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Volumn 28, Issue 7, 2011, Pages 539-555

New targets and targeted drugs for the treatment of cancer: An outlook to pediatric oncology

Author keywords

Drug targets; Molecularly targeted therapy; Tumor stroma interactions

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ALEMTUZUMAB; AZACITIDINE; BEVACIZUMAB; CETUXIMAB; CRIZOTINIB; DASATINIB; DENILEUKIN DIFTITOX; ERLOTINIB; EVEROLIMUS; GEFITINIB; GEMTUZUMAB OZOGAMICIN; IBRITUMOMAB TIUXETAN; IMATINIB; LAPATINIB; NILOTINIB; NIMOTUZUMAB; PACLITAXEL; PANITUMUMAB; PAZOPANIB; RETINOIC ACID; RETINOID; RITUXIMAB; SORAFENIB; SUNITINIB; TEMOZOLOMIDE; TEMSIROLIMUS; TRASTUZUMAB; UNINDEXED DRUG; VORINOSTAT;

EID: 80053067837     PISSN: 08880018     EISSN: 15210669     Source Type: Journal    
DOI: 10.3109/08880018.2011.613094     Document Type: Review
Times cited : (12)

References (89)
  • 2
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-674.
    • (2011) Cell. , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 7
    • 0031903646 scopus 로고    scopus 로고
    • Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185(HER2/neu) monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment
    • Pegram MD, Lipton A, Hayes DF, et al. Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractoryto chemotherapy treatment. JClin Oncol. 1998;16:2659-2671. (Pubitemid 28363029)
    • (1998) Journal of Clinical Oncology , vol.16 , Issue.8 , pp. 2659-2671
    • Pegram, M.D.1    Lipton, A.2    Hayes, D.F.3    Weber, B.L.4    Baselga, J.M.5    Tripathy, D.6    Baly, D.7    Baughman, S.A.8    Twaddell, T.9    Glaspy, J.A.10    Slamon, D.J.11
  • 8
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial
    • Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010;376:687-697.
    • (2010) Lancet , vol.376 , pp. 687-697
    • Bang, Y.J.1    Van Cutsem, E.2    Feyereislova, A.3
  • 10
    • 79955751294 scopus 로고    scopus 로고
    • A phase II study of geftinib and irradiation in children with newly diagnosed brainstem gliomas: A report from the Pediatric Brain Tumor Consortium
    • Pollack IF, Stewart CF, Kocak M, et al. A phase II study of geftinib and irradiation in children with newly diagnosed brainstem gliomas: a report from the Pediatric Brain Tumor Consortium. Neuro Oncol. 2011;13:290-297.
    • (2011) Neuro Oncol. , vol.13 , pp. 290-297
    • Pollack, I.F.1    Stewart, C.F.2    Kocak, M.3
  • 11
    • 54449085941 scopus 로고    scopus 로고
    • Pediatric phase i and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: A Children's Oncology Group Phase i Consortium Study
    • Jakacki RI, Hamilton M, Gilbertson RJ, et al. Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: a Children's Oncology Group Phase I Consortium Study. J Clin Oncol. 2008;26:4921-4927.
    • (2008) J Clin Oncol. , vol.26 , pp. 4921-4927
    • Jakacki, R.I.1    Hamilton, M.2    Gilbertson, R.J.3
  • 12
    • 56549113680 scopus 로고    scopus 로고
    • A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: Updated efcacy and biomarker analyses
    • Cameron D, Casey M, Press M, et al. A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efcacy and biomarker analyses. Breast Cancer Res Treat. 2008;112:533-543.
    • (2008) Breast Cancer Res Treat. , vol.112 , pp. 533-543
    • Cameron, D.1    Casey, M.2    Press, M.3
  • 13
    • 42949112556 scopus 로고    scopus 로고
    • Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer
    • Lin NU, Carey LA, Liu MC, et al. Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol. 2008;26:1993-1999.
    • (2008) J Clin Oncol. , vol.26 , pp. 1993-1999
    • Lin, N.U.1    Carey, L.A.2    Liu, M.C.3
  • 14
    • 79952022309 scopus 로고    scopus 로고
    • EGFR gene copy number as a predictive biomarker for patients receiving tyrosine kinase inhibitor treatment: Asystematic review and meta-analysis in non-small-cell lung cancer
    • Dahabreh IJ, Linardou H, Kosmidis P, et al. EGFR gene copy number as a predictive biomarker for patients receiving tyrosine kinase inhibitor treatment: asystematic review and meta-analysis in non-small-cell lung cancer. Ann Oncol. 2011;22:545-552.
