Radioprotective efficacy of tocopherol succinate is mediated through granulocyte-colony stimulating factor

Cytokine

Volumn 56, Issue 2, 2011, Pages 411-421

  Singh, Pankaj K ^a   Wise, Stephen Y ^a   Ducey, Elizabeth J ^a   Brown, Darren S ^a   Singh, Vijay K ^a,b  

^a ARMED FORCES RADIOBIOLOGY RESEARCH INSTITUTE   (United States)

^b Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

Author keywords

Radiation; Apoptosis; Gastrointestinal injury; Mice; Tocopherol succinate

Indexed keywords

ALPHA TOCOPHEROL SUCCINATE; GRANULOCYTE COLONY STIMULATING FACTOR; KERATINOCYTE DERIVED CHEMOKINE; KI 67 ANTIGEN; NEUTRALIZING ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; COBALT THERAPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIGESTIVE SYSTEM INJURY; DRUG MECHANISM; GAMMA RADIATION; HISTOPATHOLOGY; INTESTINE CRYPT; INTESTINE VILLUS; JEJUNUM; MALE; MITOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN INDUCTION; RADIATION DOSE; RADIATION ENTEROPATHY; RADIATION PROTECTION; SIGNAL TRANSDUCTION; WHOLE BODY RADIATION;

ANIMALS; GRANULOCYTE COLONY-STIMULATING FACTOR; IN SITU NICK-END LABELING; MALE; MICE; RADIATION-PROTECTIVE AGENTS; TOCOPHEROLS;

MUS;

EID: 80053332647     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2011.08.016     Document Type: Article

References (60)

