-
1
-
-
77953151053
-
-
American Cancer Society, American Cancer Society: Atlanta, GA, USA,; Report No.: 1
-
American Cancer Society. Cancers Facts & Figures 2010; American Cancer Society: Atlanta, GA, USA, 2010; Report No.: 1.
-
(2010)
Cancers Facts & Figures 2010
-
-
-
3
-
-
33646497027
-
Familial pancreatic cancer syndromes
-
Habbe, N.; Langer, P.; Sina-Frey, M.; Bartsch, D.K. Familial pancreatic cancer syndromes. Endocrinol. Metab. Clin. North Am. 2006, 35, 417-430.
-
(2006)
Endocrinol. Metab. Clin. North Am
, vol.35
, pp. 417-430
-
-
Habbe, N.1
Langer, P.2
Sina-Frey, M.3
Bartsch, D.K.4
-
4
-
-
62349089109
-
Pancreatic cancer: Translating lessons from mouse models and hereditary syndromes
-
Wescott, M.P.; Rustgi, A.K. Pancreatic cancer: Translating lessons from mouse models and hereditary syndromes. Cancer Prev. Res. 2008, 1, 503-506.
-
(2008)
Cancer Prev. Res
, vol.1
, pp. 503-506
-
-
Wescott, M.P.1
Rustgi, A.K.2
-
5
-
-
0034032009
-
Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: Evidence that DPC4 inactivation occurs late in neoplastic progression
-
Wilentz, R.E.; Iacobuzio-Donahue, C.A.; Argani, P.; McCarthy, D.M.; Parsons, J.L.; Yeo, C.J.; Kern, S.E.; Hruban, R.H. Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: Evidence that DPC4 inactivation occurs late in neoplastic progression. Cancer Res. 2000, 60, 2002-2006.
-
(2000)
Cancer Res
, vol.60
, pp. 2002-2006
-
-
Wilentz, R.E.1
Iacobuzio-Donahue, C.A.2
Argani, P.3
McCarthy, D.M.4
Parsons, J.L.5
Yeo, C.J.6
Kern, S.E.7
Hruban, R.H.8
-
6
-
-
34249898611
-
Molecular genetics of pancreatic intraepithelial neoplasia
-
Feldmann, G.; Geaty, R.; Hruban, R.H.; Maitra, A. Molecular genetics of pancreatic intraepithelial neoplasia. J. Hepatobiliary Pancreat. Surg. 2007, 14, 224-232.
-
(2007)
J. Hepatobiliary Pancreat. Surg
, vol.14
, pp. 224-232
-
-
Feldmann, G.1
Geaty, R.2
Hruban, R.H.3
Maitra, A.4
-
7
-
-
0024292722
-
Most human carcinomas of the exocrine pancreas contain mutant c-KRAS genes
-
Almoguera, C.; Shibata, D.; Forrester, K.; Martin, J.; Arnheim, N.; Perucho, M. Most human carcinomas of the exocrine pancreas contain mutant c-KRAS genes. Cell 1988, 53, 549-554.
-
(1988)
Cell
, vol.53
, pp. 549-554
-
-
Almoguera, C.1
Shibata, D.2
Forrester, K.3
Martin, J.4
Arnheim, N.5
Perucho, M.6
-
8
-
-
13444274253
-
Frequency of KRAS mutations in pancreatic intraductal epithelial neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: A metanalysis
-
Lohr, M.; Kloppel, G.; Maisonneuve, P.; Lowenfels, A.B.; Luttges, J. Frequency of KRAS mutations in pancreatic intraductal epithelial neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: A metanalysis. Neoplasia 2005, 7, 17-23.
-
(2005)
Neoplasia
, vol.7
, pp. 17-23
-
-
Lohr, M.1
Kloppel, G.2
Maisonneuve, P.3
Lowenfels, A.B.4
Luttges, J.5
-
9
-
-
0141742113
-
Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray
-
Maitra, A.; Adsay, N.V.; Argani, P.; Iacobuzio-Donahue, C.; De Marzo, A.; Cameron, J.L.; Yeo, C.J.; Hruban, R.H. Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray. Mod. Pathol. 2003, 16, 902-912.
-
(2003)
Mod. Pathol
, vol.16
, pp. 902-912
-
-
Maitra, A.1
Adsay, N.V.2
Argani, P.3
Iacobuzio-Donahue, C.4
de Marzo, A.5
Cameron, J.L.6
Yeo, C.J.7
Hruban, R.H.8
-
10
-
-
9144266295
-
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
-
Hingorani, S.R.; Petricoin, E.F.; Maitra, A.; Rajapakse, V.; King, C.; Jacobetz, M.A.; Ross, S.; Conrads, T.P.; Veenstra, T.D.; Hitt, B.A. et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 2003, 4, 437-450.
