Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3′-azido-2′,3′-dideoxypurine nucleosides

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 3832-3844

  Zhang, Hong Wang ^a   Detorio, Mervi ^a   Herman, Brian D ^b   Solomon, Sarah ^a   Bassit, Leda ^a   Nettles, James H ^a   Obikhod, Aleksandr ^a   Tao, Si Jia ^a   Mellors, John W ^b   Sluis Cremer, Nicolas ^b   Coats, Steven J ^c   Schinazi, Raymond F ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c RFS Pharma LLC   (United States)

Author keywords

3 Azido purine nucleosides; Antiviral agents; HBV; HIV; l Nucleoside analogs

Indexed keywords

3' AZIDO 2',3' DIDEOXY BETA ADENOSINE 5' O [PHENYL (ETHOXY ALANINYL)] PHOSPHATE; 3' AZIDO 2',3' DIDEOXY BETA ADENSOINE; 3' AZIDO 2',3' DIDEOXY BETA GUANOSINE; 9 (3 AZIDO 2,3 DIDEOXY BETA RIBOFURANOSYL) 2 AMINO 6 CHLOROPURINE; 9 (3 AZIDO 2,3 DIDEOXY BETA RIBOFURANOSYL) 2 AMINO 6 CHLOROPURINE 5 O [PHENYL (ETHOXY ALANINYL)] PHOSPHATE; 9 (3 AZIDO 2,3 DIDEOXY BETA RIBOFURANOSYL) 2 AMINO 6 METHOXYPURINE; 9 (3 AZIDO 2,3 DIDEOXY BETA RIBOFURANOSYL) 2,6 DIAMINOPURINE; 9 (3 AZIDO 2,3 DIDEOXY BETA RIBOFURANOSYL) 6 CHLORO 9H PURINE; 9 (3 AZIDO 2,3 DIDEOXY BETA RIBOFURANOSYL) 6 CHLORO 9H PURINE 5' O [PHENYL (ETHOXY L ALANINYL)] PHOSPHATE; 9 (3 AZIDO 2,3 DIDEOXY BETA RIBOFURANOSYL) 6 METHOXYL 9H PURINE; 9 (3 AZIDO 2,3 DIDEOXY BETA RIBOFURANOSYL) 6 METHYLAMINO 9H PURINE; ANTIVIRUS AGENT; LAMIVUDINE; LEVO 3' AZIDO 2',3' DIDEOXYPURINE NUCLEOSIDE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG METABOLISM; DRUG POTENCY; GLYCOSYLATION; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; MICROWAVE RADIATION;

ANTIVIRAL AGENTS; CELL LINE; GLYCOSYLATION; HEPATITIS B VIRUS; HIV-1; HUMANS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MICROWAVES; MODELS, MOLECULAR; NUCLEOSIDES; REVERSE TRANSCRIPTASE INHIBITORS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 80052957754     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.05.051     Document Type: Article

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