Tocopherol succinate: A promising radiation countermeasure

International Immunopharmacology

Volumn 9, Issue 12, 2009, Pages 1423-1430

  Singh, Vijay K ^a,b   Brown, Darren S ^b   Kao, Tzu Cheg ^a  

^a Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^b ARMED FORCES RADIOBIOLOGY RESEARCH INSTITUTE   (United States)

Author keywords

Cytokine radiation; Luminex; Mice; Radioprotection; RT PCR; Tocopherol succinate

Indexed keywords

ALPHA TOCOPHEROL SUCCINATE; COBALT 60; GRANULOCYTE COLONY STIMULATING FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; COBALT THERAPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION; RADIATION DETECTOR; RADIATION DOSE; RADIATION EXPOSURE; RADIATION PROTECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BLOOD CELL COUNT; BONE MARROW CELLS; COBALT RADIOISOTOPES; CYTOKINES; GAMMA RAYS; GRANULOCYTE COLONY-STIMULATING FACTOR; MALE; MICE; MICE, INBRED STRAINS; PANCYTOPENIA; RADIATION INJURIES; RADIATION-PROTECTIVE AGENTS; TOCOPHEROLS;

EID: 70349419512     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2009.08.020     Document Type: Article

References (58)

1. Singh V.K., and Seed T.M. Radiation effects. In: Roy M.J. (Ed). Physician's guide to terrorist attack (2003), Humana Press, Totowa 339-362
2. Pellmar T.C., and Rockwell S. Priority list of research areas for radiological nuclear threat countermeasures. Radiat Res 163 (2005) 115-123
3. Mettler Jr. F.A., and Voelz G.L. Major radiation exposure-what to expect and how to respond. N Engl J Med 346 (2002) 1554-1561
4. Grdina D.J., Murley J.S., and Kataoka Y. Radioprotectants: current status and new directions. Oncology 63 Suppl 2 (2002) 2-10
5. Singh V.K., and Yadav V.S. Role of cytokines and growth factors in radioprotection. Exp Mol Pathol 78 (2005) 156-169
6. Waddick K.G., Song C.W., Souza L., and Uckun F.M. Comparative analysis of the in vivo radioprotective effects of recombinant granulocyte colony-stimulating factor (G-CSF), recombinant granulocyte-macrophage CSF, and their combination. Blood 77 (1991) 2364-2371
7. Whitnall M.H., Elliott T.B., Landauer M.R., Jackson III W.E., Wilhelmsen C.L., McKinney L., et al. In vivo protection against gamma-irradiation with 5-androstenediol. Exp Biol Med (Maywood) 226 (2001) 625-627
8. Weiss J.F., and Landauer M.R. Radioprotection by antioxidants. Ann N Y Acad Sci 899 (2000) 44-60
9. Srinivasan V., and Weiss J.F. Radioprotection by vitamin E: injectable vitamin E administered alone or with WR-3689 enhances survival of irradiated mice. Int J Radiat Oncol Biol Phys 23 (1992) 841-845
10. Srinivasan V., Doctrow S., Singh V.K., and Whitnall M.H. Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol 30 (2008) 271-290
11. Landauer M.R., Davis H.D., Dominitz J.A., and Weiss J.F. Dose and time relationships of the radioprotector WR-2721 on locomotor activity in mice. Pharmacol Biochem Behav 27 (1987) 573-576
12. Weiss J.F., Kumar K.S., Walden T.L., Neta R., Landauer M.R., and Clark E.P. Advances in radioprotection through the use of combined agent regimens. Int J Radiat Biol 57 (1990) 709-722
13. Kumar K.S., Srinivasan V., Toles R., Jobe L., and Seed T.M. Nutritional approaches to radioprotection: vitamin E. Mil Med 167 (2002) 57-59
14. Singh V.K., Srinivasan V., Toles R., Karikari P., Seed T.M., Papas A., et al. Radiation protection by the antioxidant alpha-tocopherol succinate. NATO-RTG-099-Conference presentation: AFRRI-CD-05-02 (2005)
15. Singh V.K., Shafran R.L., Jackson III W.E., Seed T.M., and Kumar K.S. Induction of cytokines by radioprotective tocopherol analogs. Exp Mol Pathol 81 (2006) 55-61
16. Singh V.K., Shafran R.L., Inal C.E., Jackson III W.E., and Whitnall M.H. Effects of whole-body gamma irradiation and 5-androstenediol administration on serum G-CSF. Immunopharmacol Immunotoxicol 27 (2005) 521-534
17. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162 (1987) 156-159
18. Grace M.B., McLeland C.B., and Blakely W.F. Real-time quantitative RT-PCR assay of GADD45 gene expression changes as a biomarker for radiation biodosimetry. Int J Radiat Biol 78 (2002) 1011-1021
