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Volumn 66, Issue 7, 2011, Pages 431-442

Cell-free fetal nucleic acid testing: A review of the technology and its applications

Author keywords

[No Author keywords available]

Indexed keywords

DNA; RNA;

EID: 80053295974     PISSN: 00297828     EISSN: 15339866     Source Type: Journal    
DOI: 10.1097/OGX.0b013e31822dfbe2     Document Type: Review
Times cited : (23)

References (144)
  • 1
    • 0014666881 scopus 로고
    • Practical and theoretical implications of fetal-maternal lymphocyte transfer
    • Walknowska J, Conte FA, Grumbach MM. Practical and theoretical implications of fetal-maternal lymphocyte transfer. Lancet. 1969;1:1119-1122.
    • (1969) Lancet , vol.1 , pp. 1119-1122
    • Walknowska, J.1    Conte, F.A.2    Grumbach, M.M.3
  • 2
    • 0028674975 scopus 로고
    • Isolating fetal cells in maternal circulation for prenatal diagnosis
    • Simpson JL, Elias S. Isolating fetal cells in maternal circulation for prenatal diagnosis. Prenat Diagn. 1994;14:1229-1242.
    • (1994) Prenat Diagn , vol.14 , pp. 1229-1242
    • Simpson, J.L.1    Elias, S.2
  • 3
    • 0029589896 scopus 로고
    • Prenatal diagnosis by analysis of fetal cells in maternal blood
    • DOI 10.1016/S0022-3476(95)70018-8
    • Bianchi DW. Prenatal diagnosis by analysis of fetal cells in maternal blood. J Pediatr. 1995;127:847-856. (Pubitemid 26003275)
    • (1995) Journal of Pediatrics , vol.127 , Issue.6 , pp. 847-856
    • Bianchi, D.W.1
  • 5
    • 0036864219 scopus 로고    scopus 로고
    • Cell-free fetal DNA and intact fetal cells in maternal blood circulation: Implications for first and second trimester non-invasive prenatal diagnosis
    • DOI 10.1093/humupd/8.6.493
    • Bischoff FZ, Sinacori MK, Dang DD, et al. Cell-free fetal DNA and intact fetal cells in maternal blood circulation: implications for first and second trimester non-invasive prenatal diagnosis. Hum Reprod Update. 2002;8:493-500. (Pubitemid 35476796)
    • (2002) Human Reproduction Update , vol.8 , Issue.6 , pp. 493-500
    • Bischoff, F.Z.1    Sinacori, M.K.2    Dang, D.D.3    Marquez-Do, D.4    Horne, C.5    Lewis, D.E.6    Simpson, J.L.7
  • 10
    • 0033762298 scopus 로고    scopus 로고
    • Presence of fetal RNA in maternal plasma
    • Poon LL, Leung TN, Lau TK, et al. Presence of fetal RNA in maternal plasma. Clin Chem. 2000;46:1832-1834.
    • (2000) Clin Chem , vol.46 , pp. 1832-1834
    • Poon, L.L.1    Leung, T.N.2    Lau, T.K.3
  • 11
    • 12944331281 scopus 로고    scopus 로고
    • Accurate and robust quantification of circulating fetal and total DNA in maternal plasma from 5 to 41 weeks of gestation
    • DOI 10.1373/clinchem.2004.042713
    • Birch L, English CA, O'Donoghue K, et al. Accurate and robust quantification of circulating fetal and total DNA in maternal plasma from 5 to 41 weeks of gestation. Clin Chem. 2005;51:312-320. (Pubitemid 40175800)
    • (2005) Clinical Chemistry , vol.51 , Issue.2 , pp. 312-320
    • Birch, L.1    English, C.A.2    O'Donoghue, K.3    Barigye, O.4    Fisk, N.M.5    Keer, J.T.6
  • 12
    • 0033811522 scopus 로고    scopus 로고
    • Quantitative analysis of the bidirectional fetomaternal transfer of nucleated cells and plasma DNA
    • Lo YM, Lau TK, Chan LY, et al. Quantitative analysis of the bidirectional fetomaternal transfer of nucleated cells and plasma DNA. Clin Chem. 2000;46:1301-1309.
    • (2000) Clin Chem , vol.46 , pp. 1301-1309
    • Lo, Y.M.1    Lau, T.K.2    Chan, L.Y.3
  • 15
    • 33749667765 scopus 로고    scopus 로고
    • Recovery and amplification of placental RNA from dried maternal blood spots: Utility for non-invasive prenatal diagnosis
    • 2415
    • Jorgez CJ, Simpson JL, Bischoff FZ. Recovery and amplification of placental RNA from dried maternal blood spots: utility for non-invasive prenatal diagnosis. Reprod Biomed Online. 2006;13:558-561. (Pubitemid 44548793)
    • (2006) Reproductive BioMedicine Online , vol.13 , Issue.4 , pp. 558-561
    • Jorgez, C.J.1    Simpson, J.L.2    Bischoff, F.Z.3
  • 16
  • 17
    • 0036140193 scopus 로고    scopus 로고
    • Differential DNA methylation between fetus and mother as a strategy for detecting fetal DNA in maternal plasma
    • Poon LL, Leung TN, Lau TK, et al. Differential DNA methylation between fetus and mother as a strategy for detecting fetal DNA in maternal plasma. Clin Chem. 2002;48:35-41. (Pubitemid 34038120)
    • (2002) Clinical Chemistry , vol.48 , Issue.1 , pp. 35-41
    • Poon, L.L.M.1    Leung, T.N.2    Lau, T.K.3    Chow, K.C.K.4    Lo, Y.M.D.5
  • 18
    • 33846903851 scopus 로고    scopus 로고
    • Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection
    • Lo YM, Tsui NB, Chiu RW, et al. Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection. Nat Med. 2007;13:218-223.
    • (2007) Nat Med , vol.13 , pp. 218-223
    • Lo, Y.M.1    Tsui, N.B.2    Chiu, R.W.3
  • 19
    • 78650207098 scopus 로고    scopus 로고
    • Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus
    • Lo YM, Chan KC, Sun H, et al. Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus. Sci Transl Med. 2010;2:61ra91.
    • (2010) Sci Transl Med. , vol.2
    • Lo, Y.M.1    Chan, K.C.2    Sun, H.3
  • 20
    • 84885042414 scopus 로고    scopus 로고
    • In principle method for noninvasive determination of the fetal genome
    • Fan H, Quake S. In principle method for noninvasive determination of the fetal genome. Nature Precedings. 2010. Available at: http://dx.doi.org/10.1038/ npre.2010.5373.1.
    • (2010) Nature Precedings.