1. Benjamin G.C., McGeary M., McCutchen S.R. Assessing medical preparedness to respond to a terrorist nuclear event: workshop report 2009, The National Academies Press, Washington, D.C.
2. Singh V.K., Seed T.M. Radiation effects. Physician's guide to terrorist attack 2003, 339-362. Humana Press, Totowa. M.J. Roy (Ed.).
3. Waselenko J.K., MacVittie T.J., Blakely W.F., Pesik N., Wiley A.L., Dickerson W.E., et al. Medical management of the acute radiation syndrome: recommendations of the strategic national stockpile radiation working group. Ann Intern Med 2004, 140:1037-1051.
4. Pellmar T.C., Rockwell S. Priority list of research areas for radiological nuclear threat countermeasures. Radiat Res 2005, 163:115-123.
5. Hosseinimehr S.J. Trends in the development of radioprotective agents. Drug Discov Today 2007, 12:794-805.
6. Nair C.K., Devi P.U., Shimanskaya R., Kunugita N., Murase H., Gu Y.H., et al. Water soluble vitamin E (TMG) as a radioprotector. Indian J Exp Biol 2003, 41:1365-1371.
7. Devi P.U. Withania somnifera Dunal (Ashwagandha): potential plant source of a promising drug for cancer chemotherapy and radiosensitization. Indian J Exp Biol 1996, 34:927-932.
8. Yoshida Y., Niki E., Noguchi N. Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effects. Chem Phys Lipids 2003, 123:63-75.
9. Brigelius-Flohe R., Traber M.G. Vitamin E: function and metabolism. FASEB Journal 1999, 13:1145-1155.
10. Traber M.G. Vitamin E regulatory mechanisms. Ann Rev Nutr 2007, 27:347-362.
11. Singh V.K., Shafran R.L., Jackson W.E., Seed T.M., Kumar K.S. Induction of cytokines by radioprotective tocopherol analogs. Exp Mol Pathol 2006, 81:55-61.
12. Sen C.K., Khanna S., Roy S. Tocotrienols: Vitamin E beyond tocopherols. Life Sci 2006, 78:2088-2098.
13. Sen C.K., Khanna S., Rink C., Roy S. Tocotrienols: the emerging face of natural vitamin E. Vitam Horm 2007, 76:203-261.
14. Atkinson J., Epand R.F., Epand R.M. Tocopherols and tocotrienols in membranes: a critical review. Free Rad Biol Med 2008, 44:739-764.
15. Ghosh S.P., Kulkarni S., Hieber K., Toles R., Romanyukha L., Kao T.C., et al. Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector. Int J Radiat Biol 2009, 85:598-606.
16. Beekman R., Touw I.P. G-CSF and its receptor in myeloid malignancy. Blood 2010, 115:5131-5136.
17. Souza L.M., Boone T.C., Gabrilove J., Lai P.H., Zsebo K.M., Murdock D.C., et al. Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells. Science 1986, 232:61-65.
18. Dainiak N. Rationale and recommendations for treatment of radiation injury with cytokines. Health Phys 2010, 98:838-842.
19. Dainiak N., Waselenko J.K., Armitage J.O., MacVittie T.J., Farese A.M. The hematologist and radiation casualties. Hematology Am Soc Hematol Educ Program 2003, 473-496.
20. Singh V.K., Brown D.S., Kao T.C. Tocopherol succinate: a promising radiation countermeasure. Int Immunopharmacol 2009, 9:1423-1430.
21. Singh V.K., Parekh V.I., Brown D.S., Kao T.C., Mog S.R. Tocopherol succinate: modulation of antioxidant enzymes and oncogene expression, and hematopoietic recovery. Int J Radiat Oncol Biol Phys 2011, 79:571-578.
22. Singh V.K., Brown D.S., Kao T.C. Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor. Int J Radiat Biol 2010, 86:12-21.
23. Singh V.K., Brown D.S., Kao T.C., Seed T.M. Preclinical development of a bridging therapy for radiation casualties. Exp Hematol 2010, 38:61-70.
24. Withers H.R., Elkind M.M. Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation. Int J Radiat Biol Relat Stud Phys Chem Med 1970, 17:261-267.
25. Paris F., Fuks Z., Kang A., Capodieci P., Juan G., Ehleiter D., et al. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 2001, 293:293-297.
26. Kee N., Sivalingam S., Boonstra R., Wojtowicz J.M. The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis. J Neurosci Methods 2002, 115:97-105.
27. Scholzen T., Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 2000, 182:311-322.
28. Berbee M., Fu Q., Boerma M., Wang J., Kumar K.S., Hauer-Jensen M. Gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism. Radiat Res 2009, 171:596-605.
29. Singh V.K., Grace M.B., Jacobsen K.O., Chang C.M., Parekh V.I., Inal C.E., et al. Administration of 5-androstenediol to mice. pharmacokinetics and cytokine gene expression. Exp Mol Pathol 2008, 84:178-188.
30. Singh V.K., Grace M.B., Parekh V.I., Whitnall M.H., Landauer M.R. Effects of genistein administration on cytokine induction in whole-body gamma irradiated mice. Int Immunopharmacol 2009, 9:1401-1410.
31. Kulkarni S., Ghosh S.P., Hauer-Jensen M., Kumar K.S. Hematological targets of radiation damage. Curr Drug Targets 2010, 11:1375-1385.
32. Park E., Ahn G., Yun J.S., Kim M.J., Bing S.J., Kim D.S., et al. Dieckol rescues mice from lethal irradiation by accelerating hemopoiesis and curtailing immunosuppression. Int J Radiat Biol 2010, 86:848-859.
33. Singh V.K., Yadav V.S. Role of cytokines and growth factors in radioprotection. Exp Mol Pathol 2005, 78:156-169.
34. Wingard JR, Dainiak N. Treatment of radiation injury in the adult. Up-to-Date, Version 17.2. Available at: ; 2010 [accessed March 2010]. http://www.uptodate.com.
35. Asano S. Multi-organ involvement: lessons from the experience of one victim of the Tokai-mura criticality accident. Br J Radiol Suppl 2005, 27:9-12.