19. Grace M.B., McLeland C.B., Gagliardi S.J., Smith J.M., Jackson III W.E., Blakely W.F., et al. Development and assessment of a quantitative reverse transcription-PCR assay for simultaneous measurement of four amplicons. Clin Chem 49 (2003) 1467-1475
20. Jagetia G.C., Venkatesh P., and Baliga M.S. Evaluation of the radioprotective effect of bael leaf (Aegle marmelos) extract in mice. Int J Radiat Biol 80 (2004) 281-290
21. Uma Devi P. Radioprotective, anticarcinogenic and antioxidant properties of the Indian holy basil, Ocimum sanctum (Tulasi). Indian J Exp Biol 39 (2001) 185-190
22. Uma Devi P., Ganasoundari A., Vrinda B., Srinivasan K.K., and Unnikrishnan M.K. Radiation protection by the ocimum flavonoids orientin and vicenin: mechanisms of action. Radiat Res 154 (2000) 455-460
23. Davis T.A., Clarke T.K., Mog S.R., and Landauer M.R. Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival. Int J Radiat Biol 83 (2007) 141-151
24. Landauer M.R., Srinivasan V., and Seed T.M. Genistein treatment protects mice from ionizing radiation injury. J Appl Toxicol 23 (2003) 379-385
25. Wambi C., Sanzari J., Wan X.S., Nuth M., Davis J., Ko Y.H., et al. Dietary antioxidants protect hematopoietic cells and improve animal survival after total-body irradiation. Radiat Res 169 (2008) 384-396
26. Maroufi B., Kaboudanian Ardestani S., Kariminia A., and Naderimanesh H. The effect of vitamin e on splenocytes apoptosis of gamma- irradiated BALB/c mice. Iran J Allergy Asthma Immunol 4 (2005) 77-82
27. Shin S.J. Vitamin E modulates radiation-induced oxidative damage in mice fed a high-lipid diet. J Biochem Mol Biol 36 (2003) 190-195
28. Songthaveesin C., Saikhun J., Kitiyanant Y., and Pavasuthipaisit K. Radio-protective effect of vitamin E on spermatogenesis in mice exposed to gamma-irradiation: a flow cytometric study. Asian J Androl 6 (2004) 331-336
29. Nair C.K., Devi P.U., Shimanskaya R., Kunugita N., Murase H., Gu Y.H., et al. Water soluble vitamin E (TMG) as a radioprotector. Indian J Exp Biol 41 (2003) 1365-1371
30. Nair C.K., Salvi V., Kagiya T.V., and Rajagopalan R. Relevance of radioprotectors in radiotherapy: studies with tocopherol monoglucoside. J Environ Pathol Toxicol Oncol 23 (2004) 153-160
31. Satyamitra M., Uma Devi P., Murase H., and Kagiya V.T. In vivo postirradiation protection by a vitamin E analog, alpha-TMG. Radiat Res 160 (2003) 655-661
32. Cherdyntseva N., Shishkina A., Butorin I., Murase H., Gervas P., Kagiya T.V., et al. Effect of tocopherol-monoglucoside (TMG), a water-soluble glycosylated derivate of vitamin E, on hematopoietic recovery in irradiated mice. J Radiat Res (Tokyo) 46 (2005) 37-41
33. Ghosh S.P., Kulkarni S., Hieber K., Toles R., Romanyukha L., Kao T.C., et al. Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector. Int J Radiat Biol 85 (2009) 598-606
34. Berbee M., Fu Q., Boerma M., Wang J., Kumar K.S., and Hauer-Jensen M. gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism. Radiat Res 171 (2009) 596-605
35. Whitnall M.H., Elliott T.B., Harding R.A., Inal C.E., Landauer M.R., Wilhelmsen C.L., et al. Androstenediol stimulates myelopoiesis and enhances resistance to infection in gamma-irradiated mice. Int J Immunopharmacol 22 (2000) 1-14
36. Hermans M.H., van de Geijn G.J., Antonissen C., Gits J., van Leeuwen D., Ward A.C., et al. Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF-induced expansion of myeloid progenitor cells. Blood 101 (2003) 2584-2590
37. Devaraj S., and Jialal I. Alpha-tocopherol decreases tumor necrosis factor-alpha mRNA and protein from activated human monocytes by inhibition of 5-lipoxygenase. Free Radic Biol Med 38 (2005) 1212-1220
38. Yadav V.S., Mishra K.P., Singh D.P., Mehrotra S., and Singh V.K. Immunomodulatory effects of curcumin. Immunopharmacol Immunotoxicol 27 (2005) 485-497
39. Mehrotra S., Mishra K.P., Maurya R., Srimal R.C., and Singh V.K. Immunomodulation by ethanolic extract of Boerhaavia diffusa roots. Int Immunopharmacol 2 (2002) 987-996
