GW501516, a PPARδ agonist, ameliorates tubulointerstitial inflammation in proteinuric kidney disease via inhibition of TAK1-NFκB pathway in mice

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Yang, Xu ^a,b   Kume, Shinji ^a   Tanaka, Yuki ^a   Isshiki, Keiji ^a   Araki, Shin ichi ^a   Chin Kanasaki, Masami ^a   Sugimoto, Toshiro ^a   Koya, Daisuke ^c   Haneda, Masakazu ^d   Sugaya, Takeshi ^e   Li, Detian ^b   Han, Ping ^b   Nishio, Yoshihiko ^a   Kashiwagi, Atsunori ^a   Maegawa, Hiroshi ^a   Uzu, Takashi ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b CHINA MEDICAL UNIVERSITY   (China)

^c KANAZAWA MEDICAL UNIVERSITY   (Japan)

^d ASAHIKAWA MEDICAL COLLEGE   (Japan)

^e ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

[2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; ALBUMIN; FATTY ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA; MAP KINASE KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; SMALL INTERFERING RNA; THIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWNSTREAM PROCESSING; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; GENE EXPRESSION; IN VITRO STUDY; INTERSTITIAL NEPHRITIS; KIDNEY DISEASE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; MACROPHAGE; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PROTEINURIA; RENAL PROTECTION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CHROMATIN IMMUNOPRECIPITATION; DRUG EFFECT; DRUG POTENTIATION; GENETICS; IMMUNOBLOTTING; METABOLISM; POLYMERASE CHAIN REACTION;

MUS;

ANIMALS; CHEMOKINE CCL2; CHROMATIN IMMUNOPRECIPITATION; IMMUNOBLOTTING; MALE; MAP KINASE KINASE KINASES; MICE; MICE, INBRED C57BL; NEPHRITIS, INTERSTITIAL; NF-KAPPA B; POLYMERASE CHAIN REACTION; PPAR DELTA; PROTEINURIA; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; THIAZOLES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80053064710     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025271     Document Type: Article

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