    • (2011) Ann Oncol. , vol.22 , pp. 545-552
    • Dahabreh, I.J.1    Linardou, H.2    Kosmidis, P.3
  • 15
    • 69949162760 scopus 로고    scopus 로고
    • Geftinib or carboplatin-paclitaxel in pulmonary adenocar-cinoma
    • Mok TS, Wu YL, Tongprasert SY, et al. Geftinib or carboplatin-paclitaxel in pulmonary adenocar-cinoma. N Engl J Med. 2009;361:947-957.
    • (2009) N Engl J Med. , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Tongprasert, S.Y.3
  • 16
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required forpanitumumab efcacy in patients with metastatic colorectal cancer
    • Amado RG, Wolf M, Peeters M, et al. Wild-type KRAS is required forpanitumumab efcacy in patients with metastatic colorectal cancer. J Clin Oncol. 2008;26:1626-1634.
    • (2008) J Clin Oncol. , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 19
    • 67650472798 scopus 로고    scopus 로고
    • Sunitinib treatment in pediatric patients with advanced GIST following failure of imatinib
    • Janeway KA, Albritton KH, Van Den Abbeele AD, et al. Sunitinib treatment in pediatric patients with advanced GIST following failure of imatinib. Pediatr Blood Cancer. 2009;52:767-771.
    • (2009) Pediatr Blood Cancer. , vol.52 , pp. 767-771
    • Janeway, K.A.1    Albritton, K.H.2    Van Den Abbeele, A.D.3
  • 20
    • 0036645057 scopus 로고    scopus 로고
    • Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: Evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors
    • Lokker NA, Sullivan CM, Hollenbach SJ, et al. Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Cancer Res. 2002;62:3729-3735. (Pubitemid 34728854)
    • (2002) Cancer Research , vol.62 , Issue.13 , pp. 3729-3735
    • Lokker, N.A.1    Sullivan, C.M.2    Hollenbach, S.J.3    Israel, M.A.4    Giese, N.A.5
  • 24
    • 0037114829 scopus 로고    scopus 로고
    • Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML study group Ulm
    • DOI 10.1182/blood-2002-05-1440
    • Frohling S, Schlenk RF, Breitruck J, et al. Prognostic signifcance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm. Blood. 2002;100:4372-4380. (Pubitemid 35434129)
    • (2002) Blood , vol.100 , Issue.13 , pp. 4372-4380
    • Frohling, S.1    Schlenk, R.F.2    Breitruck, J.3    Benner, A.4    Kreitmeier, S.5    Tobis, K.6    Dohner, H.7    Dohner, K.8
  • 25
    • 79953124734 scopus 로고    scopus 로고
    • Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in frst relapse
    • Levis M, Ravandi F, Wang ES, et al. Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in frst relapse. Blood. 2011;117:3294-3301.
    • (2011) Blood. , vol.117 , pp. 3294-3301
    • Levis, M.1    Ravandi, F.2    Wang, E.S.3
  • 26
    • 0030695913 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts
    • DOI 10.1074/jbc.272.49.30822
    • Toretsky JA, Kalebic T, Blakesley V, et al. Te insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fbroblasts. J Biol Chem. 1997;272:30822-30827. (Pubitemid 27527522)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.49 , pp. 30822-30827
    • Toretsky, J.A.1    Kalebic, T.2    Blakesley, V.3    LeRoith, D.4    Helman, L.J.5
  • 27
    • 80053062871 scopus 로고    scopus 로고
    • Preliminary efcacy of the anti-insulin like growth factor type 1 receptor antibody fgitumumab in patients with refractory Ewing sarcoma
    • in press
    • Juergens H, Daw NC, Geoerger B, et al. Preliminary efcacy of the anti-insulin like growth factor type 1 receptor antibody fgitumumab in patients with refractory Ewing sarcoma. J Clin Oncol. 2011; in press.
    • (2011) J Clin Oncol.
    • Juergens, H.1    Daw, N.C.2    Geoerger, B.3
  • 28
    • 70349733112 scopus 로고    scopus 로고
    • Mutation-independent anaplastic lymphoma kinase overexpres-sion in poor prognosis neuroblastoma patients
    • Passoni L, Longo L, Collini P, et al. Mutation-independent anaplastic lymphoma kinase overexpres-sion in poor prognosis neuroblastoma patients. Cancer Res. 2009;69:7338-7346.
