메뉴 건너뛰기




Volumn 18, Issue 4, 2011, Pages 188-198

EPA but not DHA appears to be responsible for the efficacy of omega-3 LC-PUFA supplementation in depression: Evidence from an updated meta-analysis of randomized controlled trials

Author keywords

Depression; Dietary supplementation; Meta analysis; Omega 3 long chain polyunsaturated fatty acids

Indexed keywords

ALGAE;

EID: 80053360301     PISSN: 12588210     EISSN: 1950697X     Source Type: Journal    
DOI: 10.1684/ocl.2011.0402     Document Type: Article
Times cited : (5)

References (49)
  • 3
    • 0025134274 scopus 로고
    • Effect of high doses of essential fatty acids on the postviral fatigue syndrome
    • Behan PO, Behan WM, Horrobin D. Effect of high doses of essential fatty acids on the postviral fatigue syndrome. Acta Neurol Scand 1990; 82: 209-16. (Pubitemid 20328916)
    • (1990) Acta Neurologica Scandinavica , vol.82 , Issue.3 , pp. 209-216
    • Behan, P.O.1    Behan, W.M.H.2    Horrobin, D.3
  • 4
    • 77956263859 scopus 로고    scopus 로고
    • Eicosapentaenoic acid as an add-on to antidepressant medication for co-morbid major depression in patients with diabetes mellitus: A randomized, double-blind placebo-controlled study
    • Bot M, Pouwer F, Assies J, et al. Eicosapentaenoic acid as an add-on to antidepressant medication for co-morbid major depression in patients with diabetes mellitus: a randomized, double-blind placebo-controlled study. J Affect Disord 2010; 126: 282-6.
    • (2010) J Affect Disord , vol.126 , pp. 282-286
    • Bot, M.1    Pouwer, F.2    Assies, J.3
  • 5
    • 70350712230 scopus 로고    scopus 로고
    • Omega-3 augmentation of sertraline in treatment of depression in patients with coronary heart disease: A randomized controlled trial
    • Carney RM, Freedland KE, Rubin EH, Rich MW, Steinmeyer BC, Harris WS. Omega-3 augmentation of sertraline in treatment of depression in patients with coronary heart disease: a randomized controlled trial. JAMA 2009; 302: 1651-7.
    • (2009) JAMA , vol.302 , pp. 1651-1657
    • Carney, R.M.1    Freedland, K.E.2    Rubin, E.H.3    Rich, M.W.4    Steinmeyer, B.C.5    Harris, W.S.6
  • 6
    • 54049153609 scopus 로고    scopus 로고
    • Depression in Parkinson's disease: A doubleblind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation
    • da Silva TM, Munhoz RP, Alvarez C, et al. Depression in Parkinson's disease: a doubleblind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation. J Affect Disord 2008; 111: 351-9.
    • (2008) J Affect Disord , vol.111 , pp. 351-359
    • Da Silva, T.M.1    Munhoz, R.P.2    Alvarez, C.3
  • 8
    • 0035190361 scopus 로고    scopus 로고
    • A placebo-controlled trial of omega-3 fatty acid (ethyl eicosapentaenoic acid) supplementation for residual symptoms and cognitive impairment in schizophrenia
    • DOI 10.1176/appi.ajp.158.12.2071
    • Fenton WS, Dickerson F, Boronow J, Hibbeln JR, Knable M. A placebo-controlled trial of omega-3 fatty acid (ethyl eicosapentaenoic acid) supplementation for residual symptoms and cognitive impairment in schizophrenia. Am J Psychiatry 2001; 158: 2071-4. (Pubitemid 33104119)
    • (2001) American Journal of Psychiatry , vol.158 , Issue.12 , pp. 2071-2074
    • Fenton, W.S.1    Dickerson, F.2    Boronow, J.3    Hibbeln, J.R.4    Knable, M.5
  • 10
    • 29644443167 scopus 로고    scopus 로고
    • Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: Randomised double-blind placebo-controlled study
    • DOI 10.1192/bjp.188.1.46
    • Frangou S, Lewis M, McCrone P. Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomised double-blind placebocontrolled study. Br J Psychiatry 2006; 188: 46-50. (Pubitemid 43021926)
    • (2006) British Journal of Psychiatry , vol.188 , Issue.JAN. , pp. 46-50
    • Frangou, S.1    Lewis, M.2    McCrone, P.3
  • 11
    • 34447564983 scopus 로고    scopus 로고
    • Preliminary in vivo evidence of increased N-acetyl-aspartate following eicosapentanoic acid treatment in patients with bipolar disorder
    • DOI 10.1177/0269881106067787