-
(2003)
Cancer Cell
, vol.4
, pp. 437-450
-
-
Hingorani, S.R.1
Petricoin, E.F.2
Maitra, A.3
Rajapakse, V.4
King, C.5
Jacobetz, M.A.6
Ross, S.7
Conrads, T.P.8
Veenstra, T.D.9
Hitt, B.A.10
-
11
-
-
11144356354
-
Endogenous oncogenic KRASG12D stimulates proliferation and widespread neoplastic and developmental defects
-
Tuveson, D.A.; Shaw, A.T.; Willis, N.A.; Silver, D.P.; Jackson, E.L.; Chang, S.; Mercer, K.L.; Grochow, R.; Hock, H.; Crowley, D. et al. Endogenous oncogenic KRASG12D stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell. 2004, 5, 375-387.
-
(2004)
Cancer Cell
, vol.5
, pp. 375-387
-
-
Tuveson, D.A.1
Shaw, A.T.2
Willis, N.A.3
Silver, D.P.4
Jackson, E.L.5
Chang, S.6
Mercer, K.L.7
Grochow, R.8
Hock, H.9
Crowley, D.10
-
12
-
-
76249108357
-
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
-
Morton, J.P.; Timpsona, P.; Karima, S.A.; Ridgway, R.A.; Athineos, D.; Doyle, B.; Jamieson, N.B.; Oien, K.A.; Lowy, A.M.; Brunton, V.G.; Frame M.C. et al. Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc. Natl. Acad. Sci. USA 2010, 107, 246-251.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 246-251
-
-
Morton, J.P.1
Timpsona, P.2
Karima, S.A.3
Ridgway, R.A.4
Athineos, D.5
Doyle, B.6
Jamieson, N.B.7
Oien, K.A.8
Lowy, A.M.9
Brunton, V.G.10
Frame, M.C.11
-
13
-
-
52149123619
-
Core signaling pathways in human pancreatic cancer revealed by global genomic analysis
-
Jones, S.; Zhang, X.; Parson, W.D.; Lin, J.C.; Leary, R.J.; Angenendt, P.; Mankoo, P.; Carter, H.; Kamiyama, H.; Jimeno, A. et al. Core signaling pathways in human pancreatic cancer revealed by global genomic analysis. Science. 2008, 321, 1801-1806.
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parson, W.D.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
Mankoo, P.7
Carter, H.8
Kamiyama, H.9
Jimeno, A.10
-
14
-
-
33746808398
-
Wnt/β-catenin signaling in development and disease
-
Clevers, H. Wnt/β-catenin signaling in development and disease. Cell 2006, 127, 469-480.
-
(2006)
Cell
, vol.127
, pp. 469-480
-
-
Clevers, H.1
-
15
-
-
67650230896
-
Wnt/β-catenin signaling: Components, mechanism and disease
-
MacDonald, B.T.; Tamai, K.; He, X. Wnt/β-catenin signaling: components, mechanism and disease. Dev. Cell 2009, 17, 9-26.
-
(2009)
Dev. Cell
, vol.17
, pp. 9-26
-
-
Macdonald, B.T.1
Tamai, K.2
He, X.3
-
16
-
-
78349276165
-
Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors
-
Grumolato, L.; Guizhong, L.; Mong, P.; Mudbhary, R.; Biswas, R.; Arroyave, R.; Vijayakumar, S.; Economides, A.N.; Aaronson, S.A. Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. Genes Dev. 2010, 24, 2517-2530.
-
(2010)
Genes Dev
, vol.24
, pp. 2517-2530
-
-
Grumolato, L.1
Guizhong, L.2
Mong, P.3
Mudbhary, R.4
Biswas, R.5
Arroyave, R.6
Vijayakumar, S.7
Economides, A.N.8
Aaronson, S.A.9
-
17
-
-
0027723788
-
Catenins as mediators of the cytoplasmic functions of cadherins
-
Gumbiner, B.M.; McCrea, P.D. Catenins as mediators of the cytoplasmic functions of cadherins. J. Cell Sci. 1993, 17, 155-158.
-
(1993)
J. Cell Sci
, vol.17
, pp. 155-158
-
-
Gumbiner, B.M.1
McCrea, P.D.2
-
18
-
-
0029040123
-
Genetic and biochemical dissection of protein linkages in the cadherin-catenin complex
-
Jou, T.S.; Stewart, D.B.; Stappert, J.; Nelson, W.J.; Marrs, J.A. Genetic and biochemical dissection of protein linkages in the cadherin-catenin complex. Proc. Natl. Acad. Sci. USA 1995, 92, 5067-5071.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 5067-5071
-
-
Jou, T.S.1
Stewart, D.B.2
Stappert, J.3
Nelson, W.J.4
Marrs, J.A.5
-
19
-
-
0034214847
-
The Wnt/Ca2+ pathway: A new vertebrate Wnt signaling pathway takes shape
-
Kühl, M.; Sheldahl, L.C.; Park, M.; Miller, J.R.; Moon, R.T. The Wnt/Ca2+ pathway: A new vertebrate Wnt signaling pathway takes shape. Trends Genet. 2000, 16, 279-283.