    • Fan, H.1    Quake, S.2
  • 21
    • 0028050057 scopus 로고
    • Comparison of chorionic villus sampling and amniocentesis for fetal karyotyping at 10-13 weeks' gestation
    • DOI 10.1016/S0140-6736(94)91769-8
    • Nicolaides K, Brizot Mde L, Patel F, et al. Comparison of chorionic villus sampling and amniocentesis for fetal karyotyping at 10-13 weeks' gestation. Lancet. 1994;344:435-439. (Pubitemid 24248245)
    • (1994) Lancet , vol.344 , Issue.8920 , pp. 435-439
    • Nicolaides, K.1    Brizot, M.D.L.2    Patel, F.3    Snijders, R.4
  • 23
    • 33846695194 scopus 로고    scopus 로고
    • ACOG Committee Opinion No. 360: Sex selection
    • ACOG Committee Opinion No. 360: Sex selection. Obstet Gynecol. 2007;109:475-478.
    • (2007) Obstet Gynecol , vol.109 , pp. 475-478
  • 25
    • 0037395258 scopus 로고    scopus 로고
    • A new approach to antenatal screening for Fragile X syndrome
    • DOI 10.1002/pd.586
    • Wald NJ, Morris JK. A new approach to antenatal screening for Fragile X syndrome. Prenat Diagn. 2003;23:345-351. (Pubitemid 36457273)
    • (2003) Prenatal Diagnosis , vol.23 , Issue.4 , pp. 345-351
    • Wald, N.J.1    Morris, J.K.2
  • 26
    • 27644507366 scopus 로고    scopus 로고
    • Fragile X syndrome: Diagnostic and carrier testing
    • DOI 10.1097/01.GIM.0000182468.22666.dd
    • Sherman S, Pletcher BA, Driscoll DA. Fragile X syndrome: diagnostic and carrier testing. Genet Med. 2005;7:584-587. (Pubitemid 41566485)
    • (2005) Genetics in Medicine , vol.7 , Issue.8 , pp. 584-587
    • Sherman, S.1    Pletcher, B.A.2    Driscoll, D.A.3
  • 27
    • 0037046654 scopus 로고    scopus 로고
    • New strategy for prenatal diagnosis of X-linked disorders [6] (multiple letters)
    • DOI 10.1056/NEJM200205093461918
    • Costa JM, Benachi A, Gautier E. New strategy for prenatal diagnosis of X-linked disorders. N Engl J Med. 2002;346: 1502. (Pubitemid 34755726)
    • (2002) New England Journal of Medicine , vol.346 , Issue.19 , pp. 1502
    • Costa, J.-M.1    Benachi, A.2    Gautier, E.3
  • 28
    • 33847239357 scopus 로고    scopus 로고
    • Identification of fetal gender in maternal blood is a helpful tool in the prenatal diagnosis of haemophilia
    • Santacroce R, Vecchione G, Tomaiyolo M, et al. Identification of fetal gender in maternal blood is a helpful tool in the prenatal diagnosis of haemophilia. Haemophilia. 2006;12: 417-422.
    • (2006) Haemophilia , vol.12 , pp. 417-422
    • Santacroce, R.1    Vecchione, G.2    Tomaiyolo, M.3
  • 29
    • 77956588420 scopus 로고    scopus 로고
    • Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: An Endocrine Society clinical practice guideline
    • Speiser PW, Azziz R, Baskin LS, et al. Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2010;95:4133-4160.
    • (2010) J Clin Endocrinol Metab. , vol.95 , pp. 4133-4160
    • Speiser, P.W.1    Azziz, R.2    Baskin, L.S.3
  • 30
    • 0034818672 scopus 로고    scopus 로고
    • Fetal sex determination from maternal plasma in pregnancies at risk for congenital adrenal hyperplasia
    • Rijnders RJ, van der Schoot CE, Bossers B, et al. Fetal sex determination from maternal plasma in pregnancies at risk for congenital adrenal hyperplasia. Obstet Gynecol. 2001;98: 374-378.
    • (2001) Obstet Gynecol , vol.98 , pp. 374-378
    • Rijnders, R.J.1    Van Der Schoot, C.E.2    Bossers, B.3
  • 31
    • 0036461167 scopus 로고    scopus 로고
    • Fetal gender determination in early pregnancy through qualitative and quantitative analysis of fetal DNA in maternal serum
    • DOI 10.1007/s00439-001-0649-3
    • Honda H, Miharu N, Ohashi Y, et al. Fetal gender determination in early pregnancy through qualitative and quantitative analysis of fetal DNA in maternal serum. Hum Genet. 2002; 110:75-79. (Pubitemid 36067421)
    • (2002) Human Genetics , vol.110 , Issue.1 , pp. 75-79
    • Honda, H.1    Miharu, N.2    Ohashi, Y.3    Samura, O.4    Kinutani, M.5    Hara, T.6    Ohama, K.7
  • 33
    • 0037341393 scopus 로고    scopus 로고
    • Replicate real-time PCR testing of DNA in maternal plasma increases the sensitivity of non-invasive fetal sex determination
    • DOI 10.1002/pd.556
    • Hromadnikova I, Houbova B, Hridelova D, et al. Replicate real-time PCR testing of DNA in maternal plasma increases the sensitivity of non-invasive fetal sex determination. Prenat Diagn. 2003;23:235-238. (Pubitemid 36323685)
    • (2003) Prenatal Diagnosis , vol.23 , Issue.3 , pp. 235-238
    • Hromadnikova, I.1    Houbova, B.2    Hridelova, D.3    Voslarova, S.4    Kofer, J.5    Komrska, V.6    Habart, D.7
  • 35
    • 84857033186 scopus 로고    scopus 로고
    • International Blood Group Reference Laboratory Accessed May 6, 2011
    • International Blood Group Reference Laboratory. Overview of IBCRL reference and diagnostic services. Available at: http://ibgrl.blood.co.uk/ ReferenceServices/RefServframes. htm. Accessed May 6, 2011.
    • Overview of IBCRL Reference and Diagnostic Services
  • 36
    • 84857031436 scopus 로고    scopus 로고
    • Center for Medical Genetics Accessed May 6, 2011
    • Center for Medical Genetics. DNA fetal gender determination. Available at: http://www.geneticstesting.com/gendertest/gendertest.htm. Accessed May 6, 2011.
    • DNA Fetal Gender Determination
  • 37
    • 84857030563 scopus 로고    scopus 로고
    • DNA Plus Accessed May 6, 2011
    • DNA Plus. Fetal cell/DNA prenatal gender test. 1996-2011. Available at: http://www.dnaplus.com/fetal-cell-prenatal-geder-test.htm. Accessed May 6, 2011.
    • Fetal Cell/DNA Prenatal Gender Test 1996-2011
  • 38
    • 84857035007 scopus 로고    scopus 로고
    • Consumer Genetics Accessed May 6, 2011
    • Consumer Genetics. Early DNA gender predicting test: boy or girl? 2005-2011. Available at: http://www.tellmepinkorblue. com/Gender-Testing-Boy- Girl.php. Accessed May 6, 2011.
