Efficient and original microwave-assisted Suzuki-Miyaura cross-coupling reaction in the 4 H-pyrido[1,2-a ]pyrimidin-4-one series

Synthesis

Volumn , Issue 19, 2011, Pages 3115-3122

  Kabri, Youssef ^a   Crozet, Maxime D ^a   Szabo, Rémi ^a   Vanelle, Patrice ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

Author keywords

4 H pyrido 1,2 a pyrimidin 4 one; arylation; cross coupling; palladium; Suzuki reaction

Indexed keywords

4 H -PYRIDO[1,2- A ]PYRIMIDIN-4-ONE; ARYLATIONS; BORONIC ACID; COUPLING PROCESS; CROSS-COUPLINGS; EFFICIENT SYNTHESIS; ELECTRON-RICH; GOOD YIELD; MICROWAVE-ASSISTED; NEW SERIES; PYRIMIDIN-4-ONES; SUZUKI REACTION; SUZUKI-MIYAURA CROSS-COUPLING REACTION;

PALLADIUM; SYNTHESIS (CHEMICAL);

MICROWAVE IRRADIATION;

(7 CHLORO 3 IODO 4 OXO 4H PYRIDO [1,2 A]PYRIMIDIN 2 YL)METHYL ACETIC ACID; (7 CHLORO 4 OXO 3 O TOLYL 4H PYRIDO [1,2 A]PYRIMIDIN 2 YL)METHYL ACETIC ACID; (7 CHLORO 4 OXO 3 PHENYL 4H PYRIDO [1,2 A]PYRIMIDIN 2 YL)METHYL ACETIC ACID; (7 CHLORO 4 OXO 3 STYRYL 4H PYRIDO [1,2 A]PYRIMIDIN 2 YL)METHYL ACETIC ACID; (7 CHLORO 4 OXO 4H PYRIDO [1,2 A]PYRIMIDIN 2 YL)METHYL ACETIC ACID; 4H PYRIDO [1,2 A]PYRIMIDIN 4 ONE; 7 CHLORO 2 (CHLOROMETHYL) 3 IODO 4H PYRIDO [1,2 A]PYRIMIDIN 4 ONE; 7 CHLORO 2 (CHLOROMETHYL) 4H PYRIDO [1,2 A]PYRIMIDIN 4 ONE; 7 CHLORO 2 (HYDROXYMETHYL) 3 (4 METHOXYPHENYL) 4H PYRIDO [1,2 A]PYRIMIDIN 4 ONE; [3 [3,5 BIS(TRIFLUOROMETHYL)PHENYL] 7 CHLORO 4 OXO 4H PYRIDO [1,2,A]PYRIMIDIN 2 YL]METHYL ACETIC ACID; [7 CHLORO 3 (3 NITROPHENYL) 4 OXO 4H PYRIDO [1,2 A]PYRIMIDIN 2 YL]METHYL ACETIC ACID; [7 CHLORO 3 (4 CHLOROPHENYL) 4 OXO 4H PYRIDO [1,2 A]PYRIMIDIN 2 YL]METHYL ACETIC ACID; [7 CHLORO 3 (4 FLUOROPHENYL) 4 OXO 4H PYRIDO [1,2 A]PYRIMIDIN 2 YL]METHYL ACETIC ACID; [7 CHLORO 3 (4 METHOXYPHENYL) 4 OXO 4H PYRIDO [1,2 A]PYRIMIDIN 2 YL]METHYL ACETIC ACID; [7 CHLORO 3 (4 METHYLSTYRYL) 4 OXO 4H PYRIDO [1,2 A]PYRIMIDIN 2 YL]METHYL ACETIC ACID; [7 CHLORO 3 (FURAN 2 YL) 4 OXO 4H PYRIDO [1,2 A]PYRIMIDIN 2 YL]METHYL ACETIC ACID; [7 CHLORO 3 (NAPHTHALEN 1 YL) 4 OXO 4H PYRIDO [1,2 A]PYRIMIDIN 2 YL]METHYL ACETIC ACID; [7 CHLORO 3 (PYRIDIN 3 YL) 4 OXO 4H PYRIDO [1,2 A]PYRIMIDIN 2 YL]METHYL ACETIC ACID; [7 CHLORO 3 (PYRIDIN 4 YL) 4 OXO 4H PYRIDO [1,2 A]PYRIMIDIN 2 YL]METHYL ACETIC ACID; [7 CHLORO 4 OXO 3 (3,4,5 TRIMETHOXYPHENYL) 4H PYRIDO [1,2 A]PYRIMIDIN 2 YL]METHYL ACETIC ACID; [7 CHLORO 4 OXO 3 [3 (TRIFLUOROMETHYL)PHENYL] 4H PYRIDO [1,2 A]PYRIMIDIN 2 YL]METHYL ACETIC ACID; [7 CHLORO 4 OXO 3 [4 (TRIFLUOROMETHYL)STYRYL] 4H PYRIDO [1,2 A]PYRIMIDIN 2 YL]METHYL ACETIC ACID; BORONIC ACID DERIVATIVE; PHOSPHORIC ACID; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ARYLATION; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; DRUG ACETYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON TRANSPORT; HECK REACTION; HYDROLYSIS; MELTING POINT; MICROWAVE IRRADIATION; PROTON NUCLEAR MAGNETIC RESONANCE; SUZUKI REACTION;

EID: 80053053146     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0030-1260197     Document Type: Article

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