메뉴 건너뛰기




Volumn 40, Issue 3, 2006, Pages 472-478

Telbivudine: A novel nucleoside analog for chronic hepatitis B

Author keywords

L thymidine; Hepatitis B; Nucleosides; Telbivudine

Indexed keywords

ADEFOVIR; ALANINE AMINOTRANSFERASE; ANTIVIRUS AGENT; ASPARTATE AMINOTRANSFERASE; DNA POLYMERASE; LAMIVUDINE; NUCLEOSIDE ANALOG; PLACEBO; TELBIVUDINE; THYMIDINE; VIRUS DNA;

EID: 33645048707     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1G027     Document Type: Review
Times cited : (30)

References (35)
  • 1
    • 1542316127 scopus 로고    scopus 로고
    • Hepatitis B virus infection-natural history and clinical consequences
    • Ganem D, Prince AM. Hepatitis B virus infection-natural history and clinical consequences. N Engl J Med 2004;350:1118-29.
    • (2004) N Engl J Med , vol.350 , pp. 1118-1129
    • Ganem, D.1    Prince, A.M.2
  • 2
    • 0023762809 scopus 로고
    • The development of cirrhosis in patients with chronic type B hepatitis: A prospective study
    • Liaw YF, Tai DI, Chu CM, Chen TJ. The development of cirrhosis in patients with chronic type B hepatitis: a prospective study. Hepatology 1988;8:493-6.
    • (1988) Hepatology , vol.8 , pp. 493-496
    • Liaw, Y.F.1    Tai, D.I.2    Chu, C.M.3    Chen, T.J.4
  • 3
    • 0023933449 scopus 로고
    • Hepatitis B virus: The major etiology of hepatocellular carcinoma
    • Beasley RP. Hepatitis B virus: the major etiology of hepatocellular carcinoma. Cancer 1988;61:1942-56.
    • (1988) Cancer , vol.61 , pp. 1942-1956
    • Beasley, R.P.1
  • 4
    • 19944375424 scopus 로고    scopus 로고
    • Lamivudine treatment for acute severe hepatitis B: A pilot study
    • Schmilovitz H, Ben-Ari Z, Sikuler E, et al. Lamivudine treatment for acute severe hepatitis B: a pilot study. Liver Int 2004;24:547-51.
    • (2004) Liver Int , vol.24 , pp. 547-551
    • Schmilovitz, H.1    Ben-Ari, Z.2    Sikuler, E.3
  • 5
    • 0030707941 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Lee WM. Hepatitis B virus infection. N Engl J Med 1997;337:1733-45.
    • (1997) N Engl J Med , vol.337 , pp. 1733-1745
    • Lee, W.M.1
  • 6
    • 0027378724 scopus 로고
    • Effect of alpha-interferon in patients with hepatitis Be antigen-positive chronic hepatitis B: A meta-analysis
    • Wong DK, Cheung AM, O'Rourke K, Naylor CD, Detsky AS, Heathcote J. Effect of alpha-interferon in patients with hepatitis Be antigen-positive chronic hepatitis B: a meta-analysis. Ann Intern Med 1993;119:312-23.
    • (1993) Ann Intern Med , vol.119 , pp. 312-323
    • Wong, D.K.1    Cheung, A.M.2    O'Rourke, K.3    Naylor, C.D.4    Detsky, A.S.5    Heathcote, J.6
  • 7
    • 0025347975 scopus 로고
    • A randomized, controlled trial of interferon alfa-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B
    • Perillo RP, Schiff ER, Davis GL, et al. A randomized, controlled trial of interferon alfa-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B. N Engl J Med 1990;323:295-301.
    • (1990) N Engl J Med , vol.323 , pp. 295-301
    • Perillo, R.P.1    Schiff, E.R.2    Davis, G.L.3
  • 8
    • 19944428132 scopus 로고    scopus 로고
    • Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: A randomised trial
    • Janssen HL, van Zonneveld M, Senturk H, et al. Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial. Lancet 2005;365:123-9.
    • (2005) Lancet , vol.365 , pp. 123-129
    • Janssen, H.L.1    Van Zonneveld, M.2    Senturk, H.3
  • 9
    • 4544239807 scopus 로고    scopus 로고
    • Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B