    • (2009) Cancer Res. , vol.69 , pp. 7338-7346
    • Passoni, L.1    Longo, L.2    Collini, P.3
  • 29
    • 77953725855 scopus 로고    scopus 로고
    • Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia
    • Kantarjian H, Shah NP, Hochhaus A, et al. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. 2010;362:2260-2270.
    • (2010) N Engl J Med. , vol.362 , pp. 2260-2270
    • Kantarjian, H.1    Shah, N.P.2    Hochhaus, A.3
  • 30
    • 77953691179 scopus 로고    scopus 로고
    • Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia
    • Saglio G, Kim DW, Issaragrisil S, et al. Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia. N Engl J Med. 2010;362:2251-2259.
    • (2010) N Engl J Med. , vol.362 , pp. 2251-2259
    • Saglio, G.1    Kim, D.W.2    Issaragrisil, S.3
  • 32
    • 70449711127 scopus 로고    scopus 로고
    • Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: A children's oncology group study
    • Schultz KR, Bowman WP, Aledo A, et al. Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group study. J Clin Oncol. 2009;27:5175-5181.
    • (2009) J Clin Oncol. , vol.27 , pp. 5175-5181
    • Schultz, K.R.1    Bowman, W.P.2    Aledo, A.3
  • 33
    • 79952319155 scopus 로고    scopus 로고
    • Pediatric phase i trial and pharmacokinetic study of dasatinib: A report from the children's oncology group phase i consortium
    • Aplenc R, Blaney SM, Strauss LC, et al. Pediatric phase I trial and pharmacokinetic study of dasatinib: a report from the children's oncology group phase I consortium. J Clin Oncol. 2011;29:839-844.
    • (2011) J Clin Oncol. , vol.29 , pp. 839-844
    • Aplenc, R.1    Blaney, S.M.2    Strauss, L.C.3
  • 34
    • 70350721795 scopus 로고    scopus 로고
    • Activity of tyrosine kinase inhibitor Dasatinib in neuroblastoma cells in vitro and in orthotopic mouse model
    • Vitali R, Mancini C, Cesi V, et al. Activity of tyrosine kinase inhibitor Dasatinib in neuroblastoma cells in vitro and in orthotopic mouse model. Int J Cancer. 2009;125:2547-2555.
    • (2009) Int J Cancer. , vol.125 , pp. 2547-2555
    • Vitali, R.1    Mancini, C.2    Cesi, V.3
  • 35
    • 34047265691 scopus 로고    scopus 로고
    • Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on Src kinase for survival
    • DOI 10.1158/0008-5472.CAN-06-3469
    • Shor AC, Keschman EA, Lee FY, et al. Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and inducesapoptosis in bone sarcoma cellsdependent on SRC kinase for survival. Cancer Res. 2007;67:2800-2808. (Pubitemid 46548969)
    • (2007) Cancer Research , vol.67 , Issue.6 , pp. 2800-2808
    • Shor, A.C.1    Keschman, E.A.2    Lee, F.Y.3    Muro-Cacho, C.4    Letson, G.D.5    Trent, J.C.6    Pledger, W.J.7    Jove, R.8
  • 36
    • 77950786695 scopus 로고    scopus 로고
    • Favourableoutcome of patientswithchildhoodacute promyelocytic leukaemia after treatment with reduced cumulative anthracycline doses
    • Creutzig U, Zimmermann M, Dworzak M, et al. Favourableoutcome of patientswithchildhoodacute promyelocytic leukaemia after treatment with reduced cumulative anthracycline doses. Br J Haema-tol. 2010;149:399-409.
    • (2010) Br J Haema-tol. , vol.149 , pp. 399-409
    • Creutzig, U.1    Zimmermann, M.2    Dworzak, M.3
  • 37
    • 0021947043 scopus 로고
    • Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma
    • DOI 10.1038/313404a0
    • Tiele CJ, Reynolds CP, Israel MA. Decreased expression of N-myc precedes retinoic acid-induced morphological diferentiation of human neuroblastoma. Nature. 1985;313:404-406. (Pubitemid 15198727)
    • (1985) Nature , vol.313 , Issue.6001 , pp. 404-406
    • Thiele, C.J.1    Reynolds, C.P.2    Israel, M.A.3
  • 38
    • 61449106633 scopus 로고    scopus 로고
    • Long-term results for children with high-risk neurob-lastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: A children's oncology group study
    • Matthay KK, Reynolds CP, Seeger RC, et al. Long-term results for children with high-risk neurob-lastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children's oncology group study. J Clin Oncol. 2009;27:1007-1013.
