haematology, 20, 447-452.
10. Eldor A., Krausz, Y., Allan, H., Snyder, D., Goldfarb, A., Hy-Am, K., Rachmilewitz, E.A., Kotze, H.F. & Heyns, A.P. (1989) Platelet survival in patients with β-thalassemia. American Journal of Hematology, 32, 94-99.
11. Eldor, A., Lellouche, F., Goldfarb, A., Rachmilewilz, E.A. & Maclouf, J. (1991) In vivo platelet activation in β-thalassemia major reflected by increased platelet thromboxane-urinary-metabolites. Blood, 77, 1749-1753.
12. Eldor, E., Maclouf, J., Durst, R., Godefray, C., Hy-Am, E., Abramov, A., Goldfarb, A., Kachmilewitz, E.A., Ben Yashar, V., Barenholz, Y., de Raucourt, E. & Guillin, M.C. (1992) A chronic hypercoagulable state in β-thalassemia major exists already in childhood and may be induced by the abnormal erythrocytes. Blood, 80, (Suppl. 1), 5a.
13. Grant, G.P., Mansell, A.L., Graziano, J.H. & Mellins, R.B. (1986) The effect of transfusion on lung capacity, diffusing capacity and material oxygen saturation in patients with β-thalassemia major, Pediatric Research, 20, 20-29.
14. Grisaru, D., Rachmilewitz, H.A., Mosseri, M., Gotsman, M., Lafair, J., Okun, K., Goldfarb, A. & Hasin, Y. (1990) Cardiopulmonary assessment in β-thalassemia major. Chest, 98, 1138-1142.
15. Helley, D., Eldor, A., Girot, R., Ducrocq, R., Guillin, M.C. & Hezeaud, A. (1996) Comparison of the procoagulant activity of red blood cells from patients with homozygous sickle cell disease and β-thalassaemia, Thrombosis and Haemostasis, 76, 322-327.
16. Hermann, A. & Devaux, P.F. (1990) Alteration of the uminophospholipid translocase activity during in vivo and artificial aging of human erythrocytes. Biochimica et Biophysica Acta, 1027, 41-49.
17. Koopman, C., Reutelingsperger, C.P.M., Kuijten, G.A.M., Keehnen R.M.J., Pals, S.K. & van Oers, M.H.J. (1992) Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood, 84, 1415-1420.
18. Kuypers, H.A., Lewis, R.A., Hua, M., Schott, M.A., Discher, D., Ernst. J.D. & Lubin, B.H. (1996) Detection of altered membrane phospholipid asymmetry in subpopulations of human red blood cells using fluorescently labelled annexin V. Blood, 87, 1179-1184.
19. Longothetis, J., Consantoulakis, M., Economidou, J., Stefanis, C., Hakas, P., Angoustaki, O., Sofraniadou, K., Loewenson, R. & Bilek, M.S. (1972) Thalassaemia major (homozygous β-thaiassaemia): a survey of 138 cases with emphasis on curologic and muscular aspects. Neurology, 22, 294- 304.
20. Michaeli, J., Mittelman, M., Grisaru, D. & Rachmilewitz, A.E. (1992) Thromboembolic complications in β-thaiassaemia major. Acta Haematologica, 87, 71-74.
21. Middelkoop, H., Lubin, B.H., Hevers, E.M., Op Den Kamp, J.A.F. Comfurius, P., Chia, D.T.Y., Zwaal, R.F.A., Van Deenen, L.L.M. & Roelofsen, B. (1988) Studies on siekled erythrocytes provide evidence that the asymetric distribution of phosphatidylserine in the red cell membrane is maintained by both ATP-dependentd translocation and interaction with membrane skeletal proteins. Biochimica et Biophysica Acta, 937, 281-288.
22. 2+ ATPase, a candidate for aminophospholipid translocase. FEBS Letters, 266, 29-32.
23. Musumeci, S., Leonardi, S., Di Dio, R., Fischer, A. & Di Costa, G, (1987) Protein C and antithrombin III in polytrausfused thalassaemic patients. Acta Haematologica, 77, 30- 33.
24. Paolini, E., Monetti, V.C., Gronieri, E. & Boldrini, P. (1983) Acute cerebrovascular insults in homozygous β-thalassemia: a case report. Journal of Neurology, 230, 37-41.
25. Ruf, A. & Patscheke, H. (1995) Flow cytometric delection of activated platelets: comparison of determining shape change, fibrinogen binding, and p-selectin expression. Scminars in Thrombosis and Hemostasis, 21, 146-151.
26. Scheroit, A.J. & Zwall, R.F.A. (1991) Transbilayer movement of phospholipids in red cell and platelet membranes. Biochimica et Biophysica Acta, 1071, 313-329.
27. Shattil, S.J., Cunningham, M. & Hoxie, J.A. (1987) Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow eytometry. Blood, 70, 307-315.
28. Sinniah, D., Vignaendra, V. & Kamaruddin, A. (1972) Neurological complications of β-thalassemia major. Archives of Discases in Childhood, 52, 977-979.
29. Sklar, LA., Finney, O.A., Oades, Z.G., Jesaites. A.J., Painter, R.G. & Cochrane, C.G. (1984) The dynamics of ligand receptor interactions, Jaurnal of Biological Chemistry, 289, 5661-5665.
30. Sonakul, D., Pacharee, P., Laohapand, T., Fucharoen, S. & Wasi, P. (1990) Pulmoary artery obstruction in thalassemia. Southeast Asian Journal of Tropical Medicine and Public Health, 11, 516-523.
31. Sonakul, D. & Fucharoen, S. (1992) Pulmonary thromboembolism in thalassemic patients. Southeast Asian Journal of Tropical Medicine and Public Health, 23, (Suppl. 22), 25-28.
32. Sumiyoshi, A., Thakerngpol, K. & Sonakul, D. (1992) Pulmonary microthromboemboli in thalassemic cases, Southeast Asian Journal of Tropical Medicine and Public Health, 23, (Suppl. 22). 29-31.
33. Tait, J.F. & Gibson, D. (1994) Measurement of membrane phospholipid asymmetry in normal and sickle cell erythrocytes by means of annexin V binding, Journal of Laboratory and Clinical Medicine. 123, 741-748.
34. Wong, V., Yu. Y.L., Liany, R.S.H., Tso, W.K., Li. A.M.C. & Chan, T.K. (1990) Cerebral thrombosis in β-thalassemia/hemoglobin H disease. Stroke, 21, 812-816.
35. Wooldridge, L.C. (1886) Note on the relation of the red blood corpuscles to coagulation. Proctitioner, 38, 187-188.
36. Zwaal, R.F.A., Comfurius, R & Bevers, E.M. (1995) Mechanism and function of changes in membrane phospholipid asymmetry in platelets and erythrocytes. Biochemical Society Transactions, 21, 248-253.