Roles of the Candida aibicans mitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasis

Infection and Immunity

Volumn 66, Issue 6, 1998, Pages 2713-2721

  Csank, Csilla ^a,b,e   Schröppel, Klaus ^c   Leberer, Ekkehard ^a,d   Harcus, Doreen ^a   Mohamed, Othman ^a,d   Meloche, Sylvain ^b   Thomas, David Y ^a,d   Whiteway, Malcolm ^a,d  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^d MCGILL UNIVERSITY   (Canada)

^e GPC Biotech Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; CEK1 PROTEIN, CANDIDA ALBICANS; CPH1 PROTEIN, CANDIDA ALBICANS; CST20 PROTEIN, CANDIDA ALBICANS; FUNGAL PROTEIN; HST7 PROTEIN, CANDIDA ALBICANS; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN); RECOMBINANT PROTEIN;

ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CELL DIFFERENTIATION; COLONY FORMATION; ENZYME REGULATION; GENE DELETION; GENE DISRUPTION; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION; ANIMAL; BIOLOGICAL MODEL; CYTOLOGY; GENE DOSAGE; GENE REPRESSION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MORTALITY; MOUSE; MUTATION; PATHOGENICITY; SIGNAL TRANSDUCTION; VIRULENCE;

CANDIDA ALBICANS; SACCHAROMYCES CEREVISIAE;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CANDIDA ALBICANS; CANDIDIASIS; CELL DIFFERENTIATION; FUNGAL PROTEINS; GENE DOSAGE; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MUTATION; PROTEIN KINASES; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SUPPRESSION, GENETIC; TRANSCRIPTION FACTORS; VIRULENCE;

EID: 0031596819     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.6.2713-2721.1998     Document Type: Article

References (46)