    • (2009) J Clin Oncol. , vol.27 , pp. 1007-1013
    • Matthay, K.K.1    Reynolds, C.P.2    Seeger, R.C.3
  • 40
    • 33947305184 scopus 로고    scopus 로고
    • Phase II window study of R115777 (Zarnesta) in untreated juvenile myelomonocytic leukemia (JMML): A Children's Oncology Group study
    • Castleberry RP, Loh ML, Jayaprakash N, et al. Phase II window study of R115777 (Zarnesta) in untreated juvenile myelomonocytic leukemia (JMML): a Children's Oncology Group study. Blood. 2005;106:727a.
    • (2005) Blood. , vol.106
    • Castleberry, R.P.1    Loh, M.L.2    Jayaprakash, N.3
  • 41
    • 0031465906 scopus 로고    scopus 로고
    • Proliferation of human malignant astrocytomas is dependent on Ras activation
    • Guha A, Feldkamp MM, Lau N, et al. Proliferation of human malignant astrocytomas is dependent on Ras activation. Oncogene. 1997;15:2755-2765. (Pubitemid 28004565)
    • (1997) Oncogene , vol.15 , Issue.23 , pp. 2755-2765
    • Guha, A.1    Feldkamp, M.M.2    Lau, N.3    Boss, G.4    Pawson, A.5
  • 42
    • 79955773922 scopus 로고    scopus 로고
    • Phase II trial of tipifarnib and radiation in children with newly diagnosed difuse intrinsic pontine gliomas
    • Haas-Kogan DA, Banerjee A, Poussaint TY, et al. Phase II trial of tipifarnib and radiation in children with newly diagnosed difuse intrinsic pontine gliomas. Neuro Oncol. 2011;13:298-306.
    • (2011) Neuro Oncol. , vol.13 , pp. 298-306
    • Haas-Kogan, D.A.1    Banerjee, A.2    Poussaint, T.Y.3
  • 43
    • 0035904334 scopus 로고    scopus 로고
    • Rapamycin may prevent Post-Transplant Lymphoma
    • Garber K. Rapamycin may prevent post-transplant lymphoma. J Natl Cancer Inst. 2001;93:1519. (Pubitemid 32998478)
    • (2001) Journal of the National Cancer Institute , vol.93 , Issue.20 , pp. 1519
    • Garber, K.1
  • 45
    • 48649107474 scopus 로고    scopus 로고
    • Efcacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
    • Motzer RJ, Escudier B, Oudard S, et al. Efcacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet. 2008;372:449-456.
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 46
    • 68949102180 scopus 로고    scopus 로고
    • Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma
    • Hess G, Herbrecht R, Romaguera J, et al. Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma. J Clin Oncol. 2009;27:3822-3829.
    • (2009) J Clin Oncol. , vol.27 , pp. 3822-3829
    • Hess, G.1    Herbrecht, R.2    Romaguera, J.3
  • 48
    • 79951816312 scopus 로고    scopus 로고
    • Combination mTOR and IGF-1R inhibition: Phase i trial of everolimus and fgitumumab in patients with advanced sarcomas and other solid tumors
    • Quek R, Wang Q, Morgan JA, et al. Combination mTOR and IGF-1R inhibition: phase I trial of everolimus and fgitumumab in patients with advanced sarcomas and other solid tumors. Clin Cancer Res. 2011;17:871-879.
    • (2011) Clin Cancer Res. , vol.17 , pp. 871-879
    • Quek, R.1    Wang, Q.2    Morgan, J.A.3
  • 50
    • 58149336788 scopus 로고    scopus 로고
    • Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
    • Real PJ, Tosello V, Palomero T, et al. Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Nat Med. 2009;15:50-58.
    • (2009) Nat Med. , vol.15 , pp. 50-58
    • Real, P.J.1    Tosello, V.2    Palomero, T.3
  • 51
    • 34548592412 scopus 로고    scopus 로고
    • A phase i clinical trial of the notch inhibitor MK-0752 in patients with T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) and other leukemias
    • ASCO Annual Meeting Proceedings
    • Deangelo DJ, Stone RM, Silverman LB, et al. A phase I clinical trial of the notch inhibitor MK-0752 in patients with T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) and other leukemias. J Clin Oncol. 2006;ASCO Annual Meeting Proceedings 24(18S).
