Anti-apoptotic effects of human granulocyte colony-stimulating factor (G-CSF) on retinal ganglion cells after optic nerve crush are PI3K/AKT-dependent

Experimental Eye Research

Volumn 90, Issue 5, 2010, Pages 537-545

  Tsai, Rong Kung ^a,b   Chang, Chung Hsing ^c   Sheu, Min Muh ^a,b   Huang, Zei Lun ^a,b  

^a BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^b TZU CHI UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Anti apoptosis; Human granulocyte colony stimulating factor (G CSF); Neuroprotectant; Optic nerve crush; PI3K AKT; Retinal ganglion cell (RGC)

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; FLUOROGOLD; PHOSPHATE BUFFERED SALINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; APOPTOSIS REGULATORY PROTEIN; CHROMONE DERIVATIVE; ENZYME INHIBITOR; GRANULOCYTE COLONY STIMULATING FACTOR; MORPHOLINE DERIVATIVE; NEUROPROTECTIVE AGENT; ONCOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DENSITY; CELL LABELING; CONTROLLED STUDY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; IMMUNOHISTOCHEMISTRY; MALE; NEUROPROTECTION; NICK END LABELING; NONHUMAN; OPTIC NERVE LESION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; RETINA; RETINA GANGLION CELL; SIGNAL TRANSDUCTION; SURVIVAL RATE; WESTERN BLOTTING; ANIMAL; CELL COUNT; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYME IMMUNOASSAY; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; NERVE CRUSH; OPTIC NERVE INJURY; PATHOLOGY; WISTAR RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; CELL COUNT; CELL SURVIVAL; CHROMONES; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GRANULOCYTE COLONY-STIMULATING FACTOR; IMMUNOENZYME TECHNIQUES; IN SITU NICK-END LABELING; MALE; MORPHOLINES; NERVE CRUSH; NEUROPROTECTIVE AGENTS; ONCOGENE PROTEIN V-AKT; OPTIC NERVE INJURIES; RATS; RATS, WISTAR; RETINAL GANGLION CELLS;

EID: 77951209916     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2010.01.004     Document Type: Article

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