Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation

Journal of the American Society of Nephrology

Volumn 21, Issue 8, 2010, Pages 1398-1407

  Lefaucheur, Carmen ^a   Loupy, Alexandre ^b   Hill, Gary S ^b   Andrade, Joao ^a   Nochy, Dominique ^b   Antoine, Corinne ^a   Gautreau, Chantal ^a   Charron, Dominique ^a   Glotz, Denis ^a   Suberbielle Boissel, Caroline ^a  

^a SAINT LOUIS HOSPITAL   (France)

^b HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIBODY;

ACUTE GRAFT REJECTION; ADULT; ARTICLE; FEMALE; GRAFT SURVIVAL; HUMAN; IMMUNIZATION; KIDNEY TRANSPLANTATION; LYMPHOCYTOTOXICITY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 77955607610     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2009101065     Document Type: Article

References (46)

1. Organ Procurement and Transplantation Network: Scientific registry of transplant recipients. Available at: http://optn.transplant.hrsa.gov/data/. Accessed May 21, 2010
2. Cho YW, Cecka J: Crossmatch tests: An analysis of UNOS data from 1991 to 2000. In: Clinical Transplants, edited by Terasaki P, Los Angeles: UCLA Immunogenetics Center, 2001, pp 237-246
3. Gebel HM, Bray RA, Nickerson P: Pre-transplant assessment of donor-reactive, HLA-specific antibodies in renal transplantation: contraindication vs. risk. Am J Transplant 3: 1488-1500, 2003
4. Rapport d'activité de prélèvement et de greffe. Agence de la Biomédecine. Available at: http://www.agence-biomedecine.fr/ uploads/document/RA-1-2-entier.pdf. Accessed May 26, 2010
5. Patel R, Terasaki PI: Significance of the positive crossmatch test in kidney transplantation. N Engl J Med 280: 735-739, 1969
6. Vlad G, Ho EK, Vasilescu ER, Colovai AI, Stokes MB, Markowitz GS, D'Agati VD, Cohen DJ, Ratner LE, Suciu-Foca N: Relevance of different antibody detection methods for the prediction of antibody-mediated rejection and deceased-donor kidney allograft survival. Hum Immunol 70: 589-594, 2009
7. Patel AM, Pancoska C, Mulgaonkar S, Weng FL: Renal transplantation in patients with pre-transplant donor-specific antibodies and negative flow cytometry crossmatches. Am J Transplant 7: 2371-2377, 2007 (Pubitemid 47347867)
8. Gupta A, Iveson V, Varagunam M, Bodger S, Sinnott P, Thuraisingham RC: Pretransplant donor-specific antibodies in cytotoxic negative crossmatch kidney transplants: Are they relevant? Transplantation 85: 1200-1204, 2008 (Pubitemid 351590199)
9. Amico P, Honger G, Mayr M, Steiger J, Hopfer H, Schaub S: Clinical relevance of pretransplant donor-specific HLA antibodies detected by single-antigen flow-beads. Transplantation 87: 1681-1688, 2009
10. Mizutani K, Terasaki P, Hamdani E, Esquenazi V, Rosen A, Miller J, Ozawa M: The importance of anti-HLA-specific antibody strength in monitoring kidney transplant patients. Am J Transplant 7: 1027-1031, 2007 (Pubitemid 46481199)
11. Lefaucheur C, Suberbielle-Boissel C, Hill GS, Nochy D, Andrade J, Antoine C, Gautreau C, Charron D, Glotz D: Clinical relevance of preformed HLA donor-specific antibodies in kidney transplantation. Am J Transplant 8: 324-331, 2008
12. Akalin E, Dinavahi R, Friedlander R, Ames S, de Boccardo G, Sehgal V, Schroppel B, Bhaskaran M, Lerner S, Fotino M, Murphy B, Bromberg JS: Addition of plasmapheresis decreases the incidence of acute antibody-mediated rejection in sensitized patients with strong donor-specific antibodies. Clin J Am Soc Nephrol 3: 1160-1167, 2008
13. Reinsmoen NL, Lai CH, Vo A, Cao K, Ong G, Naim M, Wang Q, Jordan SC: Acceptable donor-specific antibody levels allowing for successful deceased and living donor kidney transplantation after desensitization therapy. Transplantation 86: 820-825, 2008
14. Bray RA, Nolen JD, Larsen C, Pearson T, Newell KA, Kokko K, Guasch A, Tso P, Mendel JB, Gebel HM: Transplanting the highly sensitized patient: The Emory algorithm. Am J Transplant 6: 2307-2315, 2006 (Pubitemid 44359415)
15. Gloor J, Cosio F, Lager DJ, Stegall MD: The spectrum of antibody-mediated renal allograft injury: Implications for treatment. Am J Transplant 8: 1367-1373, 2008 (Pubitemid 351989489)