    • Marcellin P, Lau GK, Bonino F, et al. Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B. N Engl J Med 2004;351:1206-17.
    • (2004) N Engl J Med , vol.351 , pp. 1206-1217
    • Marcellin, P.1    Lau, G.K.2    Bonino, F.3
  • 10
    • 0033592764 scopus 로고    scopus 로고
    • Lamivudine as initial treatment for chronic hepatitis B in the United States
    • Dienstag JL, Schiff ER, Wright TL, et al. Lamivudine as initial treatment for chronic hepatitis B in the United States. N Engl J Med 1999;341: 1256-63.
    • (1999) N Engl J Med , vol.341 , pp. 1256-1263
    • Dienstag, J.L.1    Schiff, E.R.2    Wright, T.L.3
  • 11
    • 0034235528 scopus 로고    scopus 로고
    • Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B
    • Liaw YF, Cheung NW, Chang TT, et al. Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Gastroenterology 2000;119:172-80.
    • (2000) Gastroenterology , vol.119 , pp. 172-180
    • Liaw, Y.F.1    Cheung, N.W.2    Chang, T.T.3
  • 12
    • 0033839986 scopus 로고    scopus 로고
    • Acute exacerbation of chronic hepatitis B virus infection after withdrawal of lamivudine therapy
    • Honkoop P, de Man RA, Niesters HO, Zondervan PE, Schalm SW. Acute exacerbation of chronic hepatitis B virus infection after withdrawal of lamivudine therapy. Hepatology 2000;32:635-9.
    • (2000) Hepatology , vol.32 , pp. 635-639
    • Honkoop, P.1    De Man, R.A.2    Niesters, H.O.3    Zondervan, P.E.4    Schalm, S.W.5
  • 13
    • 0037468421 scopus 로고    scopus 로고
    • Adefovir dipivoxil for the treatment of hepatitis Be antigen-positive chronic hepatitis B
    • Marcellin P, Chang TT, Lim SG, et al. Adefovir dipivoxil for the treatment of hepatitis Be antigen-positive chronic hepatitis B. N Engl J Med 2003;348:808-16.
    • (2003) N Engl J Med , vol.348 , pp. 808-816
    • Marcellin, P.1    Chang, T.T.2    Lim, S.G.3
  • 14
    • 0037468406 scopus 로고    scopus 로고
    • Adefovir dipivoxil for the treatment of hepatitis Be antigen-negative chronic hepatitis B
    • Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, et al. Adefovir dipivoxil for the treatment of hepatitis Be antigen-negative chronic hepatitis B. N Engl J Med 2003;348:800-7.
    • (2003) N Engl J Med , vol.348 , pp. 800-807
    • Hadziyannis, S.J.1    Tassopoulos, N.C.2    Heathcote, E.J.3
  • 15
    • 0031761652 scopus 로고    scopus 로고
    • In vitro inhibition of hepadnavirus polymerases by the triphosphates of BMS-200475 and lobucavir
    • Seifer M, Hamatake RK, Colonno RJ, Standring DN. In vitro inhibition of hepadnavirus polymerases by the triphosphates of BMS-200475 and lobucavir. Antimicrob Agents Chemother 1998;42:3200-8.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 3200-3208
    • Seifer, M.1    Hamatake, R.K.2    Colonno, R.J.3    Standring, D.N.4
  • 17
    • 0035172399 scopus 로고    scopus 로고
    • Antiviral β-L-nucleosides specific for hepatitis B virus infection
    • Bryant ML, Bridges EG, Placidi L, et al. Antiviral β-L-nucleosides specific for hepatitis B virus infection. Antimicrob Agents Chemother 2001;45:229-35.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 229-235
    • Bryant, M.L.1    Bridges, E.G.2    Placidi, L.3
  • 18
    • 0030988492 scopus 로고    scopus 로고
    • Stereoisomers of deoxynucleoside 5′-triphosphates as substrates for template-dependent and -independent DNA polymerase
    • Semizarov DG, Arzumanov AA, Dyatkina NB, et al. Stereoisomers of deoxynucleoside 5′-triphosphates as substrates for template-dependent and -independent DNA polymerase. J Biol Chem 1997;272:9556-60.