    • Early DNA Gender Predicting Test: Boy or Girl? 2005-2011
  • 40
    • 33645460941 scopus 로고    scopus 로고
    • At-home fetal DNA gender testing: Caveat emptor
    • Bianchi DW. At-home fetal DNA gender testing: caveat emptor. Obstet Gynecol. 2006;107:216-218.
    • (2006) Obstet Gynecol , vol.107 , pp. 216-218
    • Bianchi, D.W.1
  • 43
    • 58149316091 scopus 로고    scopus 로고
    • The use of maternal plasma for prenatal RhD blood group genotyping
    • Finning K, Martin P, Daniels G. The use of maternal plasma for prenatal RhD blood group genotyping. Methods Mol Biol. 2009;496:143-157.
    • (2009) Methods Mol Biol , vol.496 , pp. 143-157
    • Finning, K.1    Martin, P.2    Daniels, G.3
  • 44
    • 77950612762 scopus 로고    scopus 로고
    • Noninvasive fetal RhD genotyping from maternal blood
    • Kolialexi A, Tounta G, Mavrou A. Noninvasive fetal RhD genotyping from maternal blood. Expert Rev Mol Diagn. 2010;10:285-296.
    • (2010) Expert Rev Mol Diagn. , vol.10 , pp. 285-296
    • Kolialexi, A.1    Tounta, G.2    Mavrou, A.3
  • 45
    • 33748094813 scopus 로고    scopus 로고
    • ACOG Practice Bulletin No. 75: management of alloimmunization
    • ACOG Practice Bulletin No. 75: management of alloimmunization. Obstet Gynecol. 2006;108:457-464.
    • (2006) Obstet Gynecol , vol.108 , pp. 457-464
  • 46
    • 48549093650 scopus 로고    scopus 로고
    • Management of rhesus alloimmunization in pregnancy
    • Moise KJ Jr. Management of rhesus alloimmunization in pregnancy. Obstet Gynecol. 2008;112:164-176.
    • (2008) Obstet Gynecol , vol.112 , pp. 164-176
    • Moise Jr., K.J.1
  • 47
    • 0344303520 scopus 로고    scopus 로고
    • Thirty-five years of Rh prophylaxis
    • DOI 10.1111/j.0041-1132.2003.00632.x
    • Bowman J. Thirty-five years of Rh prophylaxis. Transfusion. 2003;43:1661-1666. (Pubitemid 37518071)
    • (2003) Transfusion , vol.43 , Issue.12 , pp. 1661-1666
    • Bowman, J.1
  • 48
    • 43049133277 scopus 로고    scopus 로고
    • Is fetal RHD typing in all RhD negative women cost effective?
    • Szczepura A, Bonsel G, Krauth C, et al. Fetal RHD typing: is fetal RHD typing in all RhD negative women cost effective? BMJ. 2008;336:906. (Pubitemid 351632011)
    • (2008) BMJ , vol.336 , Issue.7650 , pp. 906
    • Szczepura, A.1    Bonsel, G.2    Krauth, C.3    Osipenko, L.4    Haverkamp, A.5
  • 49
    • 80053299690 scopus 로고    scopus 로고
    • Should free fetal DNA testing replace antenatal anti-D administration for prevention of Rhesus alloimmunization?
    • Ma K, Rodriguez MI, Cheng Y, et al. Should free fetal DNA testing replace antenatal anti-D administration for prevention of Rhesus alloimmunization? Am J Obstet Gynecol. 2011; 204(S1):A139.
    • (2011) Am J Obstet Gynecol. , vol.204 , Issue.S1
    • Ma, K.1    Rodriguez, M.I.2    Cheng, Y.3
  • 52
    • 33748787168 scopus 로고    scopus 로고
    • Diagnostic accuracy of noninvasive fetal Rh genotyping from maternal blood-A meta-analysis
    • DOI 10.1016/j.ajog.2006.07.033, PII S0002937806009641
    • Geifman-Holtzman O, Grotegut CA, Gaughan JP. Diagnostic accuracy of noninvasive fetal Rh genotyping from maternal blood-a meta-analysis. Am J Obstet Gynecol. 2006;195: 1163-1173. (Pubitemid 44415679)
    • (2006) American Journal of Obstetrics and Gynecology , vol.195 , Issue.4 , pp. 1163-1173
    • Geifman-Holtzman, O.1    Grotegut, C.A.2    Gaughan, J.P.3
  • 54
    • 84857034966 scopus 로고    scopus 로고
    • Lenetix Medical Screening Laboratory, Inc Accessed May 6, 2011
    • Lenetix Medical Screening Laboratory, Inc. RhD genotyping. 2003-2010. Available at: http://www.lenetix.com/html/rhd-sry-genotyping.html. Accessed May 6, 2011.
    • RhD Genotyping 2003-2010
  • 55
    • 42249108710 scopus 로고    scopus 로고
    • Effect of high throughput RHD typing of fetal DNA in maternal plasma on use of anti-RhD immunoglobulin in RhD negative pregnant women: Prospective feasibility study
    • DOI 10.1136/bmj.39518.463206.25
    • Finning K, Martin P, Summers J, et al. Effect of high throughput RHD typing of fetal DNA in maternal plasma on use of anti-RhD immunoglobulin in RhD negative pregnant women: prospective feasibility study. BMJ. 2008;336:816-818. (Pubitemid 351548224)
    • (2008) BMJ , vol.336 , Issue.7648 , pp. 816-818
    • Finning, K.1    Martin, P.2    Summers, J.3    Massey, E.4    Poole, G.5    Daniels, G.6
  • 56
    • 84934442064 scopus 로고    scopus 로고
    • Maldi-TOF mass spectrometry for analyzing cell-free fetal DNA in maternal plasma
    • Ding C. Maldi-TOF mass spectrometry for analyzing cell-free fetal DNA in maternal plasma. Methods Mol Biol. 2008;444: 253-267.
    • (2008) Methods Mol Biol , vol.444 , pp. 253-267
    • Ding, C.1
  • 57
    • 41149159604 scopus 로고    scopus 로고
    • Noninvasive genotyping fetal Kell blood group (KEL1) using cell-free fetal DNA in maternal plasma by MALDI-TOF mass spectrometry
    • DOI 10.1002/pd.1936
    • Li Y, Finning K, Daniels G, et al. Noninvasive genotyping fetal Kell blood group (KEL1) using cell-free fetal DNA in maternal plasma by MALDI-TOF mass spectrometry. Prenat Diagn. 2008;28:203-208. (Pubitemid 351427938)
    • (2008) Prenatal Diagnosis , vol.28 , Issue.3 , pp. 203-208
    • Li, Y.1    Finning, K.2    Daniels, G.3    Hahn, S.4    Zhong, X.5    Holzgreve, W.6
  • 58
    • 58049202879 scopus 로고    scopus 로고
    • The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis
    • Wright CF, Burton H. The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis. Hum Reprod Update. 2009;15:139-151.