16. Kazatchkine MD, Kaveri SV: Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N Engl J Med 345: 747-755, 2001
17. Lefaucheur C, Nochy D, Andrade J, Verine J, Gautreau C, Charron D, Hill GS, Glotz D, Suberbielle-Boissel C: Comparison of combination plasmapheresis/IVIg/anti-CD20 versus high-dose IVIg in the treatment of antibody-mediated rejection. Am J Transplant 9: 1099-1107, 2009
18. Becker YT, Becker BN, Pirsch JD, Sollinger HW: Rituximab as treatment for refractory kidney transplant rejection. Am J Transplant 4: 996-1001, 2004
19. Faguer S, Kamar N, Guilbeaud-Frugier C, Fort M, Modesto A, Mari A, Ribes D, Cointault O, Lavayssiere L, Guitard J, Durand D, Rostaing L: Rituximab therapy for acute humoral rejection after kidney transplantation. Transplantation 83: 1277-1280, 2007 (Pubitemid 46743692)
20. Mulley WR, Hudson FJ, Tait BD, Skene AM, Dowling JP, Kerr PG, Kanellis J: A single low-fixed dose of rituximab to salvage renal transplants from refractory antibody-mediated rejection. Transplantation 87: 286-289, 2009
21. Lefaucheur C, Nochy D, Hill GS, Suberbielle-Boissel C, Antoine C, Charron D, Glotz D: Determinants of poor graft outcome in patients with antibody-mediated acute rejection. Am J Transplant 7: 832-841, 2007 (Pubitemid 46481179)
22. Everly MJ, Everly JJ, Arend LJ, Brailey P, Susskind B, Govil A, Rike A, Roy-Chaudhury P, Mogilishetty G, Alloway RR, Tevar A, Woodle ES: Reducing de novo donor-specific antibody levels during acute rejection diminishes renal allograft loss. Am J Transplant 9: 1063-1071, 2009
23. Gloor JM, Cosio FG, Rea DJ, Wadei HM, Winters JL, Moore SB, DeGoey SR, Lager DJ, Grande JP, Stegall MD: Histologic findings one year after positive crossmatch or ABO blood group incompatible living donor kidney transplantation. Am J Transplant 6: 1841-1847, 2006
24. Haas M, Montgomery RA, Segev DL, Rahman MH, Racusen LC, Bagnasco SM, Simpkins CE, Warren DS, Lepley D, Zachary AA, Kraus ES: Subclinical acute antibody-mediated rejection in positive crossmatch renal allografts. Am J Transplant 7: 576-585, 2007 (Pubitemid 46376440)
25. Loupy A, Suberbielle-Boissel C, Hill GS, Lefaucheur C, Anglicheau D, Zuber J, Martinez F, Thervet E, Mejean A, Charron D, van Huyen JP, Bruneval P, Legendre C, Nochy D: Outcome of subclinical antibody-mediated rejection in kidney transplant recipients with preformed donor-specific antibodies. Am J Transplant 9: 2561-2570, 2009
26. Mauiyyedi S, Pelle PD, Saidman S, Collins AB, Pascual M, Tolkoff-Rubin NE, Williams WW, Cosimi AA, Schneeberger EE, Colvin RB: Chronic humoral rejection: Identification of antibody-mediated chronic renal allograft rejection by C4d deposits in peritubular capillaries. J Am Soc Nephrol 12: 574-582, 2001 (Pubitemid 32180027)
27. Regele H, Bohmig GA, Habicht A, Gollowitzer D, Schillinger M, Rockenschaub S, Watschinger B, Kerjaschki D, Exner M: Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: A contribution of humoral immunity to chronic allograft rejection. J Am Soc Nephrol 13: 2371-2380, 2002 (Pubitemid 34925248)
28. Gloor JM, Sethi S, Stegall MD, Park WD, Moore SB, DeGoey S, Griffin MD, Larson TS, Cosio FG: Transplant glomerulopathy: Subclinical incidence and association with alloantibody. Am J Transplant 7: 2124-2132, 2007 (Pubitemid 47247042)
29. Nikaein A, Cherikh W, Nelson K, Baker T, Leffell S, Bow L, Crowe D, Connick K, Head MA, Kamoun M, Kimball P, Klohe E, Noreen H, Rebellato L, Sell T, Sullivan K, Land G: Organ Procurement and Transplantation Network/United Network for Organ Sharing Histocompatibility Committee collaborative study to evaluate prediction of cross-match results in highly sensitized patients. Transplantation 87: 557-562, 2009
30. Zangwill SD, Ellis TM, Zlotocha J, Jaquiss RD, Tweddell JS, Mussatto KA, Berger S: The virtual crossmatch: A screening tool for sensitized pediatric heart transplant recipients. Pediatr Transplant 10: 38-41, 2006
31. Zangwill S, Ellis T, Stendahl G, Zahn A, Berger S, Tweddell J: Practical application of the virtual crossmatch. Pediatr Transplant 11: 650-654, 2007
32. Zachary AA, Sholander JT, Houp JA, Leffell MS: Using real data for a virtual crossmatch. Hum Immunol 70: 574-579, 2009