    • (1997) J Biol Chem , vol.272 , pp. 9556-9560
    • Semizarov, D.G.1    Arzumanov, A.A.2    Dyatkina, N.B.3
  • 19
    • 0026799290 scopus 로고
    • Zalcitabine. A review of its pharmacology and clinical potential in acquired immunodeficiency syndrome (AIDS)
    • Whittington R, Brogden RN. Zalcitabine. A review of its pharmacology and clinical potential in acquired immunodeficiency syndrome (AIDS). Drugs 1992;44:656-83.
    • (1992) Drugs , vol.44 , pp. 656-683
    • Whittington, R.1    Brogden, R.N.2
  • 20
    • 0027380603 scopus 로고
    • Zidovudine. An update of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy
    • Wilde IM, Langtry HD. Zidovudine. An update of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs 1993;46: 515-78.
    • (1993) Drugs , vol.46 , pp. 515-578
    • Wilde, I.M.1    Langtry, H.D.2
  • 21
    • 0033604038 scopus 로고    scopus 로고
    • Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy
    • Brinkman K, Smeitink JA, Romijn JA, Reiss P. Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy. Lancet 1999;354:1112-5.
    • (1999) Lancet , vol.354 , pp. 1112-1115
    • Brinkman, K.1    Smeitink, J.A.2    Romijn, J.A.3    Reiss, P.4
  • 22
    • 7644230488 scopus 로고    scopus 로고
    • Pharmacokinetics of beta-L-deoxythymidine (LdT) in healthy subjects and patients with chronic hepatitis B virus infection
    • Hep-Dart abstracts
    • Zhou XJ, Lim SG, Lai CL, Pow DM, Brown NA, Myers MW. Pharmacokinetics of beta-L-deoxythymidine (LdT) in healthy subjects and patients with chronic hepatitis B virus infection (abstract). Antiviral Res 2001;Hep-Dart abstracts:92.
    • (2001) Antiviral Res , pp. 92
    • Zhou, X.J.1    Lim, S.G.2    Lai, C.L.3    Pow, D.M.4    Brown, N.A.5    Myers, M.W.6
  • 23
    • 4544271613 scopus 로고    scopus 로고
    • A dose-finding study of once-daily oral telbivudine in HBeAg-positive patients with chronic hepatitis B virus infection
    • DOI 10.1002/hep.2037
    • Lai CL, Lim SG, Brown NA, et al. A dose-finding study of once-daily oral telbivudine in HBeAg-positive patients with chronic hepatitis B virus infection. Hepatology 2004;40:719-26. DOI 10.1002/hep.2037
    • (2004) Hepatology , vol.40 , pp. 719-726
    • Lai, C.L.1    Lim, S.G.2    Brown, N.A.3
  • 24
    • 19044397678 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of telbivudine, a potent antiviral for hepatitis B, in subjects with impaired hepatic or renal function
    • Zhou XJ, Myers M, Chao G, Dubuc G, Brown NA. Clinical pharmacokinetics of telbivudine, a potent antiviral for hepatitis B, in subjects with impaired hepatic or renal function (abstract). J Hepatol 2004;40 (suppl 1):S134.
    • (2004) J Hepatol , vol.40 , Issue.SUPPL. 1
    • Zhou, X.J.1    Myers, M.2    Chao, G.3    Dubuc, G.4    Brown, N.A.5
  • 25
    • 0036093269 scopus 로고    scopus 로고
    • Dose range study of pharmacokinetics, safety, and preliminary antiviral activity of emtricitabine in adults with hepatitis B virus infection
    • Gish RG, Leung NW, Wright TL, et al. Dose range study of pharmacokinetics, safety, and preliminary antiviral activity of emtricitabine in adults with hepatitis B virus infection. Antimicrob Agents Chemother 2002;46: 1734-40.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 1734-1740
    • Gish, R.G.1    Leung, N.W.2    Wright, T.L.3
  • 28
    • 5044225255 scopus 로고    scopus 로고
    • Kinetics of hepatitis B viral load during 48 weeks of treatment with 600 mg vs 100 mg of lamivudine daily