-
(2000)
Trends Genet
, vol.16
, pp. 279-283
-
-
Kühl, M.1
Sheldahl, L.C.2
Park, M.3
Miller, J.R.4
Moon, R.T.5
-
20
-
-
79551587194
-
Strange as it may seem: The many links between Wnt signaling, planar cell polarity, and cilia
-
Wallingford, J.B.; Mitchell, B. Strange as it may seem: The many links between Wnt signaling, planar cell polarity, and cilia. Genes Dev. 2011, 25, 201-213.
-
(2011)
Genes Dev
, vol.25
, pp. 201-213
-
-
Wallingford, J.B.1
Mitchell, B.2
-
21
-
-
67449156114
-
Phenylmethimazole decreases toll-like receptor 3 and noncanonical WNT5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration
-
Schwartz, A.L.; Malgor, R.; Dickerson, E.; Weeraratna, A.T.; Slominski, A.; Wortsman, J.; Harii, N.; Kohn, A.D.; Moon, R.T.; Schwartz, F.L. et al. Phenylmethimazole decreases toll-like receptor 3 and noncanonical WNT5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration. Clin. Cancer Res. 2009, 15, 4114-4122.
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 4114-4122
-
-
Schwartz, A.L.1
Malgor, R.2
Dickerson, E.3
Weeraratna, A.T.4
Slominski, A.5
Wortsman, J.6
Harii, N.7
Kohn, A.D.8
Moon, R.T.9
Schwartz, F.L.10
-
22
-
-
34447326176
-
WNT5a-target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic cancer
-
Ripka, S.; Konig, A.; Buchholz, M.; Wagner, M.; Sipos, B.; Klöppel, G.; Downward, J.; Gress, T.; Michl, P. WNT5a-target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic cancer. Carcinogenesis 2007, 28, 1178-1187.
-
(2007)
Carcinogenesis
, vol.28
, pp. 1178-1187
-
-
Ripka, S.1
Konig, A.2
Buchholz, M.3
Wagner, M.4
Sipos, B.5
Klöppel, G.6
Downward, J.7
Gress, T.8
Michl, P.9
-
23
-
-
0032700298
-
Analysis of β-catenin gene mutations in pancreatic tumors
-
Gerdes, B.; Ramaswamy, A.; Simon, B.; Pietsch, T.; Bastian, D.; Kersting, M.; Moll, R.; Bartsch, D. Analysis of β-catenin gene mutations in pancreatic tumors. Digestion 1999, 60, 544-548.
-
(1999)
Digestion
, vol.60
, pp. 544-548
-
-
Gerdes, B.1
Ramaswamy, A.2
Simon, B.3
Pietsch, T.4
Bastian, D.5
Kersting, M.6
Moll, R.7
Bartsch, D.8
-
24
-
-
1642392438
-
Epithelial-cadherin and β-catenin expression changes in pancreatic intraepithelial neoplasia
-
Al-Aynati, M.M.; Radulovich, N.; Riddell, R.H.; Tsao, M.S. Epithelial-cadherin and β-catenin expression changes in pancreatic intraepithelial neoplasia. Clin. Cancer Res. 2004, 10, 1235-1240.
-
(2004)
Clin. Cancer Res
, vol.10
, pp. 1235-1240
-
-
Al-Aynati, M.M.1
Radulovich, N.2
Riddell, R.H.3
Tsao, M.S.4
-
25
-
-
33646425568
-
Aberrant Wnt/β-catenin signaling in pancreatic adenocarcinoma
-
Zeng, G.; Germinaro, M.; Micsenyi, A.; Monga, N.K.; Bell, A.; Sood, A.; Malhotra, V.; Sood, N.; Midda, V.; Monga, D.K.; Kokkinakis, D.M.; Monga, S.P. Aberrant Wnt/β-catenin signaling in pancreatic adenocarcinoma. Neoplasia 2006, 8, 279-289.
-
(2006)
Neoplasia
, vol.8
, pp. 279-289
-
-
Zeng, G.1
Germinaro, M.2
Micsenyi, A.3
Monga, N.K.4
Bell, A.5
Sood, A.6
Malhotra, V.7
Sood, N.8
Midda, V.9
Monga, D.K.10
Kokkinakis, D.M.11
Monga, S.P.12
-
26
-
-
42649138943
-
Common activation of canonical Wnt signaling in pancreatic adenocarcinoma
-
Pasca di Magliano, M.; Biankin, A.V.; Heiser, P.W.; Cano, D.A.; Gutierrez, P.J.; Deramaudt, T.; Segara, D.; Dawson, A.C.; Kench, J.G.; Henshall, S.M.; Sutherland R.L. et al. Common activation of canonical Wnt signaling in pancreatic adenocarcinoma. PLoS one 2007, 2, e1155.