33. Tambur AR, Ramon DS, Kaufman DB, Friedewald J, Luo X, Ho B, Skaro A, Caicedo J, Ladner D, Baker T, Fryer J, Gallon L, Miller J, Abecassis MM, Leventhal J: Perception versus reality? Virtual crossmatch - How to overcome some of the technical and logistic limitations. Am J Transplant 9: 1886-1893, 2009
34. Claas FH, Witvliet MD, Duquesnoy RJ, Persijn GG, Doxiadis II: The acceptable mismatch program as a fast tool for highly sensitized patients awaiting a cadaveric kidney transplantation: Short waiting time and excellent graft outcome. Transplantation 78: 190-193, 2004
35. Doxiadis II, Duquesnoy RJ, Claas FH: Extending options for highly sensitized patients to receive a suitable kidney graft. Curr Opin Immunol 17: 536-540, 2005
36. Glotz D, Antoine C, Julia P, Suberbielle-Boissel C, Boudjeltia S, Fraoui R, Hacen C, Duboust A, Bariety J: Desensitization and subsequent kidney transplantation of patients using intravenous immunoglobulins (IVIg). Am J Transplant 2: 758-760, 2002 (Pubitemid 36342618)
37. Jordan SC: Management of the highly HLA-sensitized patient: A novel role for intravenous gammaglobulin. Am J Transplant 2: 691-692, 2002
38. Jordan SC, Tyan D, Stablein D, McIntosh M, Rose S, Vo A, Toyoda M, Davis C, Shapiro R, Adey D, Milliner D, Graff R, Steiner R, Ciancio G, Sahney S, Light J: Evaluation of intravenous immunoglobulin as an agent to lower allosensitization and improve transplantation in highly sensitized adult patients with end-stage renal disease: Report of the NIH IG02 trial. J Am Soc Nephrol 15: 3256-3262, 2004
39. Stegall MD, Gloor J, Winters JL, Moore SB, Degoey S: A comparison of plasmapheresis versus high-dose IVIG desensitization in renal allograft recipients with high levels of donor specific alloantibody. Am J Transplant 6: 346-351, 2006 (Pubitemid 43382170)
40. Vo AA, Lukovsky M, Toyoda M, Wang J, Reinsmoen NL, Lai CH, Peng A, Villicana R, Jordan SC: Rituximab and intravenous immune globulin for desensitization during renal transplantation. N Engl J Med 359: 242-251, 2008 (Pubitemid 352008439)
41. Akalin E, Bromberg JS: Intravenous immunoglobulin induction treatment in flow cytometry cross-match-positive kidney transplant recipients. Hum Immunol 66: 359-363, 2005 (Pubitemid 40615790)
42. Akalin E, Ames S, Sehgal V, Murphy B, Bromberg JS, Fotino M, Friedlander R: Intravenous immunoglobulin and thymoglobulin induction treatment in immunologically high-risk kidney transplant recipients. Transplantation 79: 742, 2005 (Pubitemid 40463190)
43. Anglicheau D, Loupy A, Suberbielle C, Zuber J, Patey N, Noel LH, Cavalcanti R, Le Quintrec M, Audat F, Mejean A, Martinez F, Mamzer-Bruneel MF, Thervet E, Legendre C: Posttransplant prophylactic intravenous immunoglobulin in kidney transplant patients at high immunological risk: A pilot study. Am J Transplant 7: 1185-1192, 2007
44. Burns JM, Cornell LD, Perry DK, Pollinger HS, Gloor JM, Kremers WK, Gandhi MJ, Dean PG, Stegall MD: Alloantibody levels and acute humoral rejection early after positive crossmatch kidney transplantation. Am J Transplant 8: 2684-2694, 2008
45. Solez K, Colvin RB, Racusen LC, Haas M, Sis B, Mengel M, Halloran PF, Baldwin W, Banfi G, Collins AB, Cosio F, David DS, Drachenberg C, Einecke G, Fogo AB, Gibson IW, Glotz D, Iskandar SS, Kraus E, Lerut E, Mannon RB, Mihatsch M, Nankivell BJ, Nickeleit V, Papadimitriou JC, Randhawa P, Regele H, Renaudin K, Roberts I, Seron D, Smith RN, Valente M: Banff 07 classification of renal allograft pathology: Updates and future directions. Am J Transplant 8: 753-760, 2008 (Pubitemid 351347767)
46. Racusen LC, Colvin RB, Solez K, Mihatsch MJ, Halloran PF, Campbell PM, Cecka MJ, Cosyns JP, Demetris AJ, Fishbein MC, Fogo A, Furness P, Gibson IW, Glotz D, Hayry P, Hunsickern L, Kashgarian M, Kerman R, Magil AJ, Montgomery R, Morozumi K, Nickeleit V, Randhawa P, Regele H, Seron D, Seshan S, Sund S, Trpkov K: Antibody-mediated rejection criteria: An addition to the Banff 97 classification of renal allograft rejection. Am J Transplant 3: 708-714, 2003 (Pubitemid 36745243)