    • (2009) Hum Reprod Update , vol.15 , pp. 139-151
    • Wright, C.F.1    Burton, H.2
  • 60
    • 0034057403 scopus 로고    scopus 로고
    • Multiplex and real-time quantitative PCR on fetal DNA in maternal plasma. A comparison with fetal cells isolated from maternal blood
    • Hahn S, Zhong XY, Burk MR, et al. Multiplex and real-time quantitative PCR on fetal DNA in maternal plasma. A comparison with fetal cells isolated from maternal blood. Ann N Y Acad Sci. 2000;906:148-152. (Pubitemid 30255473)
    • (2000) Annals of the New York Academy of Sciences , vol.906 , pp. 148-152
    • Hahn, S.1    Zhong, X.Y.2    Burk, M.R.3    Troeger, C.4    Holzgreve, W.5
  • 61
    • 0035107577 scopus 로고    scopus 로고
    • Risk free simultaneous prenatal identification of fetal Rhesus D status and sex by multiplex real-time PCR using cell free fetal DNA in maternal plasma
    • Zhong XY, Holzgreve W, Hahn S. Risk free simultaneous prenatal identification of fetal Rhesus D status and sex by multiplex real-time PCR using cell free fetal DNA in maternal plasma. Swiss Med Wkly. 2001;131:70-74. (Pubitemid 32216319)
    • (2001) Swiss Medical Weekly , vol.131 , Issue.5-6 , pp. 70-74
    • Xiao Yan Zhong1    Holzgreve, W.2    Hahn, S.3
  • 62
    • 35448967926 scopus 로고    scopus 로고
    • Fetal genotyping for the K (Kell) and Rh C, c, and E blood groups on cell-free fetal DNA in maternal plasma
    • DOI 10.1111/j.1537-2995.2007.01437.x
    • Finning K, Martin P, Summers J, et al. Fetal genotyping for the K (Kell) and Rh C, c, and E blood groups on cell-free fetal DNA in maternal plasma. Transfusion. 2007;47:2126-2133. (Pubitemid 47623982)
    • (2007) Transfusion , vol.47 , Issue.11 , pp. 2126-2133
    • Finning, K.1    Martin, P.2    Summers, J.3    Daniels, G.4
  • 63
    • 47749092841 scopus 로고    scopus 로고
    • ACOG Committee Opinion No. 410: ethical issues in genetic testing
    • ACOG Committee Opinion No. 410: ethical issues in genetic testing. Obstet Gynecol. 2008;111:1495-1502.
    • (2008) Obstet Gynecol , vol.111 , pp. 1495-1502
  • 64
    • 0028487230 scopus 로고
    • A cost-effectiveness analysis of amniocentesis and chorionic villus sampling for prenatal genetic testing
    • Heckerling PS, Verp MS. A cost-effectiveness analysis of amniocentesis and chorionic villus sampling for prenatal genetic testing. Med Care. 1994;32:863-880.
    • (1994) Med Care , vol.32 , pp. 863-880
    • Heckerling, P.S.1    Verp, M.S.2
  • 65
    • 0033968645 scopus 로고    scopus 로고
    • Prenatal diagnosis of myotonic dystrophy using fetal DNA obtained from maternal plasma
    • Amicucci P, Gennarelli M, Novelli G, et al. Prenatal diagnosis of myotonic dystrophy using fetal DNA obtained from maternal plasma. Clin Chem. 2000;46:301-302. (Pubitemid 30104263)
    • (2000) Clinical Chemistry , vol.46 , Issue.2 , pp. 301-302
    • Amicucci, P.1    Gennarelli, M.2    Novelli, G.3    Dallapiccola, B.4
  • 66
    • 9644273981 scopus 로고    scopus 로고
    • Improved prenatal detection of a fetal point mutation for achondroplasia by the use of size-fractionated circulatory DNA in maternal plasma - Case report
    • DOI 10.1002/pd.1030
    • Li Y, Holzgreve W, Page-Christiaens GC, et al. Improved prenatal detection of a fetal point mutation for achondroplasia by the use of size-fractionated circulatory DNA in maternal plasma-case report. Prenat Diagn. 2004;24:896-898. (Pubitemid 39576805)
    • (2004) Prenatal Diagnosis , vol.24 , Issue.11 , pp. 896-898
    • Li, Y.1    Holzgreve, W.2    Page-Christiaens, G.C.M.L.3    Gille, J.J.P.4    Hahn, S.5
  • 68
    • 0034734711 scopus 로고    scopus 로고
    • Prenatal DNA diagnosis of a single-gene disorder from maternal plasma
    • Saito H, Sekizawa A, Morimoto T, et al. Prenatal DNA diagnosis of a single-gene disorder from maternal plasma. Lancet. 2000;356:1170.
    • (2000) Lancet , vol.356 , pp. 1170
    • Saito, H.1    Sekizawa, A.2    Morimoto, T.3
  • 70
    • 0037426408 scopus 로고    scopus 로고
    • Early Huntington disease prenatal diagnosis by maternal semiquantitative fluorescent-PCR
    • Gonzalez-Gonzalez MC, Trujillo MJ, Rodriguez de Alba M, et al. Early Huntington disease prenatal diagnosis by maternal semiquantitative fluorescent-PCR. Neurology. 2003;60: 1214-1215. (Pubitemid 36418797)
    • (2003) Neurology , vol.60 , Issue.7 , pp. 1214-1215
    • Gonzalez-Gonzalez, M.C.1    Trujillo, M.J.2    Rodriguez De Alba, M.3    Ramos, C.4
  • 71
    • 56049089009 scopus 로고    scopus 로고
    • Prenatal diagnosis of Huntington disease in maternal plasma: Direct and indirect study
    • Bustamante-Aragones A, Trujillo-Tiebas MJ, Gallego-Merlo J, et al. Prenatal diagnosis of Huntington disease in maternal plasma: direct and indirect study. Eur J Neurol. 2008;15: 1338-1344.
    • (2008) Eur J Neurol , vol.15 , pp. 1338-1344
    • Bustamante-Aragones, A.1    Trujillo-Tiebas, M.J.2    Gallego-Merlo, J.3
  • 72
    • 33751337752 scopus 로고    scopus 로고
    • Non-invasive prenatal detection of paternal origin Hb lepore in a male fetus at the 7th week of gestation
    • DOI 10.1159/000095662
    • Lazaros L, Hatzi E, Bouba I, et al. Non-invasive prenatal detection of paternal origin hb lepore in a male fetus at the 7th week of gestation. Fetal Diagn Ther. 2006;21:506-509. (Pubitemid 44804588)
    • (2006) Fetal Diagnosis and Therapy , vol.21 , Issue.6 , pp. 506-509
    • Lazaros, L.1    Hatzi, E.2    Bouba, I.3    Paraskevaidis, E.4    Georgiou, I.5
  • 73
    • 0036237659 scopus 로고    scopus 로고
    • Non-invasive determination of the paternal HLA haplotype of a fetus using kinetic PCR to detect fetal microchimerism in maternal plasma
    • DOI 10.1038/sj/bmt/1703411
    • Reed W, Kong DZ, Lee TH, et al. Non-invasive determination of the paternal HLA haplotype of a fetus using kinetic PCR to detect fetal microchimerism in maternal plasma. Bone Marrow Transplant. 2002;29:527-529. (Pubitemid 34428724)
    • (2002) Bone Marrow Transplantation , vol.29 , Issue.6 , pp. 527-529
    • Reed, W.1    Kong, D.Z.2    Lee, T.-H.3    Cowan, M.J.4    Busch, M.P.5    Baxter-Lowe, L.A.6
  • 74
    • 67049116478 scopus 로고    scopus 로고
    • Non-invasive prenatal paternity testing from maternal blood
    • Wagner J, Dzijan S, Marjanovic D, et al. Non-invasive prenatal paternity testing from maternal blood. Int J Legal Med. 2009;123:75-79.