-
(2007)
PLoS One
, vol.2
-
-
di Magliano, M.P.1
Biankin, A.V.2
Heiser, P.W.3
Cano, D.A.4
Gutierrez, P.J.5
Deramaudt, T.6
Segara, D.7
Dawson, A.C.8
Kench, J.G.9
Henshall, S.M.10
Sutherland, R.L.11
-
27
-
-
77957150824
-
KRAS, hedgehog, wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
-
Morris, J.P.; Wang, S.C.; Hebrok, M. KRAS, hedgehog, wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat. Rev. Cancer 2010, 10, 683-695.
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 683-695
-
-
Morris, J.P.1
Wang, S.C.2
Hebrok, M.3
-
28
-
-
12344308348
-
Stabilization of β-catenin in the mouse zygote leads to premature epithelial-mesemchymal transition in the epiblast
-
Kemler, R.; Hierholzer, A.; Kanzler, B.; Kuppig, S.; Hansen, K.; Taketo, M.M.; de Vries, W.N.; Knowles, B.B.; Solter, D. Stabilization of β-catenin in the mouse zygote leads to premature epithelial-mesemchymal transition in the epiblast. Development 2004, 131, 5817-5824.
-
(2004)
Development
, vol.131
, pp. 5817-5824
-
-
Kemler, R.1
Hierholzer, A.2
Kanzler, B.3
Kuppig, S.4
Hansen, K.5
Taketo, M.M.6
de Vries, W.N.7
Knowles, B.B.8
Solter, D.9
-
29
-
-
33745084564
-
Stabilization of β-catenin impacts pancreas growth
-
Heiser, P.W.; Lau, J.; Taketo, M.M.; Herrera, P.L.; Hebrok, M. Stabilization of β-catenin impacts pancreas growth. Development 2006, 133, 2023-2032.
-
(2006)
Development
, vol.133
, pp. 2023-2032
-
-
Heiser, P.W.1
Lau, J.2
Taketo, M.M.3
Herrera, P.L.4
Hebrok, M.5
-
30
-
-
34548167006
-
Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation I the pancreas
-
Strom, A.; Bonal, C.; Ashery-Padan, R.; Hashimoto, N.; Campos, M.L.; Trumpp, A.; Noda, T.; Kido, Y.; Real, F.X.; Thorel, F. et al. Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation I the pancreas. Development 2007, 134, 2719-2725.
-
(2007)
Development
, vol.134
, pp. 2719-2725
-
-
Strom, A.1
Bonal, C.2
Ashery-Padan, R.3
Hashimoto, N.4
Campos, M.L.5
Trumpp, A.6
Noda, T.7
Kido, Y.8
Real, F.X.9
Thorel, F.10
-
31
-
-
53049110158
-
Stabilization of β-catenin induces pancreas tumor formation
-
Heiser, P.W.; Cano, D.W.; Landsman, L.; Kim, G.E.; Kench, J.G.; Klimstra, D.S.; Taketo, M.M.; Biankin, A.V.; Hebrok, M. Stabilization of β-catenin induces pancreas tumor formation. Gastroenterology 2008, 135, 1288-1300.
-
(2008)
Gastroenterology
, vol.135
, pp. 1288-1300
-
-
Heiser, P.W.1
Cano, D.W.2
Landsman, L.3
Kim, G.E.4
Kench, J.G.5
Klimstra, D.S.6
Taketo, M.M.7
Biankin, A.V.8
Hebrok, M.9
-
32
-
-
64049085356
-
Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras
-
Carriere, C.; Young, A.L.; Gunn, J.R.; Longnecker, D.S.; Korc, M. Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras. Biochem. Biophys. Res. Commun. 2009, 382, 561-565.
-
(2009)
Biochem. Biophys. Res. Commun
, vol.382
, pp. 561-565
-
-
Carriere, C.1
Young, A.L.2
Gunn, J.R.3
Longnecker, D.S.4
Korc, M.5
-
33
-
-
36549077062
-
In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia
-
Strobel, O.; Dor, Y.; Alsina, J.; Stirman, A.; Lauwers, G.; Trainor, A.; Castillo, C.F.; Warshaw, A.L.; Thayer, S.P. In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia. Gastroenterology 2007, 133, 1999-2009.
-
(2007)
Gastroenterology
, vol.133
, pp. 1999-2009
-
-
Strobel, O.1
Dor, Y.2
Alsina, J.3
Stirman, A.4
Lauwers, G.5
Trainor, A.6
Castillo, C.F.7
Warshaw, A.L.8
Thayer, S.P.9
-
34
-
-
38649140167
-
Notch signaling is required for exocrine regeneration after acute pancreatitis
-
Siveke, J.T.; Lubeseder-Martellato, C.; Lee, M.; Sipos, B.; Nakhai, H.; Rad, R.; Zimber-Strobl, U.; Strobl, L.J.; Radtke, F.; Klöppel, G.; Schmid, R.M.; Siveke, J.T. Notch signaling is required for exocrine regeneration after acute pancreatitis. Gastroenterology 2008, 134, 544-555.
