Disruption of IκB kinase (IKK)-mediated RelA serine 536 phosphorylation sensitizes human multiple myeloma cells to histone deacetylase (HDAC) inhibitors

Journal of Biological Chemistry

Volumn 286, Issue 39, 2011, Pages 34036-34050

  Dai, Yun ^a   Chen, Shuang ^a   Wang, Li ^a   Pei, Xin Yan ^a   Funk, Vanessa L ^a   Kramer, Lora B ^a   Dent, Paul ^b   Grant, Steven ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING DOMAIN; COMPLEX FORMATIONS; DNA BINDING; HEMATOPOIETIC CELL; HISTONE DEACETYLASE INHIBITOR; HISTONE DEACETYLASES; HYPERACETYLATION; IMMUNOBLOTS; INHIBITORY PEPTIDES; MULTIPLE MYELOMA; NUCLEAR TRANSLOCATIONS; PHOSPHORYLATION SITES; POST-TRANSLATIONAL MODIFICATIONS; SELECTIVE INHIBITORS; SIGNALING CASCADES; TRANSACTIVATION ACTIVITY;

ACETYLATION; AMINO ACIDS; BINDING SITES; CELL DEATH; ENZYMES; PROTEINS;

PHOSPHORYLATION;

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; [5 (4 FLUOROPHENYL) 2 UREIDO]THIOPHENE 3 CARBOXAMIDE; ALANINE; ASPARTYLARGINYLGLUTAMINYLISOLEUCYLLYSYLISOLEUCYLTRYPTOPHANYLPHENYLALANYLLYSYLASPARAGINYLARGINYLARGINYLMETHIONYLLYSYLTRYPTOPHANYLLYSYLLYSYLGLUTAMINYLLEUCYLARGINYLARGINYLPROLYLSERYLASPARTYLARGINYLGLUTAMYLLEUCYLSERYLGLUTAMATE; ASPARTYLARGINYLGLUTAMINYLISOLEUCYLLYSYLISOLEUCYLTRYPTOPHANYLPHENYLALANYLLYSYLASPARAGINYLARGINYLARGINYLMETHIONYLLYSYLTRYPTOPHANYLLYSYLLYSYLTHREONYLALANYLLEUCYLASPARTYLTRYPTOPHANYLSERYLTRYPTOPHANYLLEUCYLGLUTAMINYLTHREONYLGLUTAMATE; CALYCULIN A; HISTONE DEACETYLASE INHIBITOR; I KAPPA B KINASE; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE GAMMA; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PANOBINOSTAT; PEPTIDE DERIVATIVE; SERINE; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; VORINOSTAT; HDAC1 PROTEIN, HUMAN; HISTONE DEACETYLASE 1; HYDROXAMIC ACID; RELA PROTEIN, HUMAN; TUMOR PROTEIN;

ACETYLATION; APOPTOSIS; ARTICLE; BINDING SITE; CELL DEATH; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EXPOSURE; DRUG POTENTIATION; DRUG SENSITIVITY; DRUG SENSITIZATION; DRUG TARGETING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MONOTHERAPY; MULTIPLE MYELOMA; MUTANT; MYELOMA CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; TRANSACTIVATION; ACTIVE TRANSPORT; AMINO ACID SUBSTITUTION; CELL NUCLEUS; DRUG ANTAGONISM; DRUG EFFECT; GENE SILENCING; GENETICS; METABOLISM; MISSENSE MUTATION; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

ACETYLATION; ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SUBSTITUTION; APOPTOSIS; CELL LINE, TUMOR; CELL NUCLEUS; GENE KNOCKDOWN TECHNIQUES; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE INHIBITORS; HUMANS; HYDROXAMIC ACIDS; I-KAPPA B KINASE; MULTIPLE MYELOMA; MUTATION, MISSENSE; NEOPLASM PROTEINS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TRANSCRIPTIONAL ACTIVATION;

EID: 80053192714     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.284216     Document Type: Article

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