Intrathecal methotrexate induces focal cognitive deficits and increases cerebrospinal fluid homocysteine

Pharmacology Biochemistry and Behavior

Volumn 95, Issue 4, 2010, Pages 428-433

  Li, Yan ^a   Vijayanathan, Veena ^a   Gulinello, Maria ^a   Cole, Peter D ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Acute lymphoblastic leukemia; Cytokines; Folate; Homocysteine; Interleukin 6; Intrathecal injection; Methotrexate

Indexed keywords

FOLIC ACID; HOMOCYSTEINE; METHOTREXATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CEREBROSPINAL FLUID LEVEL; COGNITIVE DEFECT; CONTROLLED STUDY; FOLIC ACID BLOOD LEVEL; HYPERHOMOCYSTEINEMIA; MALE; MEMORY DISORDER; MOTOR COORDINATION; NEUROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SPATIAL MEMORY;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BEHAVIOR, ANIMAL; CISTERNA MAGNA; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; FOLIC ACID; FOLIC ACID ANTAGONISTS; HOMOCYSTEINE; INFLAMMATION MEDIATORS; INJECTIONS, SPINAL; MALE; MEMORY DISORDERS; METHOTREXATE; MOTOR ACTIVITY; NEUROPSYCHOLOGICAL TESTS; PSYCHOMOTOR PERFORMANCE; RATS; RATS, LONG-EVANS; RECOGNITION (PSYCHOLOGY); TIME FACTORS;

ANIMALIA; RODENTIA;

EID: 77952544767     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2010.03.003     Document Type: Article

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