-
(2008)
Gastroenterology
, vol.134
, pp. 544-555
-
-
Siveke, J.T.1
Lubeseder-Martellato, C.2
Lee, M.3
Sipos, B.4
Nakhai, H.5
Rad, R.6
Zimber-Strobl, U.7
Strobl, L.J.8
Radtke, F.9
Klöppel, G.10
Schmid, R.M.11
Siveke, J.T.12
-
35
-
-
79958710624
-
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence
-
Guerra, C.; Collado, M.; Navas, C.; Schuhmacher, A.J.; Hernández-Porras, I.; Cañamero, M.; Rodriguez-Justo, M.; Serrano, M.; Barbacid, M. Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. Cancer Cell 2011, 19, 728-739.
-
(2011)
Cancer Cell
, vol.19
, pp. 728-739
-
-
Guerra, C.1
Collado, M.2
Navas, C.3
Schuhmacher, A.J.4
Hernández-Porras, I.5
Cañamero, M.6
Rodriguez-Justo, M.7
Serrano, M.8
Barbacid, M.9
-
36
-
-
69249148349
-
Ras activity levels control the development of pancreatic diseases
-
Ji, B.; Tsou, L.; Wang, H.; Gaiser, S.; Chang, D.Z.; Daniluk, J.; Bi, Y.; Grote, T.; Longnecker, D.S.; Logsdon, C.D. Ras activity levels control the development of pancreatic diseases. Gastroenterology 2009, 137, 1072-1082.
-
(2009)
Gastroenterology
, vol.137
, pp. 1072-1082
-
-
Ji, B.1
Tsou, L.2
Wang, H.3
Gaiser, S.4
Chang, D.Z.5
Daniluk, J.6
Bi, Y.7
Grote, T.8
Longnecker, D.S.9
Logsdon, C.D.10
-
37
-
-
34547667454
-
Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia
-
Zhu, L.; Shi, G.; Schmidt, C.M.; Hruban, R.H.; Konieczny, S.F. Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Am. J. Pathol. 2007, 171, 263-273.
-
(2007)
Am. J. Pathol
, vol.171
, pp. 263-273
-
-
Zhu, L.1
Shi, G.2
Schmidt, C.M.3
Hruban, R.H.4
Konieczny, S.F.5
-
38
-
-
57749116315
-
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
-
De La Oa, J.-P.; Emersonb, L.L.; Goodmana, J.L.; Froebea, S.C.; Illuma, B.E.; Curtisa, A.B.; Murtaugha, C.L. Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc. Natl. Acad. Sci. USA 2008, 105, 18907-18912.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 18907-18912
-
-
de la Oa, J.-P.1
Emersonb, L.L.2
Goodmana, J.L.3
Froebea, S.C.4
Illuma, B.E.5
Curtisa, A.B.6
Murtaugha, C.L.7
-
39
-
-
0035504739
-
Gene expression profiles of pancreatic cancer and stromal desmoplasia
-
Crnogorac-Jurcevic, T.; Efthimiou, E.; Capelli, P.; Blaveri, E.; Baron, A.; Terris, B.; Jones, M.; Tyson, K.; Bassi, C.; Scarpa, A. et al. Gene expression profiles of pancreatic cancer and stromal desmoplasia. Oncogene 2001, 20, 7437-7446.
-
(2001)
Oncogene
, vol.20
, pp. 7437-7446
-
-
Crnogorac-Jurcevic, T.1
Efthimiou, E.2
Capelli, P.3
Blaveri, E.4
Baron, A.5
Terris, B.6
Jones, M.7
Tyson, K.8
Bassi, C.9
Scarpa, A.10
-
40
-
-
55249103738
-
Activation of Wnt signaling in stroma from pancreatic cancer identified by gene expression profiling
-
Pilarsky, C.; Ammerpohl, O.; Sipos, B.; Dahl, E.; Hartmann, A.; Wellmann, A.; Braunschweig, T.; Löhr, M.; Jesnowski, R.; Friess, H. et al. Activation of Wnt signaling in stroma from pancreatic cancer identified by gene expression profiling. J. Cell. Mol. Med. 2008, 12, 2823-2835.
-
(2008)
J. Cell. Mol. Med
, vol.12
, pp. 2823-2835
-
-
Pilarsky, C.1
Ammerpohl, O.2
Sipos, B.3
Dahl, E.4
Hartmann, A.5
Wellmann, A.6
Braunschweig, T.7
Löhr, M.8
Jesnowski, R.9
Friess, H.10
-
41
-
-
27644590041
-
New notch in the HIF belt: How hypoxia impacts differentiation
-
Cejudo-Martin, P.; Johnson, R.S. A new notch in the HIF belt: How hypoxia impacts differentiation. Dev. Cell 2005, 9, 575-576.
-
(2005)
Dev. Cell
, vol.9
, pp. 575-576
-
-
Cejudo-Martin, P.1
Johnson, R.S.A.2
-
42
-
-
28844506821
-
Lasting longer without oxygen: The influence of hypoxia on Notch signaling
-
Pear, W.S.; Simon, D.C. Lasting longer without oxygen: the influence of hypoxia on Notch signaling. Cancer Cell 2005, 8, 435-437.
