Paigen diet-fed apolipoprotein e knockout mice develop severe pulmonary hypertension in an interleukin-1-Dependent Manner

American Journal of Pathology

Volumn 179, Issue 4, 2011, Pages 1693-1705

  Lawrie, Allan ^a,b   Hameed, Abdul G ^a   Chamberlain, Janet ^a   Arnold, Nadine ^a,b   Kennerley, Aneurin ^c   Hopkinson, Kay ^a   Pickworth, Josephine ^a,b   Kiely, David G ^b,d   Crossman, David C ^a,b   Francis, Sheila E ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c National Institute for Health Research ^*  (United Kingdom)

^d ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOENZYME; APOLIPOPROTEIN E; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; LIPID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CACAO; CONTROLLED STUDY; DIETARY INTAKE; DISEASE COURSE; DISEASE SEVERITY; HEART VENTRICLE REMODELING; HUMAN; HYPOTHESIS; LIPID DIET; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; SIGNAL TRANSDUCTION; SYSTOLIC BLOOD PRESSURE;

ANIMALS; APOLIPOPROTEINS E; BIOLOGICAL MARKERS; DIET, HIGH-FAT; DISEASE PROGRESSION; FEEDING BEHAVIOR; HEMODYNAMICS; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; INFLAMMATION MEDIATORS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGAN SIZE; OSTEOPROTEGERIN; PHENOTYPE; PULMONARY ARTERY; RECEPTORS, INTERLEUKIN-1; TNF-RELATED APOPTOSIS-INDUCING LIGAND; UP-REGULATION; VENTRICULAR FUNCTION, RIGHT; VENTRICULAR REMODELING;

EID: 80053277241     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.06.037     Document Type: Article

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