Probing essential nucleobase functional groups in aptamers and deoxyribozymes by nucleotide analogue interference mapping of DNA

Journal of the American Chemical Society

Volumn 133, Issue 38, 2011, Pages 14888-14891

  Wachowius, Falk ^a   Höbartner, Claudia ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMERS; CATALYTIC CORE; DEOXYRIBOZYMES; DNA APTAMERS; HIGH-THROUGHPUT; INACTIVE VARIANTS; INTERFERENCE EFFECTS; INTERFERENCE MAPPING; LIGAND BINDING; NON-ENZYMATIC; NUCLEOBASES; NUCLEOTIDE ANALOGUES; OH GROUP; RIBONUCLEOTIDES; SOLID PHASE SYNTHESIS;

BINDING SITES; CHEMICAL ANALYSIS; FUNCTIONAL GROUPS; NUCLEOTIDES; RNA;

DNA;

APTAMER; DEOXYRIBOZYME; DNA; MAGNESIUM; NUCLEIC ACID BASE; RNA;

ARTICLE; CATALYSIS; DNA STRUCTURE; ENZYME ACTIVE SITE; GENE MAPPING; HIGH THROUGHPUT SCREENING; NUCLEOTIDE ANALOGUE INTERFERENCE MAPPING; SOLID PHASE SYNTHESIS;

APTAMERS, NUCLEOTIDE; DNA; DNA, CATALYTIC; GENE LIBRARY; NUCLEOTIDES; SOLID-PHASE SYNTHESIS TECHNIQUES;

EID: 80053059928     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja205894w     Document Type: Article

References (20)

1. Cochrane, J. C.; Strobel, S. A. Acc. Chem. Res. 2008, 41, 1027
2. Lilley, D. M. Biochem. Soc. Trans. 2011, 39, 641
3. Fedor, M. J.; Williamson, J. R. Nat. Rev. Mol. Cell Biol. 2005, 6, 399
4. Nowakowski, J.; Shim, P. J.; Prasad, G. S.; Stout, C. D.; Joyce, G. F. Nat. Struct. Biol. 1999, 6, 151
5. Peracchi, A.; Bonaccio, M.; Clerici, M. J. Mol. Biol. 2005, 352, 783
6. Zaborowska, Z.; Furste, J. P.; Erdmann, V. A.; Kurreck, J. J. Biol. Chem. 2002, 277, 40617
7. Wang, B.; Cao, L.; Chiuman, W.; Li, Y.; Xi, Z. Biochemistry 2010, 49, 7553
8. Merino, E. J.; Wilkinson, K. A.; Coughlan, J. L.; Weeks, K. M. J. Am. Chem. Soc. 2005, 127, 4223
9. Suydam, I. T.; Strobel, S. A. Methods Enzymol. 2009, 468, 3
10. Gish, G.; Eckstein, F. Science 1988, 240, 1520
11. Höbartner, C.; Kreutz, C.; Flecker, E.; Ottenschläger, E.; Pils, W.; Grubmayr, K.; Micura, R. Monatsh. Chem. 2003, 134, 851
12. Huizenga, D. E.; Szostak, J. W. Biochemistry 1995, 34, 656
13. Lin, C. H.; Patel, D. J. Chem. Biol. 1997, 4, 817
14. Coppins, R. L.; Silverman, S. K. Nat. Struct. Mol. Biol. 2004, 11, 270
15. Coppins, R. L.; Silverman, S. K. J. Am. Chem. Soc. 2005, 127, 2900
16. Wachowius, F.; Javadi-Zarnaghi, F.; Höbartner, C. Angew. Chem., Int. Ed. 2010, 49, 8504
17. Purtha, W. E.; Coppins, R. L.; Smalley, M. K.; Silverman, S. K. J. Am. Chem. Soc. 2005, 127, 13124
18. Thomas, J. M.; Perrin, D. M. J. Am. Chem. Soc. 2008, 130, 15467
19. Sekhon, G. S.; Sen, D. Biochemistry 2010, 49, 9072
20. Frederiksen, J. K.; Piccirilli, J. A. Methods 2009, 49, 146