-
(2005)
Cancer Cell
, vol.8
, pp. 435-437
-
-
Pear, W.S.1
Simon, D.C.2
-
43
-
-
0033606972
-
Notch signaling controls pancreatic cell differentiation
-
Apelqvist, A.; Li, H.; Sommer, L.; Beatus, P.; Anderson, D.J.; Honjo, T.; Hrabe de Angelis, M.; Lendahl, U.; Edlund, H. Notch signaling controls pancreatic cell differentiation. Nature 1999, 400, 877-881.
-
(1999)
Nature
, vol.400
, pp. 877-881
-
-
Apelqvist, A.1
Li, H.2
Sommer, L.3
Beatus, P.4
Anderson, D.J.5
Honjo, T.6
de Hrabe, A.M.7
Lendahl, U.8
Edlund, H.9
-
44
-
-
18544404101
-
Control of endodermal endocrine development by Hes-1
-
Jensen, J.; Pederson, E.E.; Galante, P.; Hald, J.; Heller, R.S.; Ishibashi, M.; Kageyama, R.; Guillemot, F.; Serup, P.; Madsen, O.D. Control of endodermal endocrine development by Hes-1. Nat. Genet. 2000, 24, 36-44.
-
(2000)
Nat. Genet
, vol.24
, pp. 36-44
-
-
Jensen, J.1
Pederson, E.E.2
Galante, P.3
Hald, J.4
Heller, R.S.5
Ishibashi, M.6
Kageyama, R.7
Guillemot, F.8
Serup, P.9
Madsen, O.D.10
-
45
-
-
33947217823
-
Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia
-
Kaidi, A.; Williams, A.C.; Paraskeva, C. Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia. Nat. Cell. Biol. 2007, 9, 210-217.
-
(2007)
Nat. Cell. Biol
, vol.9
, pp. 210-217
-
-
Kaidi, A.1
Williams, A.C.2
Paraskeva, C.3
-
46
-
-
33646858497
-
The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-β-catenin signaling through disheveled
-
Funato, Y.; Michiue, T.; Asashima, M.; Miki, H. The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-β-catenin signaling through disheveled. Nat. Cell. Biol. 2006, 8, 501-508.
-
(2006)
Nat. Cell. Biol
, vol.8
, pp. 501-508
-
-
Funato, Y.1
Michiue, T.2
Asashima, M.3
Miki, H.4
-
47
-
-
28044449357
-
β-catenin is essential for pancreatic acinar but not islet development
-
Murtaugh, L.C.; Law, A.C.; Dor, Y.; Melton, D.A. β-catenin is essential for pancreatic acinar but not islet development. Development 2005, 132, 4663-4674.
-
(2005)
Development
, vol.132
, pp. 4663-4674
-
-
Murtaugh, L.C.1
Law, A.C.2
Dor, Y.3
Melton, D.A.4
-
48
-
-
33846807059
-
Wnt/β-catenin signaling is required for development of the exocrine pancreas
-
Wells, J.C.; Esni, F.; Boivin, G.P.; Aronow, B.J.; Stuart, W.; Combs, C.; Sklenka, A.; Leach, S.D. Lowy, A.M. Wnt/β-catenin signaling is required for development of the exocrine pancreas. BMC Dev. Biol. 2007, 7, 4.
-
(2007)
BMC Dev. Biol
, vol.7
, pp. 4
-
-
Wells, J.C.1
Esni, F.2
Boivin, G.P.3
Aronow, B.J.4
Stuart, W.5
Combs, C.6
Sklenka, A.7
Leach, S.D.8
Lowy, A.M.9
-
49
-
-
0347418260
-
Increased expression of hypoxiainducible factor-1alpha, p48, and the Notch signaling cascade during acute pancreatitis in mice
-
Gomez, G.; Englander, E.W.; Wang, G.; Greeley, G.H., Jr. Increased expression of hypoxiainducible factor-1alpha, p48, and the Notch signaling cascade during acute pancreatitis in mice. Pancreas 2004, 28, 58-64.
-
(2004)
Pancreas
, vol.28
, pp. 58-64
-
-
Gomez, G.1
Englander, E.W.2
Wang, G.3
Greeley Jr., G.H.4
-
50
-
-
65549141305
-
Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway
-
Wang, Z.; Li, Y.; Kong, D.; Banerjee, S.; Ahmad, A.; Azmi, A.S.; Ali, S.; Abbruzzese, J.L.; Gallick, G.E.; Sarkar, F.H. Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res. 2009, 69, 2400-2407.
