Novel C1q assay reveals a clinically relevant subset of human leukocyte antigen antibodies independent of immunoglobulin G strength on single antigen beads

Human Immunology

Volumn 72, Issue 10, 2011, Pages 849-858

  Chen, G ^a   Sequeira, F ^a   Tyan, D B ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antibody mediated rejection; Complement; Donor specific antibodies; HLA antibodies; Transplantation

Indexed keywords

COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C1Q ANTIBODY; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M;

ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; BINDING ASSAY; CONTROLLED STUDY; GRAFT FAILURE; GRAFT REJECTION; HLA SYSTEM; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SEROCONVERSION;

ANTIBODY SPECIFICITY; BIOLOGICAL MARKERS; COMPLEMENT C1Q; GRAFT REJECTION; HEART TRANSPLANTATION; HLA ANTIGENS; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOSORBENT TECHNIQUES; ISOANTIBODIES; KIDNEY TRANSPLANTATION; LUMINESCENT MEASUREMENTS; PROGNOSIS; PROTEIN BINDING; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 80052963404     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2011.07.001     Document Type: Article

References (31)

1. Patel R., Terasaki P.I. Significance of the positive crossmatch test in kidney transplantation. N Engl J Med 1969, 280:735-739.
2. Couzi L., Araujo C., Guidicelli G., Bachelet T., Moreau K., Morel D., et al. Interpretation of positive flow cytometric crossmatch in the era of the single-antigen bead assay. Transplantation 2011, 91:527-535.
3. Smith J.D., Hamour I.M., Banner N.R., Rose M.L. C4d fixing, Luminex binding antibodies-a new tool for prediction of graft failure after heart transplantation. Am J Transplant 2007, 7:2809-2815.
4. Wahrmann M., Exner M., Haidbauer B., Schillinger M., Regele H., Körmöczi G., et al. [C4d]FlowPRA screening-A specific assay for selective detection of complement-activating anti-HLA alloantibodies. Hum Immunol 2005, 66:526-534.
5. Wahrmann M., Bartel G., Exner M., Regele H., Körmöczi G.F., Fischer G.F., et al. Clinical relevance of preformed C4d-fixing and non-C4d-fixing HLA single antigen reactivity in renal allograft recipients. Transpl Int 2009, 22:982-989.
6. Colvin R.B. Dimensions of antibody-mediated rejection. Am J Transplant 2010, 10:1509-1510.
7. Böhmig G.A., Exner M., Watschinger B., Wenter C., Wahrmann M., Osterreicher C., et al. C4d deposits in renal allografts are associated with inferior graft outcome. Transplant Proc 2001, 33:1151-1152.
8. Zhang Q., Liang L.W., Gjertson D.W., Lassman C., Wilkinson A.H., Kendrick E., et al. Development of posttransplant antidonor HLA antibodies is associated with acute humoral rejection and early graft dysfunction. Transplantation 2005, 79:591-598.
9. Worthington J.E., McEwen A., McWilliam L.J., Picton M.L., Martin S. Association between C4d staining in renal transplant biopsies, production of donor-specific HLA antibodies, and graft outcome. Transplantation 2007, 83:398-403.
10. Salama A.D., Delikouras A., Pusey C.D., Cook H.T., Bhangal G., Lechler R.I., et al. Transplant accommodation in highly sensitized patients: a potential role for Bcl-xL and alloantibody. Am J Transplant 2001, 1:260-269.
11. Koch C.A., Khalpey Z.I., Platt J.L. Accommodation: preventing injury in transplantation and disease. J Immunol 2004, 172:5143-5148.
12. Lepin E.J., Reed E. Complement-independent mechanisms of antigraft antibodies in transplant arteriosclerosis and accommodation. Curr Opin Organ Transplant [review] 2004, 9:10-15.
13. Wu G.W., Kobashigawa J.A., Fishbein M.C., Patel J.K., Kittleson M.M., Reed E.F., et al. Asymptomatic antibody-mediated rejection after heart transplantation predicts poor outcomes. J Heart Lung Transplant 2009, 28:417-422.