    • (2009) Int J Legal Med , vol.123 , pp. 75-79
    • Wagner, J.1    Dzijan, S.2    Marjanovic, D.3
  • 76
    • 0036231537 scopus 로고    scopus 로고
    • Noninvasive prenatal exclusion of congenital adrenal hyperplasia by maternal plasma analysis: A feasibility study
    • Chiu RW, Lau TK, Cheung PT, et al. Noninvasive prenatal exclusion of congenital adrenal hyperplasia by maternal plasma analysis: a feasibility study. Clin Chem. 2002;48:778-780. (Pubitemid 34439114)
    • (2002) Clinical Chemistry , vol.48 , Issue.5 , pp. 778-780
    • Chiu, R.W.K.1    Lau, T.K.2    Cheung, P.T.3    Gong, Z.Q.4    Leung, T.N.5    Lo, Y.M.D.6
  • 77
    • 1842503944 scopus 로고    scopus 로고
    • Improvement in sensitivity of allele-specific PCR facilitates reliable noninvasive prenatal detection of cystic fibrosis
    • DOI 10.1373/clinchem.2003.025981
    • Nasis O, Thompson S, Hong T, et al. Improvement in sensitivity of allele-specific PCR facilitates reliable noninvasive prenatal detection of cystic fibrosis. Clin Chem. 2004;50: 694-701. (Pubitemid 38429332)
    • (2004) Clinical Chemistry , vol.50 , Issue.4 , pp. 694-701
    • Nasis, O.1    Thompson, S.2    Hong, T.3    Sherwood, M.4    Radcliffe, S.5    Jackson, L.6    Otevrel, T.7
  • 78
    • 0037190608 scopus 로고    scopus 로고
    • Prenatal exclusion of β thalassaemia major by examination of maternal plasma
    • DOI 10.1016/S0140-6736(02)11086-5
    • Chiu RW, Lau TK, Leung TN, et al. Prenatal exclusion of beta thalassaemia major by examination of maternal plasma. Lancet. 2002;360:998-1000. (Pubitemid 35284114)
    • (2002) Lancet , vol.360 , Issue.9338 , pp. 998-1000
    • Chiu, R.W.K.1    Lau, T.K.2    Leung, T.N.3    Chow, K.C.K.4    Chui, D.H.K.5    Dennis Lo, Y.M.6
  • 79
    • 58149401202 scopus 로고    scopus 로고
    • Noninvasive prenatal diagnosis of monogenic diseases by digital size selection and relative mutation dosage on DNA in maternal plasma
    • Lun FM, Tsui NB, Chan KC, et al. Noninvasive prenatal diagnosis of monogenic diseases by digital size selection and relative mutation dosage on DNA in maternal plasma. P Natl Acad Sci USA. 2008;105:19920-19925.
    • (2008) P Natl Acad Sci USA , vol.105 , pp. 19920-19925
    • Lun, F.M.1    Tsui, N.B.2    Chan, K.C.3
  • 80
    • 79953703694 scopus 로고    scopus 로고
    • Noninvasive prenatal diagnosis of hemophilia by microfluidics digital PCR analysis of maternal plasma DNA
    • Tsui NB, Kadir RA, Chan KC, et al. Noninvasive prenatal diagnosis of hemophilia by microfluidics digital PCR analysis of maternal plasma DNA. Blood. 2011;117:3684-3691.
    • (2011) Blood. , vol.117 , pp. 3684-3691
    • Tsui, N.B.1    Kadir, R.A.2    Chan, K.C.3
  • 82
    • 66449094745 scopus 로고    scopus 로고
    • Size fractionation of cell-free DNA in maternal plasma improves the detection of a paternally inherited beta-thalassemia point mutation by MALDITOF mass spectrometry
    • Li Y, Di Naro E, Vitucci A, et al. Size fractionation of cell-free DNA in maternal plasma improves the detection of a paternally inherited beta-thalassemia point mutation by MALDITOF mass spectrometry. Fetal Diagn Ther. 2009;25:246-249.
    • (2009) Fetal Diagn Ther , vol.25 , pp. 246-249
    • Li, Y.1    Di Naro, E.2    Vitucci, A.3
  • 83
    • 33846449071 scopus 로고    scopus 로고
    • Non-invasive prenatal detection of achondroplasia in size-fractionated cell-free DNA by MALDI-TOF MS assay
    • DOI 10.1002/pd.1608
    • Li Y, Page-Christiaens GC, Gille JJ, et al. Non-invasive prenatal detection of achondroplasia in size-fractionated cellfree DNA by MALDI-TOF MS assay. Prenat Diagn. 2007;27: 11-17. (Pubitemid 46144334)
    • (2007) Prenatal Diagnosis , vol.27 , Issue.1 , pp. 11-17
    • Li, Y.1    Page-Christiaens, G.C.M.L.2    Gille, J.J.P.3    Holzgreve, W.4    Hahn, S.5
  • 84
    • 2642540027 scopus 로고    scopus 로고
    • Size separation of circulatory DNA in maternal plasma permits ready detection of fetal DNA polymorphisms
    • DOI 10.1373/clinchem.2003.029835
    • Li Y, Zimmermann B, Rusterholz C, et al. Size separation of circulatory DNA in maternal plasma permits ready detection of fetal DNA polymorphisms. Clin Chem. 2004;50:1002-1011. (Pubitemid 38725787)
    • (2004) Clinical Chemistry , vol.50 , Issue.6 , pp. 1002-1011
    • Li, Y.1    Zimmermann, B.2    Rusterholz, C.3    Kang, A.4    Holzgreve, W.5    Hahn, S.6
  • 85
    • 13844269123 scopus 로고    scopus 로고
    • Detection of paternally inherited fetal point mutations for β-thalassemia using size-fractionated cell-free DNA in maternal plasma
    • DOI 10.1001/jama.293.7.843
    • Li Y, Di Naro E, Vitucci A, et al. Detection of paternally inherited fetal point mutations for beta-thalassemia using size-fractionated cell-free DNA in maternal plasma. JAMA. 2005;293:843-849. (Pubitemid 40250368)
    • (2005) Journal of the American Medical Association , vol.293 , Issue.7 , pp. 843-849
    • Li, Y.1    Di Naro, E.2    Vitucci, A.3    Zimmermann, B.4    Holzgreve, W.5    Hahn, S.6
  • 87
    • 70349558154 scopus 로고    scopus 로고
    • Improving enrichment of circulating fetal DNA for genetic testing: Size fractionation followed by whole gene amplification
    • Jorgez CJ, Bischoff FZ. Improving enrichment of circulating fetal DNA for genetic testing: size fractionation followed by whole gene amplification. Fetal Diagn Ther. 2009;25:314-319.
