Differential requirement of IKK2 for CYLD-dependent representation of thymic and peripheral T-cell populations

European Journal of Immunology

Volumn 41, Issue 10, 2011, Pages 3054-3062

  Tsagaratou, Ageliki ^a,b   Grammenoudi, Sofia ^b   Mosialos, George ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING   (Greece)

Author keywords

CYLD; IKK2; NF B; T cells

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GENE PRODUCT; HERMES ANTIGEN; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; L SELECTIN; PROTEIN CYLD; PROTEIN IKK2; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL POPULATION; CONTROLLED STUDY; CYLD GENE; GENE INACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE; THYMUS; TUMOR SUPPRESSOR GENE; UBIQUITINATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYSTEINE ENDOPEPTIDASES; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLOW CYTOMETRY; I-KAPPA B KINASE; IMMUNOBLOTTING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICE, KNOCKOUT; NF-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; THYMUS GLAND;

EID: 80053141202     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201041160     Document Type: Article

References (28)

1. Berg, L. J. and Kang, J., Molecular determinants of TCR expression and selection. Curr. Opin. Immunol. 2001. 13: 232-241.
2. Palmer, E., Negative selection - clearing out the bad apples from the T-cell repertoire. Nat. Rev. Immunol. 2003. 3: 383-391.
3. Egerton, M., Scollay, R. and Shortman, K., Kinetics of mature T-cell development in the thymus. Proc. Natl. Acad. Sci. USA 1990. 87: 2579-2582.
4. Singer, A., Adoro, S. and Park, J. H., Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. Nat. Rev. Immunol. 2008. 8: 788-801.
5. Carpenter, A. C. and Bosselut, R., Decision checkpoints in the thymus. Nat. Immunol. 2008. 11: 666-673.
6. Rothenberg, E. V., Moore, J. E. and Yui, M. A., Launching the T-cell-lineage developmental programme. Nat. Rev. Immunol. 2008. 8: 9-21.
7. Starr, T. K., Jameson, S. C. and Hogquist, K. A., Positive and negative selection of T cells. Annu. Rev. Immunol. 2003. 21: 139-176.
8. Sun, S. C., CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes. Cell Death Differ. 2009, 17: 25-34.
9. Reiley, W. W., Zhang, M., Jin, W., Losiewicz, M., Donohue, K. B., Norbury, C. C. and Sun, S. C., Regulation of T cell development by the deubiquitinating enzyme CYLD. Nat. Immunol. 2006. 7: 411-417.
10. Lee, A. J., Zhou, X., Chang, M., Hunzeker, J., Bonneau, R. H., Zhou, D. and Sun, S. C., Regulation of natural killer T-cell development by deubiquitinase CYLD. EMBO J. 2010. 29: 1600-1612.
11. Reiley, W. W., Jin, W., Lee, A. J., Wright, A., Wu, X., Tewalt, E. F., Leonard, T. O. et al., Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses. J. Exp. Med. 2007. 204: 1475-1485.
12. Lee, A. J., Wu, X., Cheng, H., Zhou, X., Cheng, X. and Sun, S. C., CARMA1 regulation of regulatory T cell development involves modulation of interleukin-2 receptor signaling. J. Biol. Chem. 285: 15696-15703.
13. Tsagaratou, A., Trompouki, E., Grammenoudi, S., Kontoyiannis, D. L. and Mosialos, G., Thymocyte-specific truncation of the deubiquitinating domain of CYLD impairs positive selection in a NF-kappaB essential modulator-dependent manner. J. Immunol. 2010. 185: 2032-2043.
14. Matsuzawa, A., Tseng, P. H., Vallabhapurapu, S., Luo, J. L., Zhang, W., Wang, H., Vignali, D. A. et al., Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science 2008. 321: 663-668.
15. Yamamoto, M., Okamoto, T., Takeda, K., Sato, S., Sanjo, H., Uematsu, S., Saitoh, T. et al., Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat. Immunol. 2006. 7: 962-970.
16. Jimi, E., Strickland, I., Voll, R. E., Long, M. and Ghosh, S., Differential role of the transcription factor NF-kappaB in selection and survival of CD4+ and CD8+ thymocytes. Immunity 2008. 29: 523-537.
17. Rincon, M., Whitmarsh, A., Yang, D. D., Weiss, L., Derijard, B., Jayaraj, P., Davis, R. J. and Flavell, R. A., The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes. J. Exp. Med. 1998. 188: 1817-1830.
18. Pasparakis, M., Courtois, G., Hafner, M., Schmidt-Supprian, M., Nenci, A., Toksoy, A., Krampert, M. et al., TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature 2002. 417: 861-866.
19. Schmidt-Supprian, M., Courtois, G., Tian, J., Coyle, A. J., Israel, A., Rajewsky, K. and Pasparakis, M., Mature T cells depend on signaling through the IKK complex. Immunity 2003. 19: 377-389.
20. Bendelac, A., Matzinger, P., Seder, R. A., Paul, W. E. and Schwartz, R. H., Activation events during thymic selection. J. Exp. Med. 1992. 175: 731-742.
21. Azzam, H. S., Grinberg, A., Lui, K., Shen, H., Shores, E. W. and Love, P. E., CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J. Exp. Med. 1998. 188: 2301-2311.
22. Aliahmad, P. and Kaye, J., Development of all CD4 T lineages requires nuclear factor TOX. J. Exp. Med. 2008. 205: 245-256.
23. Albu, D. I., Feng, D., Bhattacharya, D., Jenkins, N. A., Copeland, N. G., Liu, P. and Avram, D., BCL11B is required for positive selection and survival of double-positive thymocytes. J. Exp. Med. 2007. 204: 3003-3015.
24. Tanchot, C., Le Campion, A., Martin, B., Leaument, S., Dautigny, N. and Lucas, B., Conversion of naive T cells to a memory-like phenotype in lymphopenic hosts is not related to a homeostatic mechanism that fills the peripheral naive T cell pool. J. Immunol. 2002. 168: 5042-5046.
25. Voehringer, D., Liang, H. E. and Locksley, R. M., Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice. J. Immunol. 2008. 180: 4742-4753.
26. Trompouki, E., Tsagaratou, A., Kosmidis, S. K., Dolle, P., Qian, J., Kontoyiannis, D. L., Cardoso, W. V. and Mosialos, G., Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturation. Neoplasia 2009. 11: 469-476.
27. Orban, P. C., Chui, D. and Marth, J. D., Tissue- and site-specific DNA recombination in transgenic mice. Proc. Natl. Acad. Sci. USA 1992. 89: 6861-6865.
28. Trompouki, E., Hatzivassiliou, E., Tsichritzis, T., Farmer, H., Ashworth, A. and Mosialos, G., CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. Nature 2003. 424: 793-796.