Immunohistochemical evidence of activated lectin pathway in kidney allografts with peritubular capillary C4d deposition

Nephrology Dialysis Transplantation

Volumn 21, Issue 9, 2006, Pages 2589-2595

  Imai, Naofumi ^a,c   Nishi, Shinichi ^a   Alchi, Bassam ^a   Ueno, Mitsuhiro ^a   Fukase, Sachiko ^a   Arakawa, Masaaki ^a   Saito, Kazuhide ^b   Takahashi, Kota ^b   Gejyo, Fumitake ^a  

^a NIIGATA UNIVERSITY MEDICAL AND DENTAL HOSPITAL   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^c NONE   (Japan)

Author keywords

C4d; Ficolin; Kidney allograft; Lectin pathway; Peritubular capillary; Rejection

Indexed keywords

COMPLEMENT COMPONENT C4D; FICOLIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LECTIN; MANNOSE BINDING LECTIN; SERINE PROTEINASE; BIOLOGICAL MARKER; COMPLEMENT C4D; COMPLEMENT COMPONENT C4B; PEPTIDE FRAGMENT;

ADULT; ARTICLE; BLOOD GROUP ABO INCOMPATIBILITY; CONTROLLED STUDY; FEMALE; GENE LOCATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY ALLOGRAFT; KIDNEY ALLOGRAFT REJECTION; KIDNEY TUBULE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN ANALYSIS; TISSUE DISTRIBUTION; ALLOTRANSPLANTATION; BIOPSY; COMPARATIVE STUDY; FOLLOW UP; GRAFT REJECTION; IMMUNOLOGY; IN VITRO STUDY; KIDNEY TRANSPLANTATION; METABOLISM; PATHOLOGY; RETROSPECTIVE STUDY;

ADULT; BIOLOGICAL MARKERS; BIOPSY; COMPLEMENT C4B; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY TRANSPLANTATION; KIDNEY TUBULES; MALE; MANNOSE-BINDING LECTIN; PEPTIDE FRAGMENTS; RETROSPECTIVE STUDIES; TRANSPLANTATION, HOMOLOGOUS;

EID: 33750111840     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfl210     Document Type: Article

References (26)

1. Feucht HE, Felber E, Gokel MJ et al. Vascular deposition of complement-split products in kidney allografts with cell-mediated rejection. Clin Exp Immunol 1991; 86: 464-470
2. Behr TM, Feucht HE, Richter K et al. Detection of humoral rejection in human cardiac allografts by assessing the capillary deposition of complement fragment C4d in endomyocardial biopsies. J Heart Lung Transplant 1999; 18: 904-912
3. Magro CM, Pope Harman A, Klinger D et al. Use of C4d as a diagnostic adjunct in lung allograft biopsies. Am J Transplant 2003; 3: 1143-1154
4. Krukemeyer MG, Moeller J, Morawietz L et al. Description of B lymphocytes and plasma cells, complement, and chemokines/receptors in acute liver allograft rejection. Transplantation 2004; 78: 65-70
5. Nishi S, Imai N, Ito Y et al. Pathological study on the relationship between C4d, CD59 and C5b-9 in acute renal allograft rejection. Clin Transplant 2004; 18 [Suppl 11]: 18-23
6. Ikeda K, Sannoh T, Kawasaki N, Kawasaki T, Yamashina I. Serum lectin with known structure activates complement through the classical pathway. J Biol Chem 1987; 262: 7451-7454
7. Matsushita M, Fujita T. Ficolins and the lectin complement pathway. Immunol Rev 2001; 180: 78-85
8. Gemmell CH. A flow cytometric immunoassay to quantify adsorption of complement activation products (iC3b, C3d, SC5b-9) on artificial surfaces. J Biomed Mater Res 1997; 37: 474-480
9. Matsushita M, Takahashi A, Hatsuse H, Kawakami M, Fujita T. Human mannose-binding protein is identical to a component of Ra-reactive factor. Biochem Biophys Res Commun 1992; 183: 645-651
10. Sugimoto R, Yae Y, Akaiwa M et al. Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family. J Biol Chem 1998; 273: 20721-20727
11. Kilpatrick DC, Fujita T, Matsushita M. P35, an opsonic lectin of the ficolin family, in human blood from neonates, normal adults, and recurrent miscarriage patients. Immunol Lett 1999; 67: 109-112
12. Terai I, Kobayashi K, Matsushita M, Fujita T. Human serum mannose-binding lectin (MBL)-associated serine protease-1 (MASP-1): determination of levels in body fluids and identification of two forms in serum. Clin Exp Immunol 1997; 110: 317-323
13. Regele H, Exner M, Watschinger B et al. Endothelial C4d deposition is associated with inferior kidney allograft outcome independently of cellular rejection. Nephrol Dial Transplant 2001; 16: 2058-2066
14. Collins AB, Schneeberger EE, Pascual MA et al. Complement activation in acute humoral renal allograft rejection: Diagnostic significance of C4d deposits in peritubular capillaries. J Am Soc Nephrol 1999; 10: 2208-2214
15. Kluth-Pepper B, Schneeberger H, Lederer SR et al. Impact of humoral alloreactivity on the survival of renal allografts. Transplant Proc 1998; 30: 1772
16. Lederer SR, Kluth-Pepper B, Schneeberger H et al. Impact of humoral alloreactivity early after transplantation on the long-term survival of renal allografts. Kidney Int 2001; 59: 334-341
17. Bohmig GA, Exner M, Habicht A et al. Capillary C4d deposition in kidney allografts: A specific marker of alloantibody-dependent graft injury. J Am Soc Nephrol 2002; 13: 1091-1099
18. Nickeleit V, Zeiler M, Gudat F, Thiel G, Mihatsch MJ. Detection of the complement degradation product C4d in renal allografts: Diagnostic and therapeutic implications. J Am Soc Nephrol 2002; 13: 242-251
19. Kanetsuna Y, Yamaguchi Y, Horita S, Tanabe K, Toma H. C4d and/or immunoglobulins deposition in peritubular capillaries in perioperative graft biopsies in ABO-incompatible renal transplantation. Clin Transplant 2004; 18 [Suppl 11]: 13-17
20. Onitsuka S, Yamaguchi Y, Tanabe K, Takahashi K, Toma H. Peritubular capillary deposition of C4d complement fragment in ABO-incompatible renal transplantation with humoral rejection. Clin Transplant 1999; 13 [Suppl 1]: 33-37
21. Takahashi K. Accommodation in ABO-incompatible Kidney Transplantation. Elsevier, Amsterdam, The Netherlands 2004; 1-201
22. Matsushita M, Fujita T. The lectin pathway. Res Immunol 1996; 147: 115-118
23. Sund S, Hovig T, Reisaeter AV et al. Complement activation in early protocol kidney graft biopsies after living-donor transplantation. Transplantation 2003; 75: 1204-1213
24. Kawasaki N, Kawasaki T, Yamashina I. Isolation and characterization of a mannan-binding protein from human serum. J Biochem (Tokyo) 1983; 94: 937-947
25. Nickeleit V, Mihatsch MJ. Kidney transplants, antibodies and rejection: is C4d a magic marker? Nephrol Dial Transplant 2003; 18: 2232-2239
26. Mengel M, Bogers J, Bosmans JL et al. Incidence of C4d stain in protocol biopsies from renal allografts: Results from a multicenter trial. Am J Transplant 2005; 5: 1050-1056