    • (2006) J Clin Oncol. , vol.24 S , Issue.18
    • Deangelo, D.J.1    Stone, R.M.2    Silverman, L.B.3
  • 52
    • 77951171023 scopus 로고    scopus 로고
    • Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance
    • Bonapace L, Bornhauser BC, Schmitz M, et al. Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance. J Clin Invest. 2010;120:1310-1323.
    • (2010) J Clin Invest. , vol.120 , pp. 1310-1323
    • Bonapace, L.1    Bornhauser, B.C.2    Schmitz, M.3
  • 55
    • 67650447477 scopus 로고    scopus 로고
    • A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma
    • Erkizan HV, Kong Y, Merchant M, et al. A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma. Nat Med. 2009;15:750-756.
    • (2009) Nat Med. , vol.15 , pp. 750-756
    • Erkizan, H.V.1    Kong, Y.2    Merchant, M.3
  • 56
    • 77449149373 scopus 로고    scopus 로고
    • Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia
    • Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia. J Clin Oncol. 2010;28:562-569.
    • (2010) J Clin Oncol. , vol.28 , pp. 562-569
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3
  • 59
    • 63849095591 scopus 로고    scopus 로고
    • Intriguing response to azacitidine in a patient with juvenile myelomonocytic leukemia and monosomy 7
    • Furlan I, Batz C, Flotho C, et al. Intriguing response to azacitidine in a patient with juvenile myelomonocytic leukemia and monosomy 7. Blood. 2009;113:2867-2868.
    • (2009) Blood. , vol.113 , pp. 2867-2868
    • Furlan, I.1    Batz, C.2    Flotho, C.3
  • 61
    • 50449086728 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
    • San Miguel JF, Schlag R, Khuageva NK, et al. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N Engl J Med. 2008;359:906-917.
    • (2008) N Engl J Med. , vol.359 , pp. 906-917
    • San Miguel, J.F.1    Schlag, R.2    Khuageva, N.K.3
  • 63
    • 77955108100 scopus 로고    scopus 로고
    • Phase i study of bortezomib combined with chemotherapy in children with relapsed childhood acute lymphoblastic leukemia (ALL): Areport from the therapeutic advances in childhood leukemia (TACL) consortium
    • Messinger Y, Gaynon P, Raetz E, et al. Phase I study of bortezomib combined with chemotherapy in children with relapsed childhood acute lymphoblastic leukemia (ALL): areport from the therapeutic advances in childhood leukemia (TACL) consortium. Pediatr Blood Cancer. 2010;55:254-259.
    • (2010) Pediatr Blood Cancer. , vol.55 , pp. 254-259
    • Messinger, Y.1    Gaynon, P.2    Raetz, E.3
  • 64
    • 77957200763 scopus 로고    scopus 로고
    • Long-term outcome of patients in the LNH-98.5 trial the frst randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: A study by the Groupe d'Etudes des Lymphomes de l'Adulte
    • Coifer B, Tieblemont C, Van Den Neste E, et al. Long-term outcome of patients in the LNH-98.5 trial, the frst randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l'Adulte. Blood. 2010;116:2040-2045.
    • (2010) Blood. , vol.116 , pp. 2040-2045
    • Coifer, B.1    Tieblemont, C.2    Van Den Neste, E.3
  • 65
    • 33646004738 scopus 로고    scopus 로고
    • CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis difuse large-B-cell lym-phoma: A randomised controlled trial by the MabTera International Trial (MInT) Group
    • Pfreundschuh M, Trumper L, Osterborg A, et al. CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis difuse large-B-cell lym-phoma: a randomised controlled trial by the MabTera International Trial (MInT) Group. Lancet Oncol. 2006;7:379-391.
    • (2006) Lancet Oncol. , vol.7 , pp. 379-391
    • Pfreundschuh, M.1    Trumper, L.2    Osterborg, A.3
  • 67
    • 77955504706 scopus 로고    scopus 로고
    • Phase II window study on rituximab in newly diagnosed pediatric mature B-cell non-Hodgkin's lymphoma and Burkitt leukemia
    • Meinhardt A, Burkhardt B, Zimmermann M, et al. Phase II window study on rituximab in newly diagnosed pediatric mature B-cell non-Hodgkin's lymphoma and Burkitt leukemia. J Clin Oncol. 2010;28:3115-3121.
