Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4506-4520

  Cosimelli, Barbara ^a   Simorini, Francesca ^b   Taliani, Sabrina ^b   La Motta, Concettina ^b   Da Settimo, Federico ^b   Severi, Elda ^a   Greco, Giovanni ^a   Novellino, Ettore ^a   Costa, Barbara ^b   Da Pozzo, Eleonora ^b   Bendinelli, Sara ^b   Martini, Claudia ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Five membered heterocycles; Mitochondrial permeability transition; Pharmacophore topological model; Tertiary amides; Translocator protein ligands

Indexed keywords

2 [2 (4 CHLOROPHENYL) 1,3 OXAZOL 4 YL] N,N DIPENTYLACETAMIDE; 2 [2 (4 FLUOROPHENYL) 1,3 OXAZOL 4 YL] N,N DIPENTYLACETAMIDE; 2 [2 (4 METHYLPHENYL) 1,3 OXAZOL 4 YL] N,N DIPENTYLACETAMIDE; ACETAMIDE DERIVATIVE; AMIDE; ANTINEOPLASTIC AGENT; ISOXAZOLE DERIVATIVE; N,N DIPENTYL 2 (2 PHENYL 1,3 OXAZOL 4 YL)ACETAMIDE; N,N DIPENTYL 2 (5 PHENYLISOXAZOL 3 YL)ACETAMIDE; OXADIAZOLE DERIVATIVE; OXAZOLACETAMIDE; OXAZOLE DERIVATIVE; PHENYL GROUP; PROTEIN; TRANSLOCATOR PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CELL PROLIFERATION; DRUG SYNTHESIS; GLIOBLASTOMA; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; PHARMACOPHORE;

AMIDES; CELL LINE, TUMOR; CYCLIZATION; GLIOBLASTOMA; HUMANS; MOLECULAR PROBES;

EID: 80052959678     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.07.025     Document Type: Article

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