40. Mehrotra S., Mishra K.P., Maurya R., Srimal R.C., Yadav V.S., Pandey R., et al. Anticellular and immunosuppressive properties of ethanolic extract of Acorus calamus rhizome. Int Immunopharmacol 3 (2003) 53-61
41. Mehrotra S., Mishra K.P., Yadav V.S., Bhattacharya M., Pandey D., Haq W., et al. Immunomodulation by peptide analogs of retroviral envelope protein. Peptides 24 (2003) 979-985
42. Narayan P., Singh V.K., Agarwal S.S., Tandon R., Haq W., Raghubir R., et al. Immunomodulation by opioid peptidomimetic compound. Neuroimmunomodulation 9 (2001) 134-140
43. Narayan P., Tandon R., Haq W., Dhar M.M., and Singh V.K. Inhibition of antigen specific lymphocyte proliferation and cytokine stimulation by peptidomimetic opioid compound. Int Immunopharmacol 2 (2002) 751-757
44. Biswas S., Singh V.K., Rastogi A., Sharan R., Haq W., Mathur K.B., et al. Stimulation of IL-2 production and CD2R expression by splenopentin analogs. Int J Immunopharmacol 19 (1997) 341-345
45. Bajpai K., Singh V.K., Dhawan V.C., Haq W., Mathur K.B., and Agarwal S.S. Immunomodulation by two potent analogs of met-enkephalin. Immunopharmacology 35 (1997) 213-220
46. Yannaki E., Athanasiou E., Xagorari A., Constantinou V., Batsis I., Kaloyannidis P., et al. G-CSF-primed hematopoietic stem cells or G-CSF per se accelerate recovery and improve survival after liver injury, predominantly by promoting endogenous repair programs. Exp Hematol 33 (2005) 108-119
47. Xu M., Bruno E., Chao J., Ni H., Lindgren V., Nunez R., et al. The constitutive mobilization of bone marrow-repopulating cells into the peripheral blood in idiopathic myelofibrosis. Blood 105 (2005) 1699-1705
48. Carlsson G., Aprikyan A.A., Tehranchi R., Dale D.C., Porwit A., Hellstrom-Lindberg E., et al. Kostmann syndrome: severe congenital neutropenia associated with defective expression of Bcl-2, constitutive mitochondrial release of cytochrome c, and excessive apoptosis of myeloid progenitor cells. Blood 103 (2004) 3355-3361
49. Zomas A., Stefanoudaki-Sofianatou K., Fisfis M., and Anagnostopoulos N.I. Dose dependent long-term in vivo remission of AML1/ETO positive acute myeloid leukemia with G-CSF. Hematology 9 (2004) 107-111
50. Ishizawa K., Kubo H., Yamada M., Kobayashi S., Numasaki M., Ueda S., et al. Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema. FEBS Lett 556 (2004) 249-252
51. Whitnall M.H., and Pellmar T.C. New directions in development of pharmacological countermeasures for the acute radiation syndrome. In: Kasid U.N., Notario V., Haimovitz-Friedman A., and Bar-Eli M. (Eds). Reviews in Cancer Biology and Therapeutics (2007), Research Signpost, Trivandrum, India 193-209
52. Burdelya L.G., Krivokrysenko V.I., Tallant T.C., Strom E., Gleiberman A.S., Gupta D., et al. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 320 (2008) 226-230
53. Farese A.M., Casey D.B., Vigneulle R.M., Siegel N.R., Finn R.F., Klover J.A., et al. A single dose of pegylated leridistim significantly improves neutrophil recovery in sublethally irradiated rhesus macaques. Stem Cells 19 (2001) 514-521
54. Arimura K., Inoue H., Kukita T., Matsushita K., Akimot M., Kawamata N., et al. Acute lung injury in a healthy donor during mobilization of peripheral blood stem cells using granulocyte-colony stimulating factor alone. Haematologica 90 (2005) ECR10
55. Gogu S.R., Lertora J.J., George W.J., Hyslop N.E., and Agrawal K.C. Protection of zidovudine-induced toxicity against murine erythroid progenitor cells by vitamin E. Exp Hematol 19 (1991) 649-652
56. Basu A., and Imrhan V. Vitamin E and prostate cancer: is vitamin E succinate a superior chemopreventive agent?. Nutr Rev 63 (2005) 247-251
57. Fariss M.W., Fortuna M.B., Everett C.K., Smith J.D., Trent D.F., and Djuric Z. The selective antiproliferative effects of alpha-tocopheryl hemisuccinate and cholesteryl hemisuccinate on murine leukemia cells result from the action of the intact compounds. Cancer Res 54 (1994) 3346-3351
58. Erl W., Weber C., Wardemann C., and Weber P.C. alpha-Tocopheryl succinate inhibits monocytic cell adhesion to endothelial cells by suppressing NF-kappa B mobilization. Am J Physiol 273 (1997) H634-640