    • (2010) J Clin Oncol. , vol.28 , pp. 3115-3121
    • Meinhardt, A.1    Burkhardt, B.2    Zimmermann, M.3
  • 68
    • 67649908324 scopus 로고    scopus 로고
    • A Phase II study of SGN-30 (anti-CD30 mAb) in Hodgkin lymphoma or systemic anaplastic large cell lymphoma
    • Forero-Torres A, Leonard JP, Younes A, et al. A Phase II study of SGN-30 (anti-CD30 mAb) in Hodgkin lymphoma or systemic anaplastic large cell lymphoma. Br J Haematol. 2009;146:171-179.
    • (2009) Br J Haematol. , vol.146 , pp. 171-179
    • Forero-Torres, A.1    Leonard, J.P.2    Younes, A.3
  • 69
    • 70349662167 scopus 로고    scopus 로고
    • A phase II study of SGN-30 in cutaneous anaplastic large cell lymphoma and related lymphoproliferative disorders
    • Duvic M, Reddy SA, Pinter-Brown L, et al. A phase II study of SGN-30 in cutaneous anaplastic large cell lymphoma and related lymphoproliferative disorders. Clin Cancer Res. 2009;15:6217-6224.
    • (2009) Clin Cancer Res. , vol.15 , pp. 6217-6224
    • Duvic, M.1    Reddy, S.A.2    Pinter-Brown, L.3
  • 70
    • 77957341503 scopus 로고    scopus 로고
    • Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma
    • Yu AL, Gilman AL, Ozkaynak MF, et al. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. N Engl J Med. 2010;363:1324-1334.
    • (2010) N Engl J Med. , vol.363 , pp. 1324-1334
    • Yu, A.L.1    Gilman, A.L.2    Ozkaynak, M.F.3
  • 71
    • 55949118446 scopus 로고    scopus 로고
    • Phase III trial of consolidation therapy with yttrium-90-ibritumomab tiuxetan compared with no additional therapy after frst remission in advanced fol-licular lymphoma
    • Morschhauser F, Radford J, Van Hoof A, et al. Phase III trial of consolidation therapy with yttrium-90-ibritumomab tiuxetan compared with no additional therapy after frst remission in advanced fol-licular lymphoma. J Clin Oncol. 2008;26:5156-5164.
    • (2008) J Clin Oncol. , vol.26 , pp. 5156-5164
    • Morschhauser, F.1    Radford, J.2    Van Hoof, A.3
  • 72
    • 76449104667 scopus 로고    scopus 로고
    • Salvage treatment for children with refractory frst or second relapse of acute myeloid leukaemia with gemtuzumab ozogamicin: Results of a phase II study
    • Zwaan CM, Reinhardt D, Zimmerman M, et al. Salvage treatment for children with refractory frst or second relapse of acute myeloid leukaemia with gemtuzumab ozogamicin: results of a phase II study. Br J Haematol. 2010;148:768-776.
    • (2010) Br J Haematol. , vol.148 , pp. 768-776
    • Zwaan, C.M.1    Reinhardt, D.2    Zimmerman, M.3
  • 73
    • 49649120397 scopus 로고    scopus 로고
    • Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
    • Bargou R, Leo E, Zugmaier G, et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science. 2008;321:974-977.
    • (2008) Science. , vol.321 , pp. 974-977
    • Bargou, R.1    Leo, E.2    Zugmaier, G.3
  • 74
    • 79959312575 scopus 로고    scopus 로고
    • Targeted therapy with the T-cell-engaging antibody blina-tumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
    • Topp MS, Kufer P, Gokbuget N, et al. Targeted therapy with the T-cell-engaging antibody blina-tumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J Clin Oncol. 2011;29:2493-2498.
    • (2011) J Clin Oncol. , vol.29 , pp. 2493-2498
    • Topp, M.S.1    Kufer, P.2    Gokbuget, N.3
  • 75
    • 78651290248 scopus 로고    scopus 로고
    • Complete remission after blinatumomab-induced donor T-cell activation in three pediatric patients with post-transplant relapsed acute lymphoblastic leukemia
    • Handgretinger R, Zugmaier G, Henze G, et al. Complete remission after blinatumomab-induced donor T-cell activation in three pediatric patients with post-transplant relapsed acute lymphoblastic leukemia. Leukemia. 2011;25:181-184.
