PIGA (N,N-di-n-butyl-5-chloro-2-(4-chlorophenyl)indol-3-ylglyoxylamide), a new mitochondrial benzodiazepine-receptor ligand, induces apoptosis in C6 glioma cells

ChemBioChem

Volumn 6, Issue 6, 2005, Pages 1082-1088

  Chelli, Beatrice ^a   Rossi, Leonardo ^a   Da Pozzo, Eleonora ^a   Costa, Barbara ^a   Spinetti, Francesca ^a   Rechichi, Mariarosa ^a   Salvetti, Alessandra ^a   Lena, Annalisa ^a   Simorini, Francesca ^a   Vanacore, Renato ^b   Scatena, Fabrizio ^b   Da Settimo, Federico ^a   Gremigni, Vittorio ^a   Martini, Claudia ^a  

^a UNIVERSITY OF PISA   (Italy)

^b CISANELLO HOSPITAL   (Italy)

Author keywords

Amides; Apoptosis; DNA damage; Mitochondria; Permeability transition; Receptors

Indexed keywords

ANTINEOPLASTIC AGENT; BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; CASPASE 3; CYTOCHROME C; DNA FRAGMENT; LIGAND; MITOCHONDRIAL BENZODIAZEPINE RECEPTOR; N,N DI N BUTYL 5 CHLORO 2 (4 CHLOROPHENYL)INDOL 3 YLGLYOXYLAMIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CARCINOGENESIS; CELL STRAIN C6; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RELEASE; GLIOMA CELL; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; RECEPTOR BINDING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASES; CELLS, CULTURED; CYTOCHROMES C; CYTOSOL; DNA DAMAGE; GLIOMA; INDOLES; LIGANDS; MEMBRANE POTENTIALS; MITOCHONDRIA; RATS; RECEPTORS, GABA-A; TIME FACTORS;

EID: 20444472408     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200400350     Document Type: Article

References (38)

