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Solez K., Colvin R.B., Racusen L.C., Haas M., Sis B., Mengel M., Halloran P.F., Baldwin W., Banfi G., Collins A.B., et al. Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant 8 4 (2008) 753. Diagnostic categories of AMR have been updated.
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Banfi, G.9
Collins, A.B.10
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4
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33644766791
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The fate of C4d positive kidney allografts lacking histological signs of acute rejection
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This study showed that deposition of C4d with no morphologic evidence of active rejection served as a sign of on-going AMR, which benefits from antirejection therapy.
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Dickenmann M., Steiger J., Descoeudres B., Mihatsch M., and Nickeleit V. The fate of C4d positive kidney allografts lacking histological signs of acute rejection. Clin Nephrol 65 3 (2006) 173. This study showed that deposition of C4d with no morphologic evidence of active rejection served as a sign of on-going AMR, which benefits from antirejection therapy.
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This large-scale multicenter prospective study not only demonstrated the association between graft failure and HLA and MICA antibodies but also showed the importance of antibody specificities and strength determination in predicting graft survival.
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Terasaki P.I., Ozawa M., and Castro R. Four-year follow-up of a prospective trial of HLA and MICA antibodies on kidney graft survival. Am J Transplant 7 2 (2007) 408. This large-scale multicenter prospective study not only demonstrated the association between graft failure and HLA and MICA antibodies but also showed the importance of antibody specificities and strength determination in predicting graft survival.
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Terasaki P.I., and Ozawa M. Predicting kidney graft failure by HLA antibodies: a prospective trial. Am J Transplant 4 3 (2004) 438
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Extremely high association between appearance of HLA antibodies and failure of kidney grafts in a five-year longitudinal study
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Mao Q., Terasaki P.I., Cai J., Briley K., Catrou P., Haisch C., and Rebellato L. Extremely high association between appearance of HLA antibodies and failure of kidney grafts in a five-year longitudinal study. Am J Transplant 7 4 (2007) 864
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Worthington J.E., McEwen A., McWilliam L.J., Picton M.L., and Martin S. Association between C4d staining in renal transplant biopsies, production of donor-specific HLA antibodies, and graft outcome. Transplantation 83 4 (2007) 398
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11
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33644672268
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This study showed a renal graft recipient who started to develop antibodies 22 years post-transplantation and experienced AMR at the 30th year.
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Weinstein D., Braun W.E., Cook D., McMahon J.T., Myles J., and Protiva D. Ultra-late antibody-mediated rejection 30 years after a living-related renal allograft. Am J Transplant 5 10 (2005) 2576. This study showed a renal graft recipient who started to develop antibodies 22 years post-transplantation and experienced AMR at the 30th year.
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Weinstein, D.1
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12
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Pei R., Lee J.H., Shih N.J., Chen M., and Terasaki P.I. Single human leukocyte antigen flow cytometry beads for accurate identification of human leukocyte antigen antibody specificities. Transplantation 75 1 (2003) 43
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Immunoglobulin M-to-immunoglobulin G anti-human leukocyte antigen class II antibody switching in cardiac transplant recipients is associated with an increased risk of cellular rejection and coronary artery disease
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Lietz K., John R., Burke E., Schuster M., Rogers T.B., Suciu-Foca N., Mancini D., and Itescu S. Immunoglobulin M-to-immunoglobulin G anti-human leukocyte antigen class II antibody switching in cardiac transplant recipients is associated with an increased risk of cellular rejection and coronary artery disease. Circulation 112 16 (2005) 2468
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Lietz, K.1
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McAlister C.C., Gao Z.H., McAlister V.C., Gupta R., Wright Jr. J.R., MacDonald A.S., and Peltekian K. Protective anti-donor IgM production after crossmatch positive liver-kidney transplantation. Liver Transpl 10 2 (2004) 315
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17
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Griffiths E.J., Nelson R.E., Dupont P.J., and Warrens A.N. Skewing of pretransplant anti-HLA class I antibodies of immunoglobulin G isotype solely toward immunoglobulin G1 subclass is associated with poorer renal allograft survival. Transplantation 77 11 (2004) 1771
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18
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Morales-Buenrostro LE, Terasaki PI, Marino-Vazquez LA, Lee J, El-Awar NR, Alberu J: "Natural" HLA antibodies found in non-alloimmunized healthy males. Transplantation, 2008, in press
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Morales-Buenrostro LE, Terasaki PI, Marino-Vazquez LA, Lee J, El-Awar NR, Alberu J: "Natural" HLA antibodies found in non-alloimmunized healthy males. Transplantation, 2008, in press. This study identified natural antibodies in the sera of normal males. These antibodies occur in up to 60% of un-immunized subjects, and the majority seems to target infrequent HLA antigens.