-
(2009)
Cancer Res
, vol.69
, pp. 2400-2407
-
-
Wang, Z.1
Li, Y.2
Kong, D.3
Banerjee, S.4
Ahmad, A.5
Azmi, A.S.6
Ali, S.7
Abbruzzese, J.L.8
Gallick, G.E.9
Sarkar, F.H.10
-
51
-
-
77955827414
-
Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma
-
Mazur, P.K.; Einwächter, H.; Lee, M.; Sipos, B.; Nakhai, H.; Rad, R.; Zimber-Strobl, U.; Strobl, L.J.; Radtke, F.; Klöppel, G. et al. Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma. Proc. Natl. Acad. Sci. USA 2010, 107, 13438-13443.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 13438-13443
-
-
Mazur, P.K.1
Einwächter, H.2
Lee, M.3
Sipos, B.4
Nakhai, H.5
Rad, R.6
Zimber-Strobl, U.7
Strobl, L.J.8
Radtke, F.9
Klöppel, G.10
-
52
-
-
79954582454
-
Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer
-
Chang, Q.; Jurisica, I.; Do, T.; Hedley, D.W. Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer. Cancer Res. 2011, 71, 3110-3120.
-
(2011)
Cancer Res
, vol.71
, pp. 3110-3120
-
-
Chang, Q.1
Jurisica, I.2
Do, T.3
Hedley, D.W.4
-
53
-
-
66149164442
-
Selective killing of hypoxia-inducible Factor-1-Active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer
-
Kizaka-Kondoh, S.; Itasaka, S.; Zeng, L.; Tanaka, S.; Zhao, S.; Takahashi, Y.; Keiko, S.; Hirota, K.; Semenza, G.L.; Hiraoka, M. Selective killing of hypoxia-inducible Factor-1-Active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer. Clin. Cancer Res. 2009, 15, 3433-3441.
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 3433-3441
-
-
Kizaka-Kondoh, S.1
Itasaka, S.2
Zeng, L.3
Tanaka, S.4
Zhao, S.5
Takahashi, Y.6
Keiko, S.7
Hirota, K.8
Semenza, G.L.9
Hiraoka, M.10
-
54
-
-
33845398385
-
Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2
-
Masckauchan, T.N.; Agalliu, D.; Vorontchikhina, M.; Ahn, A.; Parmalee, N.L.; Li, C.M.; Khoo, A.; Tycko, B.; Brown, A.M.; Kitajewski, J. Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2. Mol. Biol. Cell 2006, 17, 5163-5172.
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 5163-5172
-
-
Masckauchan, T.N.1
Agalliu, D.2
Vorontchikhina, M.3
Ahn, A.4
Parmalee, N.L.5
Li, C.M.6
Khoo, A.7
Tycko, B.8
Brown, A.M.9
Kitajewski, J.10
-
55
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive, K.P.; Jacobetz, M.A.; Davidson, C.J.; Gopinathan, A.; McIntyre, D.; Honess, D.; Madhu, B.; Goldgraben, M.A.; Caldwell, M.E.; Allard, D. et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009, 324, 1457-1461.
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
Jacobetz, M.A.2
Davidson, C.J.3
Gopinathan, A.4
McIntyre, D.5
Honess, D.6
Madhu, B.7
Goldgraben, M.A.8
Caldwell, M.E.9
Allard, D.10
-
56
-
-
34548455927
-
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
-
Hermann, P.C.; Huber, S.L.; Herrler, T.; Aicher, A.; Ellwart, J.W.; Guba, M.; Bruns, C.J.; Heeschen, C. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 2007, 1, 313-323.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 313-323
-
-
Hermann, P.C.1
Huber, S.L.2
Herrler, T.3
Aicher, A.4
Ellwart, J.W.5
Guba, M.6
Bruns, C.J.7
Heeschen, C.8
-
57
-
-
33847052127
-
Identification of pancreatic cancer stem cells
-
Li, C.; Heidt, D.G.; Dalerba, P.; Burant, C.F.; Zhang, L.; Adsay, V.; Wicha, M.; Clarke, M.F.; Simeone, D.M. Identification of pancreatic cancer stem cells. Cancer Res. 2007, 67, 1030-1037.
-
(2007)
Cancer Res
, vol.67
, pp. 1030-1037
-
-
Li, C.1
Heidt, D.G.2
Dalerba, P.3
Burant, C.F.4
Zhang, L.5
Adsay, V.6
Wicha, M.7
Clarke, M.F.8
Simeone, D.M.9
-
58
-
-
33947254016
-
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers
-
Feldmann, G.; Dhara, S.; Fendrich, V.; Bedja, D.; Beaty, R.; Mullendore, M.; Karikari, C.; Alvarez, H.; Iacobuzio-Donahue, C.; Jimeno, A. et al. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers. Cancer Res. 2007, 67, 2187-2196.
-
(2007)
Cancer Res
, vol.67
, pp. 2187-2196
-
-
Feldmann, G.1
Dhara, S.2
Fendrich, V.3
Bedja, D.4
Beaty, R.5
Mullendore, M.6
Karikari, C.7
Alvarez, H.8
Iacobuzio-Donahue, C.9
Jimeno, A.10
-
59
-
-
79958716191
-
ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma
-
Kim, M.P.; Fleming, J.B.; Wang, H.; Abbruzzese, J.L.; Choi, W.; Kopetz, S.; McConkey, D.J.; Evans, D.B.; Gallick, G.E. ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma. PLoS one 2011, 6, e20636.
