Estimation of Michaelis-Menten constant of efflux transporter considering asymmetric permeability

International Journal of Pharmaceutics

Volumn 418, Issue 2, 2011, Pages 161-167

  Sugano, Kiyohiko ^a   Shirasaka, Yoshiyuki ^b,c   Yamashita, Shinji ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b SETSUNAN UNIVERSITY   (Japan)

^c KANAZAWA UNIVERSITY   (Japan)

Author keywords

Asymmetric; Efflux; Mechanistic model; Passive diffusion; Transporter

Indexed keywords

CARRIER PROTEIN; GLYCOPROTEIN P; VINBLASTINE;

APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; COMPARTMENT MODEL; CONCENTRATION RESPONSE; CONCEPTUAL FRAMEWORK; CYTOSOL; DRUG TRANSPORT; EPITHELIUM CELL; MICHAELIS CONSTANT; PRIORITY JOURNAL; STEADY STATE;

CELL MEMBRANE PERMEABILITY; COMPUTER SIMULATION; KINETICS; MEMBRANE TRANSPORT PROTEINS; P-GLYCOPROTEIN; PERMEABILITY;

EID: 80052966686     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.03.059     Document Type: Article

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