1. B. Amirlak, W. T. Couldwell, J. Neuro-Oncol. 2003, 63, 129-145.
2. D. R. Green, J. C. Reed, Science 1998, 281, 1309-1312.
3. P. Casellas, S. Galiegue, A. S. Basile, Neurochem. Int. 2002, 40, 475-486.
4. P. J. Marangos, J. Patel, J. P. Boulenger, R. Clark-Rosenberg, Mol. Pharmacol. 1982, 22, 26-32.
5. G. Le Fur, N. Vaucher, M. L. Perrier, A. Flamier, J. Benavides, C. Renault, M. C. Dubroeucq, A. Uzan, Life Sci. 1983, 33, 449-457.
6. D. A. Fennell, M. Corbo, A. Pallaska, F. E. Cotter, Br. J. Cancer 2001, 84, 1397-1404.
7. K. Maaser, M. Hopfner, A. Jansen, G. Weisinger, M. Gavish, A. P. Kozikowski, A. Weizman, P. Carayon, E. O. Riecken, M. Zeitz, H. Scherubl, Br. J. Cancer 2001, 85, 1771-1780.
8. A. P. Sutter, K. Maaser, M. Hopfner, B. Barthel, P. Grabowski, S. Faiss, P. Carayon, M. Zeitz, H. Scherubl, Int. J. Cancer 2002, 102, 318-327.
9. A. P. Sutter, K. Maaser, B. Barthel, H. Scherubl, Br. J. Cancer 2003, 89, 564-572.
10. A. P. Sutter, K. Maaser, B. Gerst, A. Krahn, M. Zeitz, H. Scherubl, Biochem. Pharmacol. 2004, 67, 1701-1710.
11. B. Chelli, A. Lena, R. Vanacore, E. Da Pozzo, B. Costa, L. Rossi, A. Salvetti, F. Scatena, S. Ceruti, M. P. Abbracchio, V. Gremigni, C. Martini, Biochem. Pharmacol. 2004, 68, 125-134.
12. T. Hirsch, D. Decaudin, S. A. Susin, P. Marchetti, N. Larochette, M. Resche-Rigon, G. Kroemer, Exp. Cell Res. 1998, 241, 426-434.
13. D. E. Banker, J. J. Cooper, D. A. Fennell, C. L. Willman, F. R. Appelbaum, F. E. Cotter, Leuk. Res. 2002, 26, 91-106.
14. D. E. Muscarella, K. A. O'Brien, A. T. Lemley, S. E. Bloom, Toxicol. Sci. 2003, 74, 66-73.
15. S. Galiegue, N. Tinel, P. Casellas, Curr. Med. Chem. 2003, 10, 1563-1572.
16. W. Xia, S. Spector, L. Hardy, S. Zhao, A. Saluk, L. Alemane, N. L. Spector, Proc. Natl. Acad. Sci. USA 2000, 97, 7494-7499.
17. G. Primofiore, F. Da Settimo, S. Taliani, F. Simorini, M. P. Patrizi, E. Novellino, G. Greco, E. Abignente, B. Costa, B. Chelli, C. Martini, J. Med. Chem. 2004, 47, 1852-1855.
18. A. P. Kozikowski, D. Ma, J. Brewer, S. Sun, E. Costa, E. Romeo, A. Guidotti, J. Med. Chem, 1993, 36, 2908-2920.
19. W. J. Houlihan, V. A. Parrino, Y. Uike, J. Org. Chem. 1981, 46, 4511-4515.
20. M. Landau, A. Weizman, E. Zoref-Shani, E. Beery, L. Wasseman, O. Landau, M. Gavish, S. Brenner, J. Nordenberg, Biochem. Pharmacol. 1998, 56, 1029-1034.
21. I. Carmel, F. A. Fares, S. Leschiner, H. Scherubl, G. Weisinger, M. Gavish, Biochem. Pharmacol. 1999, 58, 273-278.
22. M. Gavish, I. Bachman, R. Shoukrun, Y. Katz, L. Veenman, G. Weisinger, A. Weizman, Pharmacol. Rev. 1999, 51, 619-640.
23. D. M. Zisterer, G. Campiani, V. Nacci, D. C. Williams, J. Pharmacol. Exp. Ther. 2000, 293, 48-59.
24. E. Hosli, W. Ruhl, L. Hosli, Int. J. Dev. Neurosci. 2000, 18, 101-111.
25. A. M. Gorman, G. B. O'Beirne, C. M. Regan, D. C. Williams, J. Neurochem. 1989, 53, 849-855.
26. D. M. Zisterer, N. Hance, G. Campiani, A. Garofalo, V. Nacci, D. C. Williams, Biochem. Pharmacol. 1998, 55, 397-403.
27. D. Kletsas, W. Li, Z. Han, V. Papadopoulos, Biochem. Pharmacol. 2004, 67, 1927-1932.
28. K. Maaser, A. P. Sutter, A. Krahn, M. Hopfner, P. Grabowski, H. Scherubl, Biochem. Biophys. Res. Commun. 2004, 324, 878-886.
29. M. Hardwick, D. Fertikh, M. Culty, H. Li, B. Vidic, V. Papadopoulos, Cancer Res. 1999, 59, 831-842.
30. R. C. Brown, B. Degenhardt, M. Kotoula, V. Papadopoulous, Cancer Lett. 2000, 156, 125-132.
31. S. Ceruti, D. Barbieri, E. Veronese, F. Cattabeni, A. Cossarizza, A. M. Giammarioli, W. Malorni, C. Franceschi, M. P. Abbracchio, J. Neurosci. Res. 1997, 47, 372-383.
32. S. Shimizu, M. Narita, Y. Tsujimoto, Nature 1999, 399, 483-487.
33. M. W. McEnery, A. M. Snowman, R. R. Trifiletti, S. H. Snyder, Proc. Natl. Acad. Sci. USA 1992, 89, 3170-3174.
34. G. Kroemer, B. Dallaporta, M. Resche-Rigon, Annu. Rev. Physiol. 1998, 60, 619-642.
35. D. Krajci, V. Mares, V. Lisa, A. Spanova, J. Vorlicek, Eur. J. Cell Biol. 2000, 79, 365-376.
36. S. Ruan, M. F. Okcu, R. C. Pong, M. Andreeff, V. Levin, J. T. Hsieh, W. Zhang, Clin. Cancer Res. 1999, 5, 197-202.
37. M. M. Bradford, Anal. Biochem. 1976, 72, 248-254.
38. A. P. Kozikowski, M. Kotoula, D. Ma, N. Boujrad, W. Tuckmantel, V. Papadopoulos, J. Med. Chem. 1997, 40, 2435-2439.