-
(2011)
PLoS One
, vol.6
-
-
Kim, M.P.1
Fleming, J.B.2
Wang, H.3
Abbruzzese, J.L.4
Choi, W.5
Kopetz, S.6
McConkey, D.J.7
Evans, D.B.8
Gallick, G.E.9
-
60
-
-
77956214387
-
Tumor-initiating cells are rare in many human tumors
-
Ishizawa, K.; Rasheed, Z.A.; Karisch, R.; Wang, Q.; Kowalski, J.; Susky, E.; Pereira, K.; Karamboulas, C.; Moghal, N.; Rajeshkumar, N.V.; Hidalgo, M. et al. Tumor-initiating cells are rare in many human tumors. Cell Stem Cell 2010, 7, 279-282.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 279-282
-
-
Ishizawa, K.1
Rasheed, Z.A.2
Karisch, R.3
Wang, Q.4
Kowalski, J.5
Susky, E.6
Pereira, K.7
Karamboulas, C.8
Moghal, N.9
Rajeshkumar, N.V.10
Hidalgo, M.11
-
61
-
-
60849118097
-
A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development
-
Jimeno, A.; Feldmann, G.; Suárez-Gauthier, A.; Rasheed, Z.; Solomon, A.; Zou, G.M.; Rubio-Viqueira, B.; García-García, E.; López-Ríos, F.; Matsui, W. et al. A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development. Mol. Cancer Ther. 2009, 8, 310-314.
-
(2009)
Mol. Cancer Ther
, vol.8
, pp. 310-314
-
-
Jimeno, A.1
Feldmann, G.2
Suárez-Gauthier, A.3
Rasheed, Z.4
Solomon, A.5
Zou, G.M.6
Rubio-Viqueira, B.7
García-García, E.8
López-Ríos, F.9
Matsui, W.10
-
62
-
-
80053568372
-
Notch post-translationally regulates β-catenin protein in stem and progenitor cells
-
doi:10.1038/ncb2313
-
Kwon, C.; Cheng, P.; King, I.N.; Andersen, P.; Shenje, L.; Nigam, V.; Srivastava, D. Notch post-translationally regulates β-catenin protein in stem and progenitor cells. Nat. Cell Biol. 2011, doi:10.1038/ncb2313.
-
(2011)
Nat. Cell Biol
-
-
Kwon, C.1
Cheng, P.2
King, I.N.3
Andersen, P.4
Shenje, L.5
Nigam, V.6
Srivastava, D.7
-
63
-
-
55949116428
-
Blockade of SDF-1/CXCR4 signalling inhibits pancreatic cancer progression in vitro via inactivation of canonical Wnt pathway
-
Wang, Z.; Ma, Q.; Liu, Q.; Yu, H.; Zhao, L.; Shen, S.; Yao, J. Blockade of SDF-1/CXCR4 signalling inhibits pancreatic cancer progression in vitro via inactivation of canonical Wnt pathway. Br. J. Cancer 2008, 99, 1695-1703.
-
(2008)
Br. J. Cancer
, vol.99
, pp. 1695-1703
-
-
Wang, Z.1
Ma, Q.2
Liu, Q.3
Yu, H.4
Zhao, L.5
Shen, S.6
Yao, J.7
-
64
-
-
78650194206
-
CXCL12-CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: A novel target for therapy
-
Singh, S.; Srivastava, S.K.; Bhardwaj, A.; Owen, L.B.; Singh, A.P. CXCL12-CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: A novel target for therapy. Br. J. Cancer 2010, 103, 1671-1679.
-
(2010)
Br. J. Cancer
, vol.103
, pp. 1671-1679
-
-
Singh, S.1
Srivastava, S.K.2
Bhardwaj, A.3
Owen, L.B.4
Singh, A.P.5
-
65
-
-
36349006961
-
Development and characterization of gemcitabine-resistant pancreatic tumor cells
-
Shah, A.N.; Summy, J.M.; Zhang, J.; Park, S.I.; Parikh, N.U.; Gallick, G.E. Development and characterization of gemcitabine-resistant pancreatic tumor cells. Ann. Surg. Oncol. 2007, 14, 3629-3637.
-
(2007)
Ann. Surg. Oncol
, vol.14
, pp. 3629-3637
-
-
Shah, A.N.1
Summy, J.M.2
Zhang, J.3
Park, S.I.4
Parikh, N.U.5
Gallick, G.E.6
-
66
-
-
0034908762
-
Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway
-
Danilkovitch-Miagkova, A.; Miagkov, A.; Skeel, A.; Nakaigawa, N.; Zbar, B.; Leonard, E.J. Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway. Mol. Cell Biol. 2001, 21, 5857-5868.
-
(2001)
Mol. Cell Biol
, vol.21
, pp. 5857-5868
-
-
Danilkovitch-Miagkova, A.1
Miagkov, A.2
Skeel, A.3
Nakaigawa, N.4
Zbar, B.5
Leonard, E.J.6
|