Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist

Behavioural Brain Research

Volumn 225, Issue 2, 2011, Pages 491-497

  Vijayanathan, Veena ^a   Gulinello, Maria ^a   Ali, Nafeeza ^a   Cole, Peter D ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Cerebrospinal fluid; Dextromethorphan; Homocysteic acid; Homocysteine; Homocysteine sulfinic acid; Methotrexate

Indexed keywords

DEXTROMETHORPHAN; EXCITOTOXIN; FOLIC ACID; GLUTAMIC ACID; HOMOCYSTEINE; METHOTREXATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CEREBROSPINAL FLUID ANALYSIS; CEREBROSPINAL FLUID LEVEL; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG MECHANISM; MALE; MENTAL TASK; NEUROTOXICITY; NONHUMAN; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; RECOGNITION; SPATIAL MEMORY;

ANIMALS; COGNITION DISORDERS; DEXTROMETHORPHAN; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID ANTAGONISTS; FOLIC ACID; GLUTAMIC ACID; HOMOCYSTEINE; HUMANS; INJECTIONS, SPINAL; MALE; MEMORY DISORDERS; METHOTREXATE; RATS; RATS, LONG-EVANS; RECOGNITION (PSYCHOLOGY);

EID: 80052970915     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2011.08.006     Document Type: Article

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