    • Frangou S, Lewis M, Wollard J, Simmons A. Preliminary in vivo evidence of increased Nacetyl- aspartate following eicosapentanoic acid treatment in patients with bipolar disorder. J Psychopharmacol 2007; 21: 435-9. (Pubitemid 47077299)
    • (2007) Journal of Psychopharmacology , vol.21 , Issue.4 , pp. 435-439
    • Frangou, S.1    Lewis, M.2    Wollard, J.3    Simmons, A.4
  • 12
    • 44849122926 scopus 로고    scopus 로고
    • Omega-3 fatty acids and supportive psychotherapy for perinatal depression: A randomized placebo- controlled study
    • Freeman MP, Davis M, Sinha P, Wisner KL, Hibbeln JR, Gelenberg AJ., Omega-3 fatty acids and supportive psychotherapy for perinatal depression: a randomized placebo- controlled study. J Affect Disord 2008; 110: 142-8.
    • (2008) J Affect Disord , vol.110 , pp. 142-148
    • Freeman, M.P.1    Davis, M.2    Sinha, P.3    Wisner, K.L.4    Hibbeln, J.R.5    Gelenberg, A.J.6
  • 14
    • 33846993443 scopus 로고    scopus 로고
    • Omega-3 fatty acid supplementation in patients with recurrent self-harm. Singlecentre double-blind randomised controlled trial
    • Hallahan B, Hibbeln JR, Davis JM, Garland MR. Omega-3 fatty acid supplementation in patients with recurrent self-harm. Singlecentre double-blind randomised controlled trial. Br J Psychiatry 2007; 190: 118-22.
    • (2007) Br J Psychiatry , vol.190 , pp. 118-122
    • Hallahan, B.1    Hibbeln, J.R.2    Davis, J.M.3    Garland, M.R.4
  • 15
    • 0032542958 scopus 로고    scopus 로고
    • Fish consumption and major depression
    • Hibbeln JR. Fish consumption and major depression. Lancet 1998; 351: 1213.
    • (1998) Lancet , vol.351 , pp. 1213
    • Hibbeln, J.R.1
  • 16
    • 0036018481 scopus 로고    scopus 로고
    • Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: A cross-national, ecological analysis
    • DOI 10.1016/S0165-0327(01)00374-3, PII S0165032701003743
    • Hibbeln JR. Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a crossnational, ecological analysis. J Affect Disord 2002; 69: 15-29. (Pubitemid 34722867)
    • (2002) Journal of Affective Disorders , vol.69 , Issue.1-3 , pp. 15-29
    • Hibbeln, J.R.1
  • 23
    • 59749092927 scopus 로고    scopus 로고
    • Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: A double-blind, placebo-controlled, randomized clinical trial
    • Lucas M, Asselin G, Merette C, Poulin MJ, Dodin S. Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial. Am J Clin Nutr 2009; 89: 641-51.
    • (2009) Am J Clin Nutr , vol.89 , pp. 641-651
    • Lucas, M.1    Asselin, G.2    Merette, C.3    Poulin, M.J.4    Dodin, S.5
  • 24
    • 77958120522 scopus 로고    scopus 로고
    • Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: A randomized controlled trial
    • Makrides M, Gibson RA, McPhee AJ, Yelland L, Quinlivan J, Ryan P. Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial. JAMA 2010; 304: 1675-83.
    • (2010) JAMA , vol.304 , pp. 1675-1683
    • Makrides, M.1    Gibson, R.A.2    McPhee, A.J.3    Yelland, L.4    Quinlivan, J.5    Ryan, P.6
  • 25
    • 0037844785 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression
    • DOI 10.1176/appi.ajp.160.5.996
    • Marangell LB, Martinez JM, Zboyan HA, Kertz B, Kim HF, Puryear LJ. A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. Am J Psychiatry 2003; 160: 996-8. (Pubitemid 41079588)
    • (2003) American Journal of Psychiatry , vol.160 , Issue.5 , pp. 996-998
    • Marangell, L.B.1    Martinez, J.M.2    Zboyan, H.A.3    Kertz, B.4    Kim, H.F.S.5    Puryear, L.J.6
  • 26
    • 77954947300 scopus 로고    scopus 로고
    • EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: Evidence from a metaanalysis of randomized controlled trials
    • Martins JG. EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a metaanalysis of randomized controlled trials. J Am Coll Nutr 2009; 28: 525-42.
    • (2009) J Am Coll Nutr , vol.28 , pp. 525-542
    • Martins, J.G.1
  • 27
    • 70449752877 scopus 로고    scopus 로고
    • A double-blind, randomized controlled trial of ethyl-eicosapentaenoate for major depressive disorder