36. Maekawa K. Overview of medical care for highly exposed victims in the Tokaimura accident. The medical basis for radiation accident preparedness. The clinical care of victime 2002, 313-318. Parthenon, New York. R.C. Ricks, M.E. Berger, F.M. O'Hara (Eds.).
37. Ishii T., Futami S., Nishida M., Suzuki T., Sakamoto T., Suzuki N., et al. Brief note and evaluation of acute-radiation syndrome and treatment of a Tokai-mura criticality accident patient. J Radiat Res (Tokyo) 2001, 42(Suppl.):S167-82.
38. Igaki H., Nakagawa K., Uozaki H., Akahane M., Hosoi Y., Fukayama M., et al. Pathological changes in the gastrointestinal tract of a heavily radiation-exposed worker at the Tokai-mura criticality accident. J Radiat Res (Tokyo) 2008, 49:55-62.
39. Baranov A.E., Guskova A.K., Nadejina N.M., Nugis V.Y. Chernobyl experiences: biological indications of exposure to ionizing radiation. Stem Cells 1995, 13(Suppl):69-77.
40. Herodin F., Grenier N., Drouet M. Revisiting therapeutic strategies in radiation casualties. Exp Hematol 2007, 35:28-33.
41. Herodin F., Roy L., Grenier N., Delaunay C., Bauge S., Vaurijoux A., et al. Antiapoptotic cytokines in combination with pegfilgrastim soon after irradiation mitigates myelosuppression in nonhuman primates exposed to high irradiation dose. Exp Hematol 2007, 35:1172-1181.
42. Mac Vittie T.J., Monroy R.L., Vigneulle R.M. The relative biological effectiveness of mixed fission-neutron-gamma radiation on the hematopoietic syndrome in the canine: effect of therapy on survival. Radiat Res 1991, 128:S29.
43. Neelis K.J., Dubbelman Y.D., Qingliang L., Thomas G.R., Eaton D.L., Wagemaker G. Simultaneous administration of TPO and G-CSF after cytoreductive treatment of rhesus monkeys prevents thrombocytopenia, accelerates platelet and red cell reconstitution, alleviates neutropenia, and promotes the recovery of immature bone marrow cells. Exp Hematol 1997, 25:1084-1093.
44. Moon C., Kim S.H., Kim J.C., Hyun J.W., Lee N.H., Park J.W., et al. Protective effect of phlorotannin components phloroglucinol and eckol on radiation-induced intestinal injury in mice. Phytother Res 2008, 22:238-242.
45. Oh H., Seong J., Kim W., Park S., Koom W.S., Cho N.H., et al. Recombinant human epidermal growth factor (rhEGF) protects radiation-induced intestine injury in murine system. J Radiat Res (Tokyo) 2010, 51:535-541.
46. Potten C.S., Booth D., Haley J.D. Pretreatment with transforming growth factor beta-3 protects small intestinal stem cells against radiation damage in vivo. Br J Cancer 1997, 75:1454-1459.
47. Park E., Hwang I., Song J.Y., Jee Y. Acidic polysaccharide of Panax ginseng as a defense against small intestinal damage by whole-body gamma irradiation of mice. Acta Histochem 2011, 113:19-23.
48. Fu Q., Berbee M., Boerma M., Wang J., Schmid H.A., Hauer-Jensen M. The somatostatin analog SOM230 (pasireotide) ameliorates injury of the intestinal mucosa and increases survival after total-body irradiation by inhibiting exocrine pancreatic secretion. Radiat Res 2009, 171:698-707.
49. Yoon S.C., Park J.M., Jang H.S., Shinn K.S., Bahk Y.W. Radioprotective effect of captopril on the mouse jejunal mucosa. Int J Radiat Oncol Biol Phys 1994, 30:873-878.
50. Klocke R., Kuhlmann M.T., Scobioala S., Schabitz W.R., Nikol S. Granulocyte colony-stimulating factor (G-CSF) for cardio- and cerebrovascular regenerative applications. Curr Med Chem 2008, 15:968-977.
51. Harada M., Qin Y., Takano H., Minamino T., Zou Y., Toko H., et al. G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat Med 2005, 11:305-311.
52. Kuhlmann M.T., Kirchhof P., Klocke R., Hasib L., Stypmann J., Fabritz L., et al. G-CSF/SCF reduces inducible arrhythmias in the infarcted heart potentially via increased connexin43 expression and arteriogenesis. J Exp Med 2006, 203:87-97.
53. Schneider A., Kruger C., Steigleder T., Weber D., Pitzer C., Laage R., et al. The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J Clin Invest 2005, 115:2083-2098.
54. Wadhwa M., Thorpe R. Haematopoietic growth factors and their therapeutic use. Thromb Haemost 2008, 99:863-873.
55. Singh V.K., Singh P.K., Wise S.Y., Seed T.M. Mobilized progenitor cells as a bridging therapy for radiation casualties: A brief review of tocopherol succinate-based approaches. Int Immunopharmacol 2011, 11:839-844.
56. Luider J., Brown C., Selinger S., Quinlan D., Karlsson L., Ruether D., et al. Factors influencing yields of progenitor cells for allogeneic transplantation: optimization of G-CSF dose, day of collection, and duration of leukapheresis. J Hematother 1997, 6:575-580.
57. Damon L.E. Mobilization of hematopoietic stem cells into the peripheral blood. Expert Rev Hematol 2009, 2:717-733.
58. Jun H.S., Lee Y.M., Song K.D., Mansfield B.C., Chou J.Y. G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasis. Blood 2011, 117:3881-3892.
59. Kojima H., Otani A., Oishi A., Makiyama Y., Nakagawa S., Yoshimura N. Granulocyte colony-stimulating factor attenuates oxidative stress-induced apoptosis in vascular endothelial cells and exhibits functional and morphologic protective effect in oxygen-induced retinopathy. Blood 2011, 117:1091-1100.
60. Tsai R.K., Chang C.H., Sheu M.M., Huang Z.L. Anti-apoptotic effects of human granulocyte colony-stimulating factor (G-CSF) on retinal ganglion cells after optic nerve crush are PI3K/AKT-dependent. Exp Eye Res 2011, 90:537-545.