    • (2009) Fetal Diagn Ther , vol.25 , pp. 314-319
    • Jorgez, C.J.1    Bischoff, F.Z.2
  • 88
    • 71749110777 scopus 로고    scopus 로고
    • Microsystem for isolation of fetal DNA from maternal plasma by preparative size separation
    • Hahn T, Drese KS, O'Sullivan CK. Microsystem for isolation of fetal DNA from maternal plasma by preparative size separation. Clin Chem. 2009;55:2144-2152.
    • (2009) Clin Chem , vol.55 , pp. 2144-2152
    • Hahn, T.1    Drese, K.S.2    O'Sullivan, C.K.3
  • 92
    • 0037333249 scopus 로고    scopus 로고
    • Screening for chromosomal abnormalities in the first trimester using ultrasound and maternal serum biochemistry in a one-stop clinic: A review of three years prospective experience
    • DOI 10.1046/j.1471-0528.2003.02246.x
    • Spencer K, Spencer CE, Power M, et al. Screening for chromosomal abnormalities in the first trimester using ultrasound and maternal serum biochemistry in a one-stop clinic: a review of three years prospective experience. BJOG. 2003; 110:281-286. (Pubitemid 36298912)
    • (2003) BJOG: An International Journal of Obstetrics and Gynaecology , vol.110 , Issue.3 , pp. 281-286
    • Spencer, K.1    Spencer, C.E.2    Power, M.3    Dawson, C.4    Nicolaides, K.H.5
  • 93
    • 38449105506 scopus 로고    scopus 로고
    • Invasive prenatal testing for aneuploidy
    • ACOG Practice Bulletin No. 88, December 2007
    • ACOG Practice Bulletin No. 88, December 2007. Invasive prenatal testing for aneuploidy. Obstet Gynecol. 2007;110: 1459-1467.
    • (2007) Obstet Gynecol. , vol.110 , pp. 1459-1467
  • 95
    • 69949138533 scopus 로고    scopus 로고
    • Noninvasive prenatal diagnosis of fetal aneuploidies and Mendelian disorders: New innovative strategies
    • Hahn S, Jackson LG, Kolla V, et al. Noninvasive prenatal diagnosis of fetal aneuploidies and Mendelian disorders: new innovative strategies. Expert Rev Mol Diagn. 2009;9: 613-621.
    • (2009) Expert Rev Mol Diagn , vol.9 , pp. 613-621
    • Hahn, S.1    Jackson, L.G.2    Kolla, V.3
  • 96
    • 79952392099 scopus 로고    scopus 로고
    • Community corner: Opening the Pandora's box of prenatal genetic testing
    • Wright C, Quake SR, Bianchi D, et al. Community corner: opening the Pandora's box of prenatal genetic testing. Nat Med. 2011;17:250-251.
    • (2011) Nat Med. , vol.17 , pp. 250-251
    • Wright, C.1    Quake, S.R.2    Bianchi, D.3
  • 100
    • 34547962325 scopus 로고    scopus 로고
    • Candidate epigenetic biomarkers for non-invasive prenatal diagnosis of Down syndrome
    • 2826
    • Old RW, Crea F, Puszyk W, et al. Candidate epigenetic biomarkers for non-invasive prenatal diagnosis of Down syndrome. Reprod Biomed Online. 2007;15:227-235. (Pubitemid 47263333)
    • (2007) Reproductive BioMedicine Online , vol.15 , Issue.2 , pp. 227-235
    • Old, R.W.1    Crea, F.2    Puszyk, W.3    Hulten, M.A.4
  • 101
    • 77957736539 scopus 로고    scopus 로고
    • Quantification of fetal DNA by use of methylation-based DNA discrimination
    • Nygren AO, Dean J, Jensen TJ, et al. Quantification of fetal DNA by use of methylation-based DNA discrimination. Clin Chem. 2010;56:1627-1635.
    • (2010) Clin Chem. , vol.56 , pp. 1627-1635
    • Nygren, A.O.1    Dean, J.2    Jensen, T.J.3
  • 103
    • 79954552622 scopus 로고    scopus 로고
    • Non-invasive prenatal diagnosis of trisomy 21 by reverse transcriptase multiplex ligation-dependent probe amplification
    • Deng YH, Yin AH, He Q, et al. Non-invasive prenatal diagnosis of trisomy 21 by reverse transcriptase multiplex ligation-dependent probe amplification. Clin Chem Lab Med. 2011;49:641-646.
    • (2011) Clin Chem Lab Med. , vol.49 , pp. 641-646
    • Deng, Y.H.1    Yin, A.H.2    He, Q.3
  • 105
    • 0036151029 scopus 로고    scopus 로고
    • Novel real-time quantitative PCR test for trisomy 21
    • Zimmermann B, Holzgreve W, Wenzel F, et al. Novel realtime quantitative PCR test for trisomy 21. Clin Chem. 2002; 48:362-363. (Pubitemid 34107277)
    • (2002) Clinical Chemistry , vol.48 , Issue.2 , pp. 362-363
    • Zimmermann, B.1    Holzgreve, W.2    Wenzel, F.3    Hahn, S.4
  • 107
    • 35348999450 scopus 로고    scopus 로고
    • Detection of aneuploidy with digital polymerase chain reaction
    • DOI 10.1021/ac0709394
    • Fan HC, Quake SR. Detection of aneuploidy with digital polymerase chain reaction. Anal Chem. 2007;79:7576-7579. (Pubitemid 47606128)
    • (2007) Analytical Chemistry , vol.79 , Issue.19 , pp. 7576-7579
    • Fan, H.C.1    Quake, S.R.2
  • 108
    • 58149490683 scopus 로고    scopus 로고
    • Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma
    • Chiu RW, Chan KC, Gao Y, et al. Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma. P Natl Acad Sci USA. 2008;105:20458-20463.
    • (2008) P Natl Acad Sci USA , vol.105 , pp. 20458-20463
    • Chiu, R.W.1    Chan, K.C.2    Gao, Y.3
  • 109
    • 55849124028 scopus 로고    scopus 로고
    • Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood
    • Fan HC, Blumenfeld YJ, Chitkara U, et al. Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood. P Natl Acad Sci USA. 2008;105:16266-16271.