1. Bertram, G., R. K. Swoboda, G. W. Gooday, N. A. Gow, and A. J. Brown. 1996. Structure and regulation of the Candida albicans ADH1 gene encoding an immunogenic alcohol dehydrogenase. Yeast 12:115-127.
2. Braun, B. R., and A. D. Johnson. 1997. Control of filament formation in Candida albicans by the transcriptional represser TUP1. Science 277:105-109.
3. Clark, K. L., P. J. Feldmann, D. Dignard, R. Larocque, A. J. Brown, M. G. Lee, D. Y. Thomas, and M. Whiteway. 1995. Constitutive activation of the Saccharomyccs cerevisiae mating response pathway by a MAP kinase kinase from Candida albicans. Mol. Gen. Genet. 249:609-621.
4. Cook, J. G., L. Bardwell, and J. Thorner. 1997. Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous-growth signalling pathway. Nature 390:85-88.
5. Csank, C., C. Makris, S. Meloche, K. Schröppel, M. Röllinghoff, D. Dignard, D. Y. Thomas, and M. Whiteway. 1997. Derepressed hyphal growth and reduced virulence in a VH1 family-related protein phosphatase mutant of the human pathogen Candida albicans. Mol. Biol. Cell 8:2539-2551.
6. Doi, K., A. Gartner, G. Ammerer, B. Errede, H. Shinkawa, K. Sugimoto, and K. Matsumoto. 1994. MSG5, a novel protein phosphatase, promotes adaptation to phcromone response in S. cerevisiae. EMBO J. 13:61-70.
7. Fidel, P., Jr., and J. D. Sobel. 1994. The role of cell-mediated immunity in candidiasis. Trends Microbiol. 2:202-206.
8. Fonzi, W. A., and M. Y. Irwin. 1993. Isogenic strain construction and gene mapping in Candida albicans. Genetics 134:717-728.
9. Gillum, A. M., E. Y. H. Tsay, and D. R. Kirsch. 1984. Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. colt pvrF mutations. Mol. Gen. Genet. 198:179-182.
10. Gimeno, C. J., P. O. Ljungdahl, C. A. Styles, and G. R. Fink. 1992. Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell 68:1077-1090.
11. Gow, N. A. 1994. Growth and guidance of the fungal hypha. Microbiology 140:3193-3205.
12. Gow, N. A., and G. W. Gooday. 1982. Growth kinetics and morphology of colonies of the filamentous form of Candida albicans. J. Gen. Microbiol. 128:2187-2194.
13. Gray, J. V., J. P. Ogas, Y. Kamada, M. Stone, D. E. Levin, and I. Herskowitz. 1997. A role for the Pkcl MAP kinase pathway of Saccharomyces cerevisiae in bud emergence and identification of a putative upstream regulator. EMBO J. 16:4924-4937.
14. Hube, B., D. Sanglard, F. C. Odds, D. Hess, M. Monod, W. Schafer, A. J. Brown, and N. A. Gow. 1997. Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence. Infect. Immun. 65:3529-3538.
15. Keyse, S. M. 1995. An emerging family of dual specificity MAP kinase phosphatases. Biochim. Biophys. Acta 1265:152-160.
16. Kohler, J. R., and G. R. Fink. 1996. Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal development. Proc. Natl. Acad. Sci. USA 93:13223-13228.
17. Kubler, K., H.-U. Mösch, S, Rupp, and M. P. Lisanti. 1997. Gpa2p, a G-protein subunit, regulates growth and pseudohyphal development in Saccharomvces cerevisiae via a cAMP-dependent mechanism. J. Biol. Chem. 272:20321-20323.
18. Kurtz, M. B., M. W. Cortelyou, and D. R. Kirsch. 1986. Integrative transformation of Candida albicans, using a cloned Candida ADE2 gene. Mol. Cell. Biol. 6:142-149.
19. Leberer, E., D. Harcus, I. D. Broadbent, K. L. Clark, D. Dignard, K. Ziegelbauer, A. Schmidt, N. A. Gow, A. J. Brown, and D. Y. Thomas. 1996. Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans. Proc. Natl. Acad. Sci. USA 93:13217-13222.
20. Leberer, E., D. Y. Thomas, and M. Whiteway. 1997. Pheromone signalling and polarized morphogenesis in yeast. Curr. Opin. Genet. Dev. 7:59-66.
21. Leberer, E., C. Wu, T. Leeuw, A. Fourest-Lieuvin, J. E. Segall, and D. Y. Thomas. 1997. Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase. EMBO J. 16:83-97.
22. Leberer, E., K. Ziegelbauer, A. Schmidt, D. Harcus, D. Dignard, J. Ash, L. Johnson, and D. Y. Thomas. 1997. Virulence and hyphal formation of Candida albicans require the Ste20p-like protein kinase CaCla4p. Curr. Biol. 7:539-546.
23. Lee, K. L., H. R. Buckley, and C. C. Campbell. 1975. An amino acid liquid synthetic medium for the development of mycelial and yeast forms of Candida albicans. Sabouraudia 13:148-153.
24. Liu, H., J. Kohler, and G. R. Fink. 1994. Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science 266:1723-1726.
25. Liu, H., C. A. Styles, and G. R. Fink. 1993. Elements of the yeast pheromone response pathway required for filamentous growth of diploids. Science 262: 1741-1744.
26. Lo, H.-J., J. R. Kohler, B. DiDomenico, D. Loebenberg, A. Cacciapuoti, and G. R. Fink. 1997. Nontilamcntous C. albicans mutants are avirulent. Cell 90:939-949.
27. Madhani, H. D., and G. R. Fink. 1997. Combinatorial control required for the specificity of yeast MAPK signaling. Science 275:1314-1317.
28. Madhani, H. D., C. A. Styles, and G. R. Fink. 1997. MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation. Cell 91:673-684.
29. Malathi, K., K. Ganesan, and A. Datta. 1994. Identification of a putative transcription factor in Candida albicans that can complement the mating defect of Saccharomyces cerevisiae ste 12 mutants. J. Biol. Chem. 269:22945-22951.
30. Mosch, H. U., R. L. Roberts, and G. R. Fink. 1996. Ras2 signals via the Cdc42/Ste20/mitogen-activated protein kinase module to induce filamentous growth in Saccliaromyces cerevisiae. Proc. Natl. Acad. Sci. USA 93:5352-5356.
31. Odds, F. C. 1988. Candida and candidosis: a review and bibliography, 2nd ed. Bailliere-Tindall. London, United Kingdom.
32. Odds, F. C. 1994. Pathogenesis of Candida infections. J. Am. Acad. Dermatol. 31:S2-S5.
33. Peter, M., A. M. Neiman, H. O. Park, M. van Lohuizen, and I. Herskowitz. 1996. Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast. EMBO J. 15:7046-7059.
34. Radford, D. R., S. J. Challacombe, and J. D. Walter. 1994. A scanning electronmicroscopy investigation of the structure of colonies of different morphologies produced by phenotypic switching of Candida albicans. J. Med. Microbiol. 40:416-423.
35. Roberts, R. L., and G. R. Fink. 1994. Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth. Genes Dev. 8:2974-2985.
36. Roberts, R. L., H. U. Mosch, and G. R. Fink. 1997. 14-3-3 proteins are essential for RAS/MAPK cascade signaling during pseudohyphal development in S. cerevisiae. Cell 89:1055-1065.
37. Robinson, M. J., and M. H. Cobb. 1997. Mitogen-activated protein kinase pathways. Curr. Opin. Cell. Biol. 9:180-186.
38. Rose, M. D., F. Winston, and P. Heiter. 1990. Methods in yeast genetics: a laboratory course manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
39. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
40. Sanglard, D., B. Hube, M. Monod, F. C. Odds, and N. A. Gow. 1997. A triple deletion of the secreted aspartyl proteinase genes SAP4, SAP5, and SAP6 of Candida albicans causes attenuated virulence. Infect. Immun. 65:3539-3546.
41. Slauch, J., R. Taylor, and S. Maloy. 1997. Survival in a cruel world: how Vibrio cholerae and Salmonella respond to an unwilling host. Genes Dev. 11:1761-1774.
42. Stoldt, V. R., A. Sonneborn, C. E. Leuker, and J. F. Ernst. 1997. Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi. EMBO J. 16:1982-1991.
43. Watanabe, Y., K. Irie, and K. Matsumoto. 1995. Yeast RLM1 encodes a scrum response factor-like protein that may function downstream of the Mpk1 (SH2) mitogen-activated protein kinase pathway. Mol. Cell. Biol. 15: 5740-5749.
44. Whiteway, M., D. Dignard, and D. Y. Thomas. 1992. Dominant negative selection of heterologous genes: isolation of Candida albicans genes that interfere with Saccharomyces cerevisiae mating factor-induced cell cycle arrest. Proc. Natl. Acad. Sci. USA 89:9410-9414.
45. Zarzov, P., C. Mazzoni, and C. Mann. 1996. The SLT2(MPK1) MAP kinase is activated during periods of polarized cell growth in yeast. EMBO J. 15:83-91.
46. Zhan, X. L., R. J. Deschenes, and K. L. Guan. 1997. Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharumyces cermsiae. Genes Dev. 11:1690-1702.