Facing the gem-dialkyl effect in enzyme inhibitor design: Preparation of homocycloleucine-based azadipeptide nitriles

Chemistry - A European Journal

Volumn 17, Issue 41, 2011, Pages 11419-11423

  Frizler, Maxim ^a,b   Lohr, Friederike ^a   Lülsdorff, Michael ^a   Gütschow, Michael ^a,b  

^a UNIVERSITY OF BONN   (Germany)

^b Biomedical Center   (Germany)

Author keywords

azapeptides; cathepsin K; drug design; enzymes; inhibitors

Indexed keywords

AZAPEPTIDES; DRUG DESIGN; ENZYME INHIBITORS; GEM-DIALKYL EFFECT; LEUCINE RESIDUES; SYNTHETIC ROUTES;

AMINO ACIDS; CORROSION INHIBITORS; ENZYMES;

CYANIDES;

CATHEPSIN K; DIPEPTIDE; ENZYME INHIBITOR; LEUCINE; NITRILE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; HYDROGEN BOND; SYNTHESIS;

CATHEPSIN K; DIPEPTIDES; DRUG DESIGN; ENZYME INHIBITORS; HYDROGEN BONDING; LEUCINE; MOLECULAR STRUCTURE; NITRILES;

EID: 80053188665     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201101350     Document Type: Article

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