    • Mischoulon D, Papakostas GI, Dording CM, et al. A double-blind, randomized controlled trial of ethyl-eicosapentaenoate for major depressive disorder. J Clin Psychiatry 2009; 70: 1636-44.
    • (2009) J Clin Psychiatry , vol.70 , pp. 1636-1644
    • Mischoulon, D.1    Papakostas, G.I.2    Dording, C.M.3
  • 28
    • 0036190807 scopus 로고    scopus 로고
    • Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder
    • DOI 10.1176/appi.ajp.159.3.477
    • Nemets B, Stahl Z, Belmaker RH. Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. Am J Psychiatry 2002; 159: 477-9. (Pubitemid 34184747)
    • (2002) American Journal of Psychiatry , vol.159 , Issue.3 , pp. 477-479
    • Nemets, B.1    Stahl, Z.2    Belmaker, R.H.3
  • 29
    • 85047698720 scopus 로고    scopus 로고
    • Omega-3 treatment of childhood depression: A controlled, double-blind pilot study
    • DOI 10.1176/appi.ajp.163.6.1098
    • Nemets H, Nemets B, Apter A, Bracha Z, and Belmaker RH. Omega-3 treatment of childhood depression: a controlled, double-blind pilot study. Am J Psychiatry 2006; 163: 1098-100. (Pubitemid 44464498)
    • (2006) American Journal of Psychiatry , vol.163 , Issue.6 , pp. 1098-1100
    • Nemets, H.1    Nemets, B.2    Apter, A.3    Bracha, Z.4    Belmaker, R.H.5
  • 30
    • 0037668364 scopus 로고    scopus 로고
    • Cross-national comparisons of seafood consumption and rates of bipolar disorders
    • DOI 10.1176/appi.ajp.160.12.2222
    • Noaghiul S, Hibbeln JR. Cross-national comparisons of seafood consumption and rates of bipolar disorders. Am J Psychiatry 2003; 160: 2222-7. (Pubitemid 39619617)
    • (2003) American Journal of Psychiatry , vol.160 , Issue.12 , pp. 2222-2227
    • Noaghiul, S.1    Hibbeln, J.R.2
  • 31
    • 0036790628 scopus 로고    scopus 로고
    • A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs
    • Peet M, Horrobin DF. A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs. Arch Gen Psychiatry 2002; 59:913-9.
    • (2002) Arch Gen Psychiatry , vol.59 , pp. 913-919
    • Peet, M.1    Horrobin, D.F.2
  • 32
    • 70350540904 scopus 로고    scopus 로고
    • Effects of moderate-dose omega-3 fish oil on cardiovascular risk factors and mood after ischemic stroke: A randomized, controlled trial
    • Poppitt SD, Howe CA, Lithander FE, et al. Effects of moderate-dose omega-3 fish oil on cardiovascular risk factors and mood after ischemic stroke: a randomized, controlled trial. Stroke 2009; 40: 3485-92.
    • (2009) Stroke , vol.40 , pp. 3485-3492
    • Poppitt, S.D.1    Howe, C.A.2    Lithander, F.E.3
  • 33
    • 38849095188 scopus 로고    scopus 로고
    • Cardiovascular disease and depression: The PUFA connection
    • DOI 10.1111/j.1742-1241.2007.01649.x
    • Puri BK. Cardiovascular disease and depression: the PUFA connection. Int J Clin Pract 2008; 62: 355-7. (Pubitemid 351197415)
    • (2008) International Journal of Clinical Practice , vol.62 , Issue.3 , pp. 355-357
    • Puri, B.K.1
  • 34
    • 39049120230 scopus 로고    scopus 로고
    • Omega-3 fatty acids as a treatment for perinatal depression: Randomized double-blind placebo-controlled trial
    • DOI 10.1080/00048670701827267, PII 790366461
    • Rees AM, Austin MP, Parker GB. Omega-3 fatty acids as a treatment for perinatal depression: randomized double-blind placebo- controlled trial. Aust N Z J Psychiatry 2008; 42: 199-205. (Pubitemid 351234189)
    • (2008) Australian and New Zealand Journal of Psychiatry , vol.42 , Issue.3 , pp. 199-205
    • Rees, A.-M.1    Austin, M.-P.2    Parker, G.B.3
  • 35
    • 38049182755 scopus 로고    scopus 로고
    • No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: A randomised controlled trial
    • Rogers PJ, Appleton KM, Kessler D, et al. No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial. Br J Nutr 2008; 99: 421-31.
    • (2008) Br J Nutr , vol.99 , pp. 421-431
    • Rogers, P.J.1    Appleton, K.M.2    Kessler, D.3
  • 36
    • 77956474744 scopus 로고    scopus 로고