    • (2008) P Natl Acad Sci USA , vol.105 , pp. 16266-16271
    • Fan, H.C.1    Blumenfeld, Y.J.2    Chitkara, U.3
  • 110
    • 78650965964 scopus 로고    scopus 로고
    • Targeted massively parallel sequencing of maternal plasma DNA permits efficient and unbiased detection of fetal alleles
    • Liao GJ, Lun FM, Zheng YW, et al. Targeted massively parallel sequencing of maternal plasma DNA permits efficient and unbiased detection of fetal alleles. Clin Chem. 2011;57:92-101.
    • (2011) Clin Chem. , vol.57 , pp. 92-101
    • Liao, G.J.1    Lun, F.M.2    Zheng, Y.W.3
  • 111
    • 77955255742 scopus 로고    scopus 로고
    • Sensitivity of noninvasive prenatal detection of fetal aneuploidy from maternal plasma using shotgun sequencing is limited only by counting statistics
    • Fan HC, Quake SR. Sensitivity of noninvasive prenatal detection of fetal aneuploidy from maternal plasma using shotgun sequencing is limited only by counting statistics. PLoS One. 2010;5:e10439.
    • (2010) PLoS One. , vol.5
    • Fan, H.C.1    Quake, S.R.2
  • 112
    • 79957753496 scopus 로고    scopus 로고
    • Noninvasive prenatal diagnosis of a case of Down syndrome due to Robertsonian translocation by massively parallel sequencing of maternal plasma DNA
    • Lun FM, Jin YY, Sun H, et al. Noninvasive prenatal diagnosis of a case of Down syndrome due to Robertsonian translocation by massively parallel sequencing of maternal plasma DNA. Clin Chem. 2011;57.
    • (2011) Clin Chem. , pp. 57
    • Lun, F.M.1    Jin, Y.Y.2    Sun, H.3
  • 113
    • 78751683468 scopus 로고    scopus 로고
    • Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: Large scale validity study
    • Chiu RW, Akolekar R, Zheng YW, et al. Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study. BMJ. 2011;342: c7401.
    • (2011) BMJ. , vol.342
    • Chiu, R.W.1    Akolekar, R.2    Zheng, Y.W.3
  • 114
    • 79952302397 scopus 로고    scopus 로고
    • Noninvasive detec-tion of fetal trisomy 21 by sequencing of DNA in maternal blood: A study in a clinical setting
    • Ehrich M, Deciu C, Zwiefelhofer T, et al. Noninvasive detec-tion of fetal trisomy 21 by sequencing of DNA in maternal blood: a study in a clinical setting. Am J Obstet Gynecol. 2011;204:e201-e211.
    • (2011) Am J Obstet Gynecol. , vol.204
    • Ehrich, M.1    Deciu, C.2    Zwiefelhofer, T.3
  • 115
    • 79959759113 scopus 로고    scopus 로고
    • Optimal detection of fetal chromosomal abnormalities by massively parallel DNA sequencing of cell-free fetal DNA from maternal blood
    • Sehnert AJ, Rhees B, Comstock D, et al. Optimal detection of fetal chromosomal abnormalities by massively parallel DNA sequencing of cell-free fetal DNA from maternal blood. Clin Chem. 2011;57.
    • (2011) Clin Chem. , pp. 57
    • Sehnert, A.J.1    Rhees, B.2    Comstock, D.3
  • 116
    • 78149464048 scopus 로고    scopus 로고
    • Non-invasive prenatal detection of trisomy 21 using tandem single nucleotide polymorphisms
    • Ghanta S, Mitchell ME, Ames M, et al. Non-invasive prenatal detection of trisomy 21 using tandem single nucleotide polymorphisms. PLoS One. 2010;5:e13184.
    • (2010) PLoS One. , vol.5
    • Ghanta, S.1    Mitchell, M.E.2    Ames, M.3
  • 117
    • 39149127946 scopus 로고    scopus 로고
    • Non-invasive prenatal diagnosis of single gene disorders: How close are we?
    • Norbury G, Norbury CJ. Non-invasive prenatal diagnosis of single gene disorders: how close are we? Seminin Fetal Neonatal Med. 2008;13:76-83.
    • (2008) Seminin Fetal Neonatal Med , vol.13 , pp. 76-83
    • Norbury, G.1    Norbury, C.J.2
  • 118
    • 1642451702 scopus 로고    scopus 로고
    • Proteinuria and hypertension are independent factors affecting fetal DNA values: A retrospective analysis of affected and unaffected patients
    • DOI 10.1373/clinchem.2003.023259
    • Sekizawa A, Farina A, Sugito Y, et al. Proteinuria and hypertension are independent factors affecting fetal DNA values: a retrospective analysis of affected and unaffected patients. Clin Chem. 2004;50:221-224. (Pubitemid 38125727)
    • (2004) Clinical Chemistry , vol.50 , Issue.1 , pp. 221-224
    • Sekizawa, A.1    Farina, A.2    Sugito, Y.3    Matsuoka, R.4    Iwasaki, M.5    Saito, H.6    Okai, T.7
  • 120
    • 0036241311 scopus 로고    scopus 로고
    • The levels of circulatory cell free fetal DNA in maternal plasma are elevated prior to the onset of preeclampsia
    • Zhong XY, Holzgreve W, Hahn S. The levels of circulatory cell free fetal DNA in maternal plasma are elevated prior to the onset of preeclampsia. Hypertens Pregnancy. 2002;21: 77-83. (Pubitemid 34437747)
    • (2002) Hypertension in Pregnancy , vol.21 , Issue.1 , pp. 77-83
    • Zhong, X.Y.1    Holzgreve, W.2    Hahn, S.3
  • 121
    • 1542380964 scopus 로고    scopus 로고
    • Fetal DNA in maternal plasma as a screening variable for preeclampsia. A preliminary nonparametric analysis of detection rate in low-risk nonsymptomatic patients
    • DOI 10.1002/pd.788
    • Farina A, Sekizawa A, Sugito Y, et al. Fetal DNA in maternal plasma as a screening variable for preeclampsia. A preliminary nonparametric analysis of detection rate in low-risk nonsymptomatic patients. Prenat Diagn. 2004;24:83-86. (Pubitemid 38294411)
    • (2004) Prenatal Diagnosis , vol.24 , Issue.2 , pp. 83-86
    • Farina, A.1    Sekizawa, A.2    Sugito, Y.3    Iwasaki, M.4    Jimbo, M.5    Saito, H.6    Okai, T.7
  • 124
    • 0032512311 scopus 로고    scopus 로고
    • Maternal plasma fetal DNA as a marker for preterm labour
    • Leung TN, Zhang J, Lau TK, et al. Maternal plasma fetal DNA as a marker for preterm labour. Lancet. 1998;352:1904-1905. (Pubitemid 28561255)
    • (1998) Lancet , vol.352 , Issue.9144 , pp. 1904-1905
    • Leung, T.N.1    Zhang, J.2    Lau, T.K.3    Hjelm, N.M.4    Lo, Y.M.D.5
  • 130
    • 0242432340 scopus 로고    scopus 로고
    • The concentration of circulating corticotropin-releasing hormone mRNA in maternal plasma is increased in preeclampsia
    • DOI 10.1373/49.5.727
    • Ng EK, Leung TN, Tsui NB, et al. The concentration of circulating corticotropin-releasing hormone mRNA in maternal plasma is increased in preeclampsia. Clin Chem. 2003; 49:727-731. (Pubitemid 36513250)
    • (2003) Clinical Chemistry , vol.49 , Issue.5 , pp. 727-731
    • Ng, E.K.O.1    Leung, T.N.2    Tsui, N.B.Y.3    Lau, T.K.4    Panesar, N.S.5    Chiu, R.W.K.6    Lo, Y.M.D.7
  • 131
    • 0030473373 scopus 로고    scopus 로고
    • Ethical aspects of non-invasive prenatal diagnosis: Medical, market, or regulatory model?