    • Wang CC, Holte S, Huang ML, et al. Kinetics of hepatitis B viral load during 48 weeks of treatment with 600 mg vs 100 mg of lamivudine daily. J Viral Hepatitis 2004;11:443-7.
    • (2004) J Viral Hepatitis , vol.11 , pp. 443-447
    • Wang, C.C.1    Holte, S.2    Huang, M.L.3
  • 29
    • 0033029334 scopus 로고    scopus 로고
    • Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy
    • Tsiang M, Rooney JF, Toole JJ, Gibbs CS. Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy. Hepatology 1999;29:1863-9.
    • (1999) Hepatology , vol.29 , pp. 1863-1869
    • Tsiang, M.1    Rooney, J.F.2    Toole, J.J.3    Gibbs, C.S.4
  • 30
    • 0035991456 scopus 로고    scopus 로고
    • Viral dynamics during and after entecavir therapy in patients with chronic hepatitis B
    • Wolters LM, Hansen BE, Niesters HG, De Hertogh D, de Man RA. Viral dynamics during and after entecavir therapy in patients with chronic hepatitis B. J Hepatol 2002;37:137-44.
    • (2002) J Hepatol , vol.37 , pp. 137-144
    • Wolters, L.M.1    Hansen, B.E.2    Niesters, H.G.3    De Hertogh, D.4    De Man, R.A.5
  • 31
    • 20944447451 scopus 로고    scopus 로고
    • Results of a one-year international phase IIb trial of LdT, and LdT plus lamivudine, in patients with chronic hepatitis B
    • Han SH, Leung NY, Teo EK, et al. Results of a one-year international phase IIb trial of LdT, and LdT plus lamivudine, in patients with chronic hepatitis B (abstract). J Hepatol 2004;40(suppl 1):S16.
    • (2004) J Hepatol , vol.40 , Issue.SUPPL. 1
    • Han, S.H.1    Leung, N.Y.2    Teo, E.K.3
  • 32
    • 4744350764 scopus 로고    scopus 로고
    • Combinations of adefovir with nucleoside analogs produce additive antiviral effects against hepatitis B virus in vitro
    • Delaney WE, Yang H, Miller MD, Gibbs CS, Xiong S. Combinations of adefovir with nucleoside analogs produce additive antiviral effects against hepatitis B virus in vitro. Antimicrob Agents Chemother 2004; s48:3702-10.
    • (2004) Antimicrob Agents Chemother , vol.S48 , pp. 3702-3710
    • Delaney, W.E.1    Yang, H.2    Miller, M.D.3    Gibbs, C.S.4    Xiong, S.5
  • 33
    • 19044384326 scopus 로고    scopus 로고
    • Improving antiviral therapy in chronic hepatitis B: Maximal viral suppression at week 24 correlates with better clinical efficacy at one year
    • Poynard T, Lai CL, Leung NY, et al. Improving antiviral therapy in chronic hepatitis B: maximal viral suppression at week 24 correlates with better clinical efficacy at one year (abstract). J Hepatol 2004;40 (suppl 1):S130.
    • (2004) J Hepatol , vol.40 , Issue.SUPPL. 1
    • Poynard, T.1    Lai, C.L.2    Leung, N.Y.3
  • 34
    • 0141464269 scopus 로고    scopus 로고
    • Lamivudine-resistant HBV is cross-resistant to LdT and LcT in vitro
    • Delaney W, Yang H, Miller M, Gibbs C, Xiong S. Lamivudine-resistant HBV is cross-resistant to LdT and LcT in vitro. J Hepatol 2002;36(suppl 1):89.
    • (2002) J Hepatol , vol.36 , Issue.SUPPL. 1 , pp. 89
    • Delaney, W.1    Yang, H.2    Miller, M.3    Gibbs, C.4    Xiong, S.5
  • 35
    • 33644481515 scopus 로고    scopus 로고
    • Absence of pharmacokinetic drug-drug interaction between telbivudine and lamivudine or adefovir in healthy subjects
    • Zhou XJ, Lloyd DM, Fielman BA, Maureen MW, Chao C. Absence of pharmacokinetic drug-drug interaction between telbivudine and lamivudine or adefovir in healthy subjects (abstract). J Hepatol 2005;40(suppl 2):S197-8.
    • (2005) J Hepatol , vol.40 , Issue.SUPPL. 2
    • Zhou, X.J.1    Lloyd, D.M.2    Fielman, B.A.3    Maureen, M.W.4    Chao, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.