    • Effect of omega-3 fatty acids supplementation on depressive symptoms and on health-related quality of life in the treatment of elderly women with depression: A double-blind, placebo-controlled, randomized clinical trial
    • Rondanelli M, Giacosa A, Opizzi A, et al. Effect of omega-3 fatty acids supplementation on depressive symptoms and on health-related quality of life in the treatment of elderly women with depression: a double-blind, placebo-controlled, randomized clinical trial. J Am Coll Nutr 2010; 29: 55-64.
    • (2010) J Am Coll Nutr , vol.29 , pp. 55-64
    • Rondanelli, M.1    Giacosa, A.2    Opizzi, A.3
  • 37
    • 36048989288 scopus 로고    scopus 로고
    • Omega-3 fatty acids as treatments for mental illness: which disorder and which fatty acid
    • Ross BM, Seguin J, Sieswerda LE. Omega-3 fatty acids as treatments for mental illness: which disorder and which fatty acid? Lipids Health Dis 2007; 6: 21.
    • (2007) Lipids Health Dis , vol.6 , pp. 21
    • Ross, B.M.1    Seguin, J.2    Sieswerda, L.E.3
  • 38
    • 0036276031 scopus 로고    scopus 로고
    • Fish consumption and self-reported physical and mental health status
    • DOI 10.1079/PHN2001308
    • Silvers KM, Scott KM. Fish consumption and self-reported physical and mental health status. Public Health Nutr 2002; 5: 427-31. (Pubitemid 34614910)
    • (2002) Public Health Nutrition , vol.5 , Issue.3 , pp. 427-431
    • Silvers, K.M.1    Scott, K.M.2
  • 41
    • 0042850504 scopus 로고    scopus 로고
    • Omega-3 fatty acids in major depressive disorder: A preliminary double-blind, placebo-controlled trial
    • DOI 10.1016/S0924-977X(03)00032-4
    • Su KP, Huang SY, Chiu CC, Shen WW. Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo- controlled trial. Eur Neuropsychopharmacol 2003; 13: 267-71. (Pubitemid 36904053)
    • (2003) European Neuropsychopharmacology , vol.13 , Issue.4 , pp. 267-271
    • Su, K.-P.1    Huang, S.-Y.2    Chiu, C.-C.3    Shen, W.W.4
  • 42
    • 44849092681 scopus 로고    scopus 로고
    • Omega-3 fatty acids for major depressive disorder during pregnancy: Results from a randomized, double-blind, placebo-controlled trial
    • Su KP, Huang SY, Chiu TH, et al. Omega-3 fatty acids for major depressive disorder during pregnancy: results from a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry 2008; 69: 644-51.
    • (2008) J Clin Psychiatry , vol.69 , pp. 644-651
    • Su, K.P.1    Huang, S.Y.2    Chiu, T.H.3
  • 46
    • 51749101160 scopus 로고    scopus 로고
    • Effect of fish-oil supplementation on mental well-being in older subjects: A randomized, double-blind, placebo-controlled trial
    • van de Rest O, Geleijnse JM, Kok FJ, et al. Effect of fish-oil supplementation on mental well-being in older subjects: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2008; 88: 706-13.
    • (2008) Am J Clin Nutr , vol.88 , pp. 706-713
    • Van De Rest, O.1    Geleijnse, J.M.2    Kok, F.J.3
  • 47
    • 0032897006 scopus 로고    scopus 로고
    • The role of essential fatty acids in chronic fatigue syndrome
    • A case-controlled study of red-cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFA
    • Warren G, McKendrick M, Peet M. The role of essential fatty acids in chronic fatigue syndrome. A case-controlled study of red-cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFA. Acta Neurol Scand 1999; 99: 112-6.
    • (1999) Acta Neurol Scand , vol.99 , pp. 112-116
    • Warren, G.1    McKendrick, M.2    Peet, M.3
  • 49
    • 0037225853 scopus 로고    scopus 로고
    • Omega-3 fatty acid treatment of women with borderline personality disorder: A double-blind, placebo-controlled pilot study
    • DOI 10.1176/appi.ajp.160.1.167
    • Zanarini MC, Frankenburg FR. omega-3 Fatty acid treatment of women with borderline personality disorder: a double-blind, placebo- controlled pilot study. Am J Psychiatry 2003; 160: 167-9. (Pubitemid 36042442)
    • (2003) American Journal of Psychiatry , vol.160 , Issue.1 , pp. 167-169
    • Zanarini, M.C.1    Frankenburg, F.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.