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19
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20
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Development of nondonor-specific HLA-DR antibodies in allograft recipients is associated with shared epitopes with mismatched donor DR antigens
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Cai J., Terasaki P.I., Mao Q., Pham T., El-Awar N., Lee J.H., and Rebellato L. Development of nondonor-specific HLA-DR antibodies in allograft recipients is associated with shared epitopes with mismatched donor DR antigens. Am J Transplant 6 12 (2006) 2821
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21
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This article introduced computer-program-based HLA matching, which is currently widely used in transplant community.
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Duquesnoy R.J. HLAMatchmaker: a molecularly based algorithm for histocompatibility determination. I. Description of the algorithm. Hum Immunol 63 5 (2002) 339. This article introduced computer-program-based HLA matching, which is currently widely used in transplant community.
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Duquesnoy R.J., and Marrari M. HLAMatchmaker: a molecularly based algorithm for histocompatibility determination. II. Verification of the algorithm and determination of the relative immunogenicity of amino acid triplet-defined epitopes. Hum Immunol 63 5 (2002) 353
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Mao Q., Terasaki P.I., Cai J., El-Awar N., and Rebellato L. Analysis of HLA class I specific antibodies in patients with failed allografts. Transplantation 83 1 (2007) 54
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Serum analysis after transplant nephrectomy reveals restricted antibody specificity patterns against structurally defined HLA class I mismatches
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Adeyi O.A., Girnita A.L., Howe J., Marrari M., Awadalla Y., Askar M., Martell J., Zeevi A., Shapiro R., Nalesnik M., et al. Serum analysis after transplant nephrectomy reveals restricted antibody specificity patterns against structurally defined HLA class I mismatches. Transpl Immunol 14 1 (2005) 53
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Adeyi, O.A.1
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27
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33847689387
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El-Awar N., Lee J.H., Tarsitani C., and Terasaki P.I. HLA class I epitopes: recognition of binding sites by mAbs or eluted alloantibody confirmed with single recombinant antigens. Hum Immunol 68 3 (2007) 170
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El-Awar, N.1
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50549104856
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Deng C.T., El-Awar N., Ozawa M., Cai J., Lachmann N., and Terasaki P.I. Human Leukocyte Antigen Class II DQ Alpha and Beta Epitopes Identified From Sera of Kidney Allograft Recipients. Transplantation 86 3 (2008) 452
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30
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49149105959
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This report summarized HLA class I and class II and MICA antibody epitopes which were identified by analyzing antibody profiles of allosera. Some of the epitopes were proved using absorption and elution techniques with single antigen cell lines.
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El-Awar N., Terasaki P.I., Cai J., Deng C.T., Ozawa M., and Nguyen A. Epitopes of the HLA-A, B, C, DR, DQ and MICA antigens. Clin Transpl 2007 (2008) 175. This report summarized HLA class I and class II and MICA antibody epitopes which were identified by analyzing antibody profiles of allosera. Some of the epitopes were proved using absorption and elution techniques with single antigen cell lines.
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El-Awar N.R., Akaza T., Terasaki P.I., and Nguyen A. Human leukocyte antigen class I epitopes: update to 103 total epitopes, including the C locus. Transplantation 84 4 (2007) 532
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Kaczmarek I., Deutsch M.A., Sadoni S., Brenner P., Schmauss D., Daebritz S.H., Weiss M., Meiser B.M., and Reichart B. Successful management of antibody-mediated cardiac allograft rejection with combined immunoadsorption and anti-CD20 monoclonal antibody treatment: case report and literature review. J Heart Lung Transplant 26 5 (2007) 511
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34
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The utility of splenectomy as rescue treatment for severe acute antibody mediated rejection
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Locke J.E., Zachary A.A., Haas M., Melancon J.K., Warren D.S., Simpkins C.E., Segev D.L., and Montgomery R.A. The utility of splenectomy as rescue treatment for severe acute antibody mediated rejection. Am J Transplant 7 4 (2007) 842
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Locke, J.E.1
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Nickeleit V., and Andreoni K. The classification and treatment of antibody-mediated renal allograft injury: where do we stand?. Kidney Int 71 1 (2007) 7
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Sun Q., Liu Z.H., Cheng Z., Chen J., Ji S., Zeng C., and Li L.S. Treatment of early mixed cellular and humoral renal allograft rejection with tacrolimus and mycophenolate mofetil. Kidney Int 71 1 (2007) 24
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Tyden G., Kumlien G., and Efvergren M. Present techniques for antibody removal. Transplantation 84 12 Suppl (2007) S27
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