14. Lefaucheur C., Loupy A., Hill G.S., Andrade J., Nochy D., Antoine C., et al. Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation. J Am Soc Nephrol 2010, 21:1398-1406.
15. Zachary A.A., Sholander J.T., Houp J.A., Leffell M.S. Using real data for a virtual crossmatch. Hum Immunol 2009, 70:574-579.
16. Alexandre G.P.J., Squifflet J.P., De Bruyère M., Latinne D., Reding R., Gianello P., et al. Present experiences in a series of 26 ABO-incompatible living donor renal allografts. Transplant Proc 1987, 19:4538-4542.
17. Bray R.A., Gebel H.M. Strategies for human leukocyte antigen antibody detection. Curr Opin Organ Transplant 2009, 14:392-397.
18. Imai N., Nishi S., Alchi B., Ueno M., Fukase S., Arakawa M., et al. Immunohistochemical evidence of activated lectin pathway in kidney allografts with peritubular capillary C4d deposition. Nephrol Dial Transplant 2006, 21:2589-2595.
19. Riethmüller S., Ferrari-Lacraz S., Müller M.K., Raptis D.A., Hadaya K., Rüsi B., et al. Donor-specific antibody levels and three generations of crossmatches to predict antibody-mediated rejection in kidney transplantation. Transplantation 2010, 90:160-167.
20. Sahu A., Lambris J.D. Complement inhibitors: a resurgent concept in anti-inflammatory therapeutics. J Immunopharmacol 2000, 49:133-148.
21. Chin C., Chen G., Sequeria F., Berry G., Siehr S., Bernstein D., et al. Clinical usefulness of a novel C1q assay to detect immunoglobulin G antibodies capable of fixing complement in sensitized pediatric heart transplant patients. J Heart Lung Transplant 2011, 30:158-163.
22. Yabu J.M., Higgins J.P., Chen G., Sequeira F., Busque S., Tyan D.B. C1q-fixing human leukocyte antigen antibodies are specific for predicting transplant glomerulopathy and late graft failure after kidney transplantation. Transplantation 2011, 91:342-347.
23. Colvin R.B., Smith R.N. Antibody-mediated organ-allograft rejection. Nat Rev Immunol 2005, 5:807-817.
24. Wahrmann M., Exner M., Regele H., Derfler K., Körmöczi G.F., Lhotta K., et al. Flow cytometry based detection of HLA alloantibody mediated classical complement activation. J Immunol Methods 2003, 275:149-160.
25. Smith J.D., Fawson R.E., Balikrishnan M., Haj-Yahia S., Banner N.R., Robinson D., et al. Pre-transplant IgM non-HLA antibodies are an independent risk factor for graft survival following cardiac transplantation. Hum Immunol 2005, 66. S79-S.
26. Grothaus E.A., Flye M.W., Yunis E., Amos D.B. Human lymphocyte antigen reactivity modified by neuraminidase. Science 1971, 173:542-544.
27. Lublin D.M., Grumet F.C. Mechanisms of the CYNAP phenomenon: evidence in the Bw49/Bw50 model for epitopes with different spatial orientation of antibody. Hum Immunol 1982, 4:137-145.
28. Fuller T.C., Fuller A.A., Golden M., Rodey G.E. HLA alloantibodies and the mechanism of the antiglobulin-augmented lymphocytotoxicity procedure. Hum Immunol 1997, 56:94-105.
29. Cicciarelli J., Adamson R., Steinberg S., Browne B., Pitpitan B., Williams B., et al. Two cases of donor specific antibodies (DSA): one patient's DSA had IgG subclass 1 & 3 with graft failure, and the other patient had DSA IgG subclass 4 and the graft is functioning well. Hum Immunol [abstract] 2010, 71(Suppl 1):S5.
30. Cicciarelli J., Kasahara N., Pitpitan B., Helstab-Houston K., Hutchinson I., Shah T. IgG subclass antibodies in transplant recipient sera: an IgG subclass specific assay to determine the "good and bad" IgG immunoglobulins. Hum Immunol [abstract] 2009, 70:S103. 2009.
31. Cai J., Terasaki P.I. Post-transplantation antibody monitoring and HLA antibody epitope identification. Curr Opin Immunol 2008, 20:602-606.