    • (2011) Leukemia. , vol.25 , pp. 181-184
    • Handgretinger, R.1    Zugmaier, G.2    Henze, G.3
  • 78
    • 79951984402 scopus 로고    scopus 로고
    • Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme
    • Lai A, Tran A, Nghiemphu PL, et al. Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. J Clin Oncol. 2011;29:142-148.
    • (2011) J Clin Oncol. , vol.29 , pp. 142-148
    • Lai, A.1    Tran, A.2    Nghiemphu, P.L.3
  • 81
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008;359:378-390.
    • (2008) N Engl J Med. , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 82
    • 84856343533 scopus 로고    scopus 로고
    • A phase II trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: An Italian Sarcoma Group study
    • Epub ahead of print]
    • Grignani G, Palmerini E, Dileo P, et al. A phase II trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: an Italian Sarcoma Group study. Ann Oncol. 2011 [Epub ahead of print].
    • (2011) Ann Oncol.
    • Grignani, G.1    Palmerini, E.2    Dileo, P.3
  • 84
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
    • Sternberg CN, Davis ID, Mardiak J, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol. 2010;28:1061-1068.
    • (2010) J Clin Oncol. , vol.28 , pp. 1061-1068
    • Sternberg, C.N.1    Davis, I.D.2    Mardiak, J.3
  • 85
    • 80053089275 scopus 로고    scopus 로고
    • Cilengitide in patients with recurrent glioblastoma: The results of NABTC 03-02, a phase II trial with measures of treatment delivery
    • Epub ahead of print]
    • Gilbert MR, Kuhn J, Lamborn KR, et al. Cilengitide in patients with recurrent glioblastoma: the results of NABTC 03-02, a phase II trial with measures of treatment delivery. J Neurooncol. 2011 [Epub ahead of print].
    • (2011) J Neurooncol.
    • Gilbert, M.R.1    Kuhn, J.2    Lamborn, K.R.3
  • 87
    • 77950495095 scopus 로고    scopus 로고
    • Skin toxicity evaluation protocol with panitumumab (STEPP), a phase II, open-label, randomized trial evaluating the impact of a pre-Emptive Skin treatment regimen on skin toxicities and quality of life in patients with metastatic colorectal cancer
    • Lacouture ME, Mitchell EP, Piperdi B, et al. Skin toxicity evaluation protocol with panitumumab (STEPP), a phase II, open-label, randomized trial evaluating the impact of a pre-Emptive Skin treatment regimen on skin toxicities and quality of life in patients with metastatic colorectal cancer. J Clin Oncol. 2010;28:1351-1357.
    • (2010) J Clin Oncol. , vol.28 , pp. 1351-1357
    • Lacouture, M.E.1    Mitchell, E.P.2    Piperdi, B.3
  • 88
    • 78650694719 scopus 로고    scopus 로고
    • First-cycle rash and survival in patients with advanced non-small-cell lung cancer receiving cetuximab in combination with frst-line chemotherapy: A subgroup analysis of data from the FLEX phase 3 study
    • Gatzemeier U, von Pawel J, Vynnychenko I, et al. First-cycle rash and survival in patients with advanced non-small-cell lung cancer receiving cetuximab in combination with frst-line chemotherapy: a subgroup analysis of data from the FLEX phase 3 study. Lancet Oncol. 2011;12:30-37.
    • (2011) Lancet Oncol. , vol.12 , pp. 30-37
    • Gatzemeier, U.1    Von Pawel, J.2    Vynnychenko, I.3
  • 89
    • 77949894217 scopus 로고    scopus 로고
    • Clinical course of advanced non-small-cell lung cancer patients experiencing hypertension during treatment with bevacizumab in combination with carbo-platin and paclitaxel on ECOG 4599
    • Dahlberg SE, Sandler AB, Brahmer JR, et al. Clinical course of advanced non-small-cell lung cancer patients experiencing hypertension during treatment with bevacizumab in combination with carbo-platin and paclitaxel on ECOG 4599. J Clin Oncol. 2010;28:949-954.
    • (2010) J Clin Oncol. , vol.28 , pp. 949-954
    • Dahlberg, S.E.1    Sandler, A.B.2    Brahmer, J.R.3


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