    • DOI 10.1016/S0378-3782(96)01811-7, PII S0378378296018117
    • Annas GJ. Ethical aspects of non-invasive prenatal diagnosis: medical, market, or regulatory model? Early Hum Dev. 1996;47:S5-S11. (Pubitemid 27050926)
    • (1996) Early Human Development , vol.47 , Issue.SUPPL.
    • Annas, G.J.1
  • 132
    • 66149153067 scopus 로고    scopus 로고
    • Practical and ethical considerations of noninvasive prenatal diagnosis
    • Benn PA, Chapman AR. Practical and ethical considerations of noninvasive prenatal diagnosis. JAMA. 2009;301:2154-2156.
    • (2009) JAMA , vol.301 , pp. 2154-2156
    • Benn, P.A.1    Chapman, A.R.2
  • 133
    • 77949371495 scopus 로고    scopus 로고
    • Ethical challenges in providing noninvasive prenatal diagnosis
    • Benn PA, Chapman AR. Ethical challenges in providing noninvasive prenatal diagnosis. Curr Opin Obstet Gynecol. 2010;22:128-134.
    • (2010) Curr Opin Obstet Gynecol. , vol.22 , pp. 128-134
    • Benn, P.A.1    Chapman, A.R.2
  • 134
    • 79960197002 scopus 로고    scopus 로고
    • Should non-invasiveness change informed consent procedures for prenatal diagnosis?
    • Deans Z, Newson AJ. Should non-invasiveness change informed consent procedures for prenatal diagnosis? Health Care Anal. 2010;19:122-132.
    • (2010) Health Care Anal. , vol.19 , pp. 122-132
    • Deans, Z.1    Newson, A.J.2
  • 135
    • 80053300170 scopus 로고    scopus 로고
    • The coming revolution in prenatal genetic testing
    • Greely HT, King JS. The coming revolution in prenatal genetic testing. Prof Ethics Rep. 2010;23:1-3.
    • (2010) Prof Ethics Rep. , vol.23 , pp. 1-3
    • Greely, H.T.1    King, J.S.2
  • 137
    • 77951439873 scopus 로고    scopus 로고
    • Non-invasive prenatal diagnosis using cell-free fetal DNA technology: Applications and implications
    • Hall A, Bostanci A, Wright CF. Non-invasive prenatal diagnosis using cell-free fetal DNA technology: applications and implications. Public Health Genomics. 2010;13:246-255.
    • (2010) Public Health Genomics. , vol.13 , pp. 246-255
    • Hall, A.1    Bostanci, A.2    Wright, C.F.3
  • 138
    • 38949177074 scopus 로고    scopus 로고
    • Non-invasive prenatal diagnosis: Public and patient perceptions
    • DOI 10.1016/j.siny.2007.12.009, PII S1744165X07001552
    • Kent A. Non-invasive prenatal diagnosis: public and patient perceptions. Semin Fetal Neonatal Med. 2008;13:109-112. (Pubitemid 351227395)
    • (2008) Seminars in Fetal and Neonatal Medicine , vol.13 , Issue.2 , pp. 109-112
    • Kent, A.1
  • 139
    • 39149103375 scopus 로고    scopus 로고
    • Ethical aspects arising from non-invasive fetal diagnosis
    • Newson AJ. Ethical aspects arising from non-invasive fetal diagnosis. Semin Fetal Neonatal Med. 2008;13:103-108.
    • (2008) Semin Fetal Neonatal Med , vol.13 , pp. 103-108
    • Newson, A.J.1
  • 140
    • 70349305097 scopus 로고    scopus 로고
    • Non-invasive prenatal diagnosis: An ethical imperative
    • author reply 733
    • Ravitsky V. Non-invasive prenatal diagnosis: an ethical imperative. Nat Rev Genet. 2009;10:733; author reply 733.
    • (2009) Nat Rev Genet , vol.10 , pp. 733
    • Ravitsky, V.1
  • 141
    • 68249099156 scopus 로고    scopus 로고
    • Commentary: No risk, no objections? Ethical pitfalls of cell-free fetal DNA and RNA testing
    • Schmitz D, Henn W, Netzer C. Commentary: no risk, no objections? Ethical pitfalls of cell-free fetal DNA and RNA testing. BMJ. 2009;339:b2690.
    • (2009) BMJ , vol.339
    • Schmitz, D.1    Henn, W.2    Netzer, C.3
  • 142
    • 67651124803 scopus 로고    scopus 로고
    • An offer you can't refuse? Ethical implications of non-invasive prenatal diagnosis
    • Schmitz D, Netzer C, Henn W. An offer you can't refuse? Ethical implications of non-invasive prenatal diagnosis. Nat Rev Genet. 2009;10:515.
    • (2009) Nat Rev Genet , vol.10 , pp. 515
    • Schmitz, D.1    Netzer, C.2    Henn, W.3
  • 143
    • 33746637072 scopus 로고    scopus 로고
    • The obstetrician's view: Ethical and societal implications of non-invasive prenatal diagnosis
    • DOI 10.1002/pd.1476
    • Smith RP, Lombaard H, Soothill PW. The obstetrician's view: ethical and societal implications of non-invasive prenatal diagnosis. Prenat Diagn. 2006;26:631-634. (Pubitemid 44146778)
    • (2006) Prenatal Diagnosis , vol.26 , Issue.7 , pp. 631-634
    • Smith, R.P.1    Lombaard, H.2    Soothill, P.W.3
  • 144
    • 68249114716 scopus 로고    scopus 로고
    • Cell-free fetal DNA and RNA in maternal blood: Implications for safer antenatal testing
    • Wright CF, Chitty LS. Cell-free fetal DNA and RNA in maternal blood: implications for safer antenatal testing. BMJ. 2009;339:b2451.
    • (2009) BMJ , vol.339
    • Wright, C